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| 1 | Propofol differentially induces unconsciousness and respiratory depression through distinct interactions between GABAa receptor and GABAergic neuron in corresponding nuclei显示文摘Propofol is the most commonly used intravenous anesthetic worldwide.It can induce loss of consciousness prior to the occurrence of severe respiratory suppression,which is also a pharmacodynamic feature of all general anesthetics.However,the neural mechanisms underlying this natural phenomenon are controversial and highly related to patient safety.In the present study,we demonstrated that the pharmacodynamic effects of propofol(50 and 100 μM)on suppression of consciousness-related excitatory postsynaptic currents in the medial prefrontal cortex(mPFC)and centromedian nucleus of the thalamus(CMT)were lower than those in the kernel respiratory rhythmogenesis nucleus pre-Botzinger complex(PrBo).Furthermore,we unexpectedly found that the GABAa receptor β3 subunit is the key target for propofol's action and that it is mutually and exclusively expressed in GABAergic neurons.It is also more abundant in the mPFC and CMT,but mainly co-localized with GABAergic neurons in the PrBo.As a result,the differentiated expression pattern should mediate more neuron suppression through the activation of GABAergic neurons in the mPFC and CMT at low doses of propofol(50 μM).However,PrBo GABAergic neurons were only activated by propofol at a high dose(100 μM).These results highlight the detailed pharmacodynamic effects of propofol on consciousness-related and respiration-related nuclei and provide the distinct interaction mechanism between the β3 subunit and GABAergic neurons in mediating the suppression of consciousness compared to the inhibition of respiration. | Junli Jiang Yingfu Jiao Po Gao Wen Yin Wei Zhou Yunchun Zhang Yanjun Liu Daxiang Wen Yuan Wang Liang Zhou Tian Yu Weifeng Yu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 11 |
| 2 | Big data resource service platform for the internet financial industry显示文摘It is now the era of big data.Massive volumes of complex and dynamic data exist in a variety of industries,including internet finance.This paper briefly describes the current big data situation and its significance,discusses the big data resource service platform architecture that includes three levels:data resource identification and access,data resources storage and analysis,and network information service platform,and then introduces some work undertaken by our project team on big data analysis research and application of trusted transactions for internet finance. | Changjun Jiang Zhijun Ding Junli Wang Chungang Yan | 2014 | Chinese Science Bulletin2014，59，35： | 8 |
| 3 | High-performance quasi-2D perovskite light-emitting diodes: from materials to devices显示文摘Quasi-two-dimensional(quasi-2D)perovskites have attracted extraordinary attention due to their superior semiconducting properties and have emerged as one of the most promising materials for next-generation lightemitting diodes(LEDs).The outstanding optical properties originate from their structural characteristics.In particular,the inherent quantum-well structure endows them with a large exciton binding energy due to the strong dielectricand quantum-confinement effects;the corresponding energy transfer among different n-value species thus results in high photoluminescence quantum yields(PLQYs),particularly at low excitation intensities.The review herein presents an overview of the inherent properties of quasi-2D perovskite materials,the corresponding energy transfer and spectral tunability methodologies for thin films,as well as their application in high-performance LEDs.We then summarize the challenges and potential research directions towards developing high-performance and stable quasi-2D PeLEDs.The review thus provides a systematic and timely summary for the community to deepen the understanding of quasi-2D perovskite materials and resulting LED devices. | Li Zhang Changjiu Sun Tingwei He Yuanzhi Jiang Junli Wei Yanmin Huang Mingjian Yuan | 2021 | Light(Science & Applications)2021，10，4： | 5 |
