|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Biocompatibility of bio-Mg-Zn alloy within bone with heart, liver, kidney and spleen显示文摘A magnesium-zinc alloy rod was implanted into the marrow cavity of the distal femur in New Zealand rabbits. The femur with the implanted alloy was compared with the contralateral femur in which a bone tunnel without implant was formed as a control. Degradation of the magnesium-zinc alloy was analyzed via X-ray, scanning electron microscopy, and element energy spectrum analysis. Serum magnesium, liver and kidney function tests, and myocardial enzymes were measured. Heart, liver, kidney and spleen were sectioned for pathological analysis, and the effects of the implanted material on the histology and function of important organs were analyzed. Magnesium-zinc alloy was resorbed from the bone marrow cavity of the femur; 87% of the alloy was degraded within 14 weeks after the surgery. There were no significant differences in serum magnesium, liver or kidney function tests, or myocardial enzymes be- fore the surgery and after degradation of the magnesium-zinc alloy. Histology of the heart, liver, kidney, and spleen did not change. This study demonstrated that magnesium-zinc alloy can be resorbed in bone, and that the degradation products have good biocompatibility with heart, liver, kidney, and spleen. | HE YaoHua TAO HaiRong ZHANG Yan JIANG Yao ZHANG ShaoXiang ZHAO ChangLi LI JiaNan ZHANG BeiLei SONG Yang ZHANG XiaoNong | 2009 | Chinese Science Bulletin2009，54，3： | 18 |
| 2 | Improved dissolution and bioavailability of silymarin delivered by a solid dispersion prepared using supercritical fluids显示文摘The objective of this study was to improve the dissolution and bioavailability of silymarin(SM).Solid dispersions(SDs)were prepared using solution-enhanced dispersion by supercritical fluids(SEDS)and evaluated in vitro and in vivo,compared with pure SM powder.The particle sizes,stability,and contents of residual solvent of the prepared SM-SDs with SEDS and solvent evaporation(SE)were investigated.Four polymer matrix materials were evaluated for the preparation of SM-SD-SEDS,and the hydrophilic polymer,polyvinyl pyrrolidone K17,was selected with a ratio of 1:5 between SM and the polymer.Physicochemical analyses using X-ray diffraction and differential scanning calorimetry indicated that SM was dispersed in SD in an amorphous state.The optimized SM-SD-SEDS showed no loss of SM after storage for 6 months and negligible residual solvent(ethanol)was detected using gas chromatography.In vitro drug release was increased from the SM-SDSEDS,as compared with pure SM powder or SM-SD-SE.In vivo,the area under the rat plasma SM concentration-time curve and the maximum plasma SM concentration were 2.4-fold and 1.9-fold higher,respectively,after oral administration of SM-SD-SEDS as compared with an aqueous SM suspension.These results illustrated the potential of using SEDS to prepare SM-SD,further improving the biopharmaceutical properties of this compound. | Gang Yang Yaping Zhao Nianping Feng Yongtai Zhang Ying Liu Beilei Dang | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，3： | 6 |
| 3 | In-line X-ray phase-contrast imaging of murine liver microvasculature ex vivo显示文摘Imaging blood vessels is of importance for determining the vascular distribution of organs and tumors.Phase-contrast X-ray imaging can reveal the vessels in much more detail than conventional X-ray absorption method.Visualizing murine liver microvasculature ex vivo with phase-contrast X-ray imaging was performed at Shanghai Synchrotron Radiation Facility.Barium sulfate and physiological saline were used as contrast agents for the blood vessels.Blood vessels of <Φ20μm could be detected by replacing resident blood with physiological saline or barium sulfate.An entire branch of the portal vein (from the main axial portal vein to the ninth generation of branching) could be captured in a single phase-contrast image.It is demonstrated that selective angiography based on phase contrast X-ray imaging,with a physiological material of low Z elements (such as saline) being the contrast agent,is a viable imaging strategy.Further efforts will be focused on using the technique to image tumor angiogenesis. | LI Beilei XU Min WU Weizhong PENG Guanyun ZHANG Xi PENG Yifeng SHI Hongcheng CHEN Shaoliang | 2012 | Nuclear Science and Techniques2012，23，1： | 5 |
