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| 1 | Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis显示文摘Acute pancreatitis (AP) is an inflammatory disorder of pancreatic tissue initiated in injured acinar cells. Severe AP remains a significant challenge due to the lack of effective treatment. The widely-accepted autodigestion theory of AP is now facing challenges, since inhibiting protease activation has negligible effectiveness for AP treatment despite numerous efforts. Furthermore, accumulating evidence supports a new concept that malfunction of a self-protective mechanism, the unfolded protein response(UPR), is the driving force behind the pathogenesis of AP. The UPR is induced by endoplasmic reticulum(ER) stress, a disturbance frequently found in acinar cells, to prevent the aggravation of ER stress that can otherwise lead to cell injury. In addition, the UPR's signaling pathways control NFκB activation and autophagy flux, and these dysregulations cause acinar cell inflammatory injury in AP, but with poorly understood mechanisms. We therefore summarize the protective role of the UPR in AP, propose mechanistic models of how inadequate UPR could promote NFκB's pro-inflammatory activity and impair autophagy's protective function in acinar cells, and discuss its relevance to current AP treatment. We hope that insight provided in this review will help facilitate the research and management of AP. | Kaylene Barrera Albert Stanek Kei Okochi Zuzanna Niewiadomska Cathy Mueller Peiqi Ou Devon John Antonio E Alfonso Scott Tenner Chongmin Huan | 2018 | World Journal of Gastrointestinal Pathophysiology2018，9，2： | 9 |
| 2 | 四足机器人仿生腿结构特性及其控制系统研究显示文摘针对四足机器人整机对单个支撑腿的要求,对机械腿结构特性和控制系统展开研究。基于对四足动物腿部生理结构分析,提出具有两个主动关节和一个被动关节的四足机器人仿生腿结构,并完成运动学特性分析。通过分析仿生四足机器人控制系统功能与性能要求,提出具有开放性、模块化和结构紧凑特点的仿生四足机器人控制系统方案,基于DSP设计并实现仿生腿控制系统。实验证明仿生腿结构合理,控制系统稳定可靠且具有良好的扩展性,仿生腿系统可作为下层模块集成到仿生四足机器人系统。 | 黄林考 谭跃刚 David Nicolas Torres Barrera 赵东升 | 2018 | 机械设计与制造2018，，A01： | 7 |
| 3 | Selection of patients with hepatocellular carcinoma for livertransplantation:Past and future显示文摘The aim of liver transplantation(LT) for hepatocellular carcinoma(HCC) is to ensure a rate of disease-free survival similar to that of patients transplanted due to benign disease. Therefore, we are forced to adopt strict criteria when selecting candidates for LT and prioritizing patients on the waiting list(WL), to have clarified indications for bridging therapy for groups at risk for progression or recurrence, and to establish certain limits for downstaging therapies. Although the Milan criteria(MC) remain the standard and most employed criteria for indication of HCC patients for LT by far, in the coming years, criteria will be consolidated that take into account not only data regarding the size/volume and number of tumors but also their biology. This criteria will mainly include the alpha fetoprotein(AFP) values and, in view of their wide variability, any of the published logarithmic models for the selection of candidates for LT. Bridging therapy is necessary for HCC patients on the WL who meet the MC and have the possibility of experiencing a delay for LT greater than 6 mo or any of the known risk factors for recurrence. It is difficult to define single AFP values that would indicate bridging therapy(200, 300 or 400 ng/m L); therefore, it is preferable to rely on the criteria of a French AFP model score > 2. Other single indications for bridging therapy include a tumor diameter greater than 3 cm, more than one tumor, and having an AFP slope greater than 15 ng/m L per month or > 50 ng/m L for