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| 1 | Dendritic Cell-Derived Exosomes Stimulate Stronger CD8^+ CTL Responses and Antitumor Immunity than TVimor Cell-Derived Exosomes显示文摘从树枝状的细胞(DC ) 和肿瘤细胞导出的 Exosomes (EXO ) 被用来在动物模型并且在临床的试用刺激 antitumor 免疫者回答。然而,有不,一起, antitumor 免疫者回答的 stimulatory 效率的比较由这二支通常使用的 EXO 疫苗导致了。在这研究,我们选择了房间表示学习 EXO 的特征从一个 transfected EG7 肿瘤导出的显型 ovalbumin (卵) 和由流动 cytometry 的搏动卵的 DC。我们在在 EXO 的这二种类型之间的卵特定的有免疫力的回答的正式就职比较了 stimulatory 效果。我们发现卵搏动蛋白质的导出 DCovA 的 EXO (EXODC ) 能更高效地在 vivo 刺激天真的卵特定的 CD8+ T 房间增长和区别进细胞毒素的 T 淋巴细胞,并且比 EG7 肿瘤导致更有效的 antitumor 免疫导出房间的 EXO (EXOEG7 ) 。另外,我们阐明了在 EXO 的 stimulatory 效果被主人 DC 送到 T 房间回答的 EXO 疫苗的主人 DC 的重要角色。因此,导出 DC 的 EXO 可以在 antitumor 免疫的正式就职代表一支更有效的基于 EXO 的疫苗。 | Siguo Hao Ou Bai Jinying Yuan Mabood Qureshi Jim Xiang | 2006 | Cellular & Molecular Immunology2006，3，3： | 30 |
| 2 | Effect of local wound infiltration with ropivacaine on postoperative pain relief and stress response reduction after open hepatectomy显示文摘AIM To prospectively evaluate the effect of local wound infiltration with ropivacaine on postoperative pain relief and stress response reduction after open hepatectomy.METHODS A total of 56 patients undergoing open hepatectomy were randomly divided into two groups:a ropivacaine group(wound infiltration with ropivacaine solution)and a control group(infiltration with isotonic saline solution).A visual analog scale(VAS)at rest and on movement was used to measure postoperative pain for the first 48 h after surgery.Mean arterial pressure(MAP),heart rate(HR),time to bowel recovery,length of hospitalization after surgery,cumulative sufentanil consumption,and incidence of nausea and vomiting were compared between the two groups.Surgical stress hormones(epinephrine,norepinephrine,and cortisol)were detected using enzyme-linked immunosorbent assay,and the results were compared. RESULTS VAS scores both at rest and on movement at 24 h and48 h were similar between the two groups.Significantly lower VAS scores were detected at 0,6,and 12 h in the ropivacaine group compared with the control group(P<0.05 for all).MAP was significantly lower at 6,12,and 24 h(P<0.05 for all);HR was significantly lower at 0,6,12,and 24 h(P<0.05 for all);time to bowel recovery and length of hospitalization after surgery(P<0.05 for both)were significantly shortened;and cumulative sufentanil consumption was significantly lower at 6,12,24,and 36 h(P<0.05 for all)in the ropivacaine group than in the control group,although the incidence of nausea and vomiting showed no significant difference between the two groups.The levels of epinephrine,norepinephrine,and cortisol were significantly lower in the ropivacaine group than in the control group at 24 and 48 h(P<0.01 for all). CONCLUSION Local wound infiltration with ropivacaine after open hepatectomy can improve postoperative pain relief,reduce surgical stress response,and accelerate postoperative recovery. | Jing-Xian Sun Ke-Yun Bai Yan-Feng Liu Gang Du Zhi-Hao Fu Hao Zhang Jin-Huan Yang Ben Wang Xiu-Yu Wang Bin Jin | 2017 | World Journal of Gastroenterology2017，23，36： | 25 |
| 3 | Altered trends in carbon uptake in China’s terrestrial ecosystems under the enhanced summer monsoon and warming hiatus显示文摘The carbon budgets in terrestrial ecosystems in China are strongly coupled with climate changes.Over the past decade,China has experienced dramatic climate changes characterized by enhanced summer monsoon and decelerated warming.However,the changes in the trends of terrestrial net ecosystem production(NEP)in China under climate changes are not well documented.Here,we used three ecosystem models to simulate the spatiotemporal variations in China's NEP during 1982–2010 and quantify the