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| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | Identification of stable normalization genes for quantitative real-time PCR in porcine articular cartilage显示文摘Background: Expression levels for genes of interest must be normalized with an appropriate reference, or housekeeping gene, to make accurate comparisons of quantitative real-time PCR results. The purpose of this study was to identify the most stable housekeeping genes in porcine articular cartilage subjected to a mechanical injury from a panel of 10 candidate genes. Results: Ten candidate housekeeping genes were evaluated in three different treatment groups of mechanically impacted porcine articular cartilage. The genes evaluated were: beta actin, beta-2-microglobulin, glyceraldehyde-3-phosphate dehydrogenase, hydroxymethylbilane synthase, hypoxanthine phosphoribosyl transferase, peptidylprolyl isomerase A (cyclophilin A), ribosomal protein L4, succinate dehydrogenase flavoprotein subunit A, TATA box binding protein, and tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein-zeta polypeptide. The stability of the genes was measured using geNorm, BestKeeper, and NormFinder software. The four most stable genes measured via geNorm were (most to least stable) succinate dehydrogenase flavoprotein, subunit A, peptidylprolyl isomerase A, glyceraldehyde-3-phosphate dehydrogenase, beta actin; the four most stable genes measured via BestKeeper were glyceraldehyde-3-phosphate dehydrogenase, peptidylprolyl isomerase A, beta actin, succinate dehydrogenase flavoprotein, subunit A; and the four most stable genes measured via NormFinder were peptidylprolyl isomerase A, succinate dehydrogenase flavoprotein, subunit A, glyceraldehyde-3-phosphate dehydrogenase, beta actin. Conclusions: BestKeeper, geNorm, and NormFinder all generated similar results for the most stable genes in porcine articular cartilage. The use of these appropriate reference genes will facilitate accurate gene expression studies of porcine articular cartilage and suggest appropriate housekeeping genes for articular cartilage studies in other species. | Ryan S McCulloch Melissa S Ashwell Audrey T O'Nan Peter L Mente | 2012 | Journal of Animal Science and Biotechnology2012，3，4： | 2 |
| 3 | A paternity case with three genetic incompatibilities between father and child due to maternal uniparental disomy 21 and a mutation at the Y chromosome显示文摘 | Audrey ML Jurgen H Henke L | 2009 | Forensic Sci Int Genet2009，3，2： | 1 |
| 4 | Alteration Mapping in Exploration:Application of Short Wave Infrared (SWIR) Spectroscopy显示文摘 | Thompson Anne J B Hauff Phoebe L Audrey J Robitaille | 1999 | Society of economic geologists1999，39，： | 1 |
| 5 | The enable right vertricalar circulatory suport systom for bcating heast cornary artery bupase Groft surgery 显示文摘 | Gijs G Andre L Dekker Frederik H Vander-veen Keses B Prenger Audrey A Cramer S Jos G Davidshoshan I | 1999 | Ann Thorac Surg1999，68，： | 1 |
| 6 | Relationships between years of education and gray matter volume, metabolism and functional connectivity in healthy elders显示文摘 | Eider M. Arenaza-Urquijo Brigitte Landeau Renaud La Joie Katell Mevel Florence Mézenge Audrey Perrotin Béatrice Desgranges David Bartrés-Faz Francis Eustache Ga?l Chételat | 2013 | Neuroimage2013，，： | 1 |
| 7 | Sustainable systems theory:ecological and other aspects显示文摘 | CHRISTOPHER W PAWLOWSKI AUDREY L MAYER N THERESA HOAGLAND | 2005 | Journal of Cleaner Production2005，，13： | 1 |
| 8 | Dysplasia as a predictive marker for invasive carcinoma in Barrett esophagus: A follow-up study based on 138 cases from a diagnostic variability study显示文摘 | Elizabeth Montgomery John R Goldblum Joel K Greenson Marian M Haber Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Kay Washington Marianna L Zahurak John Hart | 2001 | Human Pathology2001，，： | 1 |
| 9 | Wastewater reclamation, recycling and reuse:past, present and future 显示文摘 | Takashi A Audrey D L | 1996 | Wat Sci Tech1996，33，1011： | 1 |
| 10 | Structure and functional properties of Ulvan- a polysaccharide from green seaweeds 显示文摘 | Marc L Audrey R | 2007 | Bio macromolecules2007，8，6： | 1 |
| 11 | Development of a new microfluidic platform integra- ting co-euhures of intestinal and liver cell lines显示文摘 | THIBAULT B PATRICK P AUDREY L | 2014 | Toxicology in Vitro2014，28，5： | 1 |
| 12 | Liver single breath-hold dynamic subtraction CT with multi-detector row helical technology-feasibility stud显示文摘 | Audrey S Rendon N Carolyn L | 2002 | Radiology2002，222，1： | 1 |
| 13 | Competitive allele specific TaqMan PCR for KRAS , BRAF and EGFR mutation detection in clinical formalin fixed paraffin embedded samples显示文摘 | Audrey Didelot Delphine Le Corre Armelle Luscan Aurélie Cazes Karine Pallier Jean-Fran?ois Emile Pierre Laurent-Puig Hélène Blons | 2012 | Experimental and Molecular Pathology2012，，3： | 1 |
| 14 | HPV genotype distribution according to severity of cervical neoplasia using the digene HPV genotyping LQ test显示文摘 | Philippe H Maria L ML Audrey R | | 0，，06： | 1 |
| 15 | Development of a new microfluidic platform integrating co-cultures of intestinal and liver cell lines显示文摘 | THIBAULT B PATRICK P AUDREY L | 2014 | Toxicology in Vitro2014，28，5： | 1 |
| 16 | 查看详情显示文摘 | Audrey L M Christopher W P Heriberto C | | 0，，： | 1 |
| 17 | Wildlife responses to recreation and associated vistor perceptions显示文摘 | Audrey R Taylor Richard L Knight | 2003 | Ecological Applications2003，13，4： | 1 |
| 18 | Effects of ascorbic acid, glutathione, thiocyanate, and iodide on antimJcrobial activity of acidi- fied nitrite显示文摘 | ALEMU F ROLF D AUDREY L | 2004 | Antimicrobial Agents and Chemotherapy2004，48，2： | 1 |
| 19 | Ascorbic acid induced deg- radation of beta-glucan: Hydroxyl radicals as intermediates stud- ied by spin trapping and electron spin resonance spectroscopy 显示文摘 | Audrey M F Mogens L A Laura N | 2012 | Carbohydrate Polymers2012，87，3： | 1 |
| 20 | Aphasia severity:association with cerebral perfusion and diffusion显示文摘 | Elena P Theodore P | 2002 | Aphasiology2002，16，： | 1 |
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