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| 1 | Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease显示文摘AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. | Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | International NeuroAIDS: prospects of HIV-1 associated neurological com-plications显示文摘Neurological complications associated with HIV-1/AIDS are being recognized with a high frequency that parallels the increased number of AIDS cases. The early infiltration by HIV-1 into the nervous system can cause primary and/or secondary neurological complications. The most common neurocognitive disorder is AIDS Dementia Complex (ADC). In developing countries of Asia the three most opportunistic infections are tuberculosis (TB), cryptococcosis, and Pneumocystis carinii pneumonia. Therefore, it is expected that secondary neurological complications due to TB and cryptococcosis will be the most common cause of morbility and mortality in HIV-1/AIDS cases in China. Research of NeuroAIDS in China is necessary to understand the impact and the biology of HIV-1 in the nervous system. Future studies would include, the molecular epidemiology and the description of opportunistic infections associated to HIV-1; the neuropathological description of primary and secondary HIV-1 complications in different groups; the HIV-1 neurot- ropism and immune response studies for China’s unique HIV-1 strains and recombinant forms derived from the nervous system, including experimental models such as the use of transgenic rats; and the study of potential resistant virus, primarily when the anti-retroviral therapy (ART) has not full access in the brain. | J Roberto TRUJILLO Gilberto JARAMILLO-RANGEL Marta ORTEGA-MARTINEZ Augusto C PENALVA de OLIVEIRA Jose E VIDAL Joseph BRYANT Robert C GALLO | 2005 | Cell Research2005，15，11： | 4 |
| 3 | Optimization of refrigerated shields using multilayer thermal insulation Cryostats designanalytical solution 显示文摘 | Augusto P A Grande T C Augusto P | 2006 | Cryogenics2006，46，： | 1 |
| 4 | Oxidative stressexpression status associated to Helicobacter pylori virulencein gastric diseases显示文摘 | Augusto A C Miguel F Mendonca S | 2007 | Clin Biochem2007，40，910： | 1 |
| 5 | Guidelines for biomonitoring persistent organic pollutants (POPs) , using lichens and aquatic mosses: a review 显示文摘 | Augusto S Maguas C Branquinho C | 2013 | Environ Pollut2013，180，： | 1 |
| 6 | Prognostic factors in advancedcancer Patients: evidence-based clinical recommendations-a study bythe Steering Committee of the European Association for palliativecare显示文摘 | Marco M Augusto C Cinzia B | 2015 | J Clin Oncol2015，23，25： | 1 |
| 7 | Modeling novel quinocofactors:an overview显示文摘 | Andrea C R Antonio R Augusto R | 1999 | Bioorg Chem1999，27，： | 1 |
| 8 | Consumer reaction to service failure and recovery: the moderat- ing role of attitude toward complaining 显示文摘 | Augusto de Matos C Vargas Rossi C A Teixeira Veiga R | 2009 | Journal of Services Marketing2009，23，7： | 1 |
| 9 | Monitoring biogenic volatile compounds emitted by Eucalyptus citriodora using SPME显示文摘 | ZINI C A AUGUSTO F CHRISTENSEN T E | 2001 | Analytical Chemistry2001，73，19： | 1 |
| 10 | Bioreduction of 2-azido-1-arylethanones mediated by Geotrichum candidum and rhodotorula glutinis 显示文摘 | Lucidio C Fardelone J Augusto R | 2006 | Journal of Molecular Catalysis B:Enzymatic2006，39，14： | 1 |
