|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 2 | Removal of natural organic matter from drinking water by advanced oxidation processes 显示文摘 | Anu M Mika S | 2010 | Chemosphere2010，80，： | 1 |
| 3 | Synthesis of mesostructured polyaniline using mixed surfactants, anionic sodium dodecylsulfate and non-ionic polymers and their applications in H2O2 and glucose sensing 显示文摘 | Anu Prathap M U Thakur B Sawant S N | 2012 | Colloids and Surfaces B: Biointerfaces2012，89，： | 1 |
| 4 | Pain intensity and pain relief after surgery 显示文摘 | K LOPFENSTE IN CE HERM ANU FR M ANIE C | 2000 | Aeta Anaesthesthesiol Scand2000，44，1： | 1 |
| 5 | Calreticulin mediated glucocorticoid receptor export is involved in β-catenin translocation and Wnt signaling inhibition in human osteoblastic cells显示文摘 | Anu O Anitta M | | 0，，： | 1 |
| 6 | Performance analysis of the minimum variance beamformer显示文摘 | WAX M ANU Y | 1996 | IEEE Trans Signal Processing1996，44，4： | 1 |
| 7 | Integraas a dermal replacement in a meshed composite skingraft in a rat model:a one-step operativep rocedure显示文摘 | Chu CS M cM anus AT Matylevich NP | 2005 | J Trauma2005，52，1： | 1 |
| 8 | Motion tracking with an active camera显示文摘 | DON M ANU P B | 1993 | IEEE Trans PAMI1993，16，5： | 1 |
| 9 | Natural organic matter removal by coagulation during drinking water treatment: A review 显示文摘 | ANU M MIKKO V MIKA S | 2010 | Advances In Colloid And Interface Science2010，，159： | 1 |
| 10 | Polyaniline-based highly sensitive microbial biosensor for selective detection of lindane显示文摘 | Anu Prathap M U Akhilesh Kumar Chaurasia Shilpa N Sawant et a1 | 2012 | Anal Chern2012，84，： | 1 |
| 11 | Removal of NOM in the different stages of the water treatment process显示文摘 | Anu M Niina L Susanna K | 2002 | Environment International2002，28，： | 1 |
| 12 | Continuous glucose monitoring in medical intensive careunit 显示文摘 | de Block CEM M anuely Keenoy B van Gaal LF | 2005 | Continuous Glucose Monitoring2005，37，： | 1 |
| 13 | Links between plant community composition, soil organic matter quality and microbial communities in contrasting tundra habitats显示文摘 | Anu Eskelinen Sari Stark Minna M?nnist? | 2009 | Oecologia2009，，1： | 1 |
| 14 | Bcl - 2 expression in neuronal cells blocks activiation of ICE/CED - 3 family protease during apoptosis显示文摘 | ANU S LYNDON M F MARRIA P T | 1996 | J Neurosci1996，16，18： | 1 |
| 15 | Performance Analysis of the Minimum Variance Beamformer 显示文摘 | Wax M Anu Y | 1996 | IEEE Trans on SP1996，44，4： | 1 |
| 16 | Is it wise not to think about intraabdom inalhyper- tension in the ICU 显示文摘 | Malbrain M anu LNG | 2004 | Current Opinion in Critical Care2004，10，2： | 1 |
| 17 | Constitutive expression of the cold - regulated Arabidopsis thaliana CORI5a gene affects both chloroplast freezing tolerance显示文摘 | Anus NN Oemura M Steponkus P L et d | 1996 | Plant Biology1996，93，13： | 1 |
| 18 | A new gypsum-based ??technique to reduce methane and phophorus release from sediments of eutrophied lakes:(Gypsum treatment to reduce internal loading)显示文摘 | Eila V Anu L Veli P S Pertti J M | 2003 | Water Research2003，37，1： | 1 |
| 19 | Links between plant community composition, soil organic matter quality and microbial communities in contrasting tundra habitats显示文摘 | Anu Eskelinen Sari Stark Minna Männistö | 2009 | Oecologia2009，，1： | 1 |
| 20 | Performance analysis of the minimum variance beamformer显示文摘 | Wax M Anu Y | 1996 | IEEE Trans Signal Processing1996，44，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员