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| 1 | Large-scale deformation monitoring in mining area by D-InSAR and 3D laser scanning technology integration显示文摘Large-scale deformation can not be detected by traditional D-InSAR technique because of the limit of its detectable deformation gradient,we propose a method that combines SAR data with point cloud data obtained by 3D laser scanning to improve the gradient of deformation detection.The proposed method takes advantage of high-density of 3D laser scanning point cloud data and its high precision of point positioning after 3D modeling.The specifc process can be described as follows:frst,large-scale deformation points in the interferogram are masked out based on interferometric coherence;second,the interferogram with holes is unwrapped to obtain a deformation map with holes,and last,the holes in the deformation map are flled with point cloud data using inverse distance weighting algorithm,which will achieve seamless connection of monitoring region.We took the embankment dam above working face of a certain mining area in Shandong province as an example to study large-scale deformation in mining area using the proposed method.The results show that the maximum absolute error is 64 mm,relative error of maximum subsidence value is 4.95%,and they are consistent with leveling data of ground observation stations,which confrms the feasibility of this method.The method we presented provides new ways and means for achieving large-scale deformation monitoring by D-InSAR in mining area. | Chen Bingqian Deng Kazhong Fan Hongdong Hao Ming | 2013 | International Journal of Mining Science and Technology2013，23，4： | 12 |
| 2 | Differentiation of embryonic stem cells into corneal epithelium显示文摘Our project was to determine whether embryonic stem (ES) cells could be induced to differentiate into corneal epithelia by superficial corneoscleral limbal stroma. To achieve this goal, ES-GFP cell line D3 was pre-induced by retinoic acid (RA). The pre-induced cells were seeded on deepithelialized superficial corneoscleral slices (SCSS) to form a monolayer, and di-vided into three groups. Group 1 was cultured and passaged in vitro for direct detection. Group 2 was exposed to air-liquid interfaces for 10 days and implanted into the subcutaneous layer of nude mice for 2 weeks for further induction in vivo. Group 3 was cultured in vitro without any in-ducing factors for control. There were no teratomas found in nude mice which were implanted with differentiated ES cells after two weeks. The differentiated cells showed an appearance of epithelia both in vitro and in vivo. Expression of CK3, P63 and PCNA was detected by immuno-histochemical staining in the differentiated cells in group 1 and 2. Microvillis and zonula oc-cludens were observed on the surface of the differentiated cells under an electron microscope. In the control group, ES cells differentiated freely without any inducing factors. Most cells were shed and formed a neuronal dendrite-like structure, and a minority of cells appeared polymorphic. These results demonstrate that ES cells can differentiate into corneal epithelia on the surface of SCSS under the controlled condition. Differentiated ES cells could be used as epithelial seeding cells for the reconstruction of ocular surface and corneal tissue engineering in the future. | WANG Zhichong GE Jian HUANG Bing GAO Qianying LIU Bingqian WANG Linghua YU Ling FAN Zhigang LU Xiaoming LIU Jingbo | 2005 | Science China(Life Sciences)2005，48，5： | 10 |
| 3 | Activation of anterior thalamic reticular nucleus GABAergic neurons promotes arousal from propofol anesthesia in mice显示文摘Propofol is widely used for the induction and maintenance of anesthesia,which causes a rapid loss of consciousness.However,the mechanisms underlying the hypnosis effect of propofol are still not fully understood.The thalamic reticular nucleus(TRN)is crucial for regulating wakefulness,sleep rhythm generation,and sleep stability,while the role of TRN in the process of propofol-induced anesthesia is still unknown.Here,we investigated the function of the anterior TRN in propofol general anesthesia.Our results demonstrated that the neural activity of anterior TRN is suppressed during propofol anesthesia,whereas it is robustly activated from anesthesia by recording the calcium signals using fiber photometry technology.The results showed that the activation of anterior TRN neurons by chemogenetic and optogenetic methods shortens the emergency time without changing the induction time.Conversely,chemogenetic or optogenetic inhibition of the TRN neurons leads to a delay in the recovery time.Our study showed that anterior TRN is crucial for behavioral arousal without affecting the induction time of propofol anesthesia. | Yanjun Liu Bing Chen Yirong Cai Yuan Han Ying Xia Nanqi Li Bingqian Fan Tianjie Yuan Junli Jiang Po Gao Weifeng Yu Yingfu Jiao Wenxian Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 3 |
