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| 1 | Long-term survival after resection of pancreatic cancer:A single-center retrospective analysis显示文摘AIM: To retrospectively analyze factors affecting the long-term survival of patients with pancreatic cancer who underwent pancreatic resection.METHODS: From January 2000 to December 2011,195 patients underwent pancreatic resection in our hospital.The prognostic factors after pancreatic resection were analyzed in all 195 patients.After excluding the censored cases within an observational period,the clinicopathological characteristics of 20 patients who survived ≥ 5(n = 20) and < 5(n = 76) years were compared.For this comparison,we analyzed the patients who underwent surgery before June 2008 and were observed for more than 5 years.For statistical analyses,the log-rank test was used to compare the cumulative survival rates,and the χ2 and Mann-Whitney tests were used to compare the two groups.The CoxHazard model was used for a multivariate analysis,and P values less than 0.05 were considered significant.A multivariate analysis was conducted on the factors that were significant in the univariate analysis.RESULTS: The median survival for all patients was 27.1 months,and the 5-year actuarial survival rate was 34.5%.The median observational period was 595 d.With the univariate analysis,the UICC stage was significantly associated with survival time,and the CA19-9 ≤ 200 U/m L,DUPAN-2 ≤ 180 U/m L,t u m o r s i ze ≤ 2 0 m m,R 0 re s e c t i o n,a b s e n c e o f lymph node metastasis,absence of extrapancreatic neural invasion,and absence of portal invasion were favorable prognostic factors.The multivariate analysis showed that tumor size ≤ 20 mm(HR = 0.40; 95%CI: 0.17-0.83,P = 0.012) and negative surgical margins(R0 resection)(HR = 0.48; 95%CI: 0.30-0.77,P = 0.003) were independent favorable prognostic factors.Among the 96 patients,20 patients survived for 5 years or more,and 76 patients died within 5 years after operation.Comparison of the 20 5-year survivors with the 76 non-survivors showed that lower concentrations of DUPAN-2(79.5 vs 312.5 U/mL,P = 0.032),tumor size ≤ 20 mm(35% vs 8%,P = 0.008),R0 resection(95% vs 61%,P = 0.004),and absence of lymph nodemetastases(60% vs 18%,P = 0.036) were significantly associated with the 5-year survival.CONCLUSION: Negative surgical margins and a tumor size ≤ 20 mm were independent favorable prognostic factors.Histologically curative resection and early tumor detection are important factors in achieving long-term survival. | Takehito Yamamoto Shintaro Yagi Hiromitsu Kinoshita Yusuke Sakamoto Kazuyuki Okada Kenji Uryuhara Takeshi Morimoto Satoshi Kaihara Ryo Hosotani | 2015 | World Journal of Gastroenterology2015，21，1： | 18 |
| 2 | Inhibitory effect of angiotensinⅡreceptor antagonist on hepatic stellate cell activation in non-alcoholic steatohepatitis显示文摘AIM: To investigate the efficacy of angiotensinⅡreceptor antagonist on hepatic stellate cells (HSCs) activation in the patients with non-alcoholic steatohepatitis (NASH). METHODS: Seven patients with NASH were prescribed losartan, a selective angiotensinⅡtype 1 receptor antagonist (50 mg/d) for 48 wk. Liver biopsies were performed both at the entry and end of the study in all patients. Quiescent and activated HSCs were identified by double immunostaining using anti-p75 andα-smooth muscle actin antibodies, and the number of each phenotype was counted. Similarly, the liver specimens obtained from the eight patients with non-alcoholic fatty liver (NAFL) were also examined as controls. RESULTS: In NASH hepatic tissues, activated HSCs were dominantly distributed as compared with those in NAFL. The 48-wk losartan treatment induced a remarkable decrease in activated HSCs and a mild increase in quiescent phenotypes. CONCLUSION: Our data suggest the crucial involvement of HSCs in anti-fibrotic effect of angiotensinⅡreceptor antagonist on patients with NASH. | Shiro Yokohama Yoshihiko Tokusashi Kimihide Nakamura Yosui Tamaki Satoshi Okamoto Mituyoshi Okada Kazunobu Aso Takenao Hasegawa Masaru Aoshima Naoyuki Miyokawa Masakazu Haneda Masashi Yoneda | 2006 | World Journal of Gastroenterology2006，12，2： | 10 |