| 4 | Activation of anterior thalamic reticular nucleus GABAergic neurons promotes arousal from propofol anesthesia in mice显示文摘Propofol is widely used for the induction and maintenance of anesthesia,which causes a rapid loss of consciousness.However,the mechanisms underlying the hypnosis effect of propofol are still not fully understood.The thalamic reticular nucleus(TRN)is crucial for regulating wakefulness,sleep rhythm generation,and sleep stability,while the role of TRN in the process of propofol-induced anesthesia is still unknown.Here,we investigated the function of the anterior TRN in propofol general anesthesia.Our results demonstrated that the neural activity of anterior TRN is suppressed during propofol anesthesia,whereas it is robustly activated from anesthesia by recording the calcium signals using fiber photometry technology.The results showed that the activation of anterior TRN neurons by chemogenetic and optogenetic methods shortens the emergency time without changing the induction time.Conversely,chemogenetic or optogenetic inhibition of the TRN neurons leads to a delay in the recovery time.Our study showed that anterior TRN is crucial for behavioral arousal without affecting the induction time of propofol anesthesia. | Yanjun Liu Bing Chen Yirong Cai Yuan Han Ying Xia Nanqi Li Bingqian Fan Tianjie Yuan Junli Jiang Po Gao Weifeng Yu Yingfu Jiao Wenxian Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 3 |
| 5 | Effect of cytotoxic T-lymphocyte antigen-4,TNF-alpha polymorphisms on osteosarcoma: evidences from a meta-analysis显示文摘Objective:Previous studies have investigated the role of cytotoxic T-lymphocyte antigen-4(CTLA-4)and tumor necrosis factor-alpha(TNF-α)in carcinogenesis of osteosarcoma,but their results were inconsistent.We aimed to clarify the associations between CTLA-4,TNF-αpolymorphism and osteosarcoma risk by using meta-analysis.Methods:We searched relevant studies without language restriction in PubMed,EMbase,Cochrane Library,Google Scholar databases,Chinese National Knowledge Infrastructure(CNKI)and conference literature in humans published prior to March 2013.The strengths of the associations between genetic variants and osteosarcoma risk were estimated by odds ratio(OR)with 95%confidence interval(95%CI).Results:A total of seven studies with 1,198 osteosarcoma patients and 1,493 controls were selected.Four studies were eligible for CTLA-4(1,003 osteosarcoma and 1,162 controls),and three studies for TNF-α(195 osteosarcoma and 331 controls).Pooled results showed that rs231775 polymorphism of CTLA-4 was associated with osteosarcoma risk(GG vs.AA:OR=1.63,95%CI=1.24-2.13;GG+GA vs.AA:OR=1.56,95%CI=1.21-2.01;AA+GA vs.GG:OR=0.83,95%CI=0.71-0.97;G vs.A:OR=1.21,95%CI=1.08-1.36).No significant heterogeneity was observed across the studies.No significant associations were found between rs5742909 polymorphism of CTLA-4 or rs1800629 polymorphism of TNF-αand osteosarcoma risk.Conclusions:These results suggest that the rs231775 polymorphism of CTLA-4 may play an important role in carcinogenesis of osteosarcoma. | Jianwei Liu Junli Wang Weiping Jiang Yujin Tang | 2013 | Chinese Journal of Cancer Research2013，25，6： | 3 |
| 6 | Glaucocalyxin A, a negative Akt regulator, specifically induces apoptosis in human brain glioblastoma U87MG cells显示文摘Akt 在反肿瘤代理人的发展正在成为一个吸引人的目标。在现在的学习,我们试图对恶意的 glioma 发现新奇否定 Akt 管理者。屏蔽站台在一根 Akt-GFP overexpression 房间线执行了的一个 Akt 管理者被开发,并且自然产品图书馆被屏蔽并且评估了使用这个平台。另外,管理者的细胞毒素的效果被 MTT 试金检测。房间 apoptosis 是由 Hoechst 33342 染色和流动 cytometry 分析的 assayed。以后,表明小径的 apoptotic 被西方的污点分析调查。Glaucocalyxin A,从 Rabdosia 孤立装饰用的梨树,作为一个有势力被识别 Akt 的否定管理者。在导出人的恶意的 glioma U87MG 房间, glaucocalyxin A 禁止了 Akt phosphorylation,压制了增长,并且支持了以一种剂量依赖者方式,然而并非在正常 glial 房间的 apoptosis。而且, glaucocalyxin A 激活 caspase-3,减少的坏 phosphorylation,并且减少了 apoptosis 的 X 连接禁止者的表示蛋白质。一起拿,这些结果显示 glaucocalyxin A 可以在恶意的 glioma 的处理成为一个有希望的候选人。 | Xian Xiao Weidong Cao Xiaofan Jiang Wei Zhang Yongqiang Zhang Bolin Liu Jinxiang Cheng Huiyong Huang Junli Huo Xiang Zhang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，11： | 2 |
