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| 1 | The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels. | Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu | 2022 | Science China(Life Sciences)2022，65，12： | 4 |
| 2 | Sodium-Ion Battery Anode Construction with SnP_(x)Crystal Domain in Amorphous Phosphorus Matrix显示文摘The high-capacity phosphorus-(P-)based anode materials for sodium-ion batteries(NIBs)often face poor performance retentions owing to the low conductivity and large volume expansion.It is thus essential to buffer these problems by appropriately alloying with other elements such as tin(Sn)and constructing well-designed microstructures.Herein,a series of P-/Sn-based composites have been synthesized by the facile and low-cost one-step ball milling.Pair distribution function(PDF)has been employed as a hardcore quantitative technique to elucidate their structures combined with other techniques,suggesting the formation and ratios of Sn4P3 and Sn crystalline domains embedded inside an amorphous P/carbon matrix.The composite with the largest amount of Sn4P3 in the P/C matrix can deliver the most balanced electrochemical performance,with a capacity of 422.3 mA-h g^(−1 )for 300 cycles at a current density of 1000mAg^(−1).The reaction mechanism has been elucidated by 23Na and 31P solid-state nuclear magnetic resonance(NMR)investigations.The study sheds light on the rational design and concrete identification of P-/Sn-based amorphous-dominant composite materials for NIBs. | Baixu Chen Yubo Yang Aibing Chen Xu Zhang Jaffer Saddique Mingxue Tang Haijun Yu | 2021 | Energy Material Advances2021，，1： | 1 |
| 3 | Responsive hyperbranched poly(formyl-1,2,3-triazole)s toward quadruple-modal information security protection显示文摘Secrecy has received tremendous attention in modern information society. Innovative polymer-based fluorescent materials with multiple mode emission are quite desirable to achieve multistage data security. Herein, a series of soluble and thermally stable hyperbranched poly(formyl-1,2,3-triazole)s(hb-PFTAs) with high molecular weights were facilely prepared by catalyst-free polycycloaddition of aldehyde-activated internal triyne and diazides. Functional moieties of triphenylamine and binaphthyl could be incorporated into the polymers to offer them with unique fluorescence and circular dichroism properties, respectively.By taking advantage of activated ethynyl and aldehyde groups on their peripheries and in the internal branch chains, the hbPFTAs can undergo efficient single-and double-stage post-functionalization. More importantly, based on the remarkable fluorescence responses to hydrazine and hydrochloric acid, the hyperbranched polymers are featured with triple-mode fluorescent patterns and have been applied in quadruple-modal information encryption and storage with enhanced security and density. Collectively, this work not only enriches the structural diversity of the existing triazole-based material library, but also provides new polymeric materials for data and information security application. | Baixue Li Zhen Li Kai You Anjun Qin Ben Zhong Tang | 2022 | Science China Chemistry2022，65，4： | 1 |
| 4 | Activated Internal Alkyne-Based Polymerization显示文摘As an emerging and efficient polymerization methodology,activated internal alkyne-based polymerization has been considered as a powerful tool for the construction of polymers with diverse architectures and versatile functions.This review focuses on the recent progresses in the polymerization using mono-activated,di-activated,in-situ generated,ring-strained ethynyl groups as substrates,coupling with post-modification on premade polymers containing activated internal ethynyl moieties.Representative examples are used to illustrate the fundamental design strategy,the development of polymerization and post-functionalization,along with the properties and potential applications of the prepared polymers.Moreover,the challenges and perspectives in terms of new-type active alkynes,green polymerization methodology,tailored regio-/stereoselectivity modulation,and potentially expanded application in this area are also discussed. | Baixue Li Jia Wang Benzhao He Anjun Qin Ben Zhong Tang | 2022 | Chinese Journal of Chemistry2022，40，16： | 0 |
| 5 | Injectable bone marrow microniches by co-culture of HSPCs with MSCs in 3D microscaffolds promote hematopoietic reconstitution from acute lethal radiation显示文摘Hematopoietic syndrome of acute radiation syndrome(h-ARS)is an acute illness resulted from the damage of bone marrow(BM)microenvironment after exposure to radiation.Currently,the clinical management of h-ARS is limited to medication-assisted treatment,while there is still no specific therapy for the hematopoietic injury from high-dose radiation exposure.Our study aimed to assemble biomimetic three-dimensional(3D)BM microniches by co-culture of hematopoietic stem and progenitor cells(HSPCs)and mesenchymal stem cells(MSCs)in porous,injectable and viscoelastic microscaffolds in vitro.The biodegradable BM microniches were then transplanted in vivo into the BM cavity for the treatment of h-ARS.We demonstrated that the maintenance of HSPCs was prolonged by co-culture with MSCs in the porous 3D microscaffolds with 84μm in pore diameter and 11.2 kPa in Young’s modulus compared with 2D co-culture system.Besides,the minimal effective dose and therapeutic effects of the BM microniches were investigated on a murine model of h-ARS,which showed that the intramedullary cavity-injected BM microniches could adequately promote hematopoietic reconstitution and mitigate death from acute lethal radiation with a dose as low as 1000 HSPCs.Furthermore,the mRNA expression of Notch1 and its downstream target gene Hes1 of HSPCs were increased when co-cultured with MSCs,while the Jagged1 expression of the co-cultured MSCs was upregulated,indicating the significance of Notch signaling pathway in maintenance of HSPCs.Collectively,our findings provide evidence that biomimetic and injectable 3D BM microniches could maintain HSPCs,promote hematopoiesis regeneration and alleviate post-radiation injury,which provides a promising approach to renovate conventional HSPCs transplantation for clinical treatment of blood and immune disorders. | Haiwei Liang Yanxiao Ao Wenjing Li Kaini Liang Baixue Tang Junyang Li Jianwei Wang Xiaoyu Zhu Yanan Du | 2023 | Bioactive Materials2023，，4： | 0 |
| 6 | Multi-features fusion for short-term photovoltaic power prediction显示文摘In recent years,in order to achieve the goal of“carbon peaking and carbon neutralization”,many countries have focused on the development of clean energy,and the prediction of photovoltaic power generation has become a hot research topic.However,many traditional methods only use meteorological factors such as temperature and irradiance as the features of photovoltaic power generation,and they rarely consider the multi-features fusion methods for power prediction.This paper first preprocesses abnormal data points and missing values in the data from 18 power stations in Northwest China,and then carries out correlation analysis to screen out 8 meteorological features as the most relevant to power generation.Next,the historical generating power and 8 meteorological features are fused in different ways to construct three types of experimental datasets.Finally,traditional time series prediction methods,such as Recurrent Neural Network(RNN),Convolution Neural Network(CNN)combined with eXtreme Gradient Boosting(XGBoost),are applied to study the impact of different feature fusion methods on power prediction.The results show that the prediction accuracy of Long Short-Term Memory(LSTM),stacked Long Short-Term Memory(stacked LSTM),Bi-directional LSTM(Bi-LSTM),Temporal Convolutional Network(TCN),and XGBoost algorithms can be greatly improved by the method of integrating historical generation power and meteorological features.Therefore,the feature fusion based photovoltaic power prediction method proposed in this paper is of great significance to the development of the photovoltaic power generation industry. | Ming Ma Xiaorun Tang Qingquan Lv Jun Shen Baixue Zhu Jinqiang Wang Binbin Yong | 2022 | Intelligent and Converged Networks2022，3，4： | 0 |
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