contribution of the strengthened summer monsoon and warming hiatus to the NEP variations in four distinct climatic regions of the country.Our results revealed a decadal-scale shift in NEP from a downtrend of–5.95 Tg C/yr^2(reduced sink)during 1982–2000 to an uptrend of 14.22 Tg C/yr^2(enhanced sink)during 2000–10.This shift was essentially induced by the strengthened summer monsoon,which stimulated carbon uptake,and the warming hiatus,which lessened the decrease in the NEP trend.Compared to the contribution of 56.3%by the climate effect,atmospheric CO2 concentration and nitrogen deposition had relatively small contributions(8.6 and 11.3%,respectively)to the shift.In conclusion,within the context of the global-warming hiatus,the strengthening of the summer monsoon is a critical climate factor that enhances carbon uptake in China due to the asymmetric response of photosynthesis and respiration.Our study not only revealed the shift in ecosystem carbon sequestration in China in recent decades,but also provides some insight for understanding ecosystem carbon dynamics in other monsoonal areas. | Honglin He Shaoqiang Wang Li Zhang Junbang Wang Xiaoli Ren Lei Zhou Shilong Piao Hao Yan Weimin Ju Fengxue Gu Shiyong Yu Yuanhe Yang Miaomiao Wang Zhongen Niu Rcmg Ge Huimin Yan Mei Huang Guoyi Zhou Yongfei Bai Zongqiang Xie Zhiyao Tang Bingfang Wu Leiming Zhang Nianpeng He Qiufeng Wang Guirui Yu | 2019 | National Science Review2019，6，3： | 24 |
| 4 | Spinal cord biological safety of image-guided radiation therapy versus conventional radiation therapy显示文摘Tumor models were simulated in purebred Beagles at the T9-10 levels of the spinal cord and treated with spinal image-guided radiation therapy or conventional radiation therapy with 50 or 70 Gy total radiation. Three months after radiation, neuronal injury at the T9-10 levels was observed, including reversible injury induced by spinal image-guided radiation therapy and apoptosis induced by conventional radiation therapy. The number of apoptotic cells and expression of the proapoptotic protein Fas were significantly reduced, but expression of the anti-apoptotic protein heat shock protein 70 was significantly increased after image-guided radiation therapy compared with the conventional method of the same radiation dose. Moreover, the spinal cord cell apoptotic index positively correlated with the ratio of Fas/heat shock protein 70. These findings indicate that 3 months of radiation therapy can induce a late response in the spinal cord to radiation therapy; image-guided radiation therapy is safer and results in less neuronal injury compared with conventional radiation therapy. | Wanlong Xu Xilinbaoleri Hao Liu Ruozheng Wang Jingping Bai | 2012 | Neural Regeneration Research2012，7，35： | 23 |
| 5 | DUF221 proteins are a family of osmosensitive calciumpermeable cation channels conserved across eukaryotes显示文摘 | Congcong Hou Wang Tian Thomas Klelst Kai He Veder Garcia Fenglin Bai Yanli Hao Sheng Luan Legong Li | 2014 | Cell Research2014，24，5： | 22 |
| 6 | Current trauma care system and trauma care training in China显示文摘损伤是威胁生活的现代疾病。结果能被成本效率、迅速的损伤照顾仅仅优化,它除了损伤照顾系统的造成分裂的革新开始必要能力和概念的革命的改进。根据来自发达国家的经验,系统的损伤照顾训练在损伤照顾上是归纳和改进的奠基石,例如进展损伤生活支持(ATLS ) 。当前,医院前紧急情况医疗服务(他们) 是在中国的健康服务的基础结构的必要元素之一,它对损伤照顾系统也基本。在此,有独立知识产权权利的训练的中国损伤照顾(CTCT ) 被开始了并且由中国损伤外科医生协会发射了也在损伤照顾的地里扩大新概念和技术在惯例增强通常接受得好的标准化协议。这篇文章考察损伤照顾系统以及训练的损伤照顾的当前的地位。 | Lian-Yang Zhang Xiu-Zhu Zhang xiang-Jun Bai Mao Zhang Xiao-Gang Zhao Yong-An Xu Hao Tan Yang Li | 2018 | Chinese Journal of Traumatology2018，21，2： | 23 |
