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| 1 | A functional polymorphism in Pre‐miR‐146a gene is associated with prostate cancer risk and mature miR‐146a expression in vivo显示文摘 | BinXu Ning‐HanFeng Peng‐ChaoLi JunTao DeyaoWu Zheng‐DongZhang NaTong Jin‐FengWang Ning‐HongSong WeiZhang Li‐XinHua Hong‐FeiWu | 2010 | Prostate2010，，5： | 1 |
| 2 | The contribution of different polyphenol compositions from chokeberry produced in China to cellular antioxidant and antiproliferative activities显示文摘Abundant polyphenols make chokeberry have beneficial antioxidant and antiproliferative activity. In order to explore the contribution of different polyphenols in chokeberry to these activities, this study was conducted to determine polyphenol composition from 7 chokeberry varieties produced in China. Totally, 11 kinds of main polyphenol monomers were identified and quantified by UPLC-Q-TOF-MS and UPLC-PDA. HepG2 cells were used to evaluate their cellular antioxidant and antiproliferative activities. Partial least squares method was utilized to analyze multivariate correlations between proportion of different composition and monomers in total polyphenols with these activities. The results showed that the highest proportion in chokeberry polyphenols was proanthocyanidins. In comparing the bioactivities of 7 varieties of chokeberry, ‘Viking' and purple chokeberry had the strongest antioxidant activity, while 'Fukangyuan 1#' had the strongest antiproliferative activity. In terms of the contribution sources of these bioactivities, the total antioxidant activity of chokeberry mainly depended on the contribution of free polyphenols. As the main source of cellular antioxidant activity, anthocyanins and neochlorogenic acid can provide more contribution. The antiproliferative activity mainly depended on the proportion of free polyphenols and proanthocyanidins in total polyphenols. The results may provide some new possibilities for the comprehensive utilization of polyphenols from chokeberry. | Ningxuan Gao Xu Si Wenzhong Han Ersheng Gong Chi Shu Jