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    题名 作者 年代 出处 被引量
1Binding Energies of Excitons in a strained wurtzite GaN/AIGaN Quantum Well influenced screening and Hydrostatic Pressure 显示文摘Hua H S Ban S L 2008J Phys: Condens Matter2008,20,08:1
2Self-adaptlve control system of grain drying device 显示文摘Li Changyou Ban Hua Shen Wenhao 2008Drying Technology2008,26,11:1
3Self-adaptive control system of grain drying device显示文摘Li Changyou Ban Hua Shen Wenhao 2008Drying Technology2008,26,11:1
4Adhesion betweenrail/wheel under water lubricated contact显示文摘CHEN Hua BAN T ISHIDA M 2002Wear2002,,253:1
5Experimental investigation of influential factors on adhesion between wheel and rail under wet conditions 显示文摘CHEN Hua BAN T ISHIDA M 2008Wear2008,265,:1
6A phase III randomized,double-blind,placebo-controlled trial of the denosumab biosimilar QL1206 in postmenopausal Chinese women with osteoporosis and high fracture risk显示文摘The current study evaluated the efficacy and safety of a denosumab biosimilar,QL1206(60 mg),compared to placebo in postmenopausal Chinese women with osteoporosis and high fracture risk.At 31 study centers in China,a total of 455 postmenopausal women with osteoporosis and high fracture risk were randomly assigned to receive QL1206(60 mg subcutaneously every 6 months)or placebo.From baseline to the 12-month follow-up,the participants who received QL1206 showed significantly increased bone mineral density(BMD)values(mean difference and 95%CI)in the lumbar spine:4.780%(3.880%,5.681%),total hip:3.930%(3.136%,4.725%),femoral neck 2.733%(1.877%,3.589%)and trochanter:4.058%(2.791%,5.325%)compared with the participants who received the placebo.In addition,QL1206 injection significantly decreased the serum levels of C-terminal crosslinked telopeptides of type 1 collagen(CTX):−77.352%(−87.080%,−66.844%),and N-terminal procollagen of type l collagen(P1NP):−50.867%(−57.184%,−45.217%)compared with the placebo over the period from baseline to 12 months.No new or unexpected adverse events were observed.We concluded that compared with placebo,QL1206 effectively increased the BMD of the lumbar spine,total hip,femoral neck and trochanter in postmenopausal Chinese women with osteoporosis and rapidly decreased bone turnover markers.This study demonstrated that QL1206 has beneficial effects on postmenopausal Chinese women with osteoporosis and high fracture risk.Hao Zhang Jie-mei Gu Ai-jun Chao Qun Cheng Dong-hui Teng Jin-ming Yu Bing-wu Wang Ya-nan Huo Li Mao Qiu Zhang Hong Yang Shi-gui Yan Ke-qin Zhang Xue-ling Zhao Hua Lin Yu Pei Zhong Yuan Ru-chun Dai Liang He Li Chen Yong-feng Su Zhong-liang Deng Li You Bo Ban Mei Zhu You-liang Cao Yi-kun Zhu Zhi-jun Li Zhi Zhang Cheng-qing Yi Yi-bing Lu Guang Wang Cui-cui Han Zhen-jiang Wang Xian-xing Li Zhen-lin Zhang 2023Acta Pharmacologica Sinica2023,44,2:1
7Dietary host-associated Bacillus subtilis supplementation improves intestinal microbiota,health and disease resistance in Chinese perch(Siniperca chuatsi)显示文摘The purpose of this study was to evaluate the potential of a host-associated Bacillus subtilis 1-C-7 as a probiotic for Chinese perch(Siniperca chuatsi).Four test diets were formulated to contain graded levels of B.subtilis 1-C-7 at 0(CY),0.85×10^(8)(Y1),0.95×10^(9)(Y2)and 0.91×10^(10)(Y3)CFU/kg diet.The test fish with initial weight 30.0±1.2 g were fed the 4 test diets with 3 replicates in an indoor water-flow aquaculture system with 12 net cages(40 fish/cage)for 10 wk.At the conclusion of the feeding trial,the probiotic effects of B.subtilis on Chinese perch were analyzed based on growth performance,serum biochemical indices,histologic morphology of liver and gut,gut microbiota and the resistance to Aero-monas hydrophila.The results showed that the percentage of weight gain had no significant change in the Y1 and Y2 groups(P>0.05)but decreased in the Y3 group compared to that in the CY group(P<0.05).The fish in the Y3 group displayed the highest activity of serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)among these 4 groups(P<0.05).The fish in the CY group had the highest value of malondialdehyde in the liver(P<0.05)and showed severe nuclear migration and vacuolization of hepatocytes.The morphology indicated that all test fish had poor intestinal health.However,the fish in the Y1 group had a relatively normal intestinal histologic structure.The mid gut microbial diversity analysis showed that dietary B.subtilis supplementation increased the abundance of probiotics such as Tenericutes and Bacteroides,whereas it reduced the abundance of pernicious bacteria such as Proteobacteria,Actinobacteria,Thermophilia and Spirochaetes.The challenge test showed that dietary B.subtilis supplementation increased the resistance to A.hydrophila in Chinese perch.In conclusion,dietary supplementation of 0.85×10^(8)CFU/kg B.subtilis 1-C-7 could improve the intestinal microbiota,intestinal health and disease resistance in Chinese perch,but more or excessive supple-mentation could reduce growth performance and have negative effects on health.Zhehui Ji Chuanzhong Zhu Xinyang Zhu Sainan Ban Lijuan Yu Juan Tian Lixue Dong Hua Wen Xing Lu Ming Jiang 2023Animal Nutrition2023,,2:0
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