| 7 | Advances in treatment of ulcerative colitis with herbs: From bench to bedside显示文摘Ulcerative colitis(UC), an idiopathic inflammatory disorder in the colon, has become a clinical challenge, owing to the increasing incidence and poor prognosis. The conventional treatments for UC including aminosalicylates, corticosteroids, and immunosuppressants, induce remission in only half of patients. Meanwhile, the treatments often come with serious side effects which can be life-threatening. Herbal medicine, one of the most common traditional Chinese medicine modalities, has been introduced for centuries into clinical treatment of many human diseases such as infections and functional disorders. Recently, the potential effectiveness of herbs has been suggested as the treatment of UC, as shown by a variety of clinical trials and experimental studies. The herbs reported in the literature include aloe vera gel, butyrate, tormentil extracts, wheat grass juice, and curcumin. In the review, bioactivity of the herbs and their involvement in UC treatment are discussed. | Ping Wan Hao Chen Yuan Guo Ai-Ping Bai | 2014 | World Journal of Gastroenterology2014，20，39： | 21 |
| 8 | Valproic acid reduces autophagy and promotes functional recovery after spinal cord injury in rats显示文摘Secondary damage is a critical determinant of the functional outcome in patients with spinal cord injury (SCI), and involves multiple mechanisms of which the most important is the loss of nerve cells mediated by multiple factors. Autophagy can result in cell death, and plays a key role in the development of SCI. It has been recognized that valproic acid (VPA) is neuroprotective in certain experimental animal models, however, the levels of autophagic changes in the process of neuroprotection by VPA treatment following SCI are still unknown. In the present study, we determined the extent of autophagy after VPA treatment in a rat model of SCI. We found that both the mRNA and protein levels of Beclin-1 and LC3 were significantly increased at 1, 2, and 6 h after SCI and peaked at 2 h; however, Western blot showed that autophagy was markedly decreased by VPA treatment at 2 h post-injury. Besides, post-SCI treatment with VPA improved the Basso-Beattie-Bresnahan scale, increased the number of ventral horn motoneurons, and reduced myelin sheath damage compared with vehicle-treated animals at 42 days after SCI. Together, our results demonstrated the characteristics of autophagy expression following SCI, and found that VPA reduced autophagy and enhanced motor function. | Hai-Hu Hao Li Wang Zhi-Jian Guo Lang Bai Rui-Ping Zhang Wei-Bing Shuang Yi-Jia Jia Jie Wang Xiao-Yu Li Qiang Liu | 2013 | Neuroscience Bulletin2013，29，4： | 19 |
| 9 | Silencing livin gene by siRNA leads to apoptosis induction,cell cycle arrest,and proliferation inhibition in malignant melanoma LiBr cells显示文摘目的:现在的学习的目的是调查 silencing 的效果由 apoptosis 上的 livin 和效果的表示上的小介入 RNA ( siRNA )的 livin 基因,房间周期,并且在人的│恶性黑瘤 LiBr cells.Methods 的增长:指向 livin 的三化学上合成的 siRNA duplexes 是短暂地 transfected 进 LiBr 房间,并且 livin 表示上的效果被即时 RT-PCR 在 mRNA 水平两个都检测,在蛋白质,由西方的 blotting.Apoptosis 的水平被终端 deoxynucleotidyl 评估 procaspase-3 的 调停transferase 的 digoxigenin-dUTP 刻痕结束标记试金,流动 cytometric 分析和由西方的弄污的激活的 caspase-3 分析。房间周期被增长是的流动 cytometry.Cell 分析由3-( 4,5-dimethylthiazol-2-yl )决定了 -2,5-diphenyltetrazolium bromide.Results : 3 设计 siRNA 之一能有效地两个都在剂量在 mRNA 和蛋白质层次将 livin 表示击倒--并且时间依赖者礼貌;有在在 48 h 的 mRNA 上的规定下面的最大值的 100 nmol/L ,并且在 transfection.Silencing livin 能显著地导致 apoptosis 以后,在在 72 h 的蛋白质上,拘捕房间在 G_0/G_1 阶段骑车,并且在 LiBr 房间禁止增长。同时, caspase-3 是 activated.Conclusion : livin 基因能为│恶性黑瘤由 siRNA 为基因治疗用作一个潜在的分子的目标。 | Hao WANG Sheng-shun TAN Xin-yang WANG Dong-hua LIU Chun-shui YU Zhuan-li BAI Da-lin HE Jun ZHAO3 | 2007 | Acta Pharmacologica Sinica2007，28，12： | 19 |