| 4 | Monascus vinegar alleviates high-fat-diet-induced inflammation in rats by regulating the NF-κB and PI3K/AKT/mTOR pathways显示文摘Monascus vinegar(MV) is a typical fermented food with various health-promoting effects. This study aimed to evaluate the role of MV in alleviating high-fat-diet-induced inflammation in rats with hyperlipidemia and elucidate the possible regulatory mechanisms. In the study, serum lipid profiles, liver pathology and liver inflammatory cytokines were analyzed in hyperlipidemia rats with MV(0.5 mL/kg mb, 2 mL/kg mb). Results showed that the administration of MV alleviated dyslipidemia by decreasing the serum and liver levels of triglyceride and total cholesterol. Increase in hepatic lipase and carnitine palmitoyl transferase 1(CPT-1)levels and decrease in hepatocyte steatosis, nephritis, and intestinal tissue injury in the HD group showed that high-dose MV can significantly suppress hepatic lipid accumulation and steatosis. In addition, compared with the model(MOD) group, the HD group showed significantly down-regulated the level of serum or hepatic alanine aminotransferase(ALT), aspartate aminotransferase(AST), CPT-1, interleukin(IL)-2, IL-6, IL-12,and tumor necrosis factor α(TNF-α). Moreover, the HD group showed repressed hepatic nuclear factor κB(NF-κB) pathway and inactivated phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR) pathway mitigated liver inflammation. Similar results were obtained from cell experiments. Collectively, these findings revealed that MV might attenuate high-fat-diet-induced inflammation by inhibiting the NF-κB and PI3K/Akt/mTOR pathways. | Huanmei Meng Jia Song Bingqian Fan Yingqi Li Jiaojiao Zhang Jinping Yu Yu Zheng Min Wang | 2022 | Food Science and Human Wellness2022，11，4： | 2 |
| 5 | Combined organic-inorganic fertilization builds higher stability of soil and root microbial networks than exclusive mineral or organic fertilization显示文摘Plant health and performance are highly dependent on the root microbiome.The impact of agricultural management on the soil microbiome has been studied extensively.However,a comprehensive understanding of how soil types and fertilization regimes affect both soil and root microbiome is still lacking,such as how fertilization regimes affect the root microbiome's stability,and whether it follows the same patterns as the soil microbiome.In this study,we carried out a longterm experiment to see how different soil types,plant varieties,and fertilizer regimens affected the soil and root bacterial communities.Our results revealed higher stability of microbial networks under combined organic-inorganic fertilization than those relied solely on inorganic or organic fertilization.The root microbiome variation was predominantly caused by total nitrogen,while the soil microbiome variation was primarily caused by pH and soil organic matter.Bacteroidetes and Firmicutes were major drivers when the soil was amended with organic fertilizer,but Actinobacteria was found to be enriched in the soil when the soil was treated with inorganic fertilizer.Our findings demonstrate how the soil and root microbiome respond to diverse fertilizing regimes,and hence contribute to a better understanding of smart fertilizer as a strategy for sustainable agriculture. | Luhua Yang Renhua Sun Jungai Li Limei Zhai Huiling Cui Bingqian Fan Hongyuan Wang Hongbin Liu | 2023 | Soil Ecology Letters2023，5，2： | 1 |
| 6 | Irrigation and nitrogen fertiliser optimisation in protected vegetable fields of northern China:Achieving environmental and agronomic sustainability显示文摘Globally,sub-optimal use of nitrogen (N) fertiliser and elevated N irrigation groundwater have led to high leached nitrate (NO_(3)^(–)) losses from protected vegetable field systems.Optimising fertiliser and irrigation management in different soil types is crucial to reduce future N loads from such systems.The present 4-year study examined leached N loads from lysimeter monitoring arrays set up across 18 protected vegetable system sites encompassing the dominant soil types of northern China.The treatments applied at each field site were:1) a high N and high irrigation input treatment (HNHI);2) a low N but high irrigation input treatment (LNHI) and 3) a low N with low irrigation input treatment (LNLI).Results showed that the mean annual leached total nitrogen loads from the HNHI,LNHI and LNLI treatments were 325,294 and 257 kg N ha^(–1) in the fluvo-aquic soil,114,100 and 78 kg N ha^(–1) in the cinnamon soil and 79,68 and 57 kg N ha^(–1) in the black soil,respectively.The N dissolved in irrigation water in the fluvo-aquic soil areas was 8.26-fold higher than in the cinnamon areas.A structural equation model showed that N fertiliser inputs and leaching water amounts explained 14.7 and 81.8%of the variation of leached N loads,respectively.Correspondingly,reducing irrigation water by 21.5%decreased leached N loads by 20.9%,while reducing manure N and chemical N inputs by 22 and 25%decreased leached N loads by only 9.5%. This study highlights that protected vegetable fields dominated by fluvo-aquic soil need management to curtail leached N losses in northern China. | Bingqian Fan Yitao Zhang Owen Fenton Karen Daly Jungai Li Hongyuan Wang Limei Zhai Xiaosheng Luo Qiuliang Lei Shuxia Wu Hongbin Liu | 2024 | Journal of Integrative Agriculture2024，23，3： | 0 |
