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| 1 | Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan显示文摘AIM:To evaluate the efficacy and safety of esomeprazole-based triple therapy compared with lansoprazole therapy as first-line eradication therapy for patients with Helicobacter pylori(H.pylori)in usual post-marketing use in Japan,where the clarithromycin(CAM)resistance rate is 30%.METHODS:For this multicenter,randomized,openlabel,non-inferiority trial,we recruited patients(≥20years of age)with H.pylori infection from 20 hospitals in Japan.We randomly allocated patients to esomeprazole therapy(esomeprazole 20 mg,CAM 400 mg,amoxicillin(AC)750 mg for the first 7 d,with all drugs given twice daily)or lansoprazole therapy(lansoprazole30 mg,CAM 400 mg,AC 750 mg for the first 7 d,with all drugs given twice daily)using a minimization method with age,sex,and institution as adjustment factors.Our primary outcome was the eradication rate by intention-to-treat(ITT)and per-protocol(PP)analyses.H.pylori eradication was confirmed by a urea breath test from 4 to 8 wk after cessation of therapy.RESULTS:ITT analysis revealed the eradication rates of 69.4%(95%CI:61.2%-76.6%)for esomeprazole therapy and 73.9%(95%CI:65.9%-80.6%)for lansoprazole therapy(P=0.4982).PP analysis showed eradication rate of 76.9%(95%CI:68.6%-83.5%)for esomeprazole therapy and 79.8%(95%CI:71.9%-86.0%)for lansoprazole therapy(P=0.6423).There were no differences in adverse effects between the two therapies.CONCLUSION:Esomeprazole showed non-inferiority and safety in a 7 day-triple therapy for eradication of H.pylori compared with lansoprazole. | Tsutomu Nishida Masahiko Tsujii Hirohisa Tanimura Shusaku Tsutsui Shingo Tsuji Akira Takeda Atsuo Inoue Hiroyuki Fukui Toshiyuki Yoshio Osamu Kishida Hiroyuki Ogawa Masahide Oshita Ichizo Kobayashi Shinichiro Zushi Makoto Ichiba Naoto Uenoyama Yuichi Yasunaga Ryu Ishihara Mamoru Yura Masato Komori Satoshi Egawa Hideki Iijima Tetsuo Takehara | 2014 | World Journal of Gastroenterology2014，20，15： | 13 |
| 2 | Generation of Pluripotent Stem Cells from Neonatal Mouse Testis显示文摘 | Mito Kanatsu-Shinohara Kimiko Inoue Jiyoung Lee Momoko Yoshimoto Narumi Ogonuki Hiromi Miki Shiro Baba Takeo Kato Yasuhiro Kazuki Shinya Toyokuni Megumi Toyoshima Ohtsura Niwa Mitsuo Oshimura Toshio Heike Tatsutoshi Nakahata Fumitoshi Ishino Atsuo Ogura T | 2004 | Cell2004，，7： | 2 |
| 3 | Reducing Peg-IFN doses causes later virologic response or no response in HCV genotype 1 patients treated with Peg-IFN alfa-2b plus ribavirin显示文摘 | Tsugiko Oze Naoki Hiramatsu Changho Song Takayuki Yakushijin Sadaharu Iio Yoshinobu Doi Masahide Oshita Hideki Hagiwara Eiji Mita Toshifumi Ito Yoshiaki Inui Taizo Hijioka Shinji Tamura Harumasa Yoshihara Atsuo Inoue Yasuharu Imai Eijiro Hayashi Michio Ka | 2012 | Journal of Gastroenterology2012，，3： | 1 |
| 4 | Adaptive Statistical Iterative Reconstruction Technique for Pulmonary CT显示文摘 | Masahiro Yanagawa Osamu Honda Shigeyuki Yoshida Ayano Kikuyama Atsuo Inoue Hiromitsu Sumikawa Mitsuhiro Koyama Noriyuki Tomiyama | 2010 | Academic Radiology2010，，： | 1 |
| 5 | Birth of Mice After Nuclear Transfer by Electrofusion U- sing Tail Tip Cells 显示文摘 | Atsuo Ogura Kimiko Inoue Kaoru Takano | 2000 | Molecular Reproduction and Development2000，57，： | 1 |
| 6 | Prouction of Male Cloned Mice from Fresh,Cultured,and Cryopreserved Immature Sertoli Cells显示文摘 | Atsuo Ogura Kimiko Inoue Narumi Ogonuki | 2000 | Biology of Reproduction2000，62，： | 1 |
| 7 | Generation of Pluripotent Stem Cells from Neonatal Mouse Testis显示文摘 | Mito Kanatsu-Shinohara Kimiko Inoue Jiyoung Lee Momoko Yoshimoto Narumi Ogonuki Hiromi Miki Shiro Baba Takeo Kato Yasuhiro Kazuki Shinya Toyokuni Megumi Toyoshima Ohtsura Niwa Mitsuo Oshimura Toshio Heike Tatsutoshi Nakahata Fumitoshi Ishino Atsuo Ogura T | 2004 | Cell2004，，7： | 1 |
| 8 | Diagnostic performance of fluorodeoxyglucose positron emission tomography/magnetic resonance imaging fusion images of gynecological malignant tumors: comparison with positron emission tomography/computed tomography显示文摘 | Kazuya Nakajo Mitsuaki Tatsumi Atsuo Inoue Kayako Isohashi Ichiro Higuchi Hiroki Kato Masao Imaizumi Takayuki Enomoto Eku Shimosegawa Tadashi Kimura Jun Hatazawa | 2010 | Japanese Journal of Radiology2010，，2： | 1 |
| 9 | Enhanced expression of interleukin-6, matrix metalloproteinase-13, and receptor activator of NF-κB ligand in cells derived from osteoarthritic subchondral bone显示文摘 | Kei Sakao Kenji A. Takahashi Osam Mazda Yuji Arai Hitoshi Tonomura Atsuo Inoue Masazumi Saito Mikihiro Fujioka Hisatake Takamiya Jiro Imanishi Toshikazu Kubo | 2008 | Journal of Orthopaedic Science2008，，3： | 1 |
| 10 | Enhanced expression of interleukin-6, matrix metalloproteinase-13, and receptor activator of NF-κB ligand in cells derived from osteoarthritic subchondral bone显示文摘 | Kei Sakao Kenji A. Takahashi Osam Mazda Yuji Arai Hitoshi Tonomura Atsuo Inoue Masazumi Saito Mikihiro Fujioka Hisatake Takamiya Jiro Imanishi Toshikazu Kubo | 2008 | Journal of Orthopaedic Science2008，，： | 1 |
| 11 | A Method to Measure Eye-Hand Coordination for Extracting Skilled Elements-Simultaneous Measurement of Eye-Gaze and Hand Location-显示文摘 | Atsuo Murata Kosuke Inoue | 2014 | Computer Technology and Application2014，5，2： | 0 |
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