| 10 | Application of 3D reconstruction for surgical treatment of hepatic alveolar echinococcosis显示文摘AIM: To evaluate the reliability and accuracy of threedimensional(3D) reconstruction for liver resection in patients with hepatic alveolar echinococcosis(HAE).METHODS: One-hundred and six consecutive patients with HAE underwent hepatectomy at our hospital between May 2011 and January 2015. Fifty-nine patients underwent preoperative 3D reconstruction and 'virtual' 3D liver resection before surgery(Group A). Another 47 patients used conventional imaging methods for preoperative assessment(Group B). Outcomes of hepatectomy were compared between the two groups.RESULTS: There was no significant difference in preoperative data between the two groups. Compared with patients in Group B, those in Group A had a significantly shorter operation time(227.1 ± 51.4 vs 304.6 ± 88.1 min; P < 0.05), less intraoperative blood loss(308.1 ± 135.4 vs 458.1 ± 175.4 m L; P < 0.05), and lower requirement for intraoperative blood transfusion(186.4 ± 169.6 vs 289.4 ± 199.2 m L; P < 0.05). Estimated resection liver volumes in bothgroups had good correlation with actual graft weight(Group A: r = 0.978; Group B: r = 0.960). There was a significant higher serum level of albumin in Group A(26.3 ± 5.9 vs 22.6 ± 4.3 g/L, P < 0.05). Other postoperative laboratory parameters(serum levels of aminotransferase and bilirubin; prothrombin time) and duration of postoperative hospital stay were similar. Sixteen complications occurred in Group A and 19 in Group B. All patients were followed for 3-46(mean, 17.3) mo. There was no recurrence of lesions in Group A, but two recurrences in Group B. There were three deaths: two from cerebrovascular accident, and one from car accident.CONCLUSION: 3D reconstruction provides comprehensive and precise anatomical information for the liver. It also improves the chance of success and reduces the risk of hepatectomy in HAE. | Yi-Biao He Lei Bai Tuerganaili Aji Yi Jiang Jin-Ming Zhao Jin-Hui Zhang Ying-Mei Shao Wen-Ya Liu Hao Wen | 2015 | World Journal of Gastroenterology2015，21，35： | 16 |
| 11 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 12 | Prognosis-related classifi cation and dynamic monitoring of immune status in patients with sepsis:A prospective observational study显示文摘BACKGROUND:The dynamic monitoring of immune status is crucial to the precise and individualized treatment of sepsis.In this study,we aim to introduce a model to describe and monitor the immune status of sepsis and to explore its prognostic value.METHODS:A prospective observational study was carried out in Zhongshan Hospital,Fudan University,enrolling septic patients admitted between July 2016 and December 2018.Blood samples were collected at days 1 and 3.Serum cytokine levels(e.g.,tumor necrosis factor-α[TNF-α],interleukin-10[IL-10])and CD14+monocyte human leukocyte antigen-D-related(HLA-DR)expression were measured to serve as immune markers.Classifi cation of each immune status,namely systemic inflammatory response syndrome(SIRS),compensatory anti-inflammatory response syndrome(CARS),and mixed antagonistic response syndrome(MARS),was defined based on levels of immune markers.Changes of immune status were classifi ed into four groups which were stabilization(SB),deterioration(DT),remission(RM),and non-remission(NR).RESULTS:A total of 174 septic patients were enrolled including 50 non-survivors.Multivariate analysis discovered that IL-10 and HLA-DR expression levels at day 3 were independent prognostic factors.Patients with MARS had the highest mortality rate.Immune status of 46.1%patients changed from day 1 to day 3.Among four groups of immune status changes,DT had the highest mortality rate,followed by NR,RM,and SB with mortality rates of 64.7%,42.9%,and 11.2%,respectively.CONCLUSIONS:Severe immune disorder defi ned as MARS or deterioration of immune status defi ned as DT lead to the worst outcomes.The preliminary model of the classifi cation and dynamic monitoring of immune status based on immune markers has prognostic values and is worthy of further investigation. | Jun Yin Yao Chen Jun-ling Huang Lei Yan Zhong-shu Kuang Ming-ming Xue Si Sun Hao Xiang Yan-yan Hu Zhi-min Dong Chao-yang Tong Chun-xue Bai Zhen-ju Song | 2021 | World Journal of Emergency Medicine2021，12，3： | 16 |
