|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | Liver type fatty acid binding protein (L-FABP) gene ablation reduces nuclear ligand distribution and peroxisome proliferator-activated receptor-α activity in cultured primary hepatocytes显示文摘 | Avery L. McIntosh Barbara P. Atshaves Heather A. Hostetler Huan Huang Jason Davis Olga I. Lyuksyutova Danilo Landrock Ann B. Kier Friedhelm Schroeder | 2009 | Archives of Biochemistry and Biophysics2009，，2： | 2 |
| 3 | Caffeine for Apnea of Prematurity Trial: Benefits May Vary in Subgroups显示文摘 | Peter G. Davis Barbara Schmidt Robin S. Roberts Lex W. Doyle Elizabeth Asztalos Ross Haslam Sunil Sinha Win Tin | 2010 | The Journal of Pediatrics2010，，： | 1 |
| 4 | Nicotine con- centrations in electronic cigarette refill and do-it-yourself fluids 显示文摘 | Barbara Davis Michael Dang Jisoo Kim | 2015 | Nicotine and Tobacco Research2015，17，2： | 1 |
| 5 | Developing a model for strategic leadership in schools显示文摘 | DAVIES BARBARA J DAVIES BRENT | 2006 | Educational Management Administration & Leadership2006，34，1： | 1 |
| 6 | An immunodominant membrane protein gene from the Western X-disease phytoplasma is distinct from those of other phytoplasmas显示文摘 | Blomquist C L Barbara D J Davies D L | 2001 | Microbiology2001，147，： | 1 |
| 7 | An innnunodominant membrane protein gene from the WesternX-disease phytoplasma is distinct from those of other phytoplasmas 显示文摘 | BLOMQUIST C L BARBARA D J DAVIES D L | 2001 | Microbiology2001，147，： | 1 |
| 8 | An immunodominanl membrane protein gene from the Western X-disease phytoplasma is distinct from those of other phytoplasmas显示文摘 | Blomquist C L Barbara D J Davies D L et ol | 2001 | Microbiology2001，147，3： | 1 |
| 9 | Evaluation of the Psychometric Properties of the Phlebitis and Infiltration Scales for the Assessment of Complications of Peripheral Vascular Access Devices显示文摘 | Dianne Groll Barbara Davies Joan Mac Donald Susanne Nelson Tazim Virani | 2010 | Journal of Infusion Nursing2010，，： | 1 |
| 10 | Leuconostoc sepsis in association with continous enteral feeding: two case reports and a review显示文摘 | JONATHAN CARAPETIS SUZANNE BISHOP JENNIFER DAVIS BARBARA BELL GEOFFREY HOGG | 1994 | The Pediatric Infectious Disease Journal1994，，9： | 1 |
| 11 | Prenatal isolated mild ventriculomegaly is associated with persistent ventricle enlargement at ages 1 and 2显示文摘 | Amanda E. Lyall Sandra Woolson Honor M. Wolfe Barbara Davis Goldman J. Steven Reznick Robert M. Hamer Weili Lin Martin Styner Guido Gerig John H. Gilmore | 2012 | Early Human Development2012，，8： | 1 |
| 12 | Tamoxifen induces apoptosis in Fas+ tumor cells by upregulating the expression of Fas ligand显示文摘 | Nisha Nagarkatti Barbara A. Davis | 2003 | Cancer Chemotherapy and Pharmacology2003，，4： | 1 |
| 13 | Evaluation of a multiple component intervention to support the implementation of a ‘Therapeutic Relationships’ best practice guideline on nurses’ communication skills显示文摘 | Nancy Edwards Wendy E. Peterson Barbara L. Davies | 2006 | Patient Education and Counseling2006，，1： | 1 |
| 14 | An immunodominant membrane protein gene from the Western X-disease phytoplasma is distinct from those of other phytoplasmas 显示文摘 | BLOMQUIST C L BARBARA D J DAVIES D L | 2001 | Microbiology2001，147，3： | 1 |
| 15 | Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials显示文摘 | Kennedy R Lees Erich Bluhmki Rüdiger von Kummer Thomas G Brott Danilo Toni James C Grotta Gregory W Albers Markku Kaste John R Marler Scott A Hamilton Barbara C Tilley Stephen M Davis Geoffrey A Donnan Werner Hacke | 2010 | The Lancet2010，，9727： | 1 |
| 16 | Prenatal isolated mild ventriculomegaly is associated with persistent ventricle enlargement at ages 1 and 2显示文摘 | Amanda E. Lyall Sandra Woolson Honor M. Wolfe Barbara Davis Goldman J. Steven Reznick Robert M. Hamer Weili Lin Martin Styner Guido Gerig John H. Gilmore | 2012 | Early Human Development2012，，8： | 1 |
| 17 | From sex roles to gender structure显示文摘 | Barbara J Risman Georgiann Davis | 2013 | Current Sociology . 2013 (5-6)2013，，5： | 1 |
| 18 | All-Fiction Issue: The Bridge Playing Ladies 显示文摘 | DAVIS Barbara Beckerman | 2003 | The Antioch Review2003，，1： | 1 |
| 19 | Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials显示文摘 | Kennedy R Lees Erich Bluhmki Rüdiger von Kummer Thomas G Brott Danilo Toni James C Grotta Gregory W Albers Markku Kaste John R Marler Scott A Hamilton Barbara C Tilley Stephen M Davis Geoffrey A Donnan Werner Hacke | 2010 | The Lancet2010，，9727： | 1 |
| 20 | The Method for Object-Based Diagnostic Evaluation (MODE) Applied to Numerical Forecasts from the 2005 NSSL/SPC Spring Program显示文摘 | Davis Christopher A Brown Barbara G Bullock Randy Halley-Gotway John | 2009 | Weather and Forecasting2009，，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员