| 7 | Microbial-driven ectopic uranium extraction with net electrical energy production显示文摘The extraction of uranium (U) from U-bearing wastewater is of paramount importance for mitigating negative environmental impacts and recovering U resources. Microbial reduction of soluble hexavalent uranium (U(VI)) to insoluble tetravalent uranium (U(IV)) holds immense potential for this purpose, but its practical application has been impeded by the challenges associated with managing U-bacterial mixtures and the biotoxicity of U. To address these challenges, we present a novel spontaneous microbial electrochemical (SMEC) method that spatially decoupled the microbial oxidation reaction and the U(VI) reduction reaction. Our results demonstrated stable and efficient U extraction with net electrical energy production, which was achieved with both synthetic and real wastewater. U(VI) removal occurred via diffusion-controlled U(VI)-to-U(IV) reduction-precipitation at the cathode, and the UIVO_(2) deposited on the surface of the cathode contributed to the stability and durability of the abiotic U(VI) reduction. Metagenomic sequencing revealed the formation of efficient electroactive communities on the anodic biofilm and enrichment of the key functional genes and metabolic pathways involved in electron transfer, energy metabolism, the TCA cycle, and acetate metabolism, which indicated the ectopic reduction of U(VI) at the cathode. Our study represents a significant advancement in the cost-effective recovery of U from U(VI)-bearing wastewater and may open a new avenue for sustainable uranium extraction. | Xin Tang Yin Ye Chunlin Wang Bingqian Wang Zemin Qin Cui Li Yanlong Chen Yuheng Wang Zhiling Li Miao Lv Aijie Wang Fan Chen | 2024 | Frontiers of Environmental Science & Engineering2024，18，1： | 0 |
| 8 | Machine learning-accelerated discovery of novel 2D ferromagnetic materials with strong magnetization显示文摘Two-dimensional ferromagnetic(2DFM)semiconductors(metals,half-metals,and so on)are important materials fornext-generation nano-electronic and nano-spintronic devices.However,these kinds of materials remain scarce,“trial anderror”experiments and calculations are both time-consumingand expensive.In the present work,in order to obtain theoptimal 2DFM materials with strong magnetization,a machinelearning(ML)framework was established to search the 2Dmaterial space containing over 2417 samples and identified 615compounds whose magnetic orders were then determined viahigh-throughput first-principles calculations.With the adoptionof ML algorithms,two classification models and a regressionmodel were trained.The interpretability of the regressionmodel was evaluated through Shapley Additive exPlanations(SHAP)analysis.Unexpectedly,it is found that Cr2NF2 is apotential antiferromagnetic ferroelectric 2D multiferroic material.More importantly,60 novel 2DFM candidates werepredicted,and among them,13 candidates have magnetic moments of>7μB.Os2Cl8,Fe3GeSe2,and Mn4N3S2 were predictedto be novel 2DFM semiconductors,metals,and half-metals,respectively.With the adoption of the ML approach in thecurrent work,the prediction of 2DFM materials with strongmagnetization can be accelerated,and the computation timecan be drastically reduced by more than one order ofmagnitude. | Chao Xin Yaohui Yin Bingqian Song Zhen Fan Yongli Song Feng Pan | 2023 | Chip2023，2，4： | 0 |
| 9 | Alum split applications strengthened phosphorus fixation and phosphate sorption in high legacy phosphorus calcareous soil显示文摘High phosphorus(P)saturation arising from historic P inputs to protected vegetable fields(PVFs)drives high P mobilisation to waterbodies.Amendment of soils with alum has shown potential in terms of fixing labile P and protecting water quality.The present 15 month pot experiment investigated P stabilisation across single alum application(Alum-1 treatment,20 g alum/kg soil incorporated into soil before the maize was sown),alum split applications(Alum-4 treatment,5 g alum/kg soil incorporated into soil before each crop was sown i.e.4×5 g/kg)and soil only treatment(Control).Results showed that the Alum-1 treatment caused the strongest stabilisation of soil labile P after maize plant removal,whereas the P stabilisation effect was gradually weakened due to the transformation of soil non-labile P to labile P and the reduced active Al^(3+)in soil solution.For the Alum-4 treatment,soil labile P decreased gradually with each crop planting and was lower than the Alum-1 treatment at the end of the final crop removal,without any impairment on plant growth.The better P stabilisation at the end of Alum-4 treatment was closely correlated with a progressive supply of Al^(3+)and a gradual decrease of pH,which resulted in higher contents of poorlycrystalline Al,Fe and exchangeable Ca.These aspects were conducive to increasing the soil P stabilisation and phosphate sorption.In terms of management,growers in continuous cropping systems could utilise split alum applications as a strategy to alleviate P losses in high-P enriched calcareous soil. | Bingqian Fan Owen Fenton Karen Daly Jiahui Ding Shuo Chen Qing Chen | 2021 | Journal of Environmental Sciences2021，33，3： | 0 |
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