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| 1 | Entransy and entropy revisited显示文摘Entransy, a recently developed concept, is the central physical quantity characterizing heat transfer processes not related to heat-to-work conversions. The entransy of an object pertains to the nature of the potential energy of heat in a thermal field and describes its heat transfer ability. In the present study, we revisit this concept, and develop its relationship to state and process quantities. This then enables a direct comparison to the more familiar concept, entropy, the central physical quantity in thermody- namics. The comparison helps to identify the role entransy has in heat transfer processes and highlight under what conditions state and process quantities related to entransy can be distinguished in such processes. As to embody the entransy loss due to work expended between the system and its environment for the irreversible heat conduction in gases, new quantities, available entransy flow and available system entransy are introduced. Both the entransy of solids and the available system entransy of gases are state quantities and their changes correspond to the entransy flow and the available entransy flow respectively. Thus there is no need to stress the difference between process quantity and state quantity in heat transfer. | HU GuoJie CAO BingYang GUO ZengYuan | 2011 | Chinese Science Bulletin2011，56，27： | 13 |
| 2 | Study on thermal wave based on the thermal mass theory显示文摘The conservation equations for heat conduction are established based on the concept of thermal mass.We obtain a general heat conduction law which takes into account the spatial and temporal inertia of thermal mass.The general law introduces a damped thermal wave equation.It reduces to the well-known CV model when the spatial inertia of heat flux and temperature and the temporal inertia of temperature are neglected,which indicates that the CV model only considers the temporal inertia of heat flux.Numerical simulations on the propagation and superposition of thermal waves show that for small thermal perturbation the CV model agrees with the thermal wave equation based on the thermal mass theory.For larger thermal perturbation,however,the physically impossible phenomenon pre-dicted by CV model,i.e.the negative temperature induced by the thermal wave superposition,is eliminated by the general heat conduction law,which demonstrates that the present heat conduction law based on the thermal mass theory is more reasonable. | HU RuiFeng CAO BingYang | 2009 | Science China(Technological Sciences)2009，52，6： | 3 |
| 3 | Combination of magnesium ions and vitamin C alleviates synovitis and osteophyte formation in osteoarthritis of mice显示文摘Introduction:We previously demonstrated that magnesium ions(Mg^(2+))was a novel therapeutic alternative for osteoarthritis(OA)through promoting the hypoxia inducible factor-1α(HIF-1α)-mediated cartilage matrix synthesis.However,oxidative stress can inhibit the expression of HIF-1α,amplify the inflammation that potentially impairs the therapeutic efficacy of Mg^(2+) in OA.Vitamin(VC),a potent antioxidant,may enhance the efficacy of Mg^(2+) in OA treatment.This study aims to investigate the efficacy of combination of Mg^(2+)and VC on alleviating joint destruction and pain in OA.Material and methods:Anterior cruciate ligament transection with partial medial meniscectomy induced mice OA model were randomly received intra-articular injection of either saline,MgCl2(0.5 mol/L),VC(3 mg/ml)or MgCl2(0.5 mol/L)plus VC(3 mg/ml)at week 2 post-operation,twice weekly,for 2 weeks.Joint pain and pathological changes were assessed by gait analysis,histology,western blotting and micro-CT.Results:Mg^(2+) and VC showed additive effects to significantly alleviate the joint destruction and pain.The efficacy of this combined therapy could sustain for 3 months after the last injection.We demonstrated that VC enhanced the promotive effect of Mg^(2+) on HIF-1αexpression in cartilage.Additionally,combination of Mg^(2+) and VC markedly promoted the M2 polarization of macrophages in synovium.Furthermore,combination of Mg^(2+) and VC inhibited osteophyte formation and expressions of pain-related neuropeptides.Conclusions:Intra-articular administration of Mg^(2+)and VC additively alleviates joint destruction and pain in OA.Our current formulation may be a cost-effective alternative treatment for OA. | Hao Yao Jiankun Xu Jiali Wang Yifeng Zhang Nianye Zheng Jiang Yue Jie Mi Lizhen Zheng Bingyang Dai Wenhan Huang Shuhang Yung Peijie Hu Yechun Ruan Qingyun Xue Kiwai Ho Ling Qin | 2021 | Bioactive Materials2021，6，5： | 1 |
| 4 | Tumor-targeted/reduction-triggered composite multifunctional nanoparticles for breast cancer chemo-photothermal combinational therapy显示文摘Breast cancer has become the most commonly diagnosed cancer type in the world.A combination of chemotherapy and photothermal therapy(PTT) has emerged as a promising strategy for breast cancer therapy.However,the intricacy of precise delivery and the ability to initiate drug release in specific tumor sites remains a challenging puzzle.Therefore,to ensure that the therapeutic agents are synchronously delivered to the tumor site for their synergistic effect,a multifunctional nanoparticle system(PCRHNs) is developed,which is grafted onto the prussian blue nanoparticles(PB NPs) by reductionresponsive camptothecin(CPT) prodrug copolymer,and then modified with tumor-targeting peptide cyclo(Asp-D-Phe-Lys-Arg-Gly)(cRGD) and hyaluronic acid(HA).PCRHNs exhibited nano-sized structure with good monodispersity,high load efficiency of CPT,triggered CPT release in response to reduction environment,and excellent photothermal conversion under laser irradiation.Furthermore,PCRHNs can act as a photoacoustic imaging contrast agent-guided PTT.In vivo studies indicate that PCRHNs exhibited excellent bio compatibility,prolonged blood circulation,enhanced tumor accumulation,allow tumor-specific che mo-photo thermal therapy to achieve synergistic antitumor effects with reduced systemic toxicity.Moreover,hyperthermia-induced upregulation of heat shock protein 70 in the tumor cells could be inhibited by CPT.Collectively,PCRHNs may be a promising therapeutic way for breast cancer therapy. | Yun Yang Danrong Hu Yi Lu Bingyang Chu Xinlong He Yu Chen Yao Xiao Chengli Yang Kai Zhou Liping Yuan Zhiyong Qian | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 1 |