| 7 | 2020 Roadmap on two-dimensional nanomaterials for environmental catalysis显示文摘Environmental catalysis has drawn a great deal ofattention due to its clean ways to produce useful chemicals or carry out some chemical processes.Photocatalysis and electrocatalysis play important roles in these fields.They can decompose and remove organic pollutants from the aqueous environment,and prepare some fine chemicals.Moreover,they also can carry out some important reactions,such as 02 reduction reaction(ORR),O2 evolution reaction(OER),H2 evolution reaction(HER),CO2 reduction reaction(C02 RR),and N2 fixation(NRR).For catalytic reactions,it is the key to develop high-performance catalysts to meet the demand fortargeted reactions.In recentyears,two-dimensional(2 D) materials have attracted great interest in environmental catalysis due to their unique layered structures,which offer us to make use of their electronic and structural characteristics.Great progress has been made so far,including graphene,black phosphorus,oxides,layered double hydroxides(LDHs),chalcogenides,bismuth-based layered compounds,MXenes,metal organic frameworks(MOFs),covalent organic frameworks(COFs),and others.This content drives us to invite many famous groups in these fields to write the roadmap on two-dimensional nanomaterials for environmental catalysis.We hope that this roadmap can give the useful guidance to researchers in future researches,and provide the research directions. | Yulu Yang Mingguang Wu Xingwang Zhu Hui Xu Si Ma Yongfeng Zhi Hong Xia Xiaoming Liu Jun Pan Jie-Yinn Tang Siang-Piao Chai Leonardo Palmisano Francesco Parrino Junli Liu Jianzhong Ma Ze-Lin Wang Ling Tan Yu-Fei Zhao Yu-Fei Song Pardeep Singh Pankaj Raizada Deli Jiang Di Li R.A.Geioushy Jizhen Ma Jintao Zhang Song Hu Rongjuan Feng Gang Liu Minghua Liu Zhenhua Li Mingfei Shao Neng Li Jiahe Peng Wee-Jun Ong Nikolay Kornienko Zhenyu Xing Xiujun Fan Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 2 |
| 8 | Correlation between radiologic features on contrastenhanced CT and pathological tumor grades in pancreatic neuroendocrine neoplasms显示文摘Contrast-enhanced computed tomography(CT)contributes to the increasing detection of pancreatic neuroendocrine neoplasms(PNENs).Nevertheless,its value for differentiating pathological tumor grades is not well recognized.In this report,we have conducted a retrospective study on the relationship between the 2017 World Health Organization(WHO)classification and CT imaging features in 94 patients.Most of the investigated features eventually provided statistically significant indicators for discerning PNENs G3 from PNENs G1/G2,including tumor size,shape,margin,heterogeneity,intratumoral blood vessels,vascular invasion,enhancement pattern in both contrast phases,enhancement degree in both phases,tumor-to-pancreas contrast ratio in both phases,common bile duct dilatation,lymph node metastases,and liver metastases.Ill-defined tumor margin was an independent predictor for PNENs G3 with the highest area under the curve(AUC)of 0.906 in the multivariable logistic regression and receiver operating characteristic curve analysis.The portal enhancement ratio(PER)was shown the highest AUC of 0.855 in terms of quantitative features.Our data suggest that the traditional contrastenhanced CT still plays a vital role in differentiation of tumor grades and heterogeneity analysis prior to treatment. | Wenbin Xu Han Yan Lulu Xu Mingna Li Wentao Gao Kuirong Jiang Junli Wu Yi Miao | 2021 | The Journal of Biomedical Research2021，35，3： | 2 |
