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| 1 | 在每日的内视镜检查法常规挑选操作员 choledochoscopy 和它的角色显示文摘 Different diagnostic procedures exist for the detection of bile duct lesions in clinical practice.However,neither retrograde contrast imaging of the bile duct endoscopic retrograde cholangiopancreatogram nor other imaging procedures allow a safe diagnosis of the lesions.Therefore choledochoscopy may be a useful diagnostic procedure in macroscopic assessing lesions of the bile duct.Even if the diagnostic sensitivity and specificity is not sufficient,first studies suggest an enhanced diagnostic accuracy for choledochoscopy.Since the progress of choledochoscopy has started in the 1970 different improvements were achieved.Meanwhile,the examination can be performed by an examiner and samples can be taken.Image and Resolution quality has improved over the past years,also.The SpyGlass system is a technically advanced cholangioscopic device to provide endoscopic diagnosis in case of inconclusive bile duct findings.Further more,two more lumina allow specific biopsy forceps and optical fibers for electrohydraulic or laser lithotripsy.The most frequent useful insert of SpyGlass in clinical practice are in complex gallstones and bile duct lesions of unclear dignity. | Arthur Hoffman Johannes Wilhelm Rey Ralf Kiesslich | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，5： | 3 |
| 2 | Efficacy of SpyGlass^(TM)-directed biopsy compared to brush cytology in obtaining adequate tissue for diagnosis in patients with biliary strictures显示文摘AIM: To evaluate the diagnostic yield(inflammatory activity) and efficiency(size of the biopsy specimen) of SpyGlassTM-guided biopsy vs standard brush cytology in patients with and without primary sclerosing cholangitis(PSC).METHODS: At the University Medical Center Mainz, Germany, 35 consecutive patients with unclear biliarylesions(16 patients) or long-standing PSC(19 patients) were screened for the study. All patients underwent a physical examination, lab analyses, and abdominal ultrasound. Thirty-one patients with non-PSC strictures or with PSC were scheduled to undergo endoscopic retrograde cholangiography(ERC) and subsequent per-oral cholangioscopy(POC). Standard ERC was initially performed, and any lesions or strictures were localized. POC was performed later during the same session. The Boston Scientific SpyGlass SystemTM(Natick, MA, United States) was used for choledochoscopy. The biliary tree was visualized, and suspected lesions or strictures were biopsied, followed by brush cytology of the same area. The study endpoints(for both techniques) were the degree of inflammation, tissue specimen size, and the patient populations(PSC vs non-PSC). Inflammatory changes were divided into three categories: none, low activity, and high activity. The specimen quantity was rated as low, moderate, or sufficient.RESULTS: SpyGlassTM imaging and brush cytology with material retrieval were performed in 29 of 31(93.5%) patients(23 of the 29 patients were male). The median patient age was 45 years(min, 20 years; max, 76 years). Nineteen patients had known PSC, and 10 showed non-PSC strictures. No procedure-related complications were encountered. However, for both methods, tissues could only be retrieved from 29 pa-tients. In cases of inflammation of the biliary tract, the diagnostic yield of the SpyGlassTM-directed biopsies was greater than that using brush cytology. More tissue material was obtained for the biopsy method than for the brush cytology method(P = 0.021). The biopsies showed significantly more inflammatory characteristics and greater inflammatory activity compared to the cy-tological investigation(P = 0.014). The greater quantity of tissue samples proved useful for both PSC and non-PSC patients.CONCLUSION: SpyGlassTM imaging can be recom-mended for proper inflammatory diagnosis in PSC pa-tients. However, its value in diagnosing dysplasia wasnot addressed in this study and requires further investi-gation. | Johannes Wilhelm Rey Torsten Hansen Sebastian Dümcke Achim Tresch Katja Kramer Peter Robert Galle Martin Goetz Marcus Schuchmann Ralf Kiesslich Arthur Hoffman | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，4： | 2 |
| 3 | Accuracy and Quality Assessment of EUS-FNA: A Single-Center Large Cohort of Biopsies显示文摘 | Benjamin Ephraim Bluen Jesse Lachter Iyad Khamaysi Yassin Kamal Leonid Malkin Ruth Keren Ron Epelbaum Yoram Kluger Arthur Hoffman | 2012 | <journal-title>Diagnostic and Therapeutic Endoscopy2012，，： | 1 |