| 5 | Recent research progress of master mold manufacturing by nanoimprint technique for the novel microoptics devices显示文摘The consumer demand for emerging technologies such as augmented reality(AR),autopilot,and three-dimensional(3D)internet has rapidly promoted the application of novel optical display devices in innovative industries.However,the micro/nanomanufacturing of high-resolution optical display devices is the primary issue restricting their development.The manufacturing technology of micro/nanostructures,methods of display mechanisms,display materials,and mass production of display devices are major technical obstacles.To comprehensively understand the latest state-of-the-art and trigger new technological breakthroughs,this study reviews the recent research progress of master molds produced using nanoimprint technology for new optical devices,particularly AR glasses,new-generation light-emitting diode car lighting,and naked-eye 3D display mechanisms,and their manufacturing techniques of master molds.The focus is on the relationships among the manufacturing process,microstructure,and display of a new optical device.Nanoimprint master molds are reviewed for the manufacturing and application of new optical devices,and the challenges and prospects of the new optical device diffraction grating nanoimprint technology are discussed. | Yuhang LIU Jianjun LIN Zuohuan HU Guoli GAO Bingyang WANG Liuyi WANG Zhiyuan PAN Jianfei JIA Qinwei YIN Dengji GUO Xujin WANG | 2022 | Frontiers of Materials Science2022，16，3： | 0 |
| 6 | Macrophage Membrane-Camouflaged shRNA and Doxorubicin:A pH-Dependent Release System for Melanoma Chemo-Immunotherapy显示文摘mproving the eficacy of melanoma treatment remains an important global challenge.Here,we combined chemotherapy with protein tyrosine phosphatase nonreceptor type 2(Ptpn2)based immunotherapy in an effort to address this challenge.Shorthairpin RNA(shRNA)targeting Ptpn2 was coencapsulated with doxorubicin(DOX)in the cell membrane of MI macrophages(MIHD@RPR).The prepared nanoparticles(NPs)were effectively phagocytosed by B16F10 cells and MI macrophages,but not by MOmacrophages.Hence,NPevasion from the reticuloendothelial system(RES)was improved and NPenrichment in tumor sites increased.MIHD@RPR can directly kill tumor cells and stimulate immunogenic cell death(ICD)by DOX and downregulate Ptpn2.It can promote Ml macrophage polarization and dendritic cell maturation and increase the proportion of CD8+T cells.MIHD@RPR killed and inhibited the growth of primary melanoma and lung metastatic tumor celis without harming the surrounding tssue.These findings establish MIHD@RPR as a safe multifunctional nanoparticle capable of effectively combining chemotherapy and gene immunotherapies against melanoma. | Chengli Yang Yang Ming Kai Zhou Ying Hao Danrong Hu Bingyang Chu Xinlong He Yun Yang Zhiyong Qian | 2022 | Research2022，，2： | 0 |
| 7 | Rendering discrete participating media using geometrical optics approximation显示文摘We consider the scattering of light in participating media composed of sparsely and randomly distributed discrete particles.The particle size is expected to range from the scale of the wavelength to several orders of magnitude greater,resulting in an appearance with distinct graininess as opposed to the smooth appearance of continuous media.One fundamental issue in the physically-based synthesis of such appearance is to determine the necessary optical properties in every local region.Since these properties vary spatially,we resort to geometrical optics approximation(GOA),a highly efficient alternative to rigorous Lorenz–Mie theory,to quantitatively represent the scattering of a single particle.This enables us to quickly compute bulk optical properties for any particle size distribution.We then use a practical Monte Carlo rendering solution to solve energy transfer in the discrete participating media.Our proposed framework is the first to simulate a wide range of discrete participating media with different levels of graininess,converging to the continuous media case as the particle concentration increases. | Jie Guo Bingyang Hu Yanjun Chen Yuanqi Li Yanwen Guo Ling-Qi Yan | 2022 | Computational Visual Media2022，8，3： | 0 |
| 8 | Million-scale data integrated deep neural network for phonon properties of heuslers spanning the periodic table显示文摘Existing machine learning potentials for predicting phonon properties of crystals are typically limited on a material-to-materialbasis, primarily due to the exponential scaling of model complexity with the number of atomic species. We address this bottleneckwith the developed Elemental Spatial Density Neural Network Force Field, namely Elemental-SDNNFF. The effectiveness andprecision of our Elemental-SDNNFF approach are demonstrated on 11,866 full, half, and quaternary Heusler structures spanning 55elements in the periodic table by prediction of complete phonon properties. Self-improvement schemes including active learningand data augmentation techniques provide an abundant 9.4 million atomic data for training. Deep insight into predicted ultralowlattice thermal conductivity (<1 Wm^(−1) K^(−1)) of 774 Heusler structures is gained by p–d orbital hybridization analysis. Additionally, aclass of two-band charge-2 Weyl points, referred to as “double Weyl points”, are found in 68% and 87% of 1662 half and 1550quaternary Heuslers, respectively. | Alejandro Rodriguez Changpeng Lin Hongao Yang Mohammed Al-Fahdi Chen Shen Kamal Choudhary Yong Zhao Jianjun Hu Bingyang Cao Hongbin Zhang Ming Hu | 2023 | npj Computational Materials2023，，1： | 0 |
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