| 4 | Software Module Clustering Algorithm Using Probability Selection显示文摘软件模块聚类问题是在其主要目标是获得软件系统的好模块化的结构的软件颠倒工程的一个重要、挑战性的问题。大复杂软件系统能被划分成是容易的通过聚类的软件模块理解并且坚持说的一些分系统。瞄准解决慢集中速度,差的聚类结果,和复杂算法的问题,用概率选择聚类算法的一个软件模块被建议。第一,我们把软件系统变换成复杂网络图,然后我们使用让软件模块聚类计划的兼并,调整和优化的操作。评估算法的有效性,一套实验在聚类问题的 5 真实世界的模块上被执行。试验性的结果的比较证明算法以及低时间复杂性和快集中速度的简洁。这个算法为聚类问题的软件模块提供一个简单、有效的工程方法。 | SUN Jiaze LING Beilei | 2018 | Wuhan University Journal of Natural Sciences2018，23，2： | 2 |
| 5 | Biological Control of Soilborne Pathogens (Fusarium oxysporum F, Sp. Cucumerinum) of Cucumber (Cucumis sativus) by Trichoderma sp,显示文摘 | Estifanos Tsegaye Redda Jing Ma Jie Mei Mei Li Beilei Wu Xiliang Jiang | 2018 | Journal of Life Sciences2018，12，1： | 2 |
| 6 | Finite Two-Arc-Regular Graphs Admitting an Almost Simple Group显示文摘This paper completes the classification of (G, 2)-arc-regular graphs of square-free order where G is an almost simple group. | Gaixia WANG Beilei GAO | 2021 | Journal of Mathematical Research with Applications2021，41，1： | 2 |
| 7 | Cancer cell reprogramming:a promising therapy converting malignancy to benignity显示文摘In the past decade, remarkable progress has been made in reprogramming terminally differentiated somatic cells and cancer cells into induced pluripotent cells and cancer cells with benign phenotypes. Recent studies have explored various approaches to induce reprogramming from one cell type to another, including lineage-specific transcription factors-, combinatorial small molecules-, microRNAs- and embryonic microenvironment-derived exosome-mediated reprogramming. These reprogramming approaches have been proven to be technically feasible and versatile to enable re-activation of sequestered epigenetic regions, thus driving fate decisions of differentiated cells. One of the significant utilities of cancer cell reprogramming is the therapeutic potential of retrieving normal cell functions from various malignancies. However, there are several major obstacles to overcome in cancer cell reprogramming before clinical translation, including characterization of reprogramming mechanisms, improvement of reprogramming efficiency and safety, and development of delivery methods. Recently, several insights in reprogramming mecha-nism have been proposed, and determining progress has been achieved to promote reprogramming efficiency and feasibility, allowing it to emerge as a promising therapy against cancer in the near future. This review aims to discuss recent applications in cancer cell reprogramming, with a focus on the clinical significance and limitations of different reprogramming approaches, while summarizing vital roles played by transcription factors, small molecules, microR-NAs and exosomes during the reprogramming process. | Lanqi Gong Qian Yan Yu Zhang Xiaona Fang Beilei Liu Xinyuan Guan | 2019 | Cancer Communications2019，39，1： | 2 |
| 8 | Phytolith carbon sequestration in bamboos of different ecotypes:a case study in China显示文摘Occlusion of carbon(C) within phytoliths(Phyt OC) is becoming one of the most promising terrestrial C sequestration mechanisms. This study explored the production of Phyt OC within 35 bamboo species belonging to three ecotypes using methods of microwave digestion. The aim of this study is to explore the present and potential C sequestration rate within phytoliths of bamboo species from three ecotypes. Phyt OC content in bamboos of three ecotypes ranges from 0.07 % to 0.42 %. The mean Phyt OC production flux decreases as: clustered bamboo(0.050 ±0.016 t CO2ha-1a-1) & mixed bamboo(0.049 ± 0.016 t CO2ha-1a-1) [ scattered bamboo(0.038 ± 0.020 t CO2ha-1a-1). The phytolith carbon sequestration in Chinese bamboo is estimated to be 0.293 ± 0.127 Tg(1 Tg =1012g) CO2a-1; approximately 75 %, 3 %, and 22 % of which is contributed from scattered, mixed and clustered bamboo, respectively. Taking the Phyt OC production flux of 0.18 ± 0.12 t CO2ha-1a-1and current annual area increasing rate of 3 %, global bamboo phytoliths wouldsequester 11.9 ± 7.9 Tg CO2a-1by 2050. Consequently,bamboo forests have significant potential to mitigate the increasing concentration of atmospheric CO2 by maximizing Phyt OC production flux and expanding bamboos. | Beilei Li Zhaoliang Song Hailong Wang Fengshan Guo Renyi Gui Xiaomin Yang Ruisheng Song | 2014 | Chinese Science Bulletin2014，59，34： | 2 |
| 9 | A micromachined ar- ray probe card-fabrication process 显示文摘 | Beiley Mark Leung Justin Wong S Simon | 1995 | IEEE Trans on Compo- nents Packaging and Manufacturing Technology--Part B1995，18，1： | 1 |
| 10 | Identification and antimicrobial susceptibility of lactic acid bacteria from retail fermented foods显示文摘 | GE Beilei PING Jiang HAN Feifei | 2007 | Journal of Food Protection2007，70，： | 1 |
| 11 | Development of a toxR-based loop-mediated isothermal amplification assay for detecting Vibrio parahaemolyticus显示文摘 | Siyi C Beilei G | 2010 | BMC Microbiology2010，10，： | 1 |