| 4 | Irritable bowel syndrome and organic diseases: A comparative analysis of esophageal motility显示文摘AIM:To assess the esophageal motility in patients with irritable bowel syndrome(IBS)and to compare those with patients with autoimmune disorders.METHODS:15 patients with IBS,22 with systemic lupus erythematosus(SLE)and 19 with systemic sclerosis(SSc)were prospectively selected from a total of 115patients at a single university centre and esophageal motility was analysed using standard manometry(Mui Scientific PIP-4-8SS).All patients underwent esophagogastro-duodenoscopy before entering the study so that only patients with normal endoscopic findings were included in the current study.All patients underwent a complete physical,blood biochemistry and urinary examination.The grade of dysphagia was determined for each patient in accordance to the intensity and frequency of the presented esophageal symptoms.Furthermore,disease activity scores(SLEDAI and modified Rodnan score)were obtained for patients with autoimmune diseases.Outcome parameter:A correlation coefficient was calculated between amplitudes,velocity and duration of the peristaltic waves throughout esophagus and patients’dysphagia for all three groups.RESULTS:There was no statistical difference in the standard blood biochemistry and urinary analysis in all three groups.Patients with IBS showed similar pathologic dysphagia scores compared to patients with SLE and SSc.The mean value of dysphagia score was in IBS group 7.3,in SLE group 6.73 and in SSc group7.56 with a P-value>0.05.However,the manometric patterns were different.IBS patients showed during esophageal manometry peristaltic amplitudes at the proximal part of esophagus greater than 60 mmHg in46%of the patients,which was significant higher in comparison to the SLE(11.8%)and SSc-Group(0%,P=0.003).Furthermore,IBS patients showed lower mean resting pressure of the distal esophagus sphincter(Lower esophageal sphincter,22 mmHg)when compared with SLE(28 mmHg,P=0.037)and SSc(26 mmHg,P=0.052).23.5%of patients with SLE showed amplitudes greater as 160 mmHg in the distal esophagus(IBS and SSc:0%)whereas 29.4%amplitudes greater as 100 mmHg in the middle one(IBS:16.7%,SSc:5.9%respectively,P=0.006).Patients with SSc demonstrated,as expected,in almost half of the cases reduced peristalsis or even aperistalsis in the lower two thirds of the esophagus.SSc patients demonstrated a negative correlation coefficient between dysphagia score,amplitude and velocity of peristaltic activity at middle and lower esophagus[r=-0.6,P | Thomas Thomaidis Martin Goetz Sebastian Paul Gregor Arthur Hoffman Elias Kouroumalis Markus Moehler Peter Robert Galle Andreas Schwarting Ralf Kiesslich | 2013 | World Journal of Gastroenterology2013，19，38： | 1 |
| 5 | Methylene blue–aided cholangioscopy unravels the endoscopic features of ischemic-type biliary lesions after liver transplantation显示文摘 | Arthur Hoffman Ralf Kiesslich Christian Moench Fernando Bittinger Gerd Otto Peter R. Galle Markus F. Neurath | 2007 | Gastrointestinal Endoscopy2007，，5： | 1 |
| 6 | Retrograde inspection vs standard forward view for the detection of colorectal adenomas during colonoscopy: A back-to-back randomized clinical trial显示文摘BACKGROUND The adenoma detection rate(ADR)is inversely associated with the incidence of interval colorectal cancer and serves as a benchmark quality criterion during screening colonoscopy.However,adenoma miss rates reach up to 26%and studies have shown that a second inspection of the right colon in retroflected view(RFV)can increase ADR.AIM To assess whether inspection of the whole colon in RFV compared to standard forward view(SFV)can increase ADR.METHODS Patients presenting for screening or surveillance colonoscopy were invited to participate in this randomized controlled trial and randomized into two arms.In RFV arm colonoscopy was initially performed with SFV,followed by a second inspection of the whole colon in RFV.In the SFV arm first withdrawal was performed with SFV,followed by a second inspection of the whole colon again with SFV.Number,size and morphology of polyps found during first and second inspection in each colonic segment were recorded and all polyps were removed and sent for histopathology in separate containers.RESULTS Two hundred and five patients were randomly assigned to the RFV(n=101)and SFV(n=104)arm.In the RFV arm,both polyp detection rate(PDR)and ADR were increased under second inspection in RFV(PDR 1st SFV:39.8%,PDR 2nd RFV:46.6%;ADR 1st SFV:35.2%,ADR 2nd RFV:42%).Likewise,in the SFV arm,PDR and ADR were increased under second inspection(PDR 1st SFV:37.5%,PDR 2nd SFV:46.6%;ADR 1st SFV:34.1%,ADR 2nd SFV:44.3%)with no significant