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| 1 | Primary and secondary hyperoxaluria: Understanding the enigma显示文摘Hyperoxaluria is characterized by an increased urinary excretion of oxalate. Primary and secondary hyperoxaluria are two distinct clinical expressions of hyperoxaluria. Primary hyperoxaluria is an inherited error of metabolism due to defective enzyme activity. In contrast, secondary hyperoxaluria is caused by increased dietary ingestion of oxalate, precursors of oxalate or alteration in intestinal microflora. The disease spectrum extends from recurrent kidney stones, nephrocalcinosis and urinary tract infections to chronic kidney disease and end stage renal disease. When calcium oxalate burden exceeds the renal excretory ability, calcium oxalate starts to deposit in various organ systems in a process called systemic oxalosis. Increased urinary oxalate levels help to make the diagnosis while plasma oxalate levels are likely to be more accurate when patients develop chronic kidney disease. Definitive diagnosis of primary hyperoxaluria is achieved by genetic studies and if genetic studies prove inconclusive, liver biopsy is undertaken to establish diagnosis. Diagnostic clues pointing towards secondary hyperoxaluria are a supportive dietary history and tests to detect increased intestinal absorption of oxalate. Conservative treatment for both types of hyperoxaluria includes vigorous hydration and crystallization inhibitors to decrease calcium oxalate precipitation. Pyridoxine is also found to be helpful in approximately 30% patients with primary hyperoxaluria type 1. Liver-kidney and isolated kidney transplantation are the treatment of choice in primary hyperoxaluria type 1 and type 2 respectively. Data is scarce on role of transplantation in primary hyperoxaluria type 3 where there are no reports of end stage renal disease so far. There are ongoing investigations into newer modalities of diagnosis and treatment of hyperoxaluria. Clinical differentiation between primary and secondary hyperoxaluria and further between the types of primary hyperoxaluria is very important because of implications in treatment and diagnosis. Hyperoxaluria continues to be a challenging disease and a high index of clinical suspicion is often the first step on the path to accurate diagnosis and management. | Bhavna Bhasin Hatice Melda ürekli Mohamed G Atta | 2015 | World Journal of Nephrology2015，4，2： | 13 |
| 2 | 基于微观力学模型的沥青混合料水损坏研究显示文摘水-荷载的耦合作用是沥青路面早期破坏的主要原因。该文提出了沥青混合料水损坏的微观力学模型,该模型可以用来量化分析在水-荷载的耦合作用下沥青混合料的损伤过程。同时,考虑到材料的力学性能是含水量的函数,利用内聚力模型对集料-沥青结合料间界面的粘结破坏进行了模拟,并通过沥青混合料内部应力、应变的变化研究了集料-沥青界面间裂缝发生的位置、时间和裂缝扩展过程。结果证明:微观力学模型可以用来揭示沥青混合料水损坏机理,并对连续损伤模型的建立具有一定指导意义。 | 张静 马士宾 魏连雨 孙敬福 Silvia Caro Eyad Masad Amit Bhasin Dallas Little | 2015 | 中外公路2015，35，6： | 8 |
| 3 | Predictors of Surgery in Patients With Severe Acute Pancreatitis Managed by the Step-Up Approach显示文摘 | Raghavendra Yalakanti Babu Rajesh Gupta Mandeep Kang Deepak Kumar Bhasin Surinder Singh Rana Rajinder Singh | 2013 | Annals of Surgery2013，，4： | 4 |
| 4 | Tracking Control of Uncertain Nonlinear Systems With Unknown Constant Input Delay显示文摘A robust delay compensator has been developed for a class of uncertain nonlinear systems with an unknown constant input delay.The control law consists of feedback terms based on the integral of past control values and a novel filtered tracking error,capable of compensating for input delays.Suitable Lyapunov-Krasovskii functionals are used to prove global uniformly ultimately bounded(GUUB)tracking,provided certain sufficient gain conditions,dependent on the bound of the delay,are satisfied.Simulation results illustrate the performance and robustness of the controller for different values of input delay. | Ashish Kumar Jain Shubhendu Bhasin | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，2： | 3 |