| 13 | Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality显示文摘Severe fever with thrombocytopenia syndrome (SFTS),an emerging tick-borne infectious disease caused by a novel phlebovirus (SFTS virus, SFTSV), was listed among the top 10 priority infectious diseases by the World Health Organization due to its high fatality of 12%-50% and possibility of pandemic transmission. Currently, effective anti-SFTSV intervention remains unavailable. Here, by screening a library of FDA-approved drugs, we found that benidipine hydrochloride, a calcium channel blocker (CCB), inhibited SFTSV replication in vitro. Benidipine hydrochloride was revealed to inhibit virus infection through impairing virus internalization and genome replication. Further experiments showed that a broad panel of CCBs, including nifedipine, inhibited SFTSV infection. The anti-SFTSV effect of these two CCBs was further an a lyzed in a humanized mouse model in which CCB treatment resulted in reduced viral load and decreased fatality rate. Importantly, by performing a retrospective clinical investigation on a large cohort of 2087 SFTS patients, we revealed that nifedipine administration enhaneed virus clearance, improved clinical recovery, and remarkably reduced the case fatality rate by >5-fold. These findings are highly valuable for developing potential host-oriented therapeutics for SFTS and other lethal acute viral infections known to be inhibited by CCBs in vitro. | Hao Li Lei-Ke Zhang Shu-Fen Li Shao-Fei Zhang Wei-Wei Wan Yu-Lan Zhang Qi-Lin Xin Ke Dai Yuan-Yuan Hu Zhi-Bo Wang Xiang-Tao Zhu Yu-Jie Fang Ning Cui Pan-He Zhang Chun Yuan Qing-Bin Lu Jie-Ying Bai Fei Deng Geng-Fu Xiao Wei Liu Ke Peng | 2019 | Cell Research2019，29，9： | 15 |
| 14 | Comparison of combined phacotrabeculectomy with trabeculectomy only in the treatment of primary angle-closure glaucoma显示文摘 | WANG Mei FANG Min BAI Yu-jing ZHANG Wei-zhong LIN Ming-kai LIU Bing-qian HAO Yuan-tao LING Yun-lan ZHUO Ye-hong GE Jian | 2012 | Chinese Medical Journal2012，，8： | 15 |
| 15 | Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF-κB signaling pathway显示文摘Rheumatoid arthritis(RA)is a chronic inflammatory disease that eventually leads to disability.Inflammatory cell infiltration,severe joint breaking and systemic bone loss are the main clinical symptoms.In this study,we established a collagen-induced arthritis(CIA)model and found a large number of M1 macrophages and pyroptosis,which are important sources of proinflammatory cytokines.Punicalagin(PUN)is an active substance extracted from pomegranate peel.We found that it inhibited joint inflammation,cartilage damage and systemic bone destruction in CIA mice.PUN effectively alleviated the high expression of inflammatory cytokines in synovial tissue in vivo.PUN treatment shifted macrophages from the M1 phenotype to the M2 phenotype after stimulation with lipopolysaccharide(LPS)and interferon(IFN)-γ.The expression of inducible nitric oxide synthase(i NOS)and other proinflammatory cytokines released by M1 macrophages was decreased in the PUN treatment group.However,simultaneously,the expression of markers of anti-inflammatory M2 macrophages,such as arginase(Arg)-1 and interleukin(IL)-10,was