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| 1 | 中国大陆肺炎发病率与死亡率:1985-2008年中英文文献的系统分析显示文摘目的肺炎是全球传染性疾病最主要的死因之一,但中国的肺炎疾病负担还知之甚少,因为很多数据资料都是以非英文文献的形式发表的。方法系统回顾了中国大陆关于肺炎发病率与死亡率的中文和英文文献,这些研究都是具有第一手数据的研究,1985-2008年有37篇论文符合纳入标准。结果各项研究的质量差异较大。5岁以下儿童肺炎发病率为(0.06~0.27)次/人年,肺炎死亡率为184/10万~1 223/10万人口。肺炎的发病率与死亡率随着时间稳定不变或者呈下降趋势,且农村高于城市。结论肺炎仍然是中国儿童的主要公共卫生问题之一。肺炎发病率与死亡率估计的变化差异大。继续降低发病率与死亡率需要可靠的监测数据和新的预防措施的实施,特别是在农村等高发地区。 | 官旭华 Benjamin J Silk Wenkai Li Aaron T. Fleishchauer 邢学森 蒋晓清 余宏杰 Sonja J. Olsen Adam L. Cohen | 2011 | 公共卫生与预防医学2011，22，1： | 54 |
| 2 | Non-transgenic Plant Genome Editing Using Purified Sequence-Specific Nucleases显示文摘Dear Editor, Sequence-specific nucleases,including zinc-finger nucleases,meganucleases,TAL effector nucleases (TALENs),and CRISPR/ Cas systems,have been used to introduce targeted mutations in a wide range of plant species (Voytas,2013;Baltes and Voytas,2015).However,delivery of these nucleases using traditional transformation methods (e.g.,particle bombardment,Agrobacterium or protoplast transformation) may result in undesired genetic alterations due to random insertion of nucleaseencoding DNA intothe host genome. | Song Luo Jin Li Thomas J. Stoddard Nicholas J. Baltes Zachary L. Demorest Benjamin M. Clasen Andrew Coffman Adam Retterath Luc Mathis Daniel F. Voytas Feng Zhang | 2015 | Molecular Plant2015，8，9： | 7 |
| 3 | Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets显示文摘AIM: To investigate the effect of protein-energy malnutrition on intestinal barrier function during rotavirus enteritis in a piglet model.METHODS: Newborn piglets were allotted at day 4 of age to the following treatments:(1) full-strength formula(FSF)/noninfected;(2) FSF/rotavirus infected;(3) half-strength formula(HSF)/noninfected;or(4) HSF/rotavirus infected.After one day of adjustment to the feeding rates,pigs were infected with rotavirus and acute effects on growth and diarrhea were monitored for 3 d and jejunal samples were collected for Ussingchamber analyses.RESULTS: Piglets that were malnourished or infected had lower body weights on days 2 and 3 post-infection(P < 0.05).Three days post-infection,marked diarrhea and weight loss were accompanied by sharp reductions in villus height(59%) and lactase activity(91%) and increased crypt depth(21%) in infected compared with non-infected pigs(P < 0.05).Malnutrition also increased crypt depth(21%) compared to full-fed piglets.Villus:crypt ratio was reduced(67%) with viral infection.There was a trend for reduction in transepithelial electrical resistance with rotavirus infection and malnutrition(P = 0.1).3H-mannitol flux was significantly increased(50%;P < 0.001) in rotavirus-infected piglets compared to non-infected piglets,but there was no effect of nutritional status.Furthermore,rotavirus infection reduced localization of the tight junction protein,occludin,in the cell membrane and increased localization in the cytosol.CONCLUSION: Overall,malnutrition had no additive effects to rotavirus infection on intestinal barrier function at day 3 post-infection in a neonatal piglet model. | Sheila K Jacobi Adam J Moeser Anthony T Blikslager J Marc Rhoads Benjamin A Corl Robert J Harrell Jack Odle | 2013 | World Journal of Gastroenterology2013，19，31： | 4 |
| 4 | Optical force-induced nonlinearity and self-guiding of light in human red blood cell suspensions显示文摘Osmotic conditions play an important role in the cell properties of human red blood cells(RBCs),which are crucial for the pathological analysis of some blood diseases such as malaria.Over the past decades,numerous efforts have mainly focused on the study of the RBC biomechanical properties that arise from the unique deformability of erythrocytes.Here,we demonstrate nonlinear optical effects from human RBCs suspended in different osmotic solutions.Specifically,we observe self-trapping and scattering-resistant nonlinear propagation of a laser beam through RBC suspensions under all three osmotic conditions,where the strength of the optical nonlinearity increases with osmotic pressure on the cells.This tunable nonlinearity is attributed to optical forces,particularly the forward-scattering and gradient forces.Interestingly,in aged blood samples(with lysed cells),a notably different nonlinear behavior is observed due to the presence of free hemoglobin.We use a theoretical model with an optical force-mediated nonlocal nonlinearity to explain the experimental observations.Our work on light self-guiding through scattering biosoft-matter may introduce new photonic tools for noninvasive biomedical imaging and medical diagnosis. | Rekha Gautam Yinxiao Xiang Josh Lamstein Yi Liang Anna Bezryadina Guo Liang Tobias Hansson Benjamin Wetzel Daryl Preece Adam White Matthew Silverman Susan Kazarian Jingjun Xu Roberto Morandotti Zhigang Chen | 2019 | Light(Science & Applications)2019，8，1： | 3 |
