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| 1 | Interferon-a plus lamivudine vslamivudine reduces breakthroughs, but does not affect sustained response in HBeAg negative chronic hepatitis B显示文摘AIM: To investigate the efficacy of combination treatment of IFN-α and lamivudine compared to lamivudine monotherapy, after 24 mo of administration in HBeAg-negative hepatitis B patients.METHODS: Fifty consecutive patients were randomly assigned to receive IFN-α-2b (5 MU thrice per week, n = 24) plus lamivudine (100 mg daily) or lamivudine only (n = 26) for 24 mo. Patients were followed up for further 6 mo. The primary outcome was the proportion with sustained virological response (undetectable serum HBV DNA concentrations) and or sustained biochemical response (transaminase levels within normal range) at 30 mo (6 mo after the end of therapy). Secondary end-points were timed from initial virological (biochemical) response to VBR (BBR, respectively) and the emergence of YMDD mutants across the two arms.RESULTS: Five of twenty-four (21%) patients in the combination arm vs 3/26 (12%) in the lamivudine arm had sustained response (i.e., normal serum transaminase levels and undetectable HBV DNA by PCR assay) 6 mo after treatment discontinuation. A reduction in the emergence of YMDD mutants and in the development of virological breakthroughs was observed in patients receiving combination treatment (10% vs46%, P= 0.01 and 14% vs46%, P= 0.03,respectively).Time from initial virologic response to virologic breakthrough (VBR) was greater among initial responders receiving combination treatment compared to those receiving lamivudine (22.9 mo vs 15.9 mo, respectively; P = 0.005).CONCLUSION: Our results demonstrate that IFN-α plus lamivudine combination therapy does not increase the sustained response, compared to lamivudine. However,combination therapy reduces the likelihood of VBR due to YMDD mutants and prolongs the time period until the breakthrough development. | Michalis Economou Spilios Manolakopoulos Thomas A Trikalinos Spyros Filis Sotiris Bethanis Dimitrios Tzourmakliotis Alec Avgerinos Sotiris Raptis Epameinondas V Tsianos | 2005 | World Journal of Gastroenterology2005，11，37： | 6 |
| 2 | Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα显示文摘 | Daniel J Peet Stephen D Turley Wenzhen Ma Bethany A Janowski Jean-Marc A Lobaccaro Robert E Hammer David J Mangelsdorf | 1998 | Cell1998，，： | 2 |
| 3 | Evaluating implicit spider fear associations using the Go/No-go Association Task显示文摘 | Teachman Bethany A | 2007 | Journal of Behavior Therapy and Experimental Psychiatry2007，38，2： | 1 |
| 4 | Tumor angiogenesis is regulated by CXC ehemokines显示文摘 | Bethany M B Douglas A A Christina A L | 1998 | J laband Clin Med1998，132，： | 1 |
| 5 | Staying Tuned to Researchin Implicit Cognition: Relevance for Clinical Practice With Anxiety Disorders显示文摘 | Teachman Bethany A Woody Sheila R | 2004 | Cognitive and Behavioral Practice2004，11，2： | 1 |
| 6 | Properties of lightweight aggregate produced by rapid sintering of incinerator bottom ash Resources显示文摘 | Cheeseman C R Makinde A Bethanis S | 2005 | Conservation and Recycling2005，43，1： | 1 |
| 7 | The praise! Project: A church-based nutrition intervention designed for cultural appropri- ateness, sustainability, and diffusion 显示文摘 | ALICE A CHANETTA W BETHANY J | 2002 | Health Promot Pract2002，，3： | 1 |
| 8 | A multilevel study of the associations between economic and social context,stage of adolescence,and physical activity and body mass index显示文摘 | MCKAY C M BETHANY A ELLISON B | 2007 | Am Academy Pediatrics2007，，119： | 1 |
| 9 | Properties of lightweight aggregate produced by rapid sintering of incinerator bottom ash显示文摘 | Cheeseman C R Makinde A Bethanis S | 2005 | Resources Conservation and Recycling2005，43，： | 1 |
| 10 | A Curve Fitting Procedure to Derive Inter-annual Phenologies from Time Series of Noisy Satellite NDVI Data显示文摘 | BETHANY A B ROBERT W J JOHN F H | | 0，，02： | 1 |
| 11 | Continuity in Representation between Children and Adults:Arithmetic Knowledge Hinders Undergraduates' Algebraic Problem Solving显示文摘 | Nicole M McNeil Bethany Rittle-Johnson Shanta Hattikudur Lori A Petersen | | 0，，11： | 1 |
| 12 | Poly (sodium styrene sulfonate)-b-poly (methyl methacrylate) dibloek eopolymers through direct atom transfer radical polymerization: Influence of hydrophilic-hydrophobic balance on self- organization in aqueous solution 显示文摘 | Oikonomou E K Bethani A Bokias G | 2011 | Eur Polym J2011，47，： | 1 |
| 13 | The solitary pulmonary nodule显示文摘 | BETHANY B KEVIN R ELLA A | 2003 | Chest2003，123，： | 1 |
| 14 | Predicting plant invasions in an era of global change显示文摘 | Bethany A B Dana M B David S W | 2010 | Trends in Ecology and Evolution2010，25，： | 1 |
| 15 | Vaeeination with recom- binant aspartic hemoglobinase reduces parasite load and blood loss after hookworm infection in dogs 显示文摘 | Loukas A Bethany JM Mendez S et 01 | 2005 | PLoS Med2005，2，10： | 1 |
| 16 | The mTOR/p70 S6K1 pathway regulates vascular smooth muscle cell differentiation显示文摘 | Kathleen A Eva M Bethany L | 2004 | Am J Physiol Cell Physiol2004，286，3： | 1 |
| 17 | Predicting how adaptation to climate change could affect eco- logical conservation:Secondary impacts of shifting agricultur- al suitability 显示文摘 | Bradley Bethany A Lyndon D Estes David G Hole | 2010 | Diversity and Distributions2010，18，5： | 1 |
| 18 | Quantifying monarch butterfly larval pigmentation using digital image analysis显示文摘 | Andrew K Bethany F Sonia A | | 0，，2： | 1 |
| 19 | Generation of reactive oxygen species after exhaustive aero- bic and isometric exercise显示文摘 | Helaine M A Ann E H Bethany K F | 2000 | Med Sci Sports Exerc2000，27，9： | 1 |
| 20 | Properties of lightweight aggregate produced by rapid sintering ofincinerator bottom ash Resources 显示文摘 | Cheeseman C R Makinde A Bethanis S | 2005 | Conservation and Recycling2005，43，1： | 1 |
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