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4篇 您的检索式：作者名="Benoit Foligne"

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		题名	作者	年代	出处	被引量
	1	Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria显示文摘AIM: To investigate the correlation between in vitro and in vivo immunomodulation potential of the probiotic strain and its ability to prevent experimental colitis in mice. METHODS: In vitro immunomodulation was assessed by measuring interleukin (IL)-12p70, IL-10, tumor necrosis factor alpha (TNFa) and interferon g (IFNg) release by human peripheral blood mononuclear cells (PBMCs) after 24 h stimulation with 13 live bacterial strains. A murine model of acute TNBS-colitis was next used to evaluate the prophylactic protective capacity of the same set of strains. RESULTS: A strain-specific in vivo protection was observed. The strains displaying an in vitro potential to induce higher levels of the anti-inflammatory cytokine IL-10 and lower levels of the inflammatory cytokine IL-12, offered the best protection in the in vivo colitis model. In contrast, strains leading to a low IL-10/IL-12 cytokine ratio could not significantly attenuate colitis symptoms. CONCLUSION: These results show that we could predict the in vivo protective capacity of the studied lactic acid bacteria (LAB) based on the cytokine profile we established in vitro. The PBMC-based assay we used may thus serve as a useful primary indicator to narrow down the number of candidate strains to be tested inmurine models for their anti-inflammatory potential.	Benoit Foligne Sophie Nutten Corinne Grangette Véronique Dennin Denise Goudercourt Sabine Poiret Joelle Dewulf Dominique Brassart Annick Mercenier Bruno Pot	2007	World Journal of Gastroenterology2007，13，2：	22
	2	Prevention and Treatment of Colitis With Lactococcus lactis Secreting the Immunomodulatory Yersinia LcrV Protein显示文摘	Benoit Foligne Rodrigue Dessein Michael Marceau Sabine Poiret Mathias Chamaillard Bruno Pot Michel Simonet Catherine Daniel	2007	Gastroenterology2007，，3：	1
	3	Changes in Cell Proliferation and Differentiation of Adult Rat Small Intestine Epithelium After Adrenalectomy显示文摘	Benoit Foligne Sabbah Aissaoui Francoise Senegas-Balas Chantal Cayuela Patrice Bernard Jean-Michel Antoine Daniel Balas	2001	Digestive Diseases and Sciences2001，，6：	1
	4	Probiotics from research to market: the possibilities, risks and challenges显示文摘	Benoit Foligné Catherine Daniel Bruno Pot	2013	Current Opinion in Microbiology2013，，：	1

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