| 3 | Highly accurate colorectal cancer prediction model based on Raman spectroscopy using patient serum显示文摘BACKGROUND Colorectal cancer(CRC) is an important disease worldwide, accounting for the second highest number of cancer-related deaths and the third highest number of new cancer cases. The blood test is a simple and minimally invasive diagnostic test. However, there is currently no blood test that can accurately diagnose CRC.AIM To develop a comprehensive, spontaneous, minimally invasive, label-free, bloodbased CRC screening technique based on Raman spectroscopy.METHODS We used Raman spectra recorded using 184 serum samples obtained from patients undergoing colonoscopies. Patients with malignant tumor histories as well as those with cancers in organs other than the large intestine were excluded. Consequently, the specific diseases of 184 patients were CRC(12), rectal neuroendocrine tumor(2), colorectal adenoma(68), colorectal hyperplastic polyp(18), and others(84). We used the 1064-nm wavelength laser for excitation. The power of the laser was set to 200 mW.RESULTS Use of the recorded Raman spectra as training data allowed the construction of a boosted tree CRC prediction model based on machine learning. Therefore, the generalized R^2 values for CRC, adenomas, hyperplastic polyps, and neuroendocrine tumors were 0.9982, 0.9630, 0.9962, and 0.9986, respectively.CONCLUSION For machine learning using Raman spectral data, a highly accurate CRC prediction model with a high R^2 value was constructed. We are currently planning studies to demonstrate the accuracy of this model with a large amount of additional data. | Hiroaki Ito Naoyuki Uragami Tomokazu Miyazaki William Yang Kenji Issha Kai Matsuo Satoshi Kimura Yuji Arai Hiromasa Tokunaga Saiko Okada Machiko Kawamura Noboru Yokoyama Miki Kushima Haruhiro Inoue Takashi Fukagai Yumi Kamijo | 2020 | World Journal of Gastrointestinal Oncology2020，12，11： | 2 |
| 4 | Prolonged Endoplasmic Reticulum Stress in Hypertrophic and Failing Heart After Aortic Constriction: Possible Contribution of Endoplasmic Reticulum Stress to Cardiac Myocyte Apoptosis显示文摘 | Ken-ichiro Okada Tetsuo Minamino Yoshitane Tsukamoto Yulin Liao Osamu Tsukamoto Seiji Takashima Akio Hirata Masashi Fujita Yoko Nagamachi Takeshi Nakatani Chikao Yutani Kentaro Ozawa Satoshi Ogawa Hitonobu Tomoike Masatsugu Hori Masafumi Kitakaze | 2004 | Circulation2004，，6： | 2 |
| 5 | Degradation of fenitrothion by ultrasound/ ferrioxalate/UV system 显示文摘 | l-Iideyuki Katsumata Toshiko Okada Satoshi Kaneco | 2010 | Ultrasonics Sonochemistry2010，17，1： | 1 |
| 6 | Intact fibroblast growth factor 23 levels predict incident cardiovascular event before but not after the start of dialysis显示文摘 | Chikako Nakano Takayuki Hamano Naohiko Fujii Yoshitsugu Obi Isao Matsui Kodo Tomida Satoshi Mikami Kazunori Inoue Akihiro Shimomura Yasuyuki Nagasawa Noriyuki Okada Yoshiharu Tsubakihara Hiromi Rakugi Yoshitaka Isaka | 2012 | Bone2012，，6： | 1 |
| 7 | Molecular structure and photochromic properties of 1,3-dimethylindoline-3,3′-alkano-2-spiro-2′-(6′-nitro)benzopyrans显示文摘 | Y Yasuo Abe H Hiromi Ebara S Satoshi Okada | 2002 | Dyes and Pigments2002，52，1： | 1 |
| 8 | Omentin, a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells显示文摘 | Hideyuki Yamawaki Junji Kuramoto Satoshi Kameshima Tatsuya Usui Muneyoshi Okada Yukio Hara | 2011 | Biochemical and Biophysical Research Communications2011，，2： | 1 |
