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| 1 | Simple and sensitive determination of sparfloxacin in pharmaceuticals and biological samples by immunoassay显示文摘Plasma quinolone concentrations are not routinely measured in clinical practice.However,in order to optimize quinolone treatment,monitoring of plasma concentrations could sometimes be useful particularly in critically ill patients.In this study,anti-sparfloxacin antibody was obtained by immunizing rabbits with sparfloxacin conjugated with bovine serum albumin using isobutyl chloroformate method.After the assay procedure was optimized,the standard curve of sparfloxacin was established.The practical measuring range of the competitive ELISA extended from 5 ng/mL to 2 mg/mL.The recovery rates and coefficients of variation for rat plasma,urine and tissues were 87.7-106.2% and 4.8-15.3%,respectively.To demonstrate the potential of the ELISA,a preliminary pharmacokinetics and tissue distribution study of sparfloxacin in rats and quantitative analysis of sparfloxacin in several pharmaceuticals were performed and compared with high-performance liquid chromatography(HPLC).The experimental data indicated that the proposed method would be a valuable tool in therapeutic drug monitoring(TDM) for sparfloxacin. | Hua-Jin Zenga,Ran Yangb,Bing Liub,Li-Fang Leib,Jian-Jun Lib,Ling-Bo Qub,c,n aSchool of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China bDepartment of Chemistry,Zhengzhou University,Zhengzhou 450001,China cSchool of Chemistry & Chemical Engineering,Henan University of Technology,Zhengzhou 450001,China | 2012 | Journal of Pharmaceutical Analysis2012，2，3： | 2 |
| 2 | Weight loss in tumour-hearing mice is not associated with changes in resistin gene expression in white adipose tissue 显示文摘 | Gomez-Ambrosi J Zabalegui N Bing C | 2002 | Horm Metab Res2002，34，1112： | 1 |
| 3 | 显示文摘 | Zhu L P Liao G H Bing N C | 2011 | Journal of Solid State Chemistry2011，184，： | 1 |
| 4 | Dual phosphors-converted white LEDs modeling by using near-field chromatic luminance data显示文摘 | BING Q C CORNELISSEN H J HU N C | 2014 | SPIE2014，9003，： | 1 |
| 5 | Self-assembled 3D BiOCl hierarchitectures:tunable synthesis and characterization显示文摘 | ZHU L P LIAO G H BING N C | | 0，，11： | 1 |
| 6 | Data and methods for estimating the severity of minor impacts 显示文摘 | Mark N B Bing C W Jonathan M L | 1995 | SAE Transaction1995，104，6： | 1 |
| 7 | Optimization and evaluation of different chemical and electrochemical hydride generation systems for the determination of arsenic by microwave plasma torch optical emission spectrometry 显示文摘 | Ozmen B Matysik F M Bings N H Broekaert J A C | 2004 | Spectrochimica Acta Part B: Atomic Spectroscopy2004，59，： | 1 |
| 8 | Atomic Spectroscopy显示文摘 | Bings N H Bogaerts A Broekacrt J A C | 2006 | J Anal Chem2006，78，12： | 1 |
| 9 | Self-assembled 3D BiOC1 hierarchitectures: tunable synthesis and characteriza- tion显示文摘 | ZHU L P LIAO G H BING N C | 2010 | Cryst Eng Commun2010，12，： | 1 |
| 10 | The synthesis of nitrigen doped carbon nanotube with different catalyst 显示文摘 | JIN H Y BING N C WANG L L | 2011 | Materials Science Forum2011，694，： | 1 |
| 11 | resistin and RELM - alpha gene expression in white adipose tissue of lactating mice显示文摘 | BING C GOMEZ- AMBROSI J ZABALEGUI N | 2002 | Biochem Biophys Res Common2002，296，2： | 1 |
| 12 | The role of copeptin as a diagnostic and prognostic biomarker for risk strati- fication in the emergency department显示文摘 | NICKEL C H BING|SSER R MORGENTHALER N G | 2012 | BMC Med2012，10，： | 1 |
| 13 | Recognition properties of PVDF hollow fiber membranes modified by levo- floxacin-imprinted polymers 显示文摘 | Bing N C Xu Z L Wang X J | 2007 | J Appl Polym Sci2007，106，： | 1 |
| 14 | Mesoporous silica helical ribbon and nanotube-within-a-nanotube synthesized by sol-gel selfassembly显示文摘 | Jin H Y Wang L J Bing N C | 2011 | Materials Letters2011，65，2： | 1 |
| 15 | From translation house to think tank: The changing role of the Chinese Communist Party's Central Compilation and Translation Bureau 显示文摘 | Bing N C | 2014 | Journal of Contemporary China2014，，： | 1 |
| 16 | Temperature Dependenceof Electric and Dielectric Behaviors of Ni/PolyvinylideneFluoride Composites显示文摘 | Xu H P Dang Z M Bing N C | 2010 | Journal of Applied Physics2010，107，03： | 1 |
| 17 | Atomic spectroscopy显示文摘 | Bings N H Bogaerts A Broekaert J A C | 2006 | Analytical Chemistry2006，78，： | 1 |
| 18 | Self-assembled 3D BiOCI hie- rarehitectures: Tunable synthesis and characterization 显示文摘 | Zhu L P Liao G H Bing N C | 2010 | Crys- tEngComm2010，12，： | 1 |
| 19 | Correlation between sperm DNA 8-Hydroxy-2'-deoxyguanosine level and semen quality显示文摘8-hydroxy-2'-deoxyguanosine (8-OHdG), a typical form ofDNA adducts, is a key molecular biomarker for DNA oxidativedamage. The aim of the present study was to evaluote the correla-tion between the sperm DNA 8-OHdG level and the semen quality.In 52 male infertile patients, the sperm DNA 8-OHdG level wasdetermined by a high performance liquid chromatograph with elec-trochemical detector and the semen quality was examined | Bing PANG Tai-Yi JIN Xue-Zhi JIANG N G Viavian H M Shen C N Ong Shanghai Medical University,Shanghai 200032,China National University of Singapore,Singapore 119074,China | 2001 | Asian Journal of Andrology2001，3，4： | 0 |
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