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| 1 | Relationship between the exocrine and endocrine pancreas after acute pancreatitis显示文摘AIM:To determine the prevalence and time course of pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.METHODS:Relevant literature cited in three major biomedical journal databases(EMBASE,MEDLINE,and Scopus)was reviewed independently by two authors.There were no language constraints but the search was limited to human studies.Studies included were cohort studies of adult patients who were discharged after an attack of acute pancreatitis.Patients were excluded if they were under 18 years of age or had a previous diagnosis of prediabetes or diabetes mellitus,pancreatic exocrine insufficiency,or chronic pancreatitis.The main outcome measure was the prevalence of concomitant pancreatic exocrine insufficiency in patients who were diagnosed with prediabetes and diabetes mellitus after an attack of acute pancreatitis.Subgroup analysis was conducted for patients who were diagnosed with prediabetes only and those who were diagnosed withdiabetes mellitus only.Subgroup analysis looking at the time course of concomitant pancreatic exocrine and endocrine insufficiency was also conducted.Pooled prevalence and corresponding 95%confidence intervals were calculated for all outcome measures and P-values<0.05 were deemed statistically significant.RESULTS:Eight clinical studies comprising of 234patients met all eligibility criteria.The pooled prevalence of newly diagnosed prediabetes or diabetes in individuals after acute pancreatitis was 43%(95%CI:30%-56%).The pooled prevalence of pancreatic exocrine insufficiency in individuals after acute pancreatitis was 29%(95%CI:19%-39%).The prevalence of concomitant pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes was 40%(95%CI:25%-55%).The prevalence of concomitant pancreatic exocrine insufficiency among individuals with prediabetes alone and diabetes mellitus alone was 41%(95%CI:12%-75%)and 39%(95%CI:28%-51%),respectively.Further analysis showed that the prevalence of concomitant pancreatic exocrine insufficiency in individuals with prediabetes or diabetes decreases over time after an attack of acute pancreatitis.CONCLUSION:Pancreatic exocrine insufficiency occurs in 40%of individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.Further studies are needed to investigate the pathogenesis of diabetes in this setting. | Stephanie L M Das James I C Kennedy Rinki Murphy Anthony R J Phillips John A Windsor Maxim S Petrov | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 2 | JAK2转基因骨髓造血干/祖细胞体外长期扩增调控及定向分化的研究显示文摘目的 探讨酪氨酸激酶JAK2转基因骨髓造血干 祖细胞体外长期扩增调控和定向分化潜能的可行性。方法 克隆了一个MSCV based逆转录病毒载体称作MGI F2Jak2 ,它编码一个绿色荧光蛋白 (GFP)和两个改进的FK5 0 6结合蛋白 (F36v)与JAK2组成的融合蛋白 ,F36v是二聚化化学诱导物AP2 0 187的结合位点。应用该载体转染GpE +86包装细胞株 ,将C5 7BL 6小鼠的骨髓细胞与照射过15 0 0cGy的GpE +86产毒细胞株共同培养实现基因转导。转导后的细胞在X VIVO 15培养体系中扩增 ,分为①空白对照组 ;②AP2 0 187组 ;③干细胞因子 (SCF)组 ;④AP2 0 187+SCF组。扩增的细胞用直接法标记藻红蛋白荧光素 (PE)结合的抗Sca1、c kit、CD34 、Gr1、CD1 1b、TER 119、CD4 1 、B2 2 0和CD3单克隆抗体以流式细胞仪检测 ,并进行定向分化、祖细胞集落培养和脾细胞集落形成单位 (CFU S)的研究。结果 只有AP2 0 187+SCF组可以持续地使转基因的骨髓造血干 祖细胞大量增殖 ,扩增 80d后细胞可达10 1 4倍 ,细胞倍增时间约 30h ,扩增细胞的表型为CD34 、c kit和Sca1等干细胞表面标志强阳性 ,其它细胞表面标志如Gr1、CD1 1b、TER119、CD4 1 、B2 2 0、CD3接近阴性。所扩增的细胞在不同的细胞因子组合下 ,可定向分化为粒细胞、巨噬细胞、红细胞、 | 赵声明 顾惜春 常乃柏 Tim Clackson C Anthony Blau | 2004 | 中华血液学杂志2004，25，2： | 8 |
| 3 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 4 | Twenty-five years of research on the effects of exercise training in breast cancer survivors:A systematic review of the literature显示文摘AIM:To investigate the role of exercise training the past 25 years on major physiological-psychological outcomes studied thus far in this patient population.METHODS:Pub Med, Medline Plus, the Cochrane Library, Web of Science, SportD iscus, Embase, Scorpus, and Google Scholar were searched from September to November 2013 to identify exercise training studies that used objective measurements of fitness and/or patient reported outcomes assessed pre and post-exercise training with statistical analyses performed in at least one of the following outcome measurements:Cardiorespiratory function, body composition, muscular strength, fatigue, depression, and overall quality of life. Five reviewers independently identified the studies that met the criteria for the review and discrepancies