increased.In addition,PUN treatment attenuated pyroptosis by downregulating the expression of NLRP3 and caspase-1,thereby preventing inflammatory cell death resulting from the release of IL-1βand IL-18.Mechanistically,PUN inhibited the activation of receptor activators of the nuclear factor-κB(NF-κB)signaling pathway,which contributes to M1 polarization and pyroptosis of macrophages.We concluded that PUN ameliorated pathological inflammation by inhibiting M1 phenotype polarization and pyroptosis and has great potential as a therapeutic treatment for human RA. | Gaoran Ge Jiaxiang Bai Qing Wang Xiaolong Liang Huaqiang Tao Hao Chen Minggang Wei Junjie Niu Huilin Yang Yaozeng Xu Yuefeng Hao Yi Xue Dechun Geng | 2022 | Science China(Life Sciences)2022，65，3： | 14 |
| 16 | On-treatment monitoring of liver fibrosis with serum hepatitis B core-related antigen in chronic hepatitis B显示文摘BACKGROUND Non-invasive evaluation for liver fibrosis is clinically important,especially in patients with undetectable hepatitis B virus(HBV)DNA treated with nucleoside analogs.AIM To clarify the monitoring power of hepatitis B core-related antigen(HBcrAg)for hepatic histologic changes in patients with chronic hepatitis B(CHB)treated with entecavir.METHODS This prospective multicenter study used multiple ordinal and multivariate logistics regression analysis to assess variables associated with Ishak fibrosis score and regression for fibrosis regression,respectively,in 403 CHB patients,including 374 with entecavir for 72 weeks(291 underwent paired liver biopsy)and 29 as controls.RESULTS Level of HBcrAg correlated negatively with liver fibrosis staging(γ=-0.357,P<0.001)in hepatitis B e antigen(HBeAg)-positive patients,and positively with liver fibrosis staging in HBeAg-negative patients.Higher HBcrAg concentration was associated with younger age,HBeAg positive status,high HBV DNA loads,high level of hepatitis B surface antigen(HBsAg)and higher necroinflammation,but not with HBV genotype.Serum concentration of HBcrAg,basal core promoter/precore(BCP/PC)mutant,quantitation of HBsAg(qHBsAg)and platelet counts were independently associated with Ishak fibrosis score on multiple ordinal regression.HBV DNA was undetectable in 88.37%of patients treated with entecavir at week 72,while their level of HBcrAg was still detectable.A greater reduction in post-treatment HBcrAg concentration was associated with the regression of hepatic fibrosis and histological improvement.HBcrAg concentration>6.33 log IU/mL at baseline and logarithmic reduction>1.03 log IU/mL at week 72 were associated with a higher chance of regression of liver fibrosis and histological improvement,respectively.CONCLUSION HBcrAg level is associated with liver fibrosis progression.HBcrAg is an excellent monitor of hepatic histological changes,especially in CHB patients treated with nucleoside analogs. | Xiu-Juan Chang Chao Sun Yan Chen Xiao-Dong Li Zu-Jiang Yu Zheng Dong Wen-Lin Bai Xiao-Dong Wang Zhi-Qin Li Da Chen Wen-Juan Du Hao Liao Qi-Yu Jiang Li-Jun Sun Yin-Yin Li Cui-Hong Zhang Dong-Ping Xu Yong-Ping Chen Qin Li Yong-Ping Yang | 2019 | World Journal of Gastroenterology2019，25，32： | 12 |
| 17 | Functional organization of complex brain networks modulated by acupuncture at different acupoints belonging to the same anatomic segment显示文摘 | CHEN Shang-jie MENG Lan YAN Hao BAI Li-jun WANG Fang HUANG Yong LI Jian-ping PENG Xu-ming SHI Xue-min | 2012 | Chinese Medical Journal2012，，15： | 12 |
