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| 1 | Orthopedic surgery and its complication in systemic lupus erythematosus显示文摘Systemic lupus erythematosus(SLE) is a multi-systemic immune-complex mediated autoimmune condition which chiefly affects women during their prime year. While the management of the condition falls into the specialty of internal medicine, patients with SLE often present with signs and symptoms pertaining to the territory of orthopedic surgery such as tendon rupture, carpal tunnel syndrome, osteonecrosis, osteoporotic fracture and infection including septic arthritis, osteomyelitis and spondylodiscitis. While these orthopedicrelated conditions are often debilitating in patients with SLE which necessitate management by orthopedic specialists, a high index of suspicion is necessary in diagnosing these conditions early because lupus patients with potentially severe orthopedic conditions such as osteomyelitis frequently present with mild symptoms and subtle signs such as low grade fever, mild hip pain and back tenderness. Additionally, even if these orthopedic conditions can be recognized, complications as a result of surgical procedures are indeed not uncommon. SLE per se and its various associated pharmacological treatments may pose lupus patients to certain surgical risks if they are not properly attended to andmanaged prior to, during and after surgery. Concerted effort of management and effective communication among orthopedic specialists and rheumatologists play an integral part in enhancing favorable outcome and reduction in postoperative complications for patients with SLE through thorough pre-operative evaluation, careful peri-operative monitoring and treatment, as well as judicious postoperative care. | Anselm Mak | 2014 | World Journal of Orthopedics2014，5，1： | 1 |
| 2 | Costimulatory Pathways: Physiology and Potential Therapeutic Manipulation in Systemic Lupus Erythematosus显示文摘 | Nien Yee Kow Anselm Mak Guixiu Shi | 2013 | Clinical and Developmental Immunology2013，，： | 1 |
| 3 | Is High Homocysteine Level a Risk Factor for Cognitive Decline in Elderly? A Systematic Review, Meta-Analysis, and Meta-Regression显示文摘 | Roger C. M. Ho Mike W. L. Cheung Erin Fu Hlaing H. Win Min Htet Zaw Amanda Ng Anselm Mak | 2011 | American Journal of Geriatric Psychiatry2011，，7： | 1 |
| 4 | Costimulatory Pathways: Physiology and Potential Therapeutic Manipulation in Systemic Lupus Erythematosus显示文摘 | Nien Yee Kow Anselm Mak Guixiu Shi | 2013 | <journal-title>Clinical and Developmental Immunology2013，，： | 1 |
| 5 | CD137L,a driver of harmful inflammation in the nervous system显示文摘CD137 (TNFRSF9,4-1BB) is a member of the tumor necrosis factor (TNF) receptor family and a potent costimulatory molecule.High levels of CD137 are expressed on T cells upon activation.CD137 signaling in T cells,either by cognate interaction with antigen-presenting cells (APC)or by agonistic anti-CD137 antibodies,strongly enhances proliferation,interferon-y secretion,and cytolytic activity of T cells.Thus,CD137 signaling is a main driver of cellular,type 1 helper T cells (Th1)and type 1 cytolytic T cells (Tc1) polarised immune responses. | Hiu Yi Wong Amanda C.Y.Chan Anselm Mak Herbert Schwarz | 2023 | Neural Regeneration Research2023，18，11： | 0 |
| 6 | 汞中毒显示文摘2008年5月,MOL船运公司一位59岁的财务官员就座时不慎跌落在地。他似乎并无严重损伤,但出现下背痛,被送来我院急诊科。接诊医生未发现躯体损伤迹象,腰椎影像检查未见异常。但是患者一直诉说下背痛。他认为自己仍在办公室内,且不能回忆起自己的姓名。血液检查和心电图均正常;未服用任何处方药或违禁药物。无其他明显病史。该患者被转入精神科病房。 | Roger C M Ho Stanley Y W Lam Evangeline S L Tan Pamela M Y Ng Anselm Mak 雷革胜(译) | 2009 | 世界临床医学2009，，11： | 0 |
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