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| 1 | Regulation of the intestinal immune system by flavonoids and its utility in chronic inflammatory bowel disease显示文摘Flavonoids are phytochemicals which can regulate the activity of the intestinal immune system. In patients with chronic inflammatory bowel disease(IBD) there is an overexpression and imbalance of the components of the inflammatory immune reactions which are chronically activated. Suppression of inflammation can be achieved by anti-inflammatory drugs which are used in clinical medicine but these can cause serious side effects. Flavonoids can have natural immunosuppressive properties and inhibit the activation of immune cells and its effectors(chemokines, TNF-, cytokines). Phytochemicals such as flavonoids bind to the nuclear Ah(aryl hydrocarbon)-receptor thereby stimulating protective enzyme activities. As shown by clinical evidence in patients and by experimental work some flavonoids(apigenin, epigallocatechin gallate) were effective in the inhibition of inflammation. Instead of or additionally to anti-inflammatory drugs flavonoids can be used in IBD patients to treat the over-reactive immunologic system. This is accomplished by upregulation of the Ah-receptor. Flavonoids interact with toll-like receptors expressing on the surface of immune cells, then they were internalized to the cytosol and transferred into the nucleus, where they were attached to the Ah-receptor. The Ah-receptor binds to the Ah-R nuclear translocator and via Ah response element beneficial protective enzymes and cytokines are induced, leading to upregulation of the anti-inflammatory system. | Harald Peter Hoensch Benno Weigmann | 2018 | World Journal of Gastroenterology2018，24，8： | 10 |
| 2 | 如何设计高质量针刺临床研究:基于证据的专家共识显示文摘本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。 | 张誉清 焦睿珉 Claudia M Witt 劳力行 刘建平 Lehana Thabane Karen J Sherman Mike Cummings Dawn P Richards Eun-Kyung Anna Kim Tae-Hun Kim Myeong Soo Lee Michael E Wechsler Benno Brinkhaus Jun J Mao Caroline A Smith 岗卫娟 刘保延 刘志顺 刘岩 郑晖 吴佳霓 AloBSO Carrasco-Labra Mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt | 2022 | 英国医学杂志中文版2022，25，6： | 7 |
| 3 | Effect of herbal medicine Juzentaihoto on hepatic and intestinal heat shock gene expression requires intestinal microflora in mouse显示文摘AIM: To evaluate the role of intestinal microflora in the effects of multi-herbal medicine on gene expression in the gut and liver. METHODS: The multi-herbal medicine Juzentaihoto (JTX) was administered to five germ-free mice and regular mice for 2 wk. Among the results of the comprehensive gene chip analysis of the intestine and liver, we featured heat shock proteins (HSPs) 70 and 105 because their gene expression changed only in the presence of microflora. Real-time RT-PCR was performed to confirm the expression levels of these HSP genes. To determine whether JTX acts directly on the HSP genes, sodium arsenite (SA) was used to induce the heat shock proteins directly. To examine the change of the intestinal microflora with administration of JTX, the terminal restriction fragment polymorphism (T-RFLP) method was used. To identify the changed bacteria, DNA sequencing was performed. RESULTS: Heat shock protein gene expression,documented by gene chip and real-time RT-PCR, changed with the administration of JTX in the regular mice but not in the germ-free mice. JTX did not suppress the direct induction of the HSPs by SA. T-RFLP suggested that JTX decreased unculturable bacteria and increased Lactobacillus johnsoni. These data suggested that JTX changed the intestinal microflora which, in turn, changed HSP gene expression. CONCLUSION: Intestinal microflora affects multi-herbal product JTX on the gene expression in the gut and liver. | Miho Kato Atsushi Ishige Naoko Anjiki Masahiro Yamamoto Yoshifumi Irie Mitsue Taniyama Ryoko Kibe Junichiro Oka Yoshimi Benno Kenji Watanabe | 2007 | World Journal of Gastroenterology2007，13，16： | 5 |
| 4 | Technology for the next gravitational wave detectors显示文摘This paper reviews some of the key enabling technologies for advanced and future laser interferometer gravitational wave detectors, which must combine test masses with the lowest possible optical and acoustic losses, with high stability lasers and various techniques for suppressing noise. Sect. 1 of this paper presents a review of the acoustic properties of test masses. Sect. 2 reviews the technology of the amorphous dielectric coatings which are currently universally used for the mirrors in advanced laser interferometers, but for which lower acoustic loss would be very advantageous. In sect. 3 a new generation of crystalline optical coatings that offer a substantial reduction in thermal noise is reviewed. The optical properties of test masses are reviewed in sect. 4, with special focus on the properties of silicon, an important candidate material for future detectors. Sect. 5 of this paper presents the very low noise, high stability laser technology that underpins all advanced and next generation laser interferometers. | MITROFANOV Valery P. CHAO Shiuh PAN Huang-Wei KUO Ling-Chi COLE Garrett DEGALLAIX Jerome WILLKE Benno | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，12： | 3 |