differences in ADR and PDR between the SFV and RFV arm.Mean number of adenomas per patient(APP)was increased in the RFV and SFV(APP RFV arm:1st SFV:1.71;2nd RFV:2.38;APP SFV arm:1st SFV:1.83,2nd SFV:2.2).The majority of adenomas additionally found during second inspection in RFV or in SFV were located in the transverse and left-sided colon and were>5 mm in size.CONCLUSION Second inspection of the whole colon leads to increased adenoma detection with no differences between SFV and RFV.Hence,increased detection is most likely a feature of the second inspection itself but not of the inspection mode. | Timo Rath Lukas Pfeifer Clemens Neufert Andreas Kremer Moritz Leppkes Arthur Hoffman Markus F Neurath Steffen Zopf | 2020 | World Journal of Gastroenterology2020，26，16： | 1 |
| 7 | Two or four Neoproterozoic glaciations? 显示文摘 | Kennedy M J Runnegar B Prave A R Hoffman C Arthur M A | 1998 | Geology1998，26，12： | 1 |
| 8 | Simultaneous confocal laser endomicroscopy and chromoendoscopy with topical cresyl violet显示文摘 | Martin Goetz Tanja Toermer Michael Vieth Kerry Dunbar Arthur Hoffman Peter R. Galle Markus F. Neurath Peter Delaney Ralf Kiesslich | 2009 | Gastrointestinal Endoscopy2009，，5： | 1 |
| 9 | Off-resonant third-order optical nonlinearities of metal-substituted phthalocyanines 显示文摘 | James S Shirk J R Lindle F J Bartoli Hoffman C A Kafafi Zakya H Snow Arthur W | 1989 | Appl Phys Lett1989，55，： | 1 |
| 10 | Antibodies Against Tumor Necrosis Factor (TNF) Induce T-Cell Apoptosis in Patients With Inflammatory Bowel Diseases via TNF Receptor 2 and Intestinal CD14 + Macrophages显示文摘 | Raja Atreya Michael Zimmer Brigitte Bartsch Maximilian J. Waldner Imke Atreya Helmut Neumann Kai Hildner Arthur Hoffman Ralf Kiesslich Andreas D. Rink Tilman T. Rau Stefan Rose–John Hermann Kessler Jan Schmidt Markus F. Neurath | 2011 | Gastroenterology2011，，6： | 1 |
| 11 | Novel Colonoscopic Imaging显示文摘 | Sanjay Murthy Martin Goetz Arthur Hoffman Ralf Kiesslich | 2012 | Clinical Gastroenterology and Hepatology2012，，9： | 1 |
| 12 | In Vivo Histology of Barrett’s Esophagus and Associated Neoplasia by Confocal Laser Endomicroscopy显示文摘 | Ralf Kiesslich Liebwin Gossner Martin Goetz Alexandra Dahlmann Michael Vieth Manfred Stolte Arthur Hoffman Michael Jung Bernhard Nafe Peter R. Galle Markus F. Neurath | 2006 | Clinical Gastroenterology and Hepatology2006，，： | 1 |
| 13 | High-Definition and Filter-Aided Colonoscopy显示文摘 | Jenny Sauk Arthur Hoffman Sharmila Anandasabapathy Ralf Kiesslich | 2010 | Gastroenterology Clinics of North America2010，，4： | 1 |
| 14 | In Vivo Histology of Barrett’s Esophagus and Associated Neoplasia by Confocal Laser Endomicroscopy显示文摘 | Ralf Kiesslich Liebwin Gossner Martin Goetz Alexandra Dahlmann Michael Vieth Manfred Stolte Arthur Hoffman Michael Jung Bernhard Nafe Peter R. Galle Markus F. Neurath | 2006 | Clinical Gastroenterology and Hepatology2006，，8： | 1 |
| 15 | Novel Colonoscopic Imaging显示文摘 | Sanjay Murthy Martin Goetz Arthur Hoffman Ralf Kiesslich | 2012 | Clinical Gastroenterology and Hepatology2012，，9： | 1 |
| 16 | Advanced imaging for detection and differentiation of colorectal neoplasia: European Society of Gastrointestinal Endoscopy (ESGE) Guideline显示文摘 | Micha? Kamiński Cesare Hassan Raf Bisschops Jürgen Pohl Maria Pellisé Evelien Dekker Ana Ignjatovic-Wilson Arthur Hoffman Gaius Longcroft-Wheaton Denis Heresbach Jean-Marc Dumonceau James East | 2014 | Endoscopy2014，，： | 1 |
| 17 | S1586: I-Scan Is As Effective As Acetic Acid Guided Chromoendoscopy and Superior to Random Biopsies Diagnosing Barrett’s Epithelium - A Prospective Randomized Trial显示文摘 | Arthur Hoffman Oliver Korczynski Fareed Rahman Thorsten Hansen Martin Goetz Peter R. Galle Ralf Kiesslich | 2010 | Gastrointestinal Endoscopy2010，，5： | 1 |
| 18 | Intraprocedural bowel cleansing with the Jet Prep cleansing system improves adenoma detection显示文摘AIM: To investigate the impact of Jet Prep cleansing on adenoma detection rates.METHODS: In this prospective,randomized,crossover trial,patients were blindly randomized to an intervention arm or a control arm.In accordance with the risk profile for the development of colorectal carcinoma,the study participants were divided into high-risk and low-risk groups.Individuals with just one criterion(age > 70 years,adenoma in medical history,and first-degree relative with colorectal cancer) were regarded as high-risk patients.Bowel preparation was performed in a standardized manner one day before the procedure.Participants in the intervention arm underwent an initial colonoscopy with standard bowel cleansing using a 250-m L syringe