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| 1 | Effects of tyrosine kinase inhibitor E7080 and eNOS inhibitor L-NIO on colorectal cancer alone and in combination显示文摘Objective:To investigate the effects of E7080 and N5-(1-iminoethyl)-L-ornithine dihydrochloride(L-NIO)on colorectal cancer alone and in combination.Methods:HT29 colorectal cancer cell line from Sap Institute was used.Real-time cell analysis(xCELLigence system)was performed to determine the effects of E7080 and L-NIO on colorectal cell proliferation.While apoptosis was determined with Annexin V staining,and the effect of agents on angiogenesis was determined with chorioallantoic membrane(CAM)model.Results:We found that E7080 has a strong antiproliferative effect with an half maximum inhibition of concentration(IC50)value of 5.60×10–8mol/L.Also it has been observed that E7080 showed antiangiogenic and apoptotic effects on HT29 colorectal cancer cells.Antiangiogenic scores of E7080 were 1.2,1.0 and 0.6for 100,10 and 1 nmol/L E7080 concentrations,respectively.Furthermore,apoptosis has been detected in71%of HT29 colorectal cancer cells after administration of 100 nmol/L E7080 which may indicate strong apoptotic effect.Meanwhile administration of L-NIO alone did not show any effect,but the combination of E7080 with L-NIO increased the antiproliferative,antiangiogenic and apoptotic effects of E7080.Conclusions:Results of this study indicate that E7080 may be a good choice in treatment of colorectal tumors.Furthermore the increased effects of E7080 when combined with L-NIO raise the possibility to use a lower dose of E7080 and therefore avoid/minimize the side effects observed with E7080. | Ahmet Altun Tijen Kaya Temiz Ezgi Balc Zübeyde Ak n Polat Mustafa Turan | 2013 | Chinese Journal of Cancer Research2013，25，5： | 4 |
| 2 | Hepatitis B-related events in autologous hematopoietic stem cell transplantation recipients显示文摘AIM: To investigate the frequency of occult hepatitis B, the clinical course of hepatitis B virus (HBV) reactivation and reverse seroconversion and associated risk factors in autologous hematopoietic stem cell transplantation (HSCT) recipients. METHODS: This study was conducted in 90 patients undergoing autologous HSCT. Occult HBV infection was investigated by HBV-DNA analysis prior to transplantation, while HBV serology and liver function tests were screened prior to and serially after transplantation. HBV-related events including reverse seroconversion and reactivation were recorded in all patients. RESULTS: None of the patients had occult HBV prior to transplantation. Six (6.7%) patients were positivefor HBV surface antigen (HBsAg) prior to transplantation and received lamivudine prophylaxis; they did not develop HBV reactivation after transplantation. Clinical HBV infection emerged in three patients after transplantation who had negative HBV-DNA prior to HSCT. Two of these three patients had HBV reactivation while one patient developed acute hepatitis B. Three patients had anti-HBc as the sole hepatitis B-related antibody prior to transplantation, two of whom developed hepatitis B reactivation while none of the patients with antibody to HBV surface antigen (anti-HBs) did so. The 14 anti-HBs-and/or anti-HBc-positive patients among the 90 HSCT recipients experienced either persistent (8 patients) or transient (6 patients) disappearance of anti-HBs and/or anti-HBc. HBsAg seroconversion and clinical hepatitis did not develop in these patients. Female gender and multiple myeloma emerged as risk factors for loss of antibody in regression analysis (P < 0.05). CONCLUSION: Anti-HBc as the sole HBV marker seems to be a risk factor for reactivation after autologous HSCT. Lamivudine prophylaxis in HbsAg-positive patients continues to be effective. | zcan eneli Zübeyde Nur zkurt Kadir Acar Seyyal Rota Sahika Zeynep Aki Zeynep Arzu Yegin Münci Yagci Seren zenirler Gülsan Türkz Sucak | 2010 | World Journal of Gastroenterology2010，16，14： | 3 |
| 3 | Wilson cirrhosis associated with membranoproliferativeglomerulonephritis显示文摘 | Zübeyde Gündüz RuhanDusunsel Ali Anarat | 1996 | Nephron1996，74，： | 1 |
| 4 | Ileal recovery of nutrients and mucin in humans fed total enteral formulas supplemented with soy fiber显示文摘 | Lien K A McBurney M I Beyde B I | 1996 | Am J Clin Nutr1996，63，： | 1 |
| 5 | Polyurethane spray foam bum显示文摘 | KESKIN M BEYDES T TOSUN Z SAVACT N | 2008 | Bums2008，34，7： | 1 |
| 6 | Removal of Pb(II) from wastewater using wheat bran显示文摘 | Yasemin Bulut Zübeyde Baysal | 2005 | Journal of Environmental Management2005，，2： | 1 |
| 7 | Reductive dechlorination of hexachlorobenzene to tri-and dichlorobenzenes in anaerobic sewage sludge显示文摘 | FATHEPURE B Z TIEDJE J M BEYD S A | | 0，，02： | 1 |
| 8 | Production and Optimization of Process Parameters for Alkaline Protease Production by a Newly Isolated Bacillus sp under Solid State Fermaentation Process 显示文摘 | Fikret Uyar Zübeyde Baysal | 2004 | Biochemistry2004，，39： | 1 |
| 9 | Removal of Pb(II) from wastewater using wheat bran显示文摘 | Yasemin Bulut Zübeyde Baysal | 2005 | Journal of Environmental Management2005，，2： | 1 |
| 10 | Ileal recovery of nutrients and mucin in humans fed total enteral formulas supplemented with soy fiber显示文摘 | McBurney MI Beyde BI | 1996 | Am J Clin Nutr1996，63，4： | 1 |
| 11 | Removal of Pb(II) from wastewater using wheat bran显示文摘 | Yasemin Bulut Zübeyde Baysal | 2005 | Journal of Environmental Management2005，，2： | 1 |
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