| 5 | Compound eyes of insects and crustaceans: Some examples that show there is still a lot of work left to be done显示文摘复合眼睛(并置和重叠)的 2 种主要类型的类似和差别简短为关于复合眼睛的研究在几个有希望的话题前被解释被介绍关于胚胎学和有重叠光学的清楚地区的眼睛是的昆虫的发展的分子的控制的研究建议之一,因为几乎所有与并置光学在过去的昆虫眼睛上的发展工作集中了于眼睛,网膜的组织的年龄相关、产地相关的 ultrastructural 研究是另一个建议和鹿恶棍 Lipoptena cervi ,它在它在哪个期间是一个几个月长的寄生阶段在它在哪个期间是无翼的期间跟随的 winged 期间有一个天线阶段,作为在眼睛结构和功能在许多种类表示自己为差别的性同种二形提供另外一个答应为复合眼睛研究人员并且那么的地是在很小的昆虫的复合眼睛小型化的一个焦点的候选人种被提及,特别水并且属于种类的那些,在哪个清楚地区的眼睛是诊断的或是不是水的,但是属于 taxa 象一样的微小的昆虫双翅目例如,在哪个开而非关上的 rhabdoms 是象 interommatidial 头发和腺一样的规则结构以及角膜的 microridges 是能产出有趣的结果并且最后在过去收到了不够的考虑的另一个领域,距离视觉和深度感觉的信息的缺乏被提及,一个请求被做在唾沫臭虫,蛹的 chrysales 和防护昆虫和甲壳纲的动物的另外的结构的泡沫躲蔽处内检验光斩的环境。 | Victor Benno Meyer-Rochow | 2015 | Insect Science2015，22，3： | 3 |
| 6 | Acupuncture and moxibustion in the treatment of ulcerative colitis: A randomized controlled study显示文摘 | Stefanie Joos Nicole Wildau Ralf Kohnen Joachim Szecsenyi Detlef Schuppan Stefan N. Willich Eckhart G. Hahn Benno Brinkhaus | 2006 | Scandinavian Journal of Gastroenterology2006，，9： | 2 |
| 7 | Patient selection based on treatment duration and liver biochemistry increases success rates after treatment withdrawal in autoimmune hepatitis显示文摘 | Johannes Hartl Hanno Ehlken Christina Weiler-Normann Marcial Sebode Benno Kreuels Nadine Pannicke Roman Zenouzi Claudia Glaubke Ansgar W. Lohse Christoph Schramm | 2014 | Journal of Hepatology2014，，： | 2 |
| 8 | Phylogenetic analysis of the human gut microbiota using 16S rDNA clone libraries and strictly anaerobic culture-based methods显示文摘 | Sakamoto M Benno Y | 2002 | Microbiol Immunol2002，46，： | 1 |
| 9 | The intestinalmicroflora of infants : composition of fecalflora in breast-fedand bottle -fed infants 显示文摘 | BENNO Y SAWADA K MITSUOKA T | 1984 | Microbiol Immunol1984，28，9： | 1 |
| 10 | The influence of drying methods on the stabilization of fish oil microcapsules:CoMParison of spray granulation, spray drying, and freeze drying 显示文摘 | Sri Haryani Anwar Benno Kunz | 2011 | Journal of Food Engineering2011，105，： | 1 |
| 11 | Reduced glutamate in the anterior cingulate cortex in depression:An in vivo proton magnetic resonance spectroscopy study显示文摘 | Dorothee PA Benno P Eduard K | 2000 | Biol Psychiatry2000，47，： | 1 |
| 12 | Role of human intestinal Prevote-llaoris in hydrolyzing ginseng saponins 显示文摘 | Hasegawa H Sung JH Benno Y | 1997 | Planta Med1997，63，5： | 1 |
| 13 | Anticarcinogenesis in mice by gin- seng-hydrolyzing colonic bacteria Microb 显示文摘 | Hasegawa H Benno Y | 2000 | Ecol Health Di2000，12，： | 1 |
| 14 | Effect of the substrate on RF power-handling capability of micro-electromechanical capacitive switches显示文摘 | Francesco Solazzi Cristiano Palego Subrata Halder James C.M. Hwang Alessandro Faes Viviana Mulloni Benno Margesin Paola Farinelli Roberto Sorrentino | 2011 | Solid State Electronics2011，，： | 1 |
| 15 | Tax Effort in Developiilg Countries and High Income Countries: The Impact of Corruption, Voice and Accountability 显示文摘 | Bird R M Martinez- vazquez J Benno T | 2008 | Economic Analysis and Policy (EAP)2008，38，1： | 1 |
| 16 | Phylosenetic analysis of the human gut microbiota using 16S rDNA clone libraries and strictly anaerobic culture-based methods 显示文摘 | HAYASHI H SAKAMOTO M BENNO Y | 2002 | Microbiol Immunol2002，46，8： | 1 |
| 17 | The biochemistry and the physiological and molecular actions of jasmonates 显示文摘 | Giinther Sewbdner Benno Parthier | 1993 | Annu Rev Plant Physiol Plant Mol Biol1993，44，： | 1 |
| 18 | Workentin, The Changing Concept of Soil Quality Journal of Soil and Water Conservation显示文摘 | Benno P | 1995 | 50:226 -2411995，50，： | 1 |
| 19 | Tax Effort in Developing Countries and High Income Countries:The Impact of Corruption,Voice and Accountability显示文摘 | Bird R M Martinez-vazquez J Benno T | 2008 | Economic Analysis and Policy (EAP)2008，38，1： | 1 |
| 20 | Attention-deficit hyperactivity disorder(ADHD) and glial integrity:S100B,cytokines and kynurenine metabolism-ef- fects of medication显示文摘 | Robert D Oades Maria R Dauvermann Benno G Schimmel- mann | 2010 | Behavioral and Brain Functions2010，6，： | 1 |
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