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| 1 | Nature:研究鉴定出蛋白Nlrp9b抵抗轮状病毒感染机制显示文摘轮状病毒(rotavirus)是婴儿和儿童罹患肠胃炎和腹泻的一种最为常见的原因,每年导致全世界大约21.5万人死亡。它是高度传染性的和潜在致命性的。这种病毒特异性地感染宿主小肠中的肠上皮细胞,并且已进化出抵抗干扰素和NF-KB信号的策略来躲避免疫系统,这就提出一个问题:其他的宿主因子是否参与肠道粘膜中的抗病毒反应。不过,针对体内(特别是通过NLR炎性体)检测和限制肠道病毒的机制,人们知之甚少。 | Shu Zhu, Zheng Wei, Noah W. Palm, Yi Yang, Hua Yu, Hua-Bing Li, Geng Wang, Xuqiu Lei, Marcel R. de Zoete, Jun Zhao, Yunjiang Zheng, Haiwei Chen, Liang Shan, Richard A. Flavell Siyuan Ding, Ningguo Feng, Harry B. Greenberg Siyuan Ding, Harry B. Greenberg Penghua Wang, Yujiao Zhao Wen Pan, Jun Lu Jun Zhao, Yuval Kluger Kellie A. Jurado, Clara Abraham, Erol Fikrig Erol Fikrig, Richard A. Flavell | 2017 | 现代生物医学进展2017，17，27： | 10 |
| 2 | Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms显示文摘刺激干扰素的基因 56 (ISG56 ) 家庭成员在堵住病毒的复制并且然而,调整细胞的功能起重要作用他们的内在的分子的机制大部分是不清楚的。这里,我们在场 ISG54 的水晶结构,有新奇 RNA 有约束力的结构的 ISG56 家庭蛋白质。结构证明 ISG54 单体有 9 tetratricopeptide 像重复的主题和伙伴到形成交换域的 dimers。C 终端部分合拢进超级螺旋状的结构并且在它的内部表面上有一条广泛地断然控告的核苷酸绑定隧道。EMSA 结果证明 ISG54 明确地绑在一些 RNA,例如 adenylate uridylate (AU ) 富有的 RNA,与或没有 5 ′triphosphorylation。Mutagenesis 和功能的研究证明这个 RNA 有约束力的能力对它的抗病毒的活动重要。我们的结果建议位于这干扰素可诱导的基因的抗病毒的活动下面的新机制 56 家庭成员。 | Zhenlin Yang Huanhuan Liang Qian Zhou Ying Li Haiwei Chen Wen Ye Danying Chen Joy Fleming Hongbing Shu Yingfang Liu | 2012 | Cell Research2012，22，9： | 8 |
| 3 | Orbital-scale Asian summer monsoon variations:Paradox and exploration显示文摘The Asian summer monsoon(ASM) is a vast climate system, whose variability is critical to the livelihoods of billions of people across the Asian continent. During the past half-century, much progress has been made in understanding variations on a wide range of timescales, yet several significant issues remain unresolved. Of note are two long-standing problems concerning orbital-scale variations of the ASM.(1) Chinese loess magnetic susceptibility records show a persistent glacial-interglacial dominated ~100 kyr(thousand years) periodicity, while the cave oxygen-isotope(δ18 O) records reveal periodicity in an almost pure precession band(~20 kyr periodicity)—the 'Chinese 100 kyr problem'.(2) ASM records from the Arabian Sea and other oceans surrounding the Asian continent show a significant lag of 8–10 kyr to Northern Hemisphere summer insolation(NHSI), whereas the Asian cave δ18 O records follow NHSI without a significant lag—a discrepancy termed the 'sea-land precession-phase paradox'. How can we reconcile these differences? Recent and more refined model simulations now provide spatial patterns of rainfall and wind across the precession cycle, revealing distinct regional divergences in the ASM domain, which can well explain a large portion of the disparities between the loess, marine, and cave proxy records. Overall, we also find that the loess, marine, and cave records are indeed complementary rather than incompatible, with each record preferentially describing a certain aspect of ASM dynamics. Our study provides new insight into the understanding of different hydroclimatic proxies and largely reconciles the 'Chinese 100 kyr problem' and 'sea-land precession-phase paradox'. | Hai CHENG Haiwei ZHANG Yanjun CAI Zhengguo SHI Liang YI Chenglong DENG Qingzhen HAO Youbing PENG Ashish SINHA Hanying LI Jingyao ZHAO Ye TIAN Jonathan BAKER Carlos PEREZ-MEJIAS | 2021 | Science China Earth Sciences2021，64，4： | 6 |
