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| 1 | 伦理学与SARS:多伦多的教训显示文摘SARS的流行说明传染病在世界范围内流行是件多么容易的事,为了更好地应对下一次流行病,我们不仅要解决医学方面的问题,也同样需要解决伦理学方面的问题。 | Peter A Singer Solomon R Benatar Mark Bernstein Abdallah S Daar Bernard M Dickens Susan K MacRae Ross E G Upshur Linda Wright Randi Zlotnik Shaul 肖月 | 2004 | 英国医学杂志中文版2004，7，4： | 3 |
| 2 | Inflammatory bowel disease patient profiles are related to specific information needs: A nationwide survey显示文摘BACKGROUND Inflammatory bowel diseases(IBD) is a heterogenous, lifelong disease, with an unpredictable and potentially progressive course, that may impose negative psychosocial impact on patients.While informed patients with chronic illness have improved adherence and outcomes, previous research showed that the majority of IBD patients receive insufficient information regarding their disease.The large heterogeneity of IBD and the wide range of information topics makes a one-size fits all knowledge resource overwhelming and cumbersome.We hypothesized that different patient profiles may have different and specific information needs, the identification of which will allow building personalized computer-based information resources in the future.AIM To evaluate the scope of disease-related knowledge among IBD patients and determine whether different patient profiles drive unique information needs.METHODS We conducted a nationwide survey addressing hospital-based IBD clinics.A Total of 571 patients completed a 28-item questionnaire, rating the amount of information received at time of diagnosis and the importance of information, as perceived by participants, for a newly diagnosed patient, and for the participants themselves, at current time.We performed an exploratory factor analysis of the crude responses aiming to create a number of representative knowledge domains(factors), and analyzed the responses of a set of 15 real-life patient profiles generated by the study team.RESULTS Participants gave low ratings for the amount of information received at disease onset(averaging 0.9/5) and high ratings for importance, both for the newly diagnosed patients(mean 4.2/5) and for the participants themselves at current time(mean 3.5/5).Factor analysis grouped responses into six informationdomains.The responses of selected profiles, compared with the rest of the participants, yielded significant associations(defined as a difference in rating of >0.5 points with a P < 0.05).Patients with active disease showed a higher interest in work-disability, stress-coping, and therapy-complications.Patients newly diagnosed at age > 50, and patients with long-standing disease(> 10 years)showed less interest in work-disability.Patients in remission with mesalamine or no therapy showed less interest in all domains except for nutrition and long-term complications.CONCLUSION We demonstrate unmet patient information needs.Analysis of various patient profiles revealed associations with specific information topics, paving the way for building patient-tailored information resources. | Saleh Daher Tawfik Khoury Ariel Benson John R Walker Oded Hammerman Ron Kedem Timna Naftali Rami Eliakim Ofer Ben-Bassat Charles N Bernstein Eran Israeli | 2019 | World Journal of Gastroenterology2019，25，30： | 3 |
| 3 | Novel diet-related mouse model of colon cancer parallels human colon cancer显示文摘AIM:To investigate the close parallels between our novel diet-related mouse model of colon cancer and human colon cancer.METHODS:Twenty-two wild-type female mice(ages 6-8 wk)were fed the standard control diet(AIN-93G)and an additional 22 female mice(ages 6-8 wk)were fed the control diet supplemented with 0.2%deoxycho-lic acid[diet+deoxycholic acid(DOC)]for 10 mo.Tu-mors occurred in the colons of mice fed diet+DOC and showed progression to colon cancer[adenocarcinoma(AC)].This progression is through the stages of tubular adenoma(TA),TA with high grade dysplasia or ad-enoma with sessile serrated morphology,intramucosal AC,AC stage T1,and AC stage T2.The mouse tumors were compared to human tumors at the same stages by histopathological analysis.Sections of the small and large intestines of mice and humans were evaluated for glandular architecture,cellular and nuclear morphology including cellular orientation,cellular and nuclear atyp-ia,pleomorphism,mitotic activity,frequency of goblet cells,crypt architecture,ulceration,penetration of crypts through the muscularis mucosa and presence of malignant crypts in the muscularis propria.In addition,preserved colonic tissues from genetically similar male mice,obtained from a prior experiment,were analyzed by immunohistochemistry.The male mice had been fed the control diet or diet+DOC.Four molecular markers were evaluated:8-OH-dG,DNA repair protein ERCC1,autophagy protein beclin-1 and the nuclear location of beta-catenin in the stem cell region of crypts.Also,male mice fed diet+DOC plus 0.007%chlorogenic acid(diet+DOC+CGA)were evaluated for ERCC1,beclin-1 and nuclear location of beta-catenin.RESULTS:Humans with high levels of diet-relatedDOC in their colons are at a substantially increased riskof developing colon cancer.The mice fed diet+DOChad levels of DOC in their colons comparable to that ofhumans on a high fat diet.The 22 mice without addedDOC in their diet had no colonic tumors while 20 ofthe 22 mice(91%)fed diet+DOC developed colonictumors.Furthermore,the tumors in 10 of these mice(45%of mice)included an adenocarcinoma.All micewere free of cancers of the small intestine.Histopatho-logically,the colonic tumor types in the mice werevirtually identical to those in humans.In humans,char-acteristic aberrant changes in molecular markers can be detected both in field defects surrounding cancers(from which cancers arise)and within cancers.In thecolonic tissues of mice fed diet+DOC similar changesin biomarkers appeared to occur.Thus,8-OH-dG wasincreased,DNA repair protein ERCC1 was decreased,autophagy protein beclin-1 was increased and,in thestem cell region at the base of crypts there was sub-stantial nuclear localization of beta-catenin as well asincreased cytoplasmic beta-catenin.However,in micefed diet+DOC+CGA(with reduced frequency ofcancer)and evaluated for ERCC1,beclin-1,and beta-catenin in the stem cell region of crypts,mouse tissueshowed amelioration of the aberrancies,suggestingthat chlorogenic acid is protective at the molecular levelagainst colon cancer.This is the first diet-related modelof colon cancer that closely parallels human progressionto colon cancer,both at the histomorphological level aswell as in its molecular profile.CONCLUSION:The diet-related mouse model of coloncancer parallels progression to colon cancer in humans,and should be uniquely useful in model studies of pre-vention and therapeutics. | Anil R Prasad Shilpa Prasad Huy Nguyen Alexaner Facista Cristy Lewis Beryl Zaitlin Harris Bernstein Carol Bernstein | 2014 | World Journal of Gastrointestinal Oncology2014，6，7： | 2 |
| 4 | Therapeutic AIDS vaccines 显示文摘 | Bourinbaiar AS Root - Bernstein RS Abulafia - Lapid R | 2006 | Cur Pharmaceutical Design2006，12，16： | 1 |
| 5 | Evidence of from Laboratory Aging and 24-year Field Aging of Polychloroprene Rubber Materials 显示文摘 | Gillen K T Bernstein R Non-Arrhenius Behaviour Derzon Dora K | 2005 | Polymer Degradation and Stability2005，87，： | 1 |
| 6 | The complexity of decentralized control of Markov decision processes显示文摘 | BERNSTEIN D S GIVAN R | 2002 | Mathematics of operations Research2002，27，4： | 1 |
| 7 | The logic of follicular unit ransplantation 显示文摘 | Bernstein R M Rassman W R | 1999 | Dermatol Clin1999，17，2： | 1 |
| 8 | The complexity of centralized control of Markov decision processes显示文摘 | Bernstein D S Givan R Immerman N | 2002 | Mathematics of Operations Research2002，，： | 1 |
| 9 | Maintenance infliximab treat- ment is associated with improved bone mineral density in crohn' s disease 显示文摘 | Bernstein M Irwin S Grunberg G R | 2005 | Am J Gastroentem12005，100，9： | 1 |
| 10 | Leveling the curve of Spee with a continuous archwire technique: a long term cephalometric study 显示文摘 | LAMPASSO J BERNSTEIN R L PRESTON C B | 2007 | Am J Orthod Dentofacial Orthop2007，131，3： | 1 |
| 11 | Multicenter phase Ⅱ study of bortezomib in patients with relapsed or refractory mantle cell lymphoma显示文摘 | FISHER R I BERNSTEIN S H KAHL B S | 2006 | J Clin Oncol2006，24，： | 1 |
| 12 | The aesthetics of follicular transplantation 显示文摘 | Bernstein R M Rassman W R | 1997 | Dermatol Surg1997，23，9： | 1 |
| 13 | Germanium geochemistry and mineralogy显示文摘 | | 1985 | Geochemica et Cosmochemica Acta1985，49，： | 1 |
| 14 | Rule based expert systems for network management and operations:an introduction显示文摘 | R N Cronk P H Callan L Bernstein | 1993 | IEEE Network1993，，： | 1 |
| 15 | Evaluation of the Best disease gene in patients with age-related macular degeneration and other maculopathies显示文摘 | Allikmets R Seddon JM Bernstein PS | 1999 | Hum Genet1999，104，： | 1 |
| 16 | The TD50: Aproposed general convention for the numerical description ofthe carcinogenic potency of chemicals in chronic-exposureanimal experiments显示文摘 | Peto R Pike MC Bernstein L | 1984 | Environental Health Perspect1984，58，： | 1 |
| 17 | Progressive angiomyolipoma with inferior vena cava tumor thrombus显示文摘 | Bernstein M R Malkowicz S B Siegelman E S | 1997 | Urology1997，50，： | 1 |
| 18 | Calculation ofcarcinogenic potency from long-term animal carcinogenesisexperiments显示文摘 | Sawyer C Peto R Bernstein L | 1984 | Biometrics1984，40，： | 1 |
| 19 | Lack of induction of autoantibody responses following immunization with cytomegalovirus (CMV) glycoprotein B(gB) in healthy CMV-seronegative subjects 显示文摘 | Schleiss M R Bernstein D I Passo M | 2004 | Vaccine2004，1623，5： | 1 |
| 20 | Active genes are tri-methylated at K4 of histone H3显示文摘 | SANTOS-ROSA H SCHNEIDER R BANNISTER A J SHERRIFF J BERNSTEIN B E | 2002 | Nature2002，419，6905： | 1 |
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