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	题名	作者	年代	出处	被引量
1	Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant显示文摘AIM: To investigate if conversion to the mammalian target of rapamycin inhibitors(mTORi) improves renal function in diabetic and/or hypertensive liver transplant patients immunosuppressed with tacrolimus or cyclosporine.METHODS: The study included 86 liver graft recipients immunosuppressed with mTORi treatment after orthotopic liver transplantation(OLT), including all liver recipients with worsening renal function before conversion to mTORi(n = 55 patients) and recipients with normal renal function who converted to m TORi for other reasons(n = 31 patients). We identified patients with diabetes mellitus(n = 28), arterial hypertension(n = 27), proteinuria(n = 27) and all three factors(n = 8)(some patients have hypertension and diabetes and no proteinuria). The primary endpoint was evolution in renal function defined as the development in plasma creatinine as a function of diabetes mellitus(DM), hypertension(HT) or proteinuria. We required elevated serum creatinine for at least two weeks to define renal dysfunction.RESULTS: Only patients that converted because of renal failure with plasma creatinine levels > 1.5 mg/dL showed an improvement of renal function(2.14 to 1.77 mg/dL)(P = 0.02). Patients with DM showed no improvement of serum creatinine levels(1.31 mg/dL to 1.37 mg/dL) compared with non DM patients(1.31 mg/dL to 1.15 mg/dL)(P = 0.01), HT patients(1.48 mg/dL to 1.5 mg/dL) with non HT patients(1.21mg/d L to 1.08 mg/dL) and patients with proteinuria(1.44 mg/dL to 1.41 mg/dL) and no proteinuria(1.31 mg/dL to 1.11 mg/dL). CONCLUSION: In OLT recipients with diabetes or hypertensive nephropathy, conversion to m TORi does not improve renal function but stabilizes plasma levels of creatinine. Proteinuria is not a contraindication to conversion to m TORi; it also stabilizes renal function. Conversion to m TORi should only be avoided in patients with diabetes, hypertension and proteinuria.	José M álamo Claudia Olivares Lydia Barrera Luis M Marín Gonzalo Suarez Carmen Bernal Juan Serrano Jordi Muntané Francisco J Padillo Miguel A Gómez	2015	World Journal of Transplantation2015，5，1：	6
2	Influenza: forecast for a pan- demic 显示文摘	De la Barrera CA Reyes-Teran G	2005	Archives of Medical Research2005，36，6：	1
3	Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice显示文摘	Zhang Y Lee FY Barrera G Lee H Vales C Gonzalez FJ		0，，：	1
4	The epidemi- ology of sepsis in Colombia: a prospective muhicenter co- hort study in ten university hospitals显示文摘	Rodriguez F Barrera L De La Rosa G	2011	Crit Care Med2011，39，7：	1
5	Sesquiterpene al-cohols from Gonospermum fructicosum显示文摘	González A G Barrera J B Méndez J T	1992	Phytochemistry1992，31，5：	1
6	Role of brain norepinephrine in the behavioral response to stress 显示文摘	Morilak DA Barrera G Echevarria DJ	2005	Progress in Neuro Psychophannacology and Biological Psychiatry2005，29，：	1
7	Improved detection of anti HCV in post-transfusion hepatitis by a third-generation ELISA 显示文摘	Barrera JM Francis B Ercilla G	1995	Vox Sang1995，68，1：	1
8	Effect of xanthan and locust bean gums on the gelling properties of myofibrillar protein显示文摘	RAMIREZ J A BARRERA M MORALES O G	2002	Food Hydrocolloids2002，16，1：	1
9	Down-regulation of Notchl expression is involved in HL-60 cell gyowth inhibition induced by 4-hydroxynonenal, a product of lipid peroxidation 显示文摘	Pizzimenti S Barrera G Calzavara E	2008	Med Chem2008，4，6：	1
10	Effective dielectric response of a composite with aligned spheroidal inclusions 显示文摘	BARRERA R G GIRALDO J MOCHAN W L	1993	Phys Rev B1993，47，14：	1
11	Improved detection of anti-HCV in post-transfusion hepatitis by a third-generation ELISA 显示文摘	Barrera JM Francis B Ercilla G	1995	VOX Sang1995，68，：	1
12	Emergence of Mycohacterium tuberculosis with extensive resistance to second-line drugs-worldwide, 2000-2004显示文摘	Wright A Bai G Barrera L	2006	MMWR2006，55，：	1
13	The epidemiology of sepsis in Colombia: a prospective multicenter cohort study in ten university hospitals 显示文摘	Rodrfguez F Barrera L De La Rosa G	2011	Crit Care Med2011，39，7：	1
14	Luffh fibers and gamma radiation as improvement tools of polymer concrete 显示文摘	Martinez - Barrera G Vigueras - Santiago E Martfnez- L6pez M	2013	Construction and Building Materials2013，47，：	1
15	Role of brain nor- epinephrine in the behavioral response to stress显示文摘	Morilak DA Barrera G Echevarria DJ	2005	Prog Neu- ropsychopharmacol Biol Psychiatry2005，29，12：	1
16	Seasonal variation in insulin sensitivity in healthy elderly 9eople显示文摘	Bunout D Barrera G delaMaza P	2003	Nutrition2003，19，4：	1
17	Optical properties of metal nanoparticles with arbitrary shapes显示文摘	Ivan O Sosa Cecila Noguez Ruben G Barrera	2003	Journal of Physical Chemistry B2003，107，26：	1
18	Recognition of bacteriophage Qβ plus strand RNA as a template by Qβ replicase:role of RNA interactions mediated by ribosomal proteins S1 and host factors显示文摘	MIRANDA G SCHUPPLI D BARRERA I	1997	Journal of Molecular Biology1997，267，：	1
19	Results of long-term follow-up after local excision for well-selected low rectal cancers显示文摘	Contreras V Bannura G Barrera A		0，，：	1
20	The epidemiology of sepsis in Colombia: a prospective multicenter cohort study in ten university hospitals 显示文摘	Rodriguez F Barrera L De La Rosa G	2011	Crit Care Med2011，39，7：	1

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