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| 1 | Use of human pluripotent stem cells to study and treat retinopathies显示文摘Human cell types affected by retinal diseases(such as age-related macular degeneration or retinitis pimentosa) are limited in cell number and of reduced accessibility. As a consequence, their isolation for in vitro studies of disease mechanisms or for drug screening efforts is fastidious. Human pluripotent stem cells(h PSCs), either of embryonic origin or through reprogramming of adult somatic cells,represent a new promising way to generate models of human retinopathies, explore the physiopathological mechanisms and develop novel therapeutic strategies. Disease-specific human embryonic stem cells were the first source of material to be used to study certain disease states. The recent demonstration that human somatic cells, such as fibroblasts or blood cells, can be genetically converted to induce pluripotent stem cells together with the continuous improvement of methods to differentiate these cells into disease-affected cellular subtypes opens new perspectives to model and understand a large number of human pathologies, including retinopathies. This review focuses on the added value of h PSCs for the disease modeling of human retinopathies and the study of their molecular pathological mechanisms. We also discuss the recent use of these cells for establishing the validation studies for therapeutic intervention and for the screening of large compound libraries to identify candidate drugs. | Karim Ben M'Barek Florian Regent Christelle Monville | 2015 | World Journal of Stem Cells2015，7，3： | 2 |
| 2 | Whole-exome sequencing as a diagnostic tool:current challenges and future opportunities 显示文摘 | Tetreault M Bareke E Nadaf J | 2015 | Expert Rev MolDiagn2015，15，6： | 1 |
| 3 | A retrospective analysis of thalidomide therapy in non-HIV-related Kaposi's sarcoma 显示文摘 | Ben M barek L Fardet L | 2007 | Dermatology2007，215，3： | 1 |
| 4 | Enhanced dielectric and electrocaloric properties in lead-free rod-like BCZT ceramics显示文摘Ba0.85Ca0.15Zr0.10Ti0.90O3(BCZT)lead-free ceramics demonstrated excellent dielectric,ferroelectric,and piezoelectric properties at the morphotropic phase boundary(MPB).So far,to study the effect of morphological changes on dielectric and ferroelectric properties in lead-free BCZT ceramics,researchers have mostly focused on the influence of spherical grain shape change.In this study,BCZT ceramics with rod-like grains and aspect ratio of about 10 were synthesized by surfactant-assisted solvothermal route.X-ray diffraction(XRD)and selected area electron diffraction(SAED)performed at room temperature confirm the crystallization of pure perovskite with tetragonal symmetry.Scanning electron microscopy(SEM)image showed that BCZT ceramics have kept the 1D rod-like grains with an average aspect ratio of about 4.Rod-like BCZT ceramics exhibit enhanced dielectric ferroelectric(εr=11,906,tanδ=0.014,Pr=6.01μC/cm^2,and Ec=2.46 kV/cm),and electrocaloric properties(ΔT=0.492 K andz=0.289(K×mm)/kV at 17 kV/cm)with respect to spherical BCZT ceramics.Therefore,rod-like BCZT lead-free ceramics have good potential to be used in solid-state refrigeration technology. | Zouhair HANANI Soukaina MERSELMIZ Abdelaadim DANINE Nicolas STEIN Daoud MEZZANE M’barek AMJOUD Mohammed LAHCINI Yaovi GAGOU Matjaz SPREITZER Damjan VENGUST Zdravko KUTNJAK Mimoun El MARSSI Igor ALUK'YANCHUK Mohamed GOUNE | 2020 | Journal of Advanced Ceramics2020，9，2： | 1 |
| 5 | Polarography and voltammetry at mercury electrodes显示文摘 | Barek J Fogg A G Muck A | 2001 | Crit Rev Anal Chem2001，31，： | 1 |
| 6 | A retrospective analysis of thalidomide therapy in non-HIV-related Kaposi's sarcoma显示文摘 | Ben M Barek L Fardet L | | 0，，： | 1 |
| 7 | Determination of resveratrol in grains,hulls and leaves of common and tartary buckwheat by HPLC with electrochemical detection at carbon paste electrode显示文摘 | Nemeova L Zima J Barek J | 2011 | Food Chemistry2011，126，1： | 1 |
| 8 | GA3 and 2,4-D prolong on - tree storage of citrus in Morocco 显示文摘 | E1-Otmani M M Barek A A Cosgins C W | 1990 | Scientia Horticulturae1990，44，34： | 1 |
| 9 | The entry inhibitor Myr-cludex-B efficiently blocks intrahepatic virus spreading in hu-manized mice previously infected with hepatitis B virus显示文摘 | Volz T Allweiss L M Barek MB | | 0，，5： | 1 |
| 10 | Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis显示文摘 | BEN M'BAREK K PLA P ORVOEN S | 2013 | J Neurosci2013，33，20： | 1 |
| 11 | GA3 and 2,4-D prolong on-tree storage of citrus in Morocco显示文摘 | El-Otmani M Barek A A Coggins C W | 1990 | Scientia Horticulturae1990，44，： | 1 |
| 12 | Voltammetric determination of selected nitro com- pounds at a polished silver solid amalgam composite electrode 显示文摘 | Vyskocil V Navratil T Danhel A Dedfk J Krej cova Z Skvorova L Tvrd i kova J and Barek J | 2011 | Electroanalysis2011，23，1： | 1 |
| 13 | Incidence,associated factors,and follow-up of hospital heart failure complicating acute anterior myocardial infarction successfully treated by primary angioplasty显示文摘 | MEIMOUN P M'BAREK D DRAGOMIR C | 2013 | Ann Cardiol Angeiol(Paris)2013，62，： | 1 |
| 14 | Voltammetric determination of trace amounts of 2-methyl-4, 6- dinitrophenol at a silver solid amalgam electrode显示文摘 | Fischer J Barek J Yosypchuk B | 2006 | Electroanal2006，18，： | 1 |
| 15 | The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus显示文摘 | Volz T AIIweiss L Barek M B | 2013 | Jhepatol2013，58，5： | 1 |
| 16 | The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus显示文摘 | Voiz T Allweiss L Barek M B | 2013 | Journal ofhepatology2013，58，5： | 1 |
| 17 | Determination of res- veratrol in grains, hulls and leaves of common and tartary buckwheat by HPLC with electrochemical detection at car- bon paste electrode 显示文摘 | Nemcova L Zima J Barek J | 2011 | Food Chemistry2011，126，1： | 1 |
| 18 | 5% topical imiquimod tolerance in transplant recipients 显示文摘 | Ben M'barek L Mebazaa A Euvrard S | 2007 | Dermatology2007，215，2： | 1 |
| 19 | Vohammetric detec- tion of damage to DNA caused by nitro derivatives of fluorene using an electrochemical DNA biosensor显示文摘 | Vyskocil V Labuda J Barek J | 2010 | Analytical and Bioanalytical Chemistry2010，397，1： | 1 |
| 20 | Analytical applications of solid and paste amalgam electrodes 显示文摘 | Yosypchuk Bogdan Jill Barek | 2009 | Critical Reviews in Analytical Chemistry2009，39，3： | 1 |
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