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| 1 | Effect of sewage sludge and sugarcane bagasse biochar on soil properties and sugar beet production显示文摘Recently, biochar has shown to be an alternative to waste disposal and a source of nutrients, acting as a soil amendment. The effects of two types of biochar on soil properties and sugar beet production as well as potential for carbon(C) sequestration were evaluated: biochar produced from sewage sludge(SB) and biochar produced from a 1:1 mixture of sewage sludge and sugarcane bagasse(MB). A greenhouse pot experiment was conducted using a sandy loam soil from the Brazilian savanna under treatments of MB applications at 2.5%, 5.0%, 7.5%, and 10.0%, SB application at 5.0%, and a conventional fertilization(CF) using lime and mineral fertilizers, with no fertilization as a control. After incubation for 45 d, seedlings were transplanted into each pot and cultivated for 55 d. Biochar characterization showed that pyrolysis reduced the biomass volume drastically, but concentrated the trace elements per unit of biochar weight. The MB treatments increased soil total C(by 27.8%) and pH(by 0.6), reduced the concentrations of nutrients, except for potassium(K), and chromium(Cr), and did not significantly alter lead(Pb) and cadmium(Cd) concentrations. Results of stable isotopes showed that all biochar treatments increased the total soil C stock and stability, suggesting a potential for application in C sequestration, and improved overall soil fertility. However, the biochar treatments also increased the concentrations of trace elements in the soil and plants. The sugar beet yields at 10.0% MB and 5.0% SB corresponded to 55%and 29% of the yield obtained in the CF treatment, respectively. These results may be due to biochar nutrients not being bioavailable when required by plants or to biochar nutrient adsorption. | Barbara Samartini Queiroz ALVES Katherin Prissila Sevilla ZELAYA Fernando COLEN Ledivan Almeida FRAZÃO Alfredo NAPOLI Sanjai J.PARIKH Luiz Arnaldo FERNANDES | 2021 | Pedosphere2021，31，4： | 4 |
| 2 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 3 | Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA , IDH1 , EGFR , and NF1显示文摘 | Roel G.W. Verhaak Katherine A. Hoadley Elizabeth Purdom Victoria Wang Yuan Qi Matthew D. Wilkerson C. Ryan Miller Li Ding Todd Golub Jill P. Mesirov Gabriele Alexe Michael Lawrence Michael O'Kelly Pablo Tamayo Barbara A. Weir Stacey Gabriel Wendy Winckler | 2010 | Cancer Cell2010，，1： | 2 |
| 4 | Inflammatory Bowel Disease in African American Children Compared With Other Racial/Ethnic Groups in a Multicenter Registry显示文摘 | Jolanda M. White Siobhán O’Connor Harland S. Winter Melvin B. Heyman Barbara S. Kirschner George D. Ferry Stanley A. Cohen Robert N. Baldassano Terry Smith Traci Clemons Benjamin D. Gold | 2008 | Clinical Gastroenterology and Hepatology2008，，12： | 1 |
| 5 | Fatigue does not correlate with the degree of hepatitis or the presence of autoimmune disorders in chronic hepatitis C infection显示文摘 | Jason Goh Barbara Coughlan John Quinn J. Conor O?Keane John Crowe | 1999 | European Journal of Gastroenterology & Hepatology1999，，8： | 1 |
| 6 | Tackling Copyright in the Digital Age:An Initiative of the University of Connecticut Libraries显示文摘 | Barbara O Betsy P Rudnick T E | 2008 | Journal of Access Services2008，，： | 1 |
| 7 | Calcium sensing receptor- dependent and receptor-independent activation of osteoblast replica- tion and survival by strontium ranelate显示文摘 | Fromigu6 O Hay E Barbara A | 2009 | J Cell Mol Med2009，13，8： | 1 |
| 8 | Siloxane-urethane membranes for removal of volatile organic solvents by pervaporation显示文摘 | CZERWIFISKI W BARBARA O G KOZAKIEWICZ J | 2004 | Desalination2004，163，： | 1 |
| 9 | bcl-2 and c-erbB-2 proteins are involved in the regulation of VEGF and of thymidine phosphorylase angiogenic activity in non-small-cell lung cancer显示文摘 | Michael I. Koukourakis Alexandra Giatromanolaki Keneth J. O’Byrne Jiles Cox Barbara Krammer Kevin C. Gatter Adrian L. Harris | 1999 | Clinical and Experimental Metastasis1999，，： | 1 |
| 10 | Relationship between bile tolerance and the presence of a ruthenium red staining layer on strains of Lactobacillus acidophilus显示文摘 | Barbara J O Edmund A Z | 1991 | J Dairy Sci1991，74，： | 1 |
| 11 | Anxiety and depression after coronary artery bypass graft surgery:most get better,some get worse显示文摘 | Barbara M M Peter C E Rosemary O H | 2008 | European Journal of Cardiovascular Prevention&Rehabilitation2008，15，4： | 1 |
| 12 | Orexins/hypocretins control bistability of hippocampal long-term synaptic plasticity through coactivation of multiple kinases显示文摘 | Selbach O Bohla C Barbara A | 2010 | Acta Physiologica2010，198，： | 1 |
| 13 | The Pediatric Investigators Collaborative Network on Infections in Canada Study of Predictors of Hospitalization for Respiratory Syncytial Virus Infection for Infants Born at 33 Through 35 Completed Weeks of Gestation显示文摘 | Barbara J. Law Joanne M. Langley Upton Allen Bosco Paes David S. C. Lee Ian Mitchell John Sampalis Hervé Walti Joan Robinson Karel O’Brien Carina Majaesic Georges Caouette Lyne Frenette Nicole Le Saux Brian Simmons Sharon Moisiuk Koravanagattu Sankaran Ce | 2004 | The Pediatric Infectious Disease Journal2004，，9： | 1 |
| 14 | Breast milk retinol concentrations are not associated with systemic inflammation among breast-feeding women in Malawi显示文摘 | BARBARA D VERONIQUE N MICHELLE O R | 2005 | Journal of Nutrition2005，135，： | 1 |
| 15 | Temperature and moisture content behaviour in microwave heated wood prior to bending Mountain Ash (Eucalyptus regnans ) 显示文摘 | Beat S Barbara O Graeme S | 2009 | European Journal of Wood and Wood Products2009，67，2： | 1 |
| 16 | Genetic fingerprinting of grape plant (Vitis vinifera) using random amplified polymorphic DNA (RAPD) analysis and dynamic size-sieving capillary electrophoresis 显示文摘 | Barbara A S Kimberly A O | 2000 | J Agric Food Chem2000，48，： | 1 |
| 17 | Early Pregnancy Loss 显示文摘 | John CP Barbara O' Brien | 2001 | Medicine Journal2001，2，11： | 1 |
| 18 | Influence of sampling on target recognition and identification 显示文摘 | RICHARD VOLLMENRHAUSEN RONALD G DRIGGERS BARBARA L O'KANE | 1999 | Optical Engineering1999，38，5： | 1 |
| 19 | A case study of locked-insyndrome:Psychological and personal perspectives显示文摘 | Barbara A Angela H Tracey O | 2011 | Brain Injury2011，25，： | 1 |
| 20 | WNT1 inducible signaling pathway protein 1 (WISPI):A novel mediator linking development and disease显示文摘 | Barbara Berschneider Melanie K(o)nigshoff | | 0，，3： | 1 |
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