| 9 | Omentin, a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells显示文摘 | Hideyuki Yamawaki Junji Kuramoto Satoshi Kameshima Tatsuya Usui Muneyoshi Okada Yukio Hara | 2011 | Biochemical and Biophysical Research Communications2011，，2： | 1 |
| 10 | Immunohistochemical Evaluation for Intraoperative Rapid Pathological Assessment of the Gastric Margin显示文摘 | Satoshi Matsusaka M.D. Ph.D. Tomohumi Nagareda M.D. Ph.D. Hajime Yamasaki M.D. Ph.D. Yoshihiro Kitayama M.D. Ph.D. Toshihiro Okada M.D. Shigeto Maeda M.D | 2003 | World Journal of Surgery2003，，6： | 1 |
| 11 | Double‐balloon enteroscopy for bilioenteric anastomotic stricture after pediatric living donor liver transplantation显示文摘 | Yukihiro Sanada Koichi Mizuta Tomonori Yano Wataru Hatanaka Noriki Okada Taiichi Wakiya Minoru Umehara Satoshi Egami Taizen Urahashi Shuji Hishikawa Takehito Fujiwara Yasunaru Sakuma Masanobu Hyodo Hironori Yamamoto Yoshikazu Yasuda Hideo Kawarasaki | 2010 | Transplant International2010，，1： | 1 |
| 12 | Orbital inflammatory pseudotumor and ischemic vasculitis in Churg-Strauss syndrome显示文摘 | Taiji Takanashi Sunao Uchida Machiko Arita Morio Okada Satoshi Kashii | 2001 | Ophthalmology2001，，6： | 1 |
| 13 | Economic Loss Assessment due to Railroad and Highway Disruptions显示文摘 | Satoshi Tsuchiya Hirokazu Tatano and Norio Okada | 2007 | Economic Systems Research2007，19，2： | 1 |
| 14 | Assessment of Gd-EOB-DTPA-enhanced MRI for HCC and dysplastic nodules and comparison of detection sensitivity versus MDCT显示文摘 | Tatsuo Inoue Masatoshi Kudo Mina Komuta Sosuke Hayaishi Taisuke Ueda Masahiro Takita Satoshi Kitai Kinuyo Hatanaka Norihisa Yada Satoru Hagiwara Hobyung Chung Toshiharu Sakurai Kazuomi Ueshima Michiie Sakamoto Osamu Maenishi Tomoko Hyodo Masahiro Okada Se | 2012 | Journal of Gastroenterology2012，，9： | 1 |
| 15 | Allogeneic stem cell transplantation as treatment for heavily treated, refractory acute graft-versus-host disease after HLA-mismatched stem cell transplantation显示文摘 | Kazuhiro Ikegame Satoshi Yoshihara Yuki Taniguchi Katsuji Kaida Takayuki Inoue Masaya Okada Kyoko Taniguchi Hitomi Hasei Hiroya Tamaki Tatsuya Fujioka Ruri Kato Toshihiro Soma Hiroyasu Ogawa | 2011 | Experimental Hematology2011，，8： | 1 |
| 16 | Measurement of Land Syrface BRDF with Spatial Instability for Vicarious Calibration显示文摘 | Satoshi Tsuchida Isao Sato Shuhei Okada | 1999 | SPIE1999，3870，： | 1 |
| 17 | A comparative clinical study of macrolide-sensitive and macrolide-resistant Mycoplasma pneumoniae infections in pediatric patients显示文摘 | Keita Matsubara Miyuki Morozumi Takafumi Okada Takahiro Matsushima Osamu Komiyama Michi Shoji Takashi Ebihara Kimiko Ubukata Yoshitake Sato Hironobu Akita Keisuke Sunakawa Satoshi Iwata | 2009 | Journal of Infection and Chemotherapy2009，，6： | 1 |
| 18 | Control of algal growth by macrophytes and macrophyte-extracted bioactive compounds显示文摘 | Satoshi N Hosomi M Okada M Murakami A | 1996 | Wa Sci Tech1996，34，78： | 1 |
| 19 | Effect of free-air CO 2 enrichment on the storage of carbohydrate fixed at different stages in rice ( Oryza sativa L.)显示文摘 | Haruto Sasaki Takahiro Hara Satoshi Ito Naoko Uehara Han-Yong Kim Mark Lieffering Masumi Okada Kazuhiko Kobayashi | 2006 | Field Crops Research2006，，1： | 1 |
| 20 | Synergistic up-regulation of Hexokinase-2, glucose transporters and angiogenic factors in pancreatic cancer cells by glucose deprivation and hypoxia显示文摘 | Mitsuteru Natsuizaka Mariko Ozasa Stephanie Darmanin Masaki Miyamoto Satoshi Kondo Suguru Kamada Masanobu Shindoh Fumihiro Higashino Wakako Suhara Hideyuki Koide Kiyoshi Aita Koji Nakagawa Takeshi Kondo Masahiro Asaka Futoshi Okada Masanobu Kobayashi | 2007 | Experimental Cell Research2007，，15： | 1 |
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