| 9 | Dexmedetomidine maintains blood-brain barrier integrity by inhibiting Drp1-related endothelial mitochondrial dysfunction in ischemic stroke显示文摘Stroke is the second leading cause of death and long-term disability worldwide,which lacks effective treatment.Perioperative stroke is associated with much higher rates of mortality and disability.The neuroprotective role of dexmedetomidine(Dex),a highly selective agonist of alpha2-adrenergic receptor,has been reported in a stroke rat model,and it was found that pretreatment of Dex before stroke could alleviate blood–brain barrier(BBB)breakdown.However,the underlying mechanisms are still unknown.As the brain endothelial cells are the main constituents of BBB and in high demand of energy,mitochondrial function of endothelial cells plays an important role in the maintenance of BBB.Given that dynamin-related protein 1(Drp1)is a protein mediating mitochondrial fission,with mitochondrial fusion that balances mitochondrial morphology and ensures mitochondria function,the present study was designed to investigate the possible role of Drp1 in endothelial cells involved in the neuroprotective effects of Dex in ischemic stroke.Our results showed that preconditioning with Dex reduced infarction volume,alleviated brain water content and BBB damage,and improved neurological scores in middle cerebral artery occlusion rats.Meanwhile,Dex enhanced cell activity and decreased cell apoptosis in oxygen-glucose deprivation human brain microvascular endothelial cells in vitro.These protective effects of Dex were correlated with the mitochondrial morphology integrality of endothelial cells,mediated by increased phosphorylation of serine 637 in Drp1,and could be reversed byα2-adrenergic receptor antagonist Yohimbine and AMP-activated protein kinase inhibitor Compound C.These findings suggest new molecular pathways involved in the neuroprotective effects of Dex in ischemic stroke.As Dex is routinely used as a sedative drug clinically,our findings provide molecular evidence that it has perioperative neuroprotection from ischemic stroke. | Wei Zhou Yunchun Zhang Yingfu Jiao Wen Yin Haiping Dong Saihong Xu Dan Tang Junli Jiang Jianlin Shao Zhenhong Wang Weifeng Yu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 2 |
| 10 | Preparation of micron-size crosslinked microspheres by dispersion copolymerization of polystyrene/2,2′-oxy-bisethanol diacrylate显示文摘 | Jinxia Huang Hongtao Zhang Junli Hou Pingping Jiang | 2002 | Reactive and Functional Polymers2002，，1： | 1 |
| 11 | CEACAM6 induces epithelial-mesenchymal transition and mediates invasionand metastasis in pancreatic cancer显示文摘 | Jianmin Chen Qiang Li Yong An Nan Lv Xiaofeng Xue Jishu Wei Kuirong Jiang Junli Wu Wentao Gao Zhuyin Qian Cuncai Dai Zekuan Xu Yi Miao | 2013 | International Journal of Oncology2013，，3： | 1 |
| 12 | During the acute phase of myo- cardial infarction in the observation and nursing of 显示文摘 | jiang Suying Zhang Junli Zhi Hua | 2012 | Handan Medical College Journal of2012，33，05： | 1 |
| 13 | Spatial scheduling algorithm minimizing makespan at block assembly shop in shipbuilding显示文摘 | ZHENG Junli JIANG Zhibin CHEN Qiang | 2011 | International Journal of Production Research2011，49，23： | 1 |
| 14 | Deregulated MIR 335 that targets MAPK 1 is implicated in poor outcome of paediatric acute lymphoblastic leukaemia显示文摘 | Junli Yan Nan Jiang Gaofeng Huang Jim L.‐S. Tay Baohong Lin Chonglei Bi Grace S. Koh Zhenhua Li Joy Tan Tae‐Hoon Chung Yi Lu Hany Ariffin Shirley K. Y. Kham Allen E. J. Yeoh Wee‐Joo Chng | 2013 | Br J Haematol2013，，1： | 1 |
| 15 | A Hierarchical Connection Graph Algorithm for Gable-roof Detection in Aerial Image显示文摘 | WANG Qiuchen JIANG Zhiguo YANG Junli | 2011 | IEEE Geoscience and Remote Sensing Letters2011，8，1： | 1 |
| 16 | The effect of high-voltage electrostatic field (HVEF) on aged rice ( Oryza sativa L.) seeds vigor and lipid peroxidation of seedlings显示文摘 | Guixue Wang Junli Huang Weina Gao Jiang Lu Jian Li Ruijin Liao Cheruth Abdul Jaleel | 2009 | Journal of Electrostatics2009，，5： | 1 |
