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| 1 | Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan显示文摘AIM:To evaluate the efficacy and safety of esomeprazole-based triple therapy compared with lansoprazole therapy as first-line eradication therapy for patients with Helicobacter pylori(H.pylori)in usual post-marketing use in Japan,where the clarithromycin(CAM)resistance rate is 30%.METHODS:For this multicenter,randomized,openlabel,non-inferiority trial,we recruited patients(≥20years of age)with H.pylori infection from 20 hospitals in Japan.We randomly allocated patients to esomeprazole therapy(esomeprazole 20 mg,CAM 400 mg,amoxicillin(AC)750 mg for the first 7 d,with all drugs given twice daily)or lansoprazole therapy(lansoprazole30 mg,CAM 400 mg,AC 750 mg for the first 7 d,with all drugs given twice daily)using a minimization method with age,sex,and institution as adjustment factors.Our primary outcome was the eradication rate by intention-to-treat(ITT)and per-protocol(PP)analyses.H.pylori eradication was confirmed by a urea breath test from 4 to 8 wk after cessation of therapy.RESULTS:ITT analysis revealed the eradication rates of 69.4%(95%CI:61.2%-76.6%)for esomeprazole therapy and 73.9%(95%CI:65.9%-80.6%)for lansoprazole therapy(P=0.4982).PP analysis showed eradication rate of 76.9%(95%CI:68.6%-83.5%)for esomeprazole therapy and 79.8%(95%CI:71.9%-86.0%)for lansoprazole therapy(P=0.6423).There were no differences in adverse effects between the two therapies.CONCLUSION:Esomeprazole showed non-inferiority and safety in a 7 day-triple therapy for eradication of H.pylori compared with lansoprazole. | Tsutomu Nishida Masahiko Tsujii Hirohisa Tanimura Shusaku Tsutsui Shingo Tsuji Akira Takeda Atsuo Inoue Hiroyuki Fukui Toshiyuki Yoshio Osamu Kishida Hiroyuki Ogawa Masahide Oshita Ichizo Kobayashi Shinichiro Zushi Makoto Ichiba Naoto Uenoyama Yuichi Yasunaga Ryu Ishihara Mamoru Yura Masato Komori Satoshi Egawa Hideki Iijima Tetsuo Takehara | 2014 | World Journal of Gastroenterology2014，20，15： | 13 |
| 2 | Anti-allergic activity of standardized extract of Albizia lebbeck with reference to catechin as a phytomarker显示文摘 | Pichairajan Venkatesh Pulok K. Mukherjee Nanjappan Satheesh Kumar Arun Bandyopadhyay Hiroyuki Fukui Hiroyuki Mizuguchi Nurul Islam | 2010 | Immunopharmacology and Immunotoxicology2010，，2： | 1 |
| 3 | Characteristics of heart failure associated with the Great East Japan Earthquake显示文摘 | Akihiro Nakamura Hiroyuki Satake Akiyo Abe Yuta Kagaya Katuya Kohzu Kenjiro Sato Sohta Nakajima Shigefumi Fukui Hideaki Endo Tohru Takahashi Eiji Nozaki Kenji Tamaki | 2013 | Journal of Cardiology2013，，1： | 1 |
| 4 | Preparation of surfactant anion selective electrodes with different selectivity coefficients and a trial to determine each component in binary surfactant mixtures 显示文摘 | HIROYUKI FUKUI AKIKO KAMINAGA TAMAKI MAEDA | 2003 | Analytica Chimica Acta2003，481，： | 1 |
| 5 | Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin显示文摘 | Yoshihiro Kamada Shinji Tamura Shinichi Kiso Hitoshi Matsumoto Yukiko Saji Yuichi Yoshida Koji Fukui Norikazu Maeda Hitoshi Nishizawa Hiroyuki Nagaretani Yoshihisa Okamoto Shinji Kihara Jun-ichiro Miyagawa Yasuhisa Shinomura Tohru Funahashi Yuji Matsuzawa | 2003 | Gastroenterology2003，，6： | 1 |
| 6 | Three-Dimensional Transesophageal Echocardiographic Evaluation of Coronary Involvement in Patients with Acute Type A Aortic Dissection显示文摘 | Shunsuke Sasaki Hiroyuki Watanabe Kentaro Shibayama Keitaro Mahara Minoru Tabata Toshihiro Fukui Tetsuya Tobaru Shuichiro Takanashi Tetsuya Sumiyoshi Hitonobu Tomoike | 2013 | Journal of the American Society of Echocardiography2013，，8： | 1 |