| 5 | Enhanced Effect of Combining Human Cardiac Stem Cells and Bone Marrow Mesenchymal Stem Cells to Reduce Infarct Size and to Restore Cardiac Function After Myocardial Infarction显示文摘 | Adam R. Williams Konstantinos E. Hatzistergos Benjamin Addicott Fred McCall Decio Carvalho Viky Suncion Azorides R. Morales Jose Da Silva Mark A. Sussman Alan W. Heldman Joshua M. Hare | 2013 | Circulation2013，，2： | 2 |
| 6 | Proximal Humerus Reconstructions for Tumors显示文摘 | Benjamin K. Potter MD Sheila C. Adams MD J. David Pitcher MD Theodore I. Malinin MD H. Thomas Temple MD | 2009 | Clinical Orthopaedics and Related Research2009，，4： | 2 |
| 7 | Wahi, a discrete global grid gazetteer built using linked open data显示文摘Discrete global grid systems have become an important component of Digital Earth systems.However,previously there has not existed an easy way to map between named places(toponyms)and the cells of a discrete global grid system.The lack of such a tool has limited the opportunities to synthesize social place-based data with the more standard Earth and environmental science data currently being analyzed in Digital Earth applications.This paper introduces Wāhi,the first gazetteer to map entities from the GeoNames database to multiple discrete global grid systems.A gazetteer service is presented that exposes the grid system and the associated gazetteer data as Linked Data.A set of use cases for the discrete global grid gazetteer is discussed. | Benjamin Adams | 2017 | International Journal of Digital Earth2017，10，5： | 2 |
| 8 | Condensed tannin biosynthesis genes are regulated separately from other flavonoid biosynthesis genes in apple fruit skin显示文摘 | Adam M T Benjamin E U Robinson S P | 2006 | Plant Science2006，170，： | 1 |
| 9 | Stability of field emission current from various types of carbon nanotube films显示文摘 | Benjamin Ulmen Vijaya Kumar-kayastha Adam DeConinck | 2006 | Diamond & Related Materials2006，15，23： | 1 |
| 10 | The staging of cholangiocarcinoma显示文摘 | BENJAMIN IS | 1992 | Clin Radiol1992，46，3： | 1 |
| 11 | Do alliances promote knowledge flows? 显示文摘 | Benjamin Gomes-Casseres J Hagedoorn and Adam B Jaffe | 2006 | Journal of Financial Economics2006，80，1： | 1 |
| 12 | Condensed tannin biosynthesis genes are regulated separatel from other flavonoid biosynthesis genes in apple fruit skin显示文摘 | Adam Matthew Takos Benjamin Ewa Ubi Simon Piers Robinson Amanda Ruth Walker | 2006 | Plant Science2006，170，： | 1 |
| 13 | Chronic exogenous kisspeptin administration accelerates gonadal development in basses of the genus Morone显示文摘 | Benjamin H B Adam F S Matthew E | | 0，，162： | 1 |
| 14 | Semicarbazide formation in azodicarbonamide -treated flour: A model study显示文摘 | ADAM B BENJAMIN P Y L DAVID L | 2004 | J Agric Food Chem2004，52，： | 1 |
| 15 | Effectiveness of Prehospital Wireless Transmission of Electrocardiograms to a Cardiologist Via Hand-Held Device for Patients With Acute Myocardial Infarction (from the Timely Intervention in Myocardial Emergency, NorthEast Experience [TIME-NE])显示文摘 | George L. Adams Paul T. Campbell John M. Adams David G. Strauss Karen Wall Janet Patterson Kathy B. Shuping Charles Maynard Dwayne Young Craig Corey Alan Thompson Benjamin A. Lee Galen S. Wagner | 2006 | The American Journal of Cardiology2006，，9： | 1 |
| 16 | The slaging of cholangiocar-cinoma显示文摘 | Adam A Benjamin IS | 1992 | Clin Radiol1992，46，3： | 1 |
| 17 | Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of Anxiety/Depression显示文摘 | Denis J. David Benjamin Adam Samuels Quentin Rainer Jing-Wen Wang Douglas Marsteller Indira Mendez Michael Drew Douglas A. Craig Bruno P. Guiard Jean-Philippe Guilloux Roman P. Artymyshyn Alain M. Gardier Christophe Gerald Irina A. Antonijevic E. David Le | 2009 | Neuron2009，，4： | 1 |
| 18 | Patterns of proton pump inhibitor use in clinical practice显示文摘 | Adam F Barrison Linda A Jarboe Benjamin M Weinberg Kiran Nimmagadda Lisa M Sullivan M.Michael Wolfe | 2001 | The American Journal of Medicine2001，，： | 1 |
| 19 | Stability of field emission current from various types of carbon nanotube films显示文摘 | Benjamin Ulmen Vijaya Kumar-kayastha Adam DeConinck | 2006 | Diamond & Related Materials2006，15，23： | 1 |
| 20 | The Role of Boards of Directors in Corporate Governance:A Conceptual Framework and Survey显示文摘 | Adams Renee B Benjamin E Hermalin Michael S Weisbach | 2010 | Journal of Economic Literature2010，48，2： | 1 |
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