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您的检索式：作者名="Bingran Yu"
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| 1 | Thermo-responsive gelatin-functionalized PCL film surfaces for improvement of cell adhesion and intelligent recovery of gene-transfected cells显示文摘Efficient local gene transfection on a tissue scaffold is dependent on good cell-adhesion characteristics. In this work, the thermoresponsive gelatin-functionalized polycaprolactone(PCL) films were proposed for improvement of cell adhesion and intelligent recovery of gene-transfected cells. Functional copolymer brushes(PCL-g-P(NIPAAm-co-MAAS)) were first prepared via surface-initiated ATRP of N-isopropylacrylamide(NIPAAm) and methacrylic acid sodium salt(MAAS) from the initiatorfuncationalized PCL surfaces. The pendant carboxyl end-groups of the PCL-g-P(NIPAAm-co-MAAS) surface were subsequently coupled with gelatin via carbodiimide chemistry to produce the thermo-responsive gelatin-functionalized PCL surface. The thermo-responsive gelatin-functionalized PCL film surface can improve cell adhesion and proliferation above the LCST of P(NIPAAm) without destroying cell detachment properties at lower temperatures. The dense transfected cells can be recovered simply by lowering culture temperature. The thermo-responsive gelatin-functionalized PCL films are potentially useful as intelligent adhesion modifiers for directing cellular functions within tissue scaffolds. | YUAN Wei ZHAO NaNa YU BingRan JIANG Hui MA Jie XU FuJian | 2014 | Science China Chemistry2014，57，4： | 2 |
| 2 | Reduction-responsive nucleic acid nanocarrier-mediated miR-22 inhibition of PI3K/AKT pathway for the treatment of patient-derived tumor xenograft osteosarcoma显示文摘miRNAs are important regulators of gene expression and play key roles in the development of cancer, including osteosarcoma. During the development of osteosarcoma, the expression of miR-22 is significantly downregulated, making miR-22 as a promising therapeutic target against osteosarcoma. To design and fabricate efficient delivery carriers of miR-22 into osteosarcoma cells, a hydroxyl-rich reduction-responsive cationic polymeric nanoparticle, TGIC-CA (TC), was developed in this work, which also enhanced the therapeutic effects of Volasertib on osteosarcoma. TC was prepared by the ring-opening reaction between amino and epoxy groups by one-pot method, which had the good complexing ability with nucleic acids, reduction-responsive degradability and gene transfection performance. TC/miR-22 combined with volasertib could inhibit proliferation, migration and promote apoptosis of osteosarcoma cells in vitro. The anti-tumor mechanisms were revealed as TC/ miR-22 and volasertib could inhibit the PI3K/Akt signaling pathway synergistically. Furthermore, this strategy showed outstanding tumor suppression performance in animal models of orthotopic osteosarcoma, especially in patient-derived chemo-resistant and chemo-intolerant patient-derived xenograft (PDX) models, which reduced the risk of tumor lung metastasis and overcame drug resistance. Therefore, it has great potential for efficient treatment of metastasis and drug resistance of osteosarcoma by the strategy of localized, sustained delivery of miR-22 using the cationic nanocarriers combined with non-traditional chemotherapy drugs. | Dafu Chen Chengyue Lei Weifeng Liu Meiyu Shao Meizhou Sun Jianxun Guo Jingjing Cao Jing-Jun Nie Peng Luo Yuwen Luo Bingran Yu Renxian Wang Shun Duan Fu-Jian Xu | 2023 | Bioactive Materials2023，，10： | 0 |
| 3 | Chemiluminescence:From mechanism to applications in biological imaging and therapy显示文摘Chemiluminescence(CL)is an emission phenomenon induced by chemical reaction.Different from the photoluminescence,CL is free from external excitation source,which is expected to show great advantages such as higher signal-to-background ratio(SBR)in bioimaging,and deeper tissue penetration in photodynamic therapy(PDT).This review introduces the theoretical aspects of CL mechanism,such as classification,energy consideration and chemiexcited/photoexcited states.Application of CL in bioimaging is highlighted.In particular,the approaches to modulate the brightness and the wavelength of CL are summarized,which are two fundamental parameters in bioimaging.Finally,the application of CL in PDT is introduced.The potential challenges and perspectives of CL in bioimaging and therapy are also discussed. | Zhijia Wang Jiaguo Huang Jingsheng Huang Bingran Yu Kanyi Pu Fu-Jian Xu | 2021 | Aggregate2021，2，6： | 0 |
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