| 18 | Thermodynamic analysis and formula optimization of steel slag-based ceramic materials by FACTsage software显示文摘Using steel slag as a main raw material of ceramics is considered as a high value-added way. However, the relationship among the initial composition, ceramic microstructure, and macroscopic properties requires further study. In this paper, a series of ceramics with different slag ratios (0-70wt%) were designed, and the software FACTsage was introduced to simulate the formation of crystalline phases. The simulation results indicate that mullite is generated but drastically reduced at the slag ratios of 0-25wt%, and anorthite is the dominant crystalline phase in the slag content of 25wt%-45wt%. When the slag ratio is above 45wt%, pyroxene is generated more than anorthite. This is because increasing magnesium can promote the formation of pyroxene. Then, the formula with a slag content of 40wt% was selected and optimized. X-ray diffraction results were good consistent with the simulation results. Finally, the water absorption and bending strength of optimized samples were measured. | Xian-bin Ai Hao Bai Li-hua Zhao Da-qiang Cang Qi Tang | 2013 | International Journal of Minerals,Metallurgy and Materials2013，20，4： | 12 |
| 19 | Breeding wheat for resistance to Fusarium head blight in the Global North: China, USA, and Canada显示文摘The objective of this paper is to review progress made in wheat breeding for Fusarium head blight(FHB) resistance in China, the United States of America(USA), and Canada. In China,numerous Chinese landraces possessing high levels of FHB resistance were grown before the 1950 s. Later, pyramiding multiple sources of FHB resistance from introduced germplasm such as Mentana and Funo and locally adapted cultivars played a key role in combining satisfactory FHB resistance and high yield potential in commercial cultivars.Sumai 3, a Chinese spring wheat cultivar, became a major source of FHB resistance in the USA and Canada, and contributed to the release of more than 20 modern cultivars used for wheat production, including the leading hard spring wheat cultivars Alsen, Glenn, Barlow and SY Ingmar from North Dakota, Faller and Prosper from Minnesota, and AAC Brandon from Canada. Brazilian wheat cultivar Frontana, T. dicoccoides and other local germplasm provided additional sources of resistance. The FHB resistant cultivars mostly relied on stepwise accumulation of favorable alleles of both genes for FHB resistance and high yield,with marker-assisted selection being a valuable complement to phenotypic selection. With the Chinese Spring reference genome decoded and resistance gene Fhb1 now cloned, new genomic tools such as genomic selection and gene editing will be available to breeders, thus opening new possibilities for development of FHB resistant cultivars. | Zhanwang Zhu Yuanfeng Hao Mohamed Mergoum Guihua Bai Gavin Humphreys Sylvie Cloutier Xianchun Xia Zhonghu He | 2019 | The Crop Journal2019，7，6： | 12 |
| 20 | Generation of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frame显示文摘导致的 pluripotent 的产生从体的细胞的茎(iPS ) 细胞被定义 reprogramming 抄写因素(TF ) 的同时的病毒的 transduction 成功地完成了。然而,这个过程为基因交货要求多重病毒的向量。作为结果,产生了 iPS 房间港口在他们的染色体的众多的病毒的集成地点。这能增加基因 mutagenesis 和 genomic 不稳定性的概率,并且介绍重要障碍给研究和 iPS 房间的临床的申请研究。在这篇论文,我们在场定义因素是的一个简单 lentivirus reprogramming 在系统经由自我劈开的 2A 序列熔化了在里面框架进一个单个开的读物框架(ORF ) 。一个 GFP 标记下游地被放 transgene 启用 transgene 表示追踪。我们证明这个 polycistronic 表示系统高效地产生 iPS 房间。产生 iPS 房间有正常 karyotypes 并且类似于鼠标在形态学和基因表示的胚胎的干细胞。而且,他们能在 vitro 并且在 vivo 试金在两个区分进三胚胎的细菌层的房间类型。显著地,大多数这些 iPS 房间仅仅怀有病毒的向量的一个单个拷贝。这个系统提供一个珍贵工具因为 iPS 房间的产生,和我们的数据建议在每个房间的 transduced reprogramming TF 的表示的平衡为 reprogramming 进程是必要的。更重要地,当由非集成的基因交货系统交付了时,这重新设计的单个 ORF 将没有基因修正便于人的 iPS 房间的有效产生。 | Lijian Shao Wei Feng Yan Sun Hao Bai Jun Liu Caroline Currie Jaejung Kim Rafael Gama Zack Wang Zhijian Qian Lucy Liaw Wen-Shu Wu | 2009 | Cell Research2009，19，3： | 12 |
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