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| 1 | Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis显示文摘AIM To investigate the effects of orally gavaged aqueous rhubarb extract(RE) on 5-fluorouracil(5-FU)-induced intestinal mucositis in rats. METHODS Female Dark Agouti rats(n = 8/group) were gavaged daily(1 mL) with water, high-dose RE(HDR; 200 mg/kg) or low-dose RE(LDR; 20mg/kg) for eight days. Intestinal mucositis was induced(day 5) with 5-FU(150 mg/kg) via intraperitoneal injection. Intestinal tissue samples were collected for myeloperoxidase(MPO) activity and histological examination. Xenopus oocytes expressing aquaporin 4 water channels were prepared to examine the effect of aqueous RE on cell volume, indicating a potential mechanism responsible for modulating net fluid absorption and secretion in the gastrointestinal tract. Statistical significance was assumed at P < 0.05 by one-way ANOVA. RESULTS B o d y w e i g h t w a s s i g n i f i c a n t l y r e d u c e d i n r a t s administered 5-FU compared to healthy controls(P < 0.01). Rats administered 5-FU significantly increased intestinal MPO levels(≥ 307%; P < 0.001), compared to healthy controls. However, LDR attenuated this effect in 5-FU treated rats, significantly decreasing ileal MPO activity(by 45%; P < 0.05), as compared to 5-FU controls. 5-FU significantly reduced intestinal mucosal thickness(by ≥ 29% P < 0.001) as compared to healthy controls. LDR significantly increased ileal mucosal thickness in 5-FU treated rats(19%; P < 0.05) relative to 5-FU controls. In xenopus oocytes expressing AQP4 water channels, RE selectively blocked water influx into the cell, induced by a decrease in external osmotic pressure. As water efflux was unaltered by the presence of extracellular RE, the directional flow of water across the epithelial barrier, in the presence of extracellular RE, indicated that RE may alleviate water loss across the epithelial barrier and promote intestinal health in chemotherapy-induced intestinal mucositis.CONCLUSION In summary, low dose RE improves selected parameters of mucosal integrity and reduces ileal inflammation, manifesting from 5-FU-induced intestinal mucositis. | Juliana E Bajic Georgina L Eden Lorrinne S Lampton Ker Y Cheah Kerry A Lymn Jinxin V Pei Andrea J Yool Gordon S Howarth | 2016 | World Journal of Gastroenterology2016，22，37： | 3 |
| 2 | Welding of rails with new technology of arc welding显示文摘 | Bajic D Vladimirovich Kuzmenko Samardzic G | 2013 | Metalurgija2013，3，52： | 1 |
| 3 | Moving region segmenta- tion from compressed video using global motion estima- tion and Markov radom fields 显示文摘 | Chert Y M Bajic I V Saeedi P | 2011 | IEEE Transaction on multimedia2011，13，3： | 1 |
| 4 | Computationalmetbods for prediction of T2cell epitopes-a framework for modeling, testing, and applications显示文摘 | Brusic V Bajic V B PetrovskyN | 2004 | Methods2004，34，4： | 1 |
| 5 | The effects of a new subway line on housing prices in metropolitan toronto显示文摘 | BAJIC V | 1983 | Urban Studies1983，，20： | 1 |
| 6 | Intracranial aneurysms associated with moyamoya disease 显示文摘 | Borota L Marinkovic S Bajic R | 1996 | Neurol Med Chir ( Tokyo )1996，36，12： | 1 |
| 7 | Region-based predictive decoding of video显示文摘 | Chen Y M Bajic I V | 2010 | lEEE Transactions on Circuits and Systems for Video Technology2010，20，3： | 1 |
| 8 | On the classification of long non-coding RNAs显示文摘 | Ma L Bajic VB Zhang Z | 2013 | RNA Bioi2013，10，6： | 1 |
| 9 | Multiresidue detemination of quinolone antibiotics using liquid chromatography coupled to atmospheric-pressure chemical ionization mass spectrometry and tandem mass spectrometry显示文摘 | Doerge D R Bajic s | 1995 | Rapid Commun Mass Spectrom1995，9，11： | 1 |
| 10 | ERGDB:estrogen responsive genes database显示文摘 | Tang S Han H Bajic V B | 2004 | Nucleic Acids Res2004，32，： | 1 |
| 11 | Welding of rails with new technology o{ arc welding 显示文摘 | Bajic D Vladimirovich Kuzmenko G Samardzic 1 | 2013 | Metalurgija2013，52，3： | 1 |
| 12 | Constant modulus blind adaptivebeamforming based on unscented Kalman filtering 显示文摘 | Bhotto M Z A Bajic I V | 2015 | IEEESignal Processing Letters2015，22，4： | 1 |
| 13 | On the classification of long non-coding RNAs显示文摘 | Lina Ma Vladimir B. Bajic Zhang Zhang | 2013 | RNA Biology2013，，： | 1 |
| 14 | Computer modelfor recognition of functional transcription start sites inRNA polymerase II promoters of vertebrates显示文摘 | Bajic V B Seah S H Chong A | 2003 | Journalof Molecular Graphics and Modeling2003，21，： | 1 |
| 15 | Multi-dimensional Diagnostics of Turbine Cavitation显示文摘 | Bajic B | 2002 | Transactions of the ASME -Journal of Fluids Engineering2002，124，12： | 1 |
| 16 | New Model and Sliding Mode Control of Hydraulic Elevator Velocity Tracking System显示文摘 | Sha Daohang Bajic V B Yang Huayong | 2002 | Simulation Practice and Theory2002，，678： | 1 |
| 17 | Choline Acetyltransferase Activity in Vascular Dementia and Stroke显示文摘 | Sharp Sally I Francis Paul T Elliott Mark S J Kalaria Rajesh N Bajic Natasha Hortobagyi Tibor Ballard Clive G | 2009 | Dementia and Geriatric Cognitive Disorders2009，，3： | 1 |
| 18 | Cholinergic imbalance in the multiple sclerosis hippocampus 显示文摘 | Kooi E J Prins M Bajic N | 2011 | Acta Neuropathol2011，122，3： | 1 |
| 19 | Computational methods for prediction of T-cell epitopes:a framework for modelling,testing,and applications显示文摘 | BRUSIC V BAJIC V B PETROVSKY N | 2004 | Methods2004，34，4： | 1 |
| 20 | Analysis of glass fragments by laser ablation-inductively coupled plasmamass spectrometry and principal component analysis 显示文摘 | Bajic S J Aeschliman D B Saetveit N J | 2005 | Journal of Forensic Sciences2005，50，5： | 1 |
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