| 5 | Adaptive Linear Quadratic Regulator for Continuous-Time Systems With Uncertain Dynamics显示文摘In this paper, adaptive linear quadratic regulator(LQR) is proposed for continuous-time systems with uncertain dynamics. The dynamic state-feedback controller uses inputoutput data along the system trajectory to continuously adapt and converge to the optimal controller. The result differs from previous results in that the adaptive optimal controller is designed without the knowledge of the system dynamics and an initial stabilizing policy. Further, the controller is updated continuously using input-output data, as opposed to the commonly used switched/intermittent updates which can potentially lead to stability issues. An online state derivative estimator facilitates the design of a model-free controller. Gradient-based update laws are developed for online estimation of the optimal gain. Uniform exponential stability of the closed-loop system is established using the Lyapunov-based analysis, and a simulation example is provided to validate the theoretical contribution. | Sumit Kumar Jha Shubhendu Bhasin | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，3： | 3 |
| 6 | Management of infected pancreatic necrosis in the setting of concomitant rectal cancer:A case report and review of literature显示文摘BACKGROUND Pancreatitis with infected necrosis is a severe complication of acute pancreatitis and carries with it high rates of morbidity and mortality. The management of infected pancreatic necrosis alongside concomitant colorectal cancer has never been described in literature.CASE SUMMARY A 77 years old gentleman presented to the Emergency Department of our hospital complaining of ongoing abdominal pain for 8 h. The patient had clinical features of pancreatitis with a raised lipase of 3810 U/L, A computed tomography(CT) abdomen confirmed pancreatitis with extensive peri-pancreatic edema. During the course of his admission, the patient had persistent high fevers and delirium thought secondary to infected necrosis, prompting the commencement of broad-spectrum antibiotic therapy with Piperacillin/Tazobactam. Subsequent CT abdomen confirmed extensive pancreatic necrosis(over 70%). Patient was managed with supportive therapy,nutritional support and gut rest initially and improved over the course of his admission and was discharged 42 d post admission. He represented 24 d following his discharge with fever and chills and a repeat CT abdomen scan noted gas bubbles within the necrotic pancreatic tissue thereby confirming infected necrotic pancreatitis. This CT scan also revealed asymmetric thickening of the rectal wall suspicious for malignancy. A rectal cancer was confirmed on flexible sigmoidoscopy. The patient underwent two endoscopic necrosectomies and was treated with intravenous antibiotics and was discharged after 28 d.Within 1 wk post discharge, the patient commenced a course of neoadjuvant radiotherapy and subsequently underwent concomitant chemotherapy prior to undergoing a successful Hartmann's procedure for treatment of his colorectal cancer.CONCLUSION This case highlights the efficacy of endoscopic necrosectomy, early enteral feeding and targeted antibiotic therapy for timely management of infected necrotic pancreatitis. The prompt resolution of pancreatitis permitted the patient to undergo neoadjuvant treatment and resection for his concomitant colorectal cancer. | Kihoon Choi David E Flynn Anitha Karunairajah Andrew Hughes Ambika Bhasin Benedict Devereaux Manju D Chandrasegaram | 2019 | World Journal of Gastrointestinal Surgery2019，11，4： | 2 |
| 7 | Endoscopic ultrasound guided interventional procedures显示文摘Endoscopic ultrasound(EUS) has emerged as an important diagnostic and therapeutic modality in the field of gastrointestinal endoscopy. EUS provides access to many organs and lesions which are in proximity to the gastrointestinal tract and thus giving an opportunity to target them for therapeutic and diagnostic purposes. This modality also provides a real time opportunityto target the required area while avoiding adjacent vascular and other structures. Therapeutic EUS has found role in management of pancreatic fluid collections, biliary and pancreatic duct drainage in cases of failed endoscopic retrograde cholangiopancreatography, drainage of gallbladder, celiac plexus neurolysis/blockage, drainage