| 4 | DYNAMIC CHARACTERISTICS OF LAG VIBRATION OF A WIND TURBINE BLADE显示文摘Lagwise dynamic characteristics of a wind turbine blade subjected to unsteady aerodynamic loads are studied in this paper.The partial diferential equations governing the coupled longitudinal-transverse vibration of the blade with large bending deflection are obtained by applying Hamilton’s principle.The modal problem of the coupled vibration is handled by using the method of numerical integration of Green’s function.Influences of the rotating speed,the pitch angle,the setting angle,and the aerodynamic loads on natural frequencies are discussed.Results show that:(1)Lagwise natural frequencies ascend with the increase of rotating speed;efects of the rotating speed on low-frequencies are dramatic while these efects on high-frequencies become less.(2)Influences of the pitch angle on natural frequencies are little;in the range of the normal rotating speed,the first frequency ascends with the increase of the absolute value of the pitch angle,while it is contrary to the second and third frequencies.(3)Efects of the setting angle on natural frequencies depend on the rotating speed;influences are not significant at low speed,while they are dramatic on the first frequency at high speed.(4)Efects of the aerodynamic loads on natural frequencies are very little;frequencies derived from the model considering aerodynamic loads are smaller than those from the model neglecting aerodynamic loads;relative errors of the results corresponding to two models ascend with the increase of the absolute value of the setting angle. | Yinghui Li Liang Li Qikuan Liu Haiwei Lv | 2013 | Acta Mechanica Solida Sinica2013，26，6： | 3 |
| 5 | Preparation and corrosion assessment of electrodeposited Ni–SiC composite thin films显示文摘 | Chunyang Ma Guiqiang Liang Yongyong Zhu Haiwei Mu Fafeng Xia | 2014 | Ceramics International2014，，： | 3 |
| 6 | Single amino acid substitution of VP1 N17D or VP2 H145Y confers acid-resistant phenotype of type Asia1 foot-and-mouth disease virus显示文摘Infection by foot-and-mouth disease virus(FMDV) is triggered by the acidic pH in endosomes after virus uptake by receptor-mediated endocytosis. However, dissociation of the FMDV 146S particle in mildly acidic conditions renders inactivated foot-and-mouth disease(FMD) vaccines much less effective. Type Asia1 FMDV mutants with increased resistance to acid inactivation were selected to study the molecular basis of viral resistance to acid-induced disassembly and improve the acid stability of FMDV. Sequencing of capsid-coding regions revealed four amino acid replacements(VP1 N17D, VP2 H145Y, VP2 G192D, and VP3 K153E) in the viral population of the acid-selected 10th passage. We performed single or combined mutagenesis using a reverse genetic system, and our results provide direct experimental evidence that VP2 H145Y or VP1 N17D substitution confers an acid-resistant phenotype to type Asia1 FMDV. | Haiwei Wang Shanshan Song Jianxiong Zeng Guohui Zhou Decheng Yang Te Liang Li Yu | 2014 | Virologica Sinica2014，29，2： | 2 |
| 7 | A freestanding Pt-nanowire membrane as a highly stable electrocatalyst for the oxygen reduction reaction 显示文摘 | LIANG Haiwei CAO Xiang ZHOU Fei | 2011 | Adv Mater2011，23，12： | 1 |
| 8 | Synthesis of an attapulgite clay@ carbon nanocomposite adsorbent by a hydrothermal carboniza- tion process and their application in the removal of toxic metal ions from water显示文摘 | Chen Lifeng Liang Haiwei Lu Yang | 2011 | Langmuir2011，27，14： | 1 |
| 9 | High‐Performance Electrocatalysts for Oxygen Reduction Derived from Cobalt Porphyrin‐Based Conjugated Mesoporous Polymers显示文摘 | Zhong‐Shuai Wu Long Chen Junzhi Liu Khaled Parvez Haiwei Liang Jie Shu Hermann Sachdev Robert Graf Xinliang Feng Klaus Müllen | 2014 | Adv. Mater2014，，9： | 1 |
