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| 1 | organic solvent tolerance and antibiotic resistance increased by over expression of marA in Escherichia coli显示文摘 | Asako H Nakajima H Kobayashi k | 1997 | Appl Environ Microbilo1997，63，4： | 1 |
| 2 | Epidemiology and Management of Drug-induced Liver Injury: Importance of the Updated RUCAM显示文摘Drug-induced liver injury(DILI)is a major cause of acute liver injury,liver failure,and liver transplantation worldwide.In recent years,immune checkpoint inhibitors have become widely used.This has led to an increase in DILI,for which pathophysiology and management methods differ significantly from the past.As the number of cases of acute liver injury and liver transplantation due to DILI is expected to increase,information about a DILI is becoming more valuable.DILI is classified into two types according to its etiology:intrinsic DILI,in which the drug or its metabolites cause liver damage that is dose-dependent and predictable;and idiosyncratic DILI,in which liver damage is also dose-independent but unpredictable.In addition,depending on the course of the disease,chronic DILI or drug-induced autoimmune hepatitis may be present.The number of DILI cases caused by antimicrobial agents is decreasing,whereas that caused by drugs for malignant tumors and health foods is increasing.The Roussel Uclaf Causality Assessment Method is widely used to assess causality in DILI.Liver injury is a type of immune-related adverse event.The pattern of hepatic injury in immune-related adverse events is mostly hepatocellular,but mixed type and bile stasis have also been reported.Sclerosing cholangitis caused by immune checkpoint inhibitors has also been reported as a unique type of injury.Treatment mainly comprises withdrawal of immune checkpoint inhibitors and steroid administration;however,mycophenolate mofetil may be considered if the disease is refractory to steroids. | Takashi Kobayashi Michihiro Iwaki Asako Nogami Masato Yoneda | 2023 | Journal of Clinical and Translational Hepatology2023，11，5： | 1 |
| 3 | Organic solvent tolerance and antibiotic resistance increased by overexpression of marA in Escherichia coli显示文摘 | Nakajima H Kobayashi K | 1997 | Appl Environ Microbiol1997，63，4： | 1 |
| 4 | Organic solvent tolerance and antibiotic resistance increased by over- expression of marA in Escherichia coli 显示文摘 | ASAKO H NAKAJIMA H KOBAYASHI K | 1997 | Appl Environm Microbiol1997，63，4： | 1 |
| 5 | Organic solvent tolerance and antibiotic resistance increased by over expression of marA in Escherichia coli 显示文摘 | Asako H Nakajima H Kobayashi K | 1997 | Appl Environ Microbiol1997，63，4： | 1 |
| 6 | Organic solvent tolerance and antibiotic resistance increased by overexpression of marA in Escherichia coli显示文摘 | Asako H Nakajima H Kobayashi K | 1997 | Applied and Environmental Microbiology1997，63，4： | 1 |
| 7 | Organic solvent tolerance and antibiotic resistance increased by over expression of marA in Escherichia coli显示文摘 | Asako H Nakajima H Kobayashi K | 1997 | Appl Environ Microbiol1997，63，4： | 1 |
| 8 | Organic solvent tolerance and antibiotic resistance increased by over expression of marA in Escherichia coli显示文摘 | ASAKO H NAKAJIMA H KOBAYASHI K | 1997 | Appl Environ Microbiol1997，63，4： | 1 |
| 9 | Integrated genome-wide differentiation and association analyses identify causal genes underlying breeding-selected grain quality traits in japonica rice显示文摘Improving grain quality is a primary objective in contemporary rice breeding.Japanese modern rice breeding has developed two different types of rice,eating and sake-brewing rice,with different grain characteristics,indicating the selection of variant gene alleles during the breeding process.Given the critical importance of promptly and efficiently identifying genes selected in past breeding for future molecular breeding,we conducted genome scans for divergence,genome-wide association studies,and map-based cloning.Consequently,we successfully identified two genes,OsMnS and OsWOX9D,both contributing to rice grain traits.OsMnS encodes a mannan synthase that increases the white core frequency in the endosperm,a desirable trait for sake brewing but decreases the grain appearance quality.OsWOX9D encodes a grass-specific homeobox-containing transcription factor,which enhances grain width for better sake brewing.Furthermore,haplotype analysis revealed that their defective alleles were selected in East Asia,but not Europe,during modern improvement.In addition,our analyses indicate that a reduction in grain mannan content during African rice domestication may also be caused a defective OsMnS allele due to breeding selection.This study not only reveals the delicate balance between grain appearance quality and nutrition in rice but also provides a new strategy for isolating causal genes underlying complex traits,based on the concept of“breeding-assisted genomics”in plants. | Hideki Yoshida Satoshi Okada Fanmiao Wang Shohei Shiota Masaki Mori Mayuko Kawamura Xue Zhao Yiqiao Wang Naho Nishigaki Asako Kobayashi Kotaro Miura Shinya Yoshida Masaru Ikegami Akitoshi Ito Lin-Tzu Huang Yue-le Caroline Hsing Yoshiyuki Yamagata Yoichi Morinaka Masanori Yamasaki Toshihisa Kotake Eiji Yamamoto Jian Sun Ko Hirano Makoto Matsuoka | 2023 | Molecular Plant2023，16，9： | 0 |
| 10 | Pan-peroxisome proliferator-activated receptor agonist lanifibranor as a dominant candidate pharmacological therapy for nonalcoholic fatty liver disease显示文摘As obesity incidence increases worldwide,nonalcoholic fatty liver disease(NAFLD)has become the most common form of liver disease,with a reported global prevalence of 25.2%(1).Nonalcoholic steatohepatitis(NASH)is a severe form of NAFLD.However,the precise natural history of NAFLD/NASH remains unclear.NASH is rapidly becoming the leading cause of end-stage liver disorders and liver transplants and is associated with increased cardiovascular disease risk(2).As a result,it poses critical health issues globally from both medical and socioeconomic perspectives. | Masato Yoneda Takashi Kobayashi Nogami Asako Michihiro Iwaki Satoru Saito Atsushi Nakajima | 2022 | Hepatobiliary Surgery and Nutrition2022，11，3： | 0 |
| 11 | Tropifexor,a selective non-acid farnesoid X receptor agonist,improved nonalcoholic steatohepatitis in a phase 2 trial,but several issues remain to be resolved显示文摘As obesity continues to escalate worldwide,nonalcoholic fatty liver disease(NAFLD)has emerged as the most prevalent form of liver disease,with a reported global prevalence of 30.1%(1).The prevalence of NAFLD,which was around 25%in the 1990s,has been increasing year by year in recent years and has exceeded 35%in the past few years(1).The spectrum of disease includes nonalcoholic fatty liver(NAFL),characterized by macrovesicular hepatic steatosis that may be accompanied by mild inflammation,and nonalcoholic steatohepatitis(NASH),which is additionally characterized by the presence of inflammation and cellular injury(2). | Masato Yoneda Takashi Kobayashi Naohiro Wada Tomohiro Otani Asako Nogami Michihiro Iwaki Atsushi Nakajima | 2023 | Hepatobiliary Surgery and Nutrition2023，12，5： | 0 |
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