three months during strict monitoring while on the WL. When considering the inclusion of patients on the WL who do not meet the MC, it is mandatory to determine their eligibility for downstaging therapy prior to inclusion. The upper limit for this therapy could be one lesion up to 8 cm, 2-3 lesions with a total tumor diameter up to 8 cm, or a total tumor volume of 115 cm^3. Lastly, liver allocation and the prioritization of patients with HCC onthe WL should take into account the recently described HCC model for end-stage liver disease, which considers hepatic function, HCC size and the number and the log of AFP values. This formula has been calibrated with the survival data of non-HCC patients and produces a dynamic and more accurate assessment model. | Arturo Soriano Aranzazu Varona Rajesh Gianchandani Modesto Enrique Moneva Javier Arranz Antonio Gonzalez Manuel Barrera | 2016 | World Journal of Hepatology2016，8，1： | 6 |
| 4 | A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C显示文摘 | Bruno Sangro Carlos Gomez-Martin Manuel de la Mata Mercedes I?arrairaegui Elena Garralda Pilar Barrera Jose Ignacio Riezu-Boj Esther Larrea Carlos Alfaro Pablo Sarobe Juan José Lasarte Jose L. Pérez-Gracia Ignacio Melero Jesús Prieto | 2013 | Journal of Hepatology2013，，： | 6 |
| 5 | Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant显示文摘AIM: To investigate if conversion to the mammalian target of rapamycin inhibitors(mTORi) improves renal function in diabetic and/or hypertensive liver transplant patients immunosuppressed with tacrolimus or cyclosporine.METHODS: The study included 86 liver graft recipients immunosuppressed with mTORi treatment after orthotopic liver transplantation(OLT), including all liver recipients with worsening renal function before conversion to mTORi(n = 55 patients) and recipients with normal renal function who converted to m TORi for other reasons(n = 31 patients). We identified patients with diabetes mellitus(n = 28), arterial hypertension(n = 27), proteinuria(n = 27) and all three factors(n = 8)(some patients have hypertension and diabetes and no proteinuria). The primary endpoint was evolution in renal function defined as the development in plasma creatinine as a function of diabetes mellitus(DM), hypertension(HT) or proteinuria. We required elevated serum creatinine for at least two weeks to define renal dysfunction.RESULTS: Only patients that converted because of renal failure with plasma creatinine levels > 1.5 mg/dL showed an improvement of renal function(2.14 to 1.77 mg/dL)(P = 0.02). Patients with DM showed no improvement of serum creatinine levels(1.31 mg/dL to 1.37 mg/dL) compared with non DM patients(1.31 mg/dL to 1.15 mg/dL)(P = 0.01), HT patients(1.48 mg/dL to 1.5 mg/dL) with non HT patients(1.21mg/d L to 1.08 mg/dL) and patients with proteinuria(1.44 mg/dL to 1.41 mg/dL) and no proteinuria(1.31 mg/dL to 1.11 mg/dL). CONCLUSION: In OLT recipients with diabetes or hypertensive nephropathy, conversion to m TORi does not improve renal function but stabilizes plasma levels of creatinine. Proteinuria is not a contraindication to conversion to m TORi; it also stabilizes renal function. Conversion to m TORi should only be avoided in patients with diabetes, hypertension and proteinuria. | José M álamo Claudia Olivares Lydia Barrera Luis M Marín Gonzalo Suarez Carmen Bernal Juan Serrano Jordi Muntané Francisco J Padillo Miguel A Gómez | 2015 | World Journal of Transplantation2015，5，1： | 6 |