followed by a second colonoscopy that included irrigation by the use of the Jet Prep cleansing system.The reverse sequence was used in the control arm.The study participants were divided into a high-risk group and a low-risk group according to their respective risk profiles for the development of colorectal carcinoma.RESULTS: A total of 64 patients(34 men and 30 women) were included in the study; 22 were included in the high-risk group.After randomization,30 patients were assigned to the control group(group A) and 34 to the intervention group(group B).The average Boston Bowel Preparation Scale score was 5.15 ± 2.04.The withdrawal time needed for the first step was significantly longer in group A using the Jet Prep system(9.41 ± 3.34 min) compared to group B(7.5 ± 1.92 min).A total of 163 polyps were discovered in 64 study participants who underwent both investigation steps.In group A,49.4% of the polyps were detected during the step of standard bowel cleansing while the miss rate constituted 50.7%.Group B underwent cleansing with the Jet Prep system during the first examination step,and as many as 73.9% of polyps were identified during this step.Thus,the miss rate in group B was a mere 26.1%(P < 0.001).When considering only the right side of the colon,the miss rate in group A during the first examination was 60.6%,in contrast to a miss rate of 26.4% in group B(P < 0.001).CONCLUSION: Jet Prep is recommended for use during colonoscopy because a better prepared bowel enables a better adenoma detection,particularly in the proximal colon. | Arthur Hoffman Sanjay Murthy Lena Pompetzki Johannes Wilhelm Rey Martin Goetz Achim Tresch Peter Robert Galle Ralf Kiesslich | 2015 | World Journal of Gastroenterology2015，21，26： | 0 |
| 19 | Mini-laparoscopy in the endoscopy unit:Safety and outcomes in over one thousand patients显示文摘AIM:To investigate the safety of consecutive mini-lapar oscopy guided liver biopsies for the diagnosis and staging of liver diseases. METHODS: In this study we retrospectively analyzed the safety of mini-laparoscopic liver biopsy performed in an endoscopy unit in 1071 patients. We measured the incidence of bleeding and evaluated the management and outcome of bleeding interventions.were viral hepatitis and autoimmune liver disease. 250 patients had macroscopically and histologically proven cirrhosis. 13 patients had no pathological f indings. 33% of all patients had bleeding that required argon plasma coagulation of the puncture site during laparoscopy. Signif icant bleeding occurred more often in patients with liver cirrhosis compared to non-cirrhotic liver dise ases but was effectively treated with laparoscopic coag ulation. CONCLUSION: In conclusion, mini-laparoscopy liver biopsy can be performed safely and effectively in high risk patients with advanced liver disease; mini-lapar osc opy with liver biopsy can be done safely in an endos copy unit. | Arthur Hoffman Fareed Rahman Sarah Prengel Marcus Schuchmann Martin Gotz Markus Moehler Peter Robert Galle Ziping Li Anthony Nicolas Kalloo Ralf Kiesslich | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，1： | 0 |
| 20 | New aspects of modern endoscopy显示文摘The prognosis for patients with malignancies of the ga-strointestinal-tract is strictly dependent on early detec-tion of premalignant and malignant lesions. However, small, flat or depressed neoplastic lesions remain dif-ficult to detect with these technologies thereby limiting their value for polyp and cancer screening. At the same time computer and chip technologies have undergone major technological changes which have greatly im-proved endoscopic diagnostic investigation. New imag-ing modalities and techniques are very notable aspects of modern endoscopy. Chromoendoscopy or filter-aided colonoscopy(virtual chromoendoscopy) with high defi-nition endoscopes is able to enhance the detection and characterization of lesions. Finally, confocal laser en-domicroscopy provides histological confirmation of the presence of neoplastic changes. The developing tech-niques around colonoscopy such as the retro-viewing colonoscope, the balloon-colonoscope or the 330-de-grees-viewing colonoscope try to enhance the efficacy by reducing the adenoma miss rate in right-sided, non-polypoid lesions. Colon capsule endoscopy is limited to identifying cancer and not necessarily small adenomas. Preliminary attempts have been made to introduce this technique in clinical routine. | Johannes Wilhelm Rey Ralf Kiesslich Arthur Hoffman | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，8： | 0 |
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