| 17 | Reduced graphene oxide-platinum nanoparticles composites based imprinting sensor for sensitively electrochemical analysis of 17β-estradiol显示文摘 | Tingting Wen Cheng Xue Yun Li Yang Wang Ruoyu Wang Junli Hong Xuemin Zhou Huijun Jiang | 2012 | Journal of Electroanalytical Chemistry2012，，： | 1 |
| 18 | Transcriptome and co-expression network analyses provide insights into fruit shading that enhances carotenoid accumulation in pomelo(Citrus grandis)显示文摘Carotenoids are indispensable for human health,and citrus fruit are a crucial source of dietary carotenoids.Bagging,an important orchard practice to enhance fruit economic value,is widely used in many horticultural crops,including citrus fruit.The bagged‘Majiayou’pomelo(Citrus grandis)produces vivid deeper red pulp,a fantastic agronomic trait,but the underlying molecular regulatory mechanism remains largely unexplored.Here,the enhancement of carotenoids,especially lycopene,was confirmed by HPLC analysis of carotenoids in the pulp of bagged fruit and controls.qRT-PCR analysis of the 14 carotenoid pathway genes further revealed that upregulated PSY and downregulated CCD1 expression in bagged fruit could directly enhance the accumulation of carotenoids.In addition,RNA-seq analysis identified 311 differentially expressed genes(DEGs)in the bagged fruit and controls in five developmental stages.Weighted gene co-expression network analysis(WGCNA)identified 13 critical candidate genes among the DEGs,which are closely associated with lycopene accumulation.The underlying regulatory mechanism of these candidate genes on the transcription of carotenoid pathway genes in the bagged fruit was discussed.Considering that the candidate genes were involved in the corresponding metabolic pathways,the increase in sucrose content and decrease in ABA in bagged fruit were also identified,implying that these candidate genes may be indirectly related to carotenoid enhancement in pulp by regulating phytohormones,primary metabolism,and stress responses.The results provide new insights into the potential regulatory mechanism of lycopene enhancement in the pulp of bagged‘Majiayou’pomelo,facilitating breeding and orchard management efforts to improve the nutritional quality and esthetic value of citrus,and perhaps other fruit crops. | Qihang Jiang Junli Ye Kaijie Zhu Fangfang Wu Lijun Chai Qiang Xu Xiuxin Deng | 2022 | Horticultural Plant Journal2022，8，4： | 1 |
| 19 | Genetic Architecture and Functional Implications of the CSF‑Contacting Nucleus显示文摘We previously identified a unique nucleus,the cerebrospinal fluid(CSF)-contacting nucleus.This study aims to understand its gene architecture and preliminarily suggest its functions.The results showed that there were about 19,666 genes in this nucleus,of which 913 were distinct from the dorsal raphe nucleus(non-CSF contacting).The top 40 highly-expressed genes are mainly related to energy metabolism,protein synthesis,transport,secretion,and hydrolysis.The main neurotransmitter is 5-HT.The receptors of 5-HT and GABA are abundant.The channels for Cl–,Na+,K+,and Ca2+are routinely expressed.The signaling molecules associated with the CaMK,JAK,and MAPK pathways were identified accurately.In particular,the channels of transient receptor potential associated with nociceptors and the solute carrier superfamily members associated with cell membrane transport were significantly expressed.The relationship between the main genes of the nucleus and life activities is preliminarily verified. | Siyuan Song Yumin Yuan Lingling Xu Jun Jiang Ying Li Yao Yan Qing Li Fang Zhou Junli Cao Licai Zhang | 2023 | Neuroscience Bulletin2023，39，11： | 1 |
| 20 | Block spatial scheduling modeling and application inshipbuilding显示文摘 | ZHENG Junli JIANG Zhibin | 2012 | International Journal of Production Research2012，50，10： | 1 |
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