| 11 | Angiotensin-Converting Enzyme 2 Activation Improves Endothelial Function显示文摘 | Rodrigo A. Fraga-Silva Fabiana P. Costa-Fraga Tatiane M. Mur?a Patrícia L. Moraes Augusto Martins Lima Roberto Q. Lautner Carlos H. Castro Célia Maria A. Soares Clayton L. Borges Ana Paula Nadu Marilene L. Oliveira Vinayak Shenoy Michael J. Katovich Robso | 2013 | Hypertension2013，，6： | 1 |
| 12 | Cu-and Fe-ZSM-5 as catalysts for phenol hydroxylation显示文摘 | Aida Luz Villa César Augusto Caro Consuelo Montes de Correa | 2005 | Journal of Molecular Catalysis A:Chemical2005，228，12： | 1 |
| 13 | Consumer Reaction to Product Recalls:Factors Influencing Product Judgment and Behavioral Intentions 显示文摘 | MATOS D AUGUSTO C CARLOS A V R | 2007 | International Journal of Consumer Studies2007，31，1： | 1 |
| 14 | Gabapentin for neuropathiccancer pain:A randomized controlled trial from the gabapentin cancerpain study group显示文摘 | Augusto C Ernesto Z Cesare B | 2004 | J Clin Oncol?2004，22，14： | 1 |
| 15 | Modeling novel quinocofactors: an overview显示文摘 | Andrea C R Antonio R Augusto R | 1999 | Bioorg Chem1999，27，4： | 1 |
| 16 | Predictive validity of Perceived Emotional Intelligence on nursingstudents' self-concept 显示文摘 | Augusto Landa JM L6pez-Zafra E Aguilar-Luz6n Mdel C | 2009 | Nurse Educ Today2009，29，7： | 1 |
| 17 | Esophagogastric junction outflow obstruction successfully treated with laparoscopic Heller myotomy and Dor fundoplication: First case report in the literature显示文摘BACKGROUND Esophagogastric junction outflow obstruction(EGJOO) is a rare syndrome,characterized by an elevation of the integrated relaxation pressure of the lower esophageal sphincter, not accompanied by alterations in esophageal motility that may lead to the criteria for achalasia. We were unable to find any prior report of the combination of Heller myotomy with anterior partial fundoplication(Dor) as the treatment for EGJOO. We herein report a case of EGJOO treated with laparoscopic Heller myotomy combined with Dor fundoplication.CASE SUMMARY A 26-year-old man presented with a 3-year history of solid dysphagia and a 30-kg weight loss. He was treated with oral nifedipine, isosorbide, and omeprazole,without resolution of symptoms. An upper gastrointestinal series(barium swallow) revealed a 'bird's beak' sign. Esophagogastroduodenoscopy was positive for Los Angeles grade A peptic esophagitis. High-resolution esophageal manometry was compatible with EGJOO. Esophageal pH monitoring showed pathological acid reflux both in orthostatic and decubitus position. An 8-cm laparoscopic Heller myotomy combined with an anterior 220° Dor fundoplication was performed. Solid diet was introduced on postoperative day 2, and the patient was discharged home the same day. At 17-mo follow-up, he reported no symptoms. Barium swallow was compatible with complete radiologic resolution.Both esophageal manometry and upper endoscopy showed normal findings 9 mo after the operation.CONCLUSION Surgical treatment with Heller myotomy and Dor fundoplication is a potential treatment option for EGJOO refractory to medical treatment. | Pedro F Pereira Andre RP Rosa Leonardo A Mesquita Marcelle J Anzolch Rafael N Branchi Augusto L Giongo Francisco C Paix?o Marcio F Chedid Cleber DP Kruel | 2019 | World Journal of Gastrointestinal Surgery2019，11，2： | 1 |
| 18 | Pyrimidine Ortho-quinodimathanes显示文摘 | AUGUSTO C T | 1996 | Tetrahedron1996，52，5： | 1 |
| 19 | Bilateral stress fracture of theDatellae: a case reDort显示文摘 | Mario C Caio Augusto de SN LuizAM | 2006 | The Knee2006，12，3： | 1 |
| 20 | Bilateral stress fracture of the patellae:a case report显示文摘 | Mario C Caio Augusto de SN Luiz AM | 2006 | The Knee2006，12，3： | 1 |
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