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| 1 | A guide to diagnosis of iron deficiency and iron deficiency anemia in digestive diseases显示文摘Iron deficiency (ID), with or without anemia, is often caused by digestive diseases and should always be investigated, except in very specific situations, as its causes could be serious diseases, such as cancer. Diagnosis of ID is not always easy. Low serum levels of ferritin or transferrin saturation, imply a situation of absolute or functional ID. It is sometimes difficult to differentiate ID anemia from anemia of chronic diseases, which can coexist. In this case, other parameters, such as soluble transferrin receptor activity can be very useful. After an initial evaluation by clinical history, urine analysis, and serological tests for celiac disease, gastroscopy and colonoscopy are the key diagnostic tools for investigating the origin of ID, and will detect the most important and prevalent diseases. If both tests are normal and anemia is not severe, treatment with oral iron can be indicated, along with stopping any treatment with non-steroidal anti-inflammatory drugs. In the absence of response to oral iron, or if the anemia is severe or clinical suspicion of important disease persists, we must insist on diagnostic evaluation. Repeat endoscopic studies should be considered in many cases and if both still show normal results, investigating the small bowel must be considered. The main techniques in this case are capsule endoscopy, followed by enteroscopy. | Fernando Bermejo Santiago García-López | 2009 | World Journal of Gastroenterology2009，15，37： | 14 |
| 2 | Optimized Nonbismuth Quadruple Therapies Cure Most Patients With Helicobacter pylori Infection in Populations With High Rates of Antibiotic Resistance显示文摘 | Javier Molina–Infante Marco Romano Miguel Fernandez–Bermejo Alessandro Federico Antonietta G. Gravina Liliana Pozzati Elena Garcia–Abadia Gema Vinagre–Rodriguez Carmen Martinez–Alcala Moises Hernandez–Alonso Agnese Miranda Maria Rosaria Iovene Carmen Pazo | 2013 | Gastroenterology2013，，1： | 8 |
| 3 | Second-line Therapy With Levofloxacin After Failure of Treatment to Eradicate Helicobacter pylori Infection: Time Trends in a Spanish Multicenter Study of 1000 Patients显示文摘 | Javier P. Gisbert ángeles Pérez-Aisa Fernando Bermejo Manuel Castro-Fernández Pedro Almela Jesús Barrio ángel Cosme Inés Modolell Felipe Bory Miguel Fernández-Bermejo Luis Rodrigo Jesús Ortu?o Pilar Sánchez-Pobre Sam Khorrami Alejandro Franco Albert Tomas | 2013 | Journal of Clinical Gastroenterology2013，，2： | 5 |
| 4 | Nonbismuth Quadruple (Concomitant) Therapy: Empirical and Tailored Efficacy versus Standard Triple Therapy for Clarithromycin‐Susceptible Helicobacter pylori and versus Sequential Therapy for Clarithromycin‐Resistant Strains显示文摘 | Javier Molina‐Infante Carmen Pazos‐Pacheco Gema Vinagre‐Rodriguez Belen Perez‐Gallardo Carmen Due?as‐Sadornil Moisés Hernandez‐Alonso Guadalupe Gonzalez‐Garcia Jose M. Mateos‐Rodriguez Miguel Fernandez‐Bermejo Javier P. Gisbert | 2012 | Helicobacter2012，，4： | 4 |
| 5 | Ectopic papilla of Vater in the pylorus显示文摘The major papilla of Vater is usually located in the second portion of the duodenum, to the posterior medial wall. Sometimes the mouth of the biliary duct is located in other areas. Drainage of the common bile duct into the pylorus is extremely rare. A 73-year old man, with a history of duodenal ulcer, was admitted to hospital with the diagnosis of cholangitis. Dilatation of the extrahepatic biliary duct was observed by abdominal ultrasonography, and endoscopic retrograde cholangiopancreatography (ERCP) was performed. No area suggesting the presence of the papilla of Vater was found within the second duodenal portion. Finally the major papilla was located in the theoretical