| 12 | Different patterns of agonist-induced modulation of α_(1B)-adrenoceptor density at different initial expression levels显示文摘We compared the norepinephrine (NE) induced α1B-adrenoceptor (α1B-AR) expression modulation between two transfected human embryonic kidney (HEK) 293 cell lines in which α1B-AR densities were (6 336 ±913) and (773±164) fmol · mg -1, respectively. Treatment of cells with NE (10 μmol · L1) for 48 h decreased high-level expressed α1B-AR density, but increased low-level expressed α1B-AR density. The protein kinase C inhibitor Calphostin C or Ro-31-8220 reversed, and its activator PMA mimicked the NE-induced down-regulation of high-level expressed α1B-AR. Moreover, PMA induced a down-regulation of low-level expressed α1B-AR. The endoplasmic reticulum Ca2+-ATPase inhibitor cyclopiazonic acid (CPA) and the calcium chelator BAPTA/AM did not affect the down-regulation of high-level expressed α1B-AR, but inhibited the up-regulation of low-level expression α1B-AR induced by NE. These results suggest that α1B-adrenoceptor densities at different initial expression levels are differentially regulated | LEI Beilei & HAN QideInstitute of Vascular Medicine, The Third Hospital, Beijing Medical University, Beijing 100083, China Correspondence should be addressed to Han Qide | 2000 | Chinese Science Bulletin2000，45，17： | 1 |
| 13 | Amorphous IZO-based transparent thin film transistors显示文摘 | D C Yaglioglu B Beiley Z | 2008 | Thin Solid Films2008，516，17： | 1 |
| 14 | The production of phytolith-occluded carbon in China's forests: im- plications to biogeochemieal carbon sequestration 显示文摘 | SONG Zhaoliang LIU Hongyan LI Beilei et 01 | 2013 | Glob Change Biol2013，19，9： | 1 |
| 15 | Enhanced tolerance to low temperature in tobacco by over-expression of a new maize protein phosphatase 2C, ZmPP2C2显示文摘 | Xiaoli Hu Lixia Liu Beilei Xiao Dapeng Li Xin Xing Xiangpei Kong Dequan Li | 2010 | Journal of Plant Physiology2010，，15： | 1 |
| 16 | Immunogenicity of Iodine 131 chimeric tumor necrosis therapy monoclonal antibody in advanced lung cancer patients显示文摘 | Hui Wang Chuanping Cao Beilei Li Shaoliang Chen Jun Yin Jing Shi Dan Ye Qun Tao Peisheng Hu Alan Epstein Dianwen Ju | 2008 | Cancer Immunology Immunotherapy2008，，5： | 1 |
| 17 | Miniature Filter for Digital Receiver显示文摘 | Alex Beiley | 1992 | IEEE MTT-S Digest Part1992，，2： | 1 |
| 18 | Super-ferric Dipole Prototype for Super-FRS of FAIR显示文摘 | Yuan Ping Ma Lizhen H. Leibrock Zhang Xiaoqi Zhang Bin Yao Qinggao Wu Weiyue Wang Qiuliang Wu Wei Wu xi Yang Tongjun Cuo Beilei Han Shaofei He Yuan Zhang Siling | 2009 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2009，，1： | 1 |
| 19 | Preparation and investigation of a novel iodine-based visible polyvinyl alcohol embolization material显示文摘Polyvinyl alcohol(PVA) embolization particles, currently used in clinical practice, have good expansibility and are capable of permanent embolization. However, the lack of adhesion of embolization particles contributes to facilitated recanalization after embolization, while the lack of visualization facilitates misembolization. At present, embolization materials with good expansion, adhesion, and visualization potential are urgently required in clinical practice. Here, we report the development of PVA/gelatin/iohexol(I) fiber blocks as a novel embolization material for liver embolization in rats. In our work, electrospun PVA/gelatin/I nanofibrous mats were first prepared, homogenized, centrifuged in a gradient manner, and freeze-dried to obtain fiber blocks(fiber diameter =296.2 ± 74.23 nm, length 99.6 ± 17.0 μm × width 46.9 ± 13.3 μm). The fiber blocks exhibited excellent cytocompatibility and hemocompatibility. Fiber blocks with a PVA/gelatin/I mass ratio of 8:2:10 were selected due to their excellent expansibility and adhesive properties. The PVA/gelatin/I fiber blocks display excellent liver embolic effects and computed tomography(CT) imaging potential due to a combination of the following characteristics: expansibility of PVA and gelatin, adhesive property of gelatin, and CT imaging potential of I. The developed fiber block material is an embolic material that may potentially be used in interventional medicine. | Yupeng Yang Rui Yang Beilei Zhang Ye Tian Yanqi Lu Xiao An Xiangyang Shi | 2022 | Journal of Interventional Medicine2022，5，2： | 1 |
| 20 | A PCR- ELISA for detecting Shiga toxin- producing Escherichia coli 显示文摘 | Beilei Ge Shaohua Zhao Robert Hall | 2002 | Microbes and Infection2002，4，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员