| 10 | Synthesis of an attapulgite clay and carbon nanocomposite adsorbent by a hydrothermal carbonization process and their application in the removal of toxic metal ions from water 显示文摘 | Chen Lifeng Liang Haiwei Lu Yang et at | 2011 | Langmuir2011，27，4： | 1 |
| 11 | Prediction of Primary Dendrite Arm Spacing in Pulsed Laser Surface Melted Single Crystal Superalloy显示文摘Primary dendritic arm spacing(PDAS)is an important microstructure feature of the nickel-base single crystal superalloys.In this paper,a numerical model predicting the PDAS evolution with additive manufacturing parameters using pulsed laser is established,which combines the theoretical PDAS models with the temperature field calculation model during pulsed laser process.Based on this model,processing maps that related process parameters to the evolution of PDAS are generated.To obtain more accurate prediction model,the parameters of different solidification conditions,G^(-0.5)V^(-0.25) and G^(-0.5)V^(-0.25),are selected to calculate PDAS.The simulation results show that the PDAS increases as the arise of P and t.The processmgPDAS map can accurately predict the evolution of PDAS with pulsed laser process parameters,which is well in accordance with the experimental results.Additionally,the PDAS values calculated by the G^(-0.5)V^(-0.25) are more in line with the experimental results than those calculated by the G^(-0.5)V^(-0.25). | Shiwei Ci Jingjing Liang Jinguo Li Haiwei Wang Yizhou Zhou Xiaofeng Sun Hongwei Zhang Yutian Ding Xin Zhou | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，4： | 1 |
| 12 | Synthesis of an attapulg- ite clay@carbon nanoeomposite adsorbent by a hydrothermal carbonization process and their application in the removal of toxic metal ions from water显示文摘 | Lifeng Chen Haiwei Liang Yang Lu | 2011 | Langmuir2011，27，14： | 1 |
| 13 | Carbon nanofibers decorated with molybdenum disulfide nanosheets:synergistic lithium storage and enhanced electrochemical performance显示文摘 | ZHOU Fei XIN Sen LIANG Haiwei | 2014 | Angew Chem2014，53，11： | 1 |
| 14 | Injectable bone marrow microniches by co-culture of HSPCs with MSCs in 3D microscaffolds promote hematopoietic reconstitution from acute lethal radiation显示文摘Hematopoietic syndrome of acute radiation syndrome(h-ARS)is an acute illness resulted from the damage of bone marrow(BM)microenvironment after exposure to radiation.Currently,the clinical management of h-ARS is limited to medication-assisted treatment,while there is still no specific therapy for the hematopoietic injury from high-dose radiation exposure.Our study aimed to assemble biomimetic three-dimensional(3D)BM microniches by co-culture of hematopoietic stem and progenitor cells(HSPCs)and mesenchymal stem cells(MSCs)in porous,injectable and viscoelastic microscaffolds in vitro.The biodegradable BM microniches were then transplanted in vivo into the BM cavity for the treatment of h-ARS.We demonstrated that the maintenance of HSPCs was prolonged by co-culture with MSCs in the porous 3D microscaffolds with 84μm in pore diameter and 11.2 kPa in Young’s modulus compared with 2D co-culture system.Besides,the minimal effective dose and therapeutic effects of the BM microniches were investigated on a murine model of h-ARS,which showed that the intramedullary cavity-injected BM microniches could adequately promote hematopoietic reconstitution and mitigate death from acute lethal radiation with a dose as low as 1000 HSPCs.Furthermore,the mRNA expression of