were resolved by consensus among all authors.RESULTS:Fifty-one studies were included in this review with 5 from the period between 1989-1999, 11 from 2000-2006, and 35 from 2007-2013. The evolution of study designs changed from aerobic only exercise training interventions(1989-1999), to a combination of aerobic and resistance training(2000-2006), to studies including an arm of resistance training or examining the effects of resistance training as the main mode of exercise(2007-2013). Overall, the benefits of exercise showed improvements in cardiorespiratory function, body composition, strength, and patient reported outcomes including fatigue, depression, and quality of life.CONCLUSION:Exercise training appears to be safe for most breast cancer patients and improvements in physiological, psychological, and functional parameters can be attained with regular participation in moderate intensity exercise. | Claudio L Battaglini Robert C Mills Brett L Phillips Jordan T Lee Christina E Story Marcelo GB Nascimento Anthony Carl Hackney | 2014 | World Journal of Clinical Oncology2014，5，2： | 3 |
| 5 | Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis显示文摘 | Benjamin MP Tang Guy D Eslick Jonathan C Craig Anthony S McLean | 2007 | The Lancet Infectious Diseases2007，，3： | 3 |
| 6 | Fate and Transport of Antibiotic Residues and Antibiotic Resistance Genes following Land Application of Manure Waste显示文摘 | Chee-Sanford Joanne C Mackie Roderick I Koike Satoshi Krapac Ivan G Lin Yu-Feng Yannarell Anthony C Maxwell Scott Aminov Rustam I | 2009 | Journal of Environmental Quality2009，，3： | 3 |
| 7 | The impact of patient age and aortic size on the results of aortobifemoral bypass grafting 1 1 Competition of interest: none. Published online Mar 6, 2003显示文摘 | Amy B Reed Michael S Conte Magruder C Donaldson John A Mannick Anthony D Whittemore Michael Belkin | 2003 | Journal of Vascular Surgery2003，，： | 2 |
| 8 | An evidence-based clinical guideline for the diagnosis and treatment of lumbar disc herniation with radiculopathy显示文摘 | D. Scott Kreiner Steven W. Hwang John E. Easa Daniel K. Resnick Jamie L. Baisden Shay Bess Charles H. Cho Michael J. DePalma Paul Dougherty Robert Fernand Gary Ghiselli Amgad S. Hanna Tim Lamer Anthony J. Lisi Daniel J. Mazanec Richard J. Meagher Robert C | 2014 | The Spine Journal2014，，： | 2 |
| 9 | Glutathione- S -transferase family of enzymes显示文摘 | Richard C Strange Monica A Spiteri Sudarshan Ramachandran Anthony A Fryer | 2001 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2001，，1： | 2 |
| 10 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 11 | Limits of the ' Mini-Mental State' as a screening test for dementia and delirium among hospital patients显示文摘 | Anthony J C LeResche L | 1982 | Psychol Med1982，12，2： | 1 |
| 12 | Sorbent cost and performance in CO2 capture systems显示文摘 | Abanades J C Rubin E S Anthony E J | 2004 | Industrial & Engineering ChemistryResearch2004，43，13： | 1 |
| 13 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 14 | Interleukin-1β-induced changes in blo-od-brain barrier permeability,apparent diffusion coefficient,and cerebral blood volume in the rat brain:a magnetic resonce study 显示文摘 | Blamire A M Anthony D C Rajagpalan B | 2000 | J Neurosci2000，20，21： | 1 |
| 15 | Why is CO2 so soluble in imidazolium-based ionic liquids显示文摘 | Caser C Anthony J L Shah J K | 2004 | Journal of the American Chemical Society2004，126，16： | 1 |
| 16 | Total gastrectomy:options for the restoration of gastrointestinal continuity显示文摘 | Chin Anthony C Espat NJ | 2003 | Lancet Oncol2003，4，5： | 1 |
| 17 | Hotelling's 'Economics of Exhaustible Resources ' : Fifty Years Later 显示文摘 | Shantayanan Devarajan Fisher Anthony C | 1981 | Journal of Economic Literature1981，19，1： | 1 |
| 18 | Business Sustain- ability Performance and Cost of Equity Capital 显示文摘 | Anthony C Ng Zabihollah Rezaee | 2015 | Jour- nal of Corporate Finanee2015，34，： | 1 |
| 19 | Analysis of regulation and policy o private toll roads in a build-operate-transfer scheme under demand uncertainty 显示文摘 | Anthony C Kitti S | 2007 | Transportation Research Part A:Policy and Practice2007，41，6： | 1 |
| 20 | Tumor targeting by conjugation of DHA to paclitaxel显示文摘 | Bradley M O Stindell C S Anthony F H | 2001 | Control Release2001，74，13： | 1 |
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