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| 1 | Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis显示文摘AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(BIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospectively completed clinical evaluations and nutritional assessment by BIA to obtain PAs during a 36-mo follow-up period. Mortality risk was analyzed by applying the PA cutoff point recently proposed as a malnutrition marker(PA ≤ 4.9°) in Kaplan-Meier curves and multivariate Cox regression models. RESULTS The patients were divided into two groups according to the PA cutoff value(PA > 4.9°, n = 73; PA ≤ 4.9°, n = 61). Weight, height, and body mass index were similar in both groups, but patients with PAs > 4.9° were younger and had higher mid-arm muscle circumference, albumin, and handgrip-strength values and lower severe ascites and encephalopathy incidences, interleukin(IL)-6/IL-10 ratios and C-reactive protein levels than did patients with PAs ≤ 4.9°(P ≤ 0.05). Forty-eight(35.80%) patients died due to cirrhosis, with a median of 18 mo(interquartile range, 3.3-25.6 mo) follow-up until death. Thirty-one(64.60%) of these patients were from the PA ≤ 4.9° group. PA ≤ 4.9° significantly and independently affected the mortality model adjusted for Model for End-Stage Liver Disease score and age(hazard ratio = 2.05, 95%CI: 1.11-3.77, P = 0.021). In addition, Kaplan-Meier curves showed that patients with PAs ≤ 4.9° were significantly more likely to die. CONCLUSION In male patients with cirrhosis, the PA ≤ 4.9° cutoff was associated independently with mortality and identified patients with worse metabolic, nutritional, and disease progression profiles. The PA may be a useful and reliable bedside tool to evaluate prognosis in cirrhosis. | Giliane Belarmino Maria Cristina Gonzalez Raquel S Torrinhas Priscila Sala Wellington Andraus Luiz Augusto Carneiro D'Albuquerque Rosa Maria R Pereira Valéria F Caparbo Graziela R Ravacci Lucas Damiani Steven B Heymsfield Dan L Waitzberg | 2017 | World Journal of Hepatology2017，9，7： | 11 |
| 2 | Perspectives on new biomarkers in gastric cancer: Diagnostic and prognostic applications显示文摘Gastric cancer is considered one of the most deadly tumors worldwide. Even with the decline in its incidence, the mortality rate of this disease has remained high, mainly due to its late diagnosis and to the lack of precise prognostic markers. The main purpose of this review is to present genetic, epigenetic and proteomic molecular markers that may be used in a diagnostic and prognostic manner and to discuss the pros and cons of each type of marker for improving clinical practice. In this sense, we observed that the use of genetic markers, especially mutations and polymorphisms, should be carefully considered, as they are strongly affected by ethnicity. Proteomic-based markers show promise, but the higher costs of the associated techniques con-tinue to make this approach expensive for routine use. Alternatively, epigenetic markers appear to be very promising, as they can be detected in bodily fluids as well as tissues. However, such markers must be used carefully because epigenetic changes may occur due to environmental factors and aging. Despite the advances in technology and its access, to date, there are few defined biomarkers of prognostic and diagnostic use for gastric tumors. Therefore, the use of a panel of several approaches(genetic, epigenetic and proteomic) should be considered the best alternative for clinical practice. | Danilo do Rosário Pinheiro Wallax Augusto Silva Ferreira Mariceli Baia Leo Barros Mariana Diniz Araújo Symara Rodrigues-Antunes Bárbara do Nascimento Borges | 2014 | World Journal of Gastroenterology2014，20，33： | 4 |
| 3 | Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression显示文摘 | Yoo Byoung Kwon Emdad Luni Su Zao-zhong Villanueva Augusto Chiang Derek Y Mukhopadhyay Nitai D Mills Alan Scott Waxman Samuel Fisher Robert A Llovet Josep M Fisher Paul B Sarkar Devanand | 2009 | Journal of Clinical Investigation2009，，3： | 2 |
| 4 | Grain-size end-members and environmentally sensitive grain-size components: A comparative study in the mud shelf depocenters off southern Brazil显示文摘The current study aims to do a comparative analysis of the results obtained with two End-Member(EM)grain-size modeling techniques(AnalySize and BasEMMA)and the Environmental Sensitive Grain-Size(ESGS)modeling for sediment samples collected in the mudbelts of the southern Brazilian shelf.The methods were compared using grain-size data from the south Brazilian shelf,and the results are discussed here.It is the first time that the concept of ESGS,in its present form,is utilized outside China.The results show that despite its relative ease of use,the ESGS is not fully comparable to the EM analyses,and only two grain-size ESGS classes were recognized as analogous to EMs.The comparison of the AnalySize