pyloric duct. Cholangiography was performed and choledocholithiasis was found in the biliary tree. The patient underwent dilatation of the papilla with a balloon tyre and removal of a 7 mm stone using a Dormia basket, which solved the problem without further complications. This anomaly increased the difficulty of performing therapeutic interventions during ERCP. This alteration in anatomy may increase the risk of complications during papillotomy, with a theoretically higher risk of perforation. Dilatation using a balloon was the chosen therapeutic technique both in our case and in the literature, due to its low rate of complications. | Iván Guerra Luis Ramón Rábago Fernando Bermejo Elvira Quintanilla Silvia García-Garzón | 2009 | World Journal of Gastroenterology2009，15，41： | 3 |
| 6 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 7 | Long‐term oncological outcomes after laparoscopic radical prostatectomy显示文摘 | Marcel Hruza Justo Lorenzo Bermejo Bettina Flinspach Michael Schulze Dogu Teber Hans Joachim Rumpelt Jens Jochen Rassweiler | 2012 | BJU Int2012，，： | 2 |
| 8 | Wind effects on the migration routes of trans-Saharan soaring raptors: geographical, seasonal, and interspecific variation显示文摘 | Javier VIDAL-MATEO Ugo MELLONE Pascual LOPEZ-LOPEZ Javier De LA PUENTE clara GARCIA-RIPOLLES Ana BERMEJO Vicente URIOS | 2016 | Current Zoology2016，62，2： | 2 |
| 9 | Causes of isehemie stroke in young adults, and evolution of the etiological diagnosis over the long term显示文摘 | Varona J F Guerra J M Bermejo F | 2007 | Eur Neurol2007，57，4： | 1 |
| 10 | Active Antifungal Substances from Natural Sources显示文摘 | ABAD M J ANSUATEGUI M BERMEJO P | 2007 | Arkivoc2007，，7： | 1 |
| 11 | Predominance of Th2 cytokines, CXC chemokines and innate immunity mediators at the mucosal level during severe respiratory syncytial virus infection in children 显示文摘 | Bermejo Martin JF Garcia Arevalo MC De Lejarazu | 2007 | Eur Cytokine Netw2007，8，3： | 1 |
| 12 | Pitch-based carbon com-posites with granular reinforcements for frictional applications显示文摘 | Blanco C Santamaría R Bermejo J | 2000 | Carbon2000，38，7： | 1 |
| 13 | Echocardiographicassessm- ent of valve stenosis: EAE/ASE recommendations for clinical practice显示文摘 | Baumgartner H Hung J Bermejo J | 2009 | J Am Soc Echocardiogr2009，22，1： | 1 |
| 14 | Fully human anti-interleukin 8 antibody inhibits tumor growth in orthotopic bladder cancer xenografts via down-regulation of matrix metalloproteases and nuclear factor-kappaB显示文摘 | Mian BM Dinney CP Bermejo CE | 2003 | Clin Cancer Res2003，9，8： | 1 |
| 15 | A comparative study on the application of advanced bacteria/ foraging mod- els to image registration显示文摘 | BERMEJO E CORDAN DAMAS S | 2015 | Information Sciences2015，，1： | 1 |
| 16 | Spatial variations of heavy metals contamination in sediments from Odiel river(Southwest Spain)显示文摘 | BERMEJO J C S BELTRAN R ARIZA J L | 2003 | Environment International2003，29，： | 1 |
| 17 | Analysis of bioactive compounds in seven citrus cultivars显示文摘 | BERMEJO A LLOSA M J CANO A | | 0，，01： | 1 |
| 18 | Vascular dementia: Diagnostic criteria for research studies: Report of the NINDS-AIREN International Workshop*显示文摘 | G. C. Román T. K. Tatemichi T. Erkinjuntti J. L. Cummings J. C. Masdeu J. H. Garcia L. Amaducci J.-M. Orgogozo A. Brun A. Hofman D. M. Moody M. D. O?Brien T. Yamaguchi J. Grafman B. P. Drayer D. A. Bennett M. Fisher J. Ogata E. Kokmen F. Bermejo P. A. Wol | 1993 | Neurology1993，，2： | 1 |
| 19 | Update on medical therapy for obscure gastrointestinal hemorrhage显示文摘 | Molina Infante J Pérez Gallardo B Fernández Bermejo M | 2007 | Revista Espaola de Enfermedades Digestivas2007，99，8： | 1 |
| 20 | Stroke in young adults显示文摘 | Varona JF Guerra JM Bermejo F | 2004 | Med Clin2004，122，： | 1 |
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