| 3 | Phosphatidylserine externalized on the colonic capillaries as a novel pharmacological target for IBD therapy显示文摘Inflammatory bowel disease(IBD)is a chronic and relapsing disorder for many people associated with poor health.Although there are some clinical drugs for IBD treatment,the development of effective therapeutics on IBD patients has always been necessary.Here,we show that externalized phosphatidylserine(PS)is observed on the surface of colonic capillaries.Annexin A5(ANXA5)with high affinity for PS has a good targeting to the colon and effectively alleviates experimental colitis.In contrast,ANXA5 mutant(A5m)lacking the PS-binding ability,has no accumulation in the colon and no therapeutic effects on colitis.Mechanistic investigations indicate that ANXA5 reduces the inflammatory cell infiltration by inhibiting endothelial cell activation dependent on PS-binding ability.With the increasing of PS exposure on activated HUVECs(human umbilical vein endothelial cells),ANXA5 binding induces the internalization of TLR4 via PS-dependent endocytosis.We provide new insights on the molecular mechanism of ANXA5 for its anti-inflammatory effect.Our data suggest that PS-externalization is a potential target of ANXA5 aiming at targeted drug delivery(TDD)for IBD treatment. | Xuerui Zhang Lulu Song Lin Li Banghui Zhu Lina Huo Zhaoqing Hu Xinran Wang Jie Wang Mengyue Gao Jing Zhang Zichun Hua | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 1 |
| 4 | Prediction of Apple Fruit Quality by Soil Nutrient Content and Artificial Neural Network显示文摘The effect of soil nutrient content on fruit yield and fruit quality is very important.To explore the effect of soil nutrients on apple quality we investigated 200 fruit samples from 40 orchards in Feng County,Jiangsu Province.Soil mineral elements and fruit quality were measured.The effect of soil nutrient content on fruit quality was analyzed by artificial neural network(ANN)model.The results showed that the prediction accuracy was highest(R2=0.851,0.847,0.885,0.678 and 0.746)in mass per fruit(MPF),hardness(HB),soluble solids concentrations(SSC),titratable acid concentration(TA)and solid-acid ratio(SSC/TA),respectively.The sensitivity analysis of the prediction model showed that soil available P,K,Ca and Mg contents had the greatest impact on the quality of apple fruit.Response surface method(RSM)was performed to determine the optimum range of the available P,K,Ca,and Mg contents in orchards In Feng County,which were 10∼20 mg⋅kg^(−1),170∼200 mg⋅kg^(−1),1000∼1500 mg⋅kg^(−1),and 80∼200 mg⋅kg^(−1),respectively.The research also concluded that improving the content of available P and available Ca in orchard soil was crucial to improve apple fruit quality in Feng County,Jiangsu Province. | Mengyao Yan Xianqi Zeng Banghui Zhang Hui Zhang Di Tan Binghua Cai Shenchun Qu Sanhong Wang | 2023 | Phyton-International Journal of Experimental Botany2023，92，1： | 0 |
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