| 6 | Ketamine anesthesia reduces intestinal ischemia/reperfusion injury in rats显示文摘AIM: To investigate the effects of ketamine anesthesia on the motility alterations and tissue injury caused by ischemia/reperfusion in rats. METHODS: Thirty male Wistar rats weighing 200-250 g were used. Ischemia was induced by ob-structing blood flow in 25% of the total small intesti-nal length (ileum) with a vascular clamp for 45 min, after which either 60 min or 24 h of reperfusion was allowed. Rats were either anesthetized with pento-barbital sodium (50 mg/kg) or ketamine (100 mg/kg). Control groups received sham surgery. After 60 min of reperfusion, the intestine was examined for mor-phological alterations, and after 24 h intestinal basic electrical rhythm (BER) frequency was calculated, and intestinal transit determined in all groups. RESULTS: The intestinal mucosa in rats that were anesthetized with ketamine showed moderate altera-tions such as epithelial lifting, while ulceration and hemorrhage was observed in rats that received pento-barbital sodium after 60 min of reperfusion. Quantita-tive analysis of structural damage using the Chiu scaleshowed significantly less injury in rats that received ketamine than in rats that did not (2.35 ± 1.14 vs 4.58 ± 0.50, P < 0.0001). The distance traveled by a mark-er, expressed as percentage of total intestinal length, in rats that received pentobarbital sodium was 20% ± 2% in comparison with 25.9% ± 1.64% in rats that re-ceived ketamine (P = 0.017). BER was not statistically different between groups. CONCLUSION: Our results show that ketamine anesthesia is associated with diminished intestinal injury and abolishes the intestinal transit delay induced by ischemia/reperfusion. | Carlos Rodrigo Cámara Francisco Javier Guzmán Ernesto Alexis Barrera Andrés Jesús Cabello Armando Garcia Nancy Esthela Fernández Eloy Caballero Jesus Ancer | 2008 | World Journal of Gastroenterology2008，14，33： | 5 |
| 7 | High prevalence of hepatic steatosis and vascular thrombosis in COVID-19:A systematic review and meta-analysis of autopsy data显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)disease can frequently affect the liver.Data on hepatic histopathological findings in COVID-19 is scarce.AIM To characterize hepatic pathological findings in patients with COVID-19.METHODS We conducted a systematic review with meta-analysis registered on PROSPERO(CRD42020192813),following PRISMA guidelines.Eligible trials were those including patients of any age and COVID-19 diagnosis based on a molecular test.Histopathological reports from deceased COVID-19 patients undergoing autopsy or liver biopsy were reviewed.Articles including less than ten patients were excluded.Proportions were pooled using random-effects models.Q statistic and I2 were used to assess heterogeneity and levels of evidence,respectively.RESULTS We identified 18 studies from 7 countries;all were case reports and case series from autopsies.All the patients were over 15 years old,and 67.2%were male.We performed a meta-analysis of 5 studies,including 116 patients.Pooled prevalence estimates of liver histopathological findings were hepatic steatosis 55.1%[95%confidence interval(CI):46.2-63.8],congestion of hepatic sinuses 34.7%(95%CI:7.9-68.4),vascular thrombosis 29.4%(95%CI:0.4-87.2),fibrosis 20.5%(95%CI:0.6-57.9),Kupffer cell hyperplasia 13.5%(95%CI:0.6-54.3),portal inflammation 13.2%(95%CI:0.1-48.8),and lobular inflammation 11.6%(95%CI:0.3-35.7).We also identified the presence of venous outflow obstruction,phlebosclerosis of the portal vein,herniated portal vein,periportal abnormal vessels,hemophagocytosis,and necrosis.CONCLUSION We found a high prevalence of hepatic steatosis and vascular thrombosis as major histological liver features.Other frequent findings included portal and lobular inflammation and Kupffer cell hyperplasia or proliferation.Further studies are needed to establish the mechanisms and implications of these findings. | Luis Antonio Díaz Francisco Idalsoaga Macarena Cannistra Roberto Candia Daniel Cabrera Francisco Barrera Alejandro Soza Rondell Graham Arnoldo Riquelme Marco Arrese Michael D Leise Juan Pablo Arab | 2020 | World Journal of Gastroenterology2020，26，48： | 3 |