of mediastinal and intra-abdominal abscesses and collections and in targeted cancer chemotherapy and radiotherapy. Infact, therapeutic EUS has emerged as the therapy of choice for management of pancreatic pseudocysts and recent innovations like fully covered removable metallic stents have improved results in patients with organised necrosis. Similarly, EUS guided drainage of biliary tract and pancreatic duct helps drainage of these systems in patients with failed cannulation, inaccessible papilla as with duodenal/gastric obstruction or surgically altered anatomy. EUS guided gall bladder drainage is a useful emergent procedure in patients with acute cholecystitis who are not fit for surgery. EUS guided celiac plexus neurolysis and blockage is more effective and less morbid vis-à-vis the percutaneous technique. The field of interventional EUS is rapidly advancing and many more interventions are being continuously added. This review focuses on the current status of evidence vis-à-vis the established indications of therapeutic EUS. | Vishal Sharma Surinder S Rana Deepak K Bhasin | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，6： | 2 |
| 8 | Role of <sup>18</sup> F ‐fluorodeoxyglucose positron emission tomography/computed tomography in the characterization of pancreatic masses: Experience from tropics显示文摘 | Sampath Santhosh Bhagwant Rai Mittal Deepak Bhasin Radhika Srinivasan Surinder Rana Ashim Das Ritambhra Nada Anish Bhattacharya Rajesh Gupta Rakesh Kapoor | 2013 | J Gastroenterol Hepatol2013，，2： | 2 |
| 9 | Sarcopenia: An Undiagnosed Condition in Older Adults. Current Consensus Definition: Prevalence, Etiology, and Consequences. International Working Group on Sarcopenia显示文摘 | Roger A. Fielding Bruno Vellas William J. Evans Shalender Bhasin John E. Morley Anne B. Newman Gabor Abellan van Kan Sandrine Andrieu Juergen Bauer Denis Breuille Tommy Cederholm Julie Chandler Capucine De Meynard Lorenzo Donini Tamara Harris Aimo Kannt F | 2011 | Journal of the American Medical Directors Association2011，，4： | 2 |
| 10 | Mechanisms of edema formation after intracerebral hemorrhage:effects of extravasated red blood cells on blood flow and blood-brain barrier integrity显示文摘 | Hua Y Bhasin RR | 2001 | Stroke2001，32，12： | 1 |
| 11 | Testosterone therapy in adult men with androgen deficiency syndromes:an endocrine society clinical practice guideline显示文摘 | Bhasin S Cunningham GR Hayes FJ | 2006 | Clin Endocrinol Metab2006，91，： | 1 |
| 12 | Bcipep: A database of B-cell epitopes 显示文摘 | Saha S Bhasin M Raghava G P S | 2005 | BMC Genomics2005，6，1： | 1 |
| 13 | A centralized energy-efficient routing protocol for wireless sensor networks 显示文摘 | MURUGANATHAN S D MAD C F BHASIN R I | 2005 | IEEE Radio Communication2005，43，3： | 1 |
| 14 | Space Internet architectures and technologies for NASA enterprises 显示文摘 | BHASIN K HAYDEN J L | 2002 | International Journal of Satellite Communications2002，20，3： | 1 |
| 15 | Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatin显示文摘 | Reisz-Porszasz S Bhasin S Artaza JN | 2003 | Am J Physiol Endocrinol Metab2003，285，： | 1 |
| 16 | A framework to quantify the effect of healing in bituminous materials using material properties显示文摘 | Bhasin A Little D N Bommavaram R | 2008 | Road Materials and Pavement Design2008，9，1： | 1 |
| 17 | Effects of Graded Doses of Testosterone on Erythropoiesis in Healthy Young and Older Men显示文摘 | Andrea D. Coviello Beth Kaplan Kishore M. Lakshman Tai Chen Atam B. Singh Shalender Bhasin | 2008 | The Journal of Clinical Endocrinology & Metabolism2008，，3： | 1 |
| 18 | Mechanisms of edema formation after intracerebral hemorrhage:effects of extravasated red blood cells on blood flow and blood-brain barrier integrity显示文摘 | Xi G Hua Y Bhasin RR | 2001 | Stroke2001，32，12： | 1 |
| 19 | The genetic basis of male infer tility显示文摘 | Bhasin S Ma K Sinha I | 1998 | Endocrinol Metab Clin North Am1998，27，4： | 1 |
| 20 | Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression 显示文摘 | Ma K Mallidis C Bhasin S | 2003 | Am J Physiol Eudocrinol Metab2003，285，2： | 1 |
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