| 7 | Three-Dimensional Transesophageal Echocardiographic Evaluation of Coronary Involvement in Patients with Acute Type A Aortic Dissection显示文摘 | Shunsuke Sasaki Hiroyuki Watanabe Kentaro Shibayama Keitaro Mahara Minoru Tabata Toshihiro Fukui Tetsuya Tobaru Shuichiro Takanashi Tetsuya Sumiyoshi Hitonobu Tomoike | 2013 | Journal of the American Society of Echocardiography2013，，8： | 1 |
| 8 | The First Isolation of Lignan Tri- and TetraGlycosides 显示文摘 | Katsura Fukui Hiroyuki Higuchi | 1991 | Chem Pharm Bull1991，39，6： | 1 |
| 9 | The first isolation tri - and tetra - glycosides 显示文摘 | Junei Kinjo Katsura Fukui Hiroyuki Higuchi et at | 1991 | chem Pharm Bull1991，39，6： | 1 |
| 10 | Novel refrigeration lubricants for use with HFC refrigerants 显示文摘 | Hiroyuki Fukui Ken-ichi Sanechika Masanori Ikeda | 2000 | Tribology International2000，33，2000： | 1 |
| 11 | The first isolation tri- and tetra- glycosides 显示文摘 | Junei Kinjo Katsura Fukui Hiroyuki Higuchi | 1991 | Chem Pharm Bull1991，39，6： | 1 |
| 12 | 基于特征分布的电动机定子绕组短路故障概率诊断显示文摘本文提出了一种电动机定子绕组匝间短路故障诊断的新方法。这种方法利用了进入线圈的电流的两种特征,即它的大小和相位。根据目标电动机电流的大小和相位,用事先获得的它们的分布就可以计算出故障概率。对定子绕组匝间短路故障电动机进行的测试也进一步证实了这种方法的有效性。 | Hiroyuki Fukui | 2012 | 国外大电机2012，，3： | 0 |
| 13 | Vitamin E reduces liver stiffness in nonalcoholic fatty liver disease显示文摘AIM: To evaluate the efficacy of vitamin E treatment on liver stiffness in nonalcoholic fatty liver disease(NAFLD).METHODS: Thirty-eight NAFLD patients were administered vitamin E for > 1 year. The doses of vitamin E were 150, 300, or 600 mg; three times per day after each meal. Responses were assessed by liver enzyme levels [aspartate aminotransferase(AST), alanine aminotranferease(ALT), and γ-glutamyl transpeptidase(γ-GTP)], noninvasive scoring systems of hepatic fibrosis-4 [FIB-4 index and aspartate aminotransferaseto-platelet index(APRI)], and liver stiffness [velocity of shear wave(Vs)] measured by acoustic radiation force impulse elastography. Vs measurements were performed at baseline and 12 mo after baseline. The patients were genotyped for the patatin-like phospholipase domain containing 3(PNPLA3) polymorphisms and then divided into either the CC/CG or GG group to examine each group's responses to vitamin E treatment. RESULTS: We found marked differences in the platelet count, serum albumin levels, alkaline phosphatase levels, FIB-4 index, APRI, and Vs at baseline depending on the PNPLA3 polymorphism. AST, ALT, and γ-GTP levels(all P < 0.001); FIB-4 index(P = 0.035); APRI(P < 0.001); and Vs(P < 0.001) significantly decreased from baseline to 12 mo in the analysis of all patients. In the subset analyses of PNPLA3 genotypes, AST levels(P = 0.011), ALT levels(P < 0.001), γ-GTP levels(P = 0.005), APRI(P = 0.036), and Vs(P = 0.029) in genotype GG patients significantly improved, and AST and ALT levels(both P < 0.001), γ-GTP levels(P = 0.003), FIB-4 index(P = 0.017), and APRI(P < 0.001) in genotype CC/CG patients. CONCLUSION: One year of vitamin E treatment improved noninvasive fibrosis scores and liver stiffness in NAFLD patients. The responses were similar between different PNPLA3 genotypes. | Aiko Fukui Naoto Kawabe Senju Hashimoto Michihito Murao Takuji Nakano Hiroaki Shimazaki Toshiki Kan Kazunori Nakaoka Masashi Ohki Yuka Takagawa Tomoki Takamura Hiroyuki Kamei Kentaro Yoshioka | 2015 | World Journal of Hepatology2015，7，27： | 0 |
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