| 8 | 经皮经导管射频消融去肾交感神经术与螺内酯对难治性高血压昼夜节律和血压变异性的影响显示文摘经皮经导管射频消融去肾交感神经术(sympathetic renal denervation,SRD)可作为药物控制不佳的难治性高血压患者的一种替代治疗方法,SRD对减少短期血压变异性(blood pressure variability,BPV)有效。然而,这个作用尚未在随机对照试验中证实。本研究旨在比较螺内酯和SRD对昼夜血压和BPV的影响。方法:对一项随机试验进行析因分析, | de la Sierra A Pareja J Armario P Barrera Yun S Vázquez S Sans L Pascual J Oliveras A 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 9 | A narrative review of the success of intramuscular gluteal injections and its impact in psychiatry显示文摘 | Erfan Soliman Sarujan Ranjan Tianyou Xu Carol Gee Aidan Harker Alvaro Barrera John Geddes | 2018 | Bio-Design and Manufacturing2018，1，3： | 3 |
| 10 | Simple Non-Invasive Systems Predict Long-Term Outcomes of Patients With Nonalcoholic Fatty Liver Disease显示文摘 | Paul Angulo Elisabetta Bugianesi Einar S. Bjornsson Phunchai Charatcharoenwitthaya Peter R. Mills Francisco Barrera Svanhildur Haflidadottir Christopher P. Day Jacob George | 2013 | Gastroenterology2013，，： | 2 |
| 11 | Single-Incision Surgery Has Higher Cost with Equivalent Pain and Quality-of-Life Scores Compared with Multiple-Incision Laparoscopic Cholecystectomy: A Prospective Randomized Blinded Comparison显示文摘 | Dennis Leung Amy K. Yetasook JoAnn Carbray Zeeshan Butt Yumiko Hoeger Woody Denham Ermilo Barrera Michael B. Ujiki | 2012 | Journal of the American College of Surgeons2012，，5： | 2 |
| 12 | Influenza: forecast for a pan- demic 显示文摘 | De la Barrera CA Reyes-Teran G | 2005 | Archives of Medical Research2005，36，6： | 1 |
| 13 | IL-10 down-regulate costimulatory molecule on mycobacterium tuberculosispulsed macrophages and impair the lytic activity of CD4 and CD8 CTL in tuberculosis patlents显示文摘 | De la Barrera S Aleman M Musella R | 2004 | Clin Exp Immunol2004，138，1： | 1 |
| 14 | Dietary zinc, copper and selenium, and risk of lung cancer显示文摘 | MAHABIR S SPITZ M R BARRERA S L | 2007 | Int J Cancer2007，120，5： | 1 |
| 15 | Severe myoclonic epi- lepsy in childhood显示文摘 | Nieto Barrera M Lillo MM Rodriguez C | 2000 | Rev Neurol2000，30，7： | 1 |
| 16 | Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice显示文摘 | Zhang Y Lee FY Barrera G Lee H Vales C Gonzalez FJ | | 0，，： | 1 |
| 17 | The epidemi- ology of sepsis in Colombia: a prospective muhicenter co- hort study in ten university hospitals显示文摘 | Rodriguez F Barrera L De La Rosa G | 2011 | Crit Care Med2011，39，7： | 1 |
| 18 | Longitudinal study of children with perinatal braindamage in whom early neurohabilitation was applied: Pre- liminary report显示文摘 | Harmony T Barrera Resendiz J Juarez Colin M E | 2015 | Neurosci Lett2015，611，： | 1 |
| 19 | HUMAN IMPACTS HAVE SHAPED HISTORICAL AND RECENT EVOLUTION IN AEDES AEGYPTI , THE DENGUE AND YELLOW FEVER MOSQUITO显示文摘 | Julia E. Brown Benjamin R. Evans Wei Zheng Vanessa Obas Laura Barrera‐Martinez Andrea Egizi Hongyu Zhao Adalgisa Caccone Jeffrey R. Powell | 2014 | Evolution2014，，： | 1 |
| 20 | Effect of xanthan and locust bean gums on thegelling properties of myofibrillar protein显示文摘 | Ramirez J A Barrera M Morales | 2002 | Food Hydrocolloids2002，16，1： | 1 |
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