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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 3 | 育龄期妊娠和非妊娠女性的初次脑卒中发生率比较:以英国人口为基础的队列研究显示文摘与相似年龄的非妊娠女性相比,妊娠女性的脑卒中风险可能增加,但这种风险的严重程度和影响时机尚不清楚。该研究调查了育龄女性初次发生脑卒中事件的风险,并比较了在妊娠期间与产后早期与平时的风险差异。 | 刘莉 叶鹏 Ban L Sprigg N Abdul Sultan A Nelson-Piercy C Bath PM Ludvigsson JF Stephansson O Tata LJ | 2017 | 中华高血压杂志2017，25，5： | 2 |
| 4 | Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovascular disease显示文摘 | Bath P Algert C Chapman N | 2004 | Stroke2004，35，： | 1 |
| 5 | Interventions for deliberately alteringblood pressure in acute stroke显示文摘 | Geeganage C M Bath P M | 2009 | Stroke2009，40，8： | 1 |
| 6 | Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovascular disease显示文摘 | Bath P Algert C Chapman N | 2004 | Stroke2004，35，3： | 1 |
| 7 | Triple antiplatelet therapy for preventing vascular events:a systematic review and meta-analysis显示文摘 | Geegannge C Wilcox R Bath PM | 2010 | BMC Med2010，8，1： | 1 |
| 8 | Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovaseular disease显示文摘 | Bath P Algert C Chapman N | 2004 | Stroke2004，35，3： | 1 |
| 9 | A mixed displacement-based finite element formulation for acoustic fluid-structure interaction显示文摘 | Bathe K J Nitikitpaiboon C Wang X | 1995 | Computers & Structures1995，56，23： | 1 |
| 10 | Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovascular disease显示文摘 | Bath P Algert C Chapman N | 2004 | Stroke2004，35，3： | 1 |
| 11 | Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovascular disease 显示文摘 | Bath P Algert C Chapman N | 2004 | Stroke2004，35，3： | 1 |
| 12 | Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovascular disease显示文摘 | Bath P Algert C | | 0，，03： | 1 |
| 13 | Relationship between therapeu-tic changes in blood pressure and outcomes in acute stroke:ametaregression显示文摘 | Geeganage C M Bath P M | 2009 | Hypertension2009，54，4： | 1 |
| 14 | Sheep may not be an important zoonotic reservoir for Cryptosporidium and Giardia parasites显示文摘 | Ryan U M Bath C Robertson I | 2005 | Appl Environ Microbiol2005，71，9： | 1 |
| 15 | Electro-optical characterization of h-BN thin film waveguides by prism coupling technique显示文摘 | Boudiombo J Loulergue J C Bath A | 1999 | Materials Science and Engineering B1999，59，： | 1 |
| 16 | Strain induced crystallization in stereoregular polynetworks显示文摘 | KUO C M BATHES K P MILLER R L | 1997 | Rub Chem and Tech1997，70，5： | 1 |
| 17 | Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovascular disease显示文摘 | Bath P Algert C Chapman N | | 0，，03： | 1 |
| 18 | Temperature and salinity effects on strontium incorporation in otoliths of larval spot (Leiostomus xanthurus)显示文摘 | Bath M G Thorrold S R Jones C M | 2004 | Can J Fish Aquat Sci2004，61，： | 1 |
| 19 | Sheep may not be an important zoonotic reservoir for Cryptosporidium and Giardia parasites显示文摘 | Ryan U M Bath C Robertson I | 2005 | Appl Environ Microbiol2005，71，9： | 1 |
| 20 | Molecular diversity and routes of colonization of Candida albicans in a surgical intensive care unit ,as studied using microsatellite markers 显示文摘 | Stephan F Bath MS Desterke C | 2002 | Clin Infect Dis2002，35，12： | 1 |
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