and BasEMMA procedures also revealed significant differences between the techniques.A comparative analysis between the two EM techniques revealed advantages in the BasEMMA,especially in the better correlation of the end-members with the original grain size distribution.The analysis of the geographical distribution of the EM abundances allowed point sources of sandy populations to be recognized as well as the contribution of the Rio de la Plata as a source of silty sediments to be inferred. | Michel Michaelovitch de Mahiques Samara Cazzoli y Goya Maria Carolina da Silva Nogueira de Matos Rodrigo Augusto Udenal de Oliveira Bianca Sung Mi Kim Paulo Alves de Lima Ferreira Rubens Cesar Lopes Figueira Marcia Caruso Bícego | 2021 | International Journal of Sediment Research2021，36，2： | 2 |
| 5 | A constructive approach to hardware/software partitioning显示文摘 | LEILA S AUGUSTO S EDNA B | 2004 | Formal Methods in System Design2004，24，1： | 1 |
| 6 | Prognostic factors in advancedcancer Patients: evidence-based clinical recommendations-a study bythe Steering Committee of the European Association for palliativecare显示文摘 | Marco M Augusto C Cinzia B | 2015 | J Clin Oncol2015，23，25： | 1 |
| 7 | Exploring the relationship between perceived emotional intelligence, coping, social support and men- tal health in nursing students 显示文摘 | Montes-Berges B Augusto JM | 2007 | J Psychiatr Ment Health Nurs2007，14，2： | 1 |
| 8 | Gabapentin for neuropathiccancer pain:A randomized controlled trial from the gabapentin cancerpain study group显示文摘 | Augusto C Ernesto Z Cesare B | 2004 | J Clin Oncol?2004，22，14： | 1 |
| 9 | Exploring the relationship between perceived emotional intelligence, coping, social support and mental health in nursing students 显示文摘 | Montes Berges B Augusto JM | 2007 | Journal of Psychiatric and Mental Health Nursing2007，14，2： | 1 |
| 10 | Multi-objective Genetic Algorithms: a Way to Improve the Convergence Rate 显示文摘 | Augusto O B Rabeau S | 2006 | Engineering Applications of Artificial Intelligence2006，19，5： | 1 |
| 11 | An outcome research project to evaluate the epidemiology, the quality and the effects of pain treatment in cancer patients 显示文摘 | Giovanni A Oscar B Augusto C : Pain in cancer | 2006 | Health and Quality of Life Outcomes2006，4，7： | 1 |
| 12 | Septicshock sera containing circulating histones induce dendritic cellregulatednecrosis in fatal septic shock patients显示文摘 | Raffray L Douchet I Augusto JF Youssef J Contin-BordesC Richez C Duffau P Truchetet ME Moreau JF Cazanave C Leroux L Mourrissoux G Camou F Clouzeau B Jeannin P Delneste Y Gabinski C Guisset O Lazaro E Blanco P | 2015 | Crit CareMed2015，43，4： | 1 |
| 13 | Design and experimentalvalidation of a cooperative driving system in the grand cooperativedriving challenge 显示文摘 | Kianfar R Augusto B Ebadighajari A | 2012 | Intelligent Transportation Systems IEEE Transactionson2012，13，3： | 1 |
| 14 | Thromboembolic prophylaxis with use of Aspirin,exercise,and graded elastic stockings or intermittent compression devices in patients managed with total hip or arthropasty显示文摘 | AUGUSTO A C SARMSENTO G B GABLES C J | 1999 | J Bone Joint Surg(Am)1999，8，： | 1 |
| 15 | Use of intravenous immunoglobulin in patients with acquired von Willebrand syndrome显示文摘 | FEDERICI AB | 2005 | Human Immunology2005，66，： | 1 |
| 16 | Improving hydrological information acquisition from DEM processing in flood- plains显示文摘 | AUGUSTO C V G MARIE P B OTTO C R F | 2009 | Hydrological Processes2009，23，： | 1 |
| 17 | On the performance of Fe and Fe, F doped Ti-Pt/PbO2 electrodes in the electrooxidation of the Blue Reactive 19 dye in simulated textile wastewater显示文摘 | Leonardo S Andrade a Luis Augusto M Ruotolo b Romeu C Rocha-Filho | 2007 | Chemo- sphere2007，66，： | 1 |
| 18 | Prediction of the Chromatographic Re- tention of Saturated Alcohols on Stationary Phases of Different Polarity Applying the Novel Semi Empirical Topological Index显示文摘 | da Silva Junkes B Dias de Mello Castanho Amhoni R Augusto Yunes R | 2003 | Anal Chim Acta2003，477，： | 1 |
| 19 | Determinants and Correlates of Target Lesion Calcium in Coronary Artery Disease: A Clinical, Angiographic and Intravascular Ultrasound Study显示文摘 | Gary S Mintz Augusto D Pichard Jeffrey J Popma Kenneth M Kent Lowell F Satler Theresa A Bucher Martin B Leon | | Journal of the American College of Cardiology0，，： | 1 |
| 20 | 5-year outcomes of transcatheter aortic valve replacement compared with standard treatment for patients with inoperable aortic stenosis (PARTNER 1): a randomised controlled trial显示文摘 | Samir R Kapadia Martin B Leon Raj R Makkar E Murat Tuzcu Lars G Svensson Susheel Kodali John G Webb Michael J Mack Pamela S Douglas Vinod H Thourani Vasilis C Babaliaros Howard C Herrmann Wilson Y Szeto Augusto D Pichard Mathew R Williams Gregory P Fontan | 2015 | The Lancet . 2015 (9986)2015，，： | 1 |
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