Notch1 and its downstream target gene Hes1 of HSPCs were increased when co-cultured with MSCs,while the Jagged1 expression of the co-cultured MSCs was upregulated,indicating the significance of Notch signaling pathway in maintenance of HSPCs.Collectively,our findings provide evidence that biomimetic and injectable 3D BM microniches could maintain HSPCs,promote hematopoiesis regeneration and alleviate post-radiation injury,which provides a promising approach to renovate conventional HSPCs transplantation for clinical treatment of blood and immune disorders. | Haiwei Liang Yanxiao Ao Wenjing Li Kaini Liang Baixue Tang Junyang Li Jianwei Wang Xiaoyu Zhu Yanan Du | 2023 | Bioactive Materials2023，，4： | 0 |
| 15 | Spatially Isolated Noble-Metal-Free Redox Cocatalysts on CdS Nanorods for Increased Photocatalytic Hydrogen Generation显示文摘Spatially isolated oxidation and reduction cocatalysts on a semiconductor can realize efficient charge separation and thereby lead to increased photocatalytic hydrogen generation. However, the effective preparation of such photocatalysts has proven challenging.Herein, we report the facile synthesis of a novel noblemetal-free CdS/MoS/CoPi ternary photocatalyst via a visible light-induced synthesis route, in which MoSreduction cocatalysts were precisely grown on the two terminals of CdS nanorods, while CoPi oxidation cocatalysts were preferentially anchored onto the sidewalls of CdS nanorods. Such spatially isolated MoSand CoPi redox cocatalysts endow CdS nanorods with a rapid charge separation, which enhances their hydrogen generation activity. The CdS/MoS/CoPi photocatalyst with optimized CoPi amount achieves the highest Hgeneration rate of 206 μmol/h, which is 21 and 2 times higher than that achieved by using CdS alone(9.7 μmol/h) and CdS/MoS(105 μmol/h), respectively. The present work highlights the effectiveness of the spatial isolation of reduction and oxidation sites for efficient charge separation and thereby provides a promising strategy for the preparation of highly active photocatalysts. | Xiaomeng Zhang Gege Zhao Zhongfei Li Liang Zhu Yingpeng Cheng Haiwei Du Chuhong Zhu Ya Dang Daochuan Jiang Yupeng Yuan | 2022 | Chinese Journal of Structural Chemistry2022，41，9： | 0 |
| 16 | Facile preparation and characterization of novel oleanane-type triterpene functionalized β-cyclodextrin conjugates显示文摘Oleanolic acid(OA) and echinocystic acid(EA), two naturally occurring pentacyclic oleanane triterpenes,are gaining increasing attention due to their promising pharmacological activities. Conjugation with amphiphilic α(β)-cyclodextrin(CD) via 'click chemistry' can improve their solubility and anti-HCV entry potency. In the present work,four water-soluble β-CD-pentacyclic triterpene conjugates were designed and synthesized, in which OA and EA was coupled to one of the primary hydroxyl groups of β-CD via ester and amide bonds. The structures of the conjugates were unambiguously determined by ~1H NMR, ^(13)C NMR and HRMS or MALDI-TOF-MS. All the conjugates showed lower hydrophobicity(AlogP) than their parent compounds and no significant cytotoxicity was found to HL-60, A549, Hela and Bel-7402 cells at concentrations up to 10 μmol/L. Further anti-HCV entry activity and mechanism studies are under way in our laboratory. | Pingxuan Jiao Shouxin Wang Shuobin Liang Man Li Qianqian Gao Dezhong Ji Yingying Chen Haiwei Li Fuxiang Ran Yongmin Zhang Lihe Zhang Demin Zhou Sulong Xiao | 2019 | Chinese Chemical Letters2019，30，3： | 0 |
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