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| 1 | Interaction of multi-walled carbon nanotubes and zinc ions enhances cytotoxicity of zinc ions显示文摘More and more nanomaterials enter the environment along with their production, application and deposal. They may alter the biological effect of pollutants already existing in the real environment by different interactions. Therefore efforts should also be paid to investigate the combined toxicity of nanomaterials and pollutants. Herein, we studied the combined toxicity of oxidized multi-walled carbon nanotubes(O-MWCNTs) and zinc ions on cells. It is found that cytotoxicity of the combined O-MWCNTs and zinc ions elevates significantly, compared with O-MWCNTs or zinc ions alone. This result comes from the assays of cell morphology, cell viability and proliferation, cell membrane integrity, mitochondrial membrane potential and cell apoptosis. Mechanism studies indicate that O-MWCNTs absorb zinc ions and form slight aggregation. These enhance remarkably the cellular uptake of O-MWCNTs, and thus induce the death of cells by bringing in more zinc ions into cells. Our study indicates that the existence of nanomaterials could change the bioconsequence of other pollutants and emphasizes the importance of the combined toxicity research in the presence of nanomaterials. | Lin Wang Jia-Hui Liu Zheng-Mei Song Yi-Xin Yang Aoneng Cao Yuanfang Liu Haifang Wang | 2016 | Science China Chemistry2016，59，7： | 2 |
| 2 | Stable isotope labeling of nanomaterials for biosafety evaluation and drug development显示文摘Quantitative information,such as environmental migration,absorption,biodistribution,biotransformation,and elimination,is fundamental and essential for the nanosafety evaluations of nanomaterials.Due to the complexity of biological and environmental systems,it is challenging to develop quantitative approaches and tools that could characterize intrinsic behaviors of nanomaterials in the organisms.The isotopic tracers are ideal candidates to tune the physical properties of nanomaterials while preserving their chemical properties.In this review article,we summarized the stable isotope labeling methods of nanomaterials for evaluating their environmental and biological effects.The skeleton labeling protocols of carbon nanomaterials and metal/metal oxide nanoparticles were introduced.The advantages and disadvantages of stable isotope labeling were discussed in comparison with other quantitative methods for nanomaterials.The quantitative information of nanomaterials in environmental and biological systems was summarized along with the biosafety data.The benefits for drug development of nanomedicine were analyzed based on the targeting effects,persistent accumulation,and safety.Finally,the challenges and future perspectives of stable isotope labeling in nanoscience and nanotechnology were discussed. | Xue-Ling Chang Lingyun Chen Boning Liu Sheng-Tao Yang Haifang Wang Aoneng Cao Chunying Chen | 2022 | Chinese Chemical Letters2022，33，7： | 2 |
| 3 | High activity of Mj HSP16.5 under acidic condition显示文摘Small heat shock proteins (sHSPs) exist ubiquitously among all organisms, with a variety of functions. All small heat shock proteins assemble into a native large oligomeric state containing 9-40 monomers. The sHSPs show chaperone-like activity to prevent the aggregation of nonnative proteins under stressful cellular conditions such as non-optimal temperatures, pH changes, osmotic pressure, and exposure to toxic chemicals. It was found that a common dimeric subunit of sHSPs might be the major active species, but whether the native large oligomeric state is only a storage state or a state crucial to its molecular chaperone activity is still under debate. The native large oligomeric state of the small heat shock protein from a hyperthermophilic methanarchaeon, Methanococcus jannaschii (Mj HSP 16.5), is a stable icositetramer, which is a symmetric hollow sphere that is very stable even at 85℃, and no small active subunit has been detected till now. Our results show that Mj sHSP 16.5 changes into small and active oligomeric state at pH 3, likely as octamers (average result) at 25℃, and dimers at 65℃. The dimer of Mj HSP 16.5 at pH 3.0 and 65℃ is very active and efficient, even 7-fold more efficient than the high-temperature-activated icositetramer at neutral pH. Monomer exchange can be observed between dimers of Mj HSP 16.5 at pH 3.0 and 65℃. These results not only demonstrate that the icositetramer structure of Mj sHSP16.5 is not necessary for its molecular chaperone activity, but also suggest that Mj sHSP16.5 is a very efficient chaperone acting at high temperature and under the acidic condition. Even though it is not clear whether the native environment of Methanococcus jannaschii is acidic or not, given its ability to excrete acidic compounds, it is likely that Methanococcus jannaschii will encounter acidic internal or external environments at high temperature. Our results demonstrate that Mj HSP 16.5 may help Methanococcus jannaschii to survive better under those extreme environmental conditions. | WANG Zheng CAO AoNeng LAI LuHua | 2009 | Science China Chemistry2009，52，3： | 1 |
| 4 | 显示文摘 | LU Punchao CAO Aoneng LI Luhua | 2007 | Colloids Surf:A2007，292，： | 1 |
| 5 | Interactions of β- lactoglobulin with sodium decylsulfonate, decyhriethylammonium bromide, and their mixtures 显示文摘 | LU RUNCHAO CAO AONENG LAI LUHUA | 2006 | Journal of Colloid & Interface Science2006，299，2： | 1 |
| 6 | A facile one-step method to produce gra- pbene-CdS quantum dot nanocomposites as promising optoe- lectronie materials显示文摘 | Cao Aoneng | 2010 | Adv Mater2010，22，1： | 1 |
| 7 | In vitro toxicity evaluation of graphene oxide on A549 cells显示文摘 | Yanli Chang Sheng-Tao Yang Jia-Hui Liu Erya Dong Yanwen Wang Aoneng Cao Yuanfang Liu Haifang Wang | 2010 | Toxicology Letters2010，，3： | 1 |
| 8 | A facile onestep method to produce grapheme-CdS quantum dot nanocomposites as promising optoelectronic materials 显示文摘 | Cao Aoneng Liu Zhen Chu Saisai | 2010 | Adv Mater2010，22，： | 1 |
| 9 | Evaluation of the toxicity of food additive silica nanoparticles on gastrointestinal cells显示文摘 | Yi‐Xin Yang Zheng‐Mei Song Bin Cheng Kun Xiang Xin‐Xin Chen Jia‐Hui Liu Aoneng Cao Yanli Wang Yuanfang Liu Haifang Wang | 2014 | J Appl Toxicol2014，，4： | 1 |
| 10 | Silica nanoparticle with a single His-tag for addressable functionalization, reversible assembly, and recycling显示文摘 | Yuye Cao Yangdong Cui Yu Yang Jie Hua Zheng-Mei song Haifang Wang Yuanfang Liu Aoneng Cao | 2018 | Nano Research2018，11，5： | 0 |
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