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33篇 您的检索式：作者名="Beste O"

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	题名	作者	年代	出处	被引量
1	Targeting chronic lymphocytic leukemia cells in the tumor microenviroment: A review of the in vitro and clinical trials to date显示文摘Chronic lymphocytic leukemia(CLL) is the most common leukemia in the western world. Despite significantadvances in therapy over the last decade CLL remains incurable. Current front-line therapy often consists of chemoimmunotherapy-based regimens, most commonly the fludarabine, cyclophosphamide plus rituximab combination, but rates of relapse and refractory disease are high among these patients. Several key signaling pathways are now known to mediate the survival and proliferation of CLL cells in vivo, the most notable of which are the pathways mediated by the B-cell receptor(BCR) and cytokine receptors. A better understanding of the pathogenesis of the disease, the underlying biology of the CLL-cell and the roles of the tumour microenvironment has provided the rationale for trials of a range of novel, more targeted therapeutic agents. In particular, clinical trials of ibrutinib and idelalisib, which target the Brutons tyrosine kinase and the delta isoform of phosphoinositol-3 kinase components of the BCR signaling pathway respectively, have shown extremely promising results. Here we review the current literature on the key signaling pathways and interactions of CLL cells that mediate the survival and proliferation of the leukemic cells. For each we describe the results of the recent clinical trials and in vitro studies of novel therapeutic agents.	Kyle Crassini Stephen P Mulligan O Giles Best	2015	World Journal of Clinical Cases2015，3，8：	5
2	Coherent and incoherent spectral broadening in a photonlc crystal fiber显示文摘	GROSS C BEST T VAN O D	2007	Opt Lett2007，32，13：	1
3	Analysis of Nonlinear Problemswith Particular Reference to Jointed Rock Systems显示文摘	Zienkiewicz O C Best B Dullage C	1970	International Society forRock Mechanics1970，，3：	1
4	Emergency logistics planning in natural disasters显示文摘	Linet O Ediz E Beste K	2004	Annals of Operations Research2004，129，7：	1
5	Polymorphisms of the angiotensin- converting enzyme and angiotensinogen gene in patients with atrial fibrillation显示文摘	Nurdan PT Beste O Veysel S	2011	Jraas2011，12，4：	1
6	Two-phase flow modelling of a solar concentrator applied as ammonia vapor generator in an absorption refrigerator 显示文摘	Ortega N Garcia V O Best R	2008	Renewable Energy2008，33，9：	1
7	Acute muscle strain injuries: a proposed new classification system显示文摘	Chan O Del Buono A Best T M	2012	Knee Surg Sports Trau- matol Arthrosc2012，，：	1
8	Utility of preemptive local analgesia in vaginal hysterectomy显示文摘	O'Neal MG Beste T Shackelford DP	2003	Am J Obstet Gynecol2003，189，：	1
9	State selective production of molecules in optical lattices显示文摘	Rom T Best T Mandel O	2004	Phys Rev Lett2004，93，07：	1
10	Diabetic dyslipidemia:current treatment recommendations显示文摘	O'Neal DN	2000	Drugs2000，，：	1
11	Grading quality of evidence and strength of recotmnendations 显示文摘	Atkins D Best D Briss PA Eccles M Falck-Ytter Y Flottorp S Guyatt GH Harbour R T Haugh MC Henry D Hill S Jaeschke R Leng G Liberati A Magrini N Mason J Middleton P Mrukowicz J O'Connell D Oxman AD Phillips B Schunemann HJ Edejer TT Varonen H Vist GE Williams JW Jr Zaza S GRADE Working Group	2004	BMJ2004，328，7454：	1
12	Cognitive function and assistive tech- nology for cognition: A systematic review 显示文摘	Gillespie A Best C O'Neill B	2012	J Int Neuropsychol Soc2012，18，1：	1
13	c-Jun N-terminal kinase is essential for growth of human T98G glioblastoma cells显示文摘	Potapova O Gorespe M Best F	2000	J Biol Chem2000，275，24：	1
14	Update on collagen receptor interaction in platelets:is the two-state model still valid?显示文摘	Watson S Berlanga O Best D	2000	Platelets2000，11，：	1
15	Emergency logistics planning in natural disasters显示文摘	Ozdamar O L Ekinci E Beste K	2004	Annals of Operations Research2004，129，3：	1
16	Emergency logistics planning in natural disasters显示文摘	LINET O EDIZ E BESTE K	2004	Annals of Operations Research2004，129，1234：	1
17	Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study显示文摘	T. M. E. Davis R. Ting J. D. Best M. W. Donoghoe P. L. Drury D. R. Sullivan A. J. Jenkins R. L. O’Connell M. J. Whiting P. P. Glasziou R. J. Simes Y. A. Kes?niemi V. J. Gebski R. S. Scott A. C. Keech	2011	Diabetologia2011，，2：	1
18	Increasing prevalence of Helicobacter pylori infection with age continuous risk of infection in adults rather than cobort effect显示文摘	Veldhuyzen van Zanten S J O Pollak P T Best L M	1994	J Infect Dis1994，169，2：	1
19	Insulin and glucose levels during CPR in the carine model显示文摘	Martim GB O'Brien JF Best R	1985	Am Emerg Med1985，14，4：	1
20	Primary malignant melanoma of the anterior mediastinum in a child 显示文摘	Vlodavsky E Ben-Izhak O Best LA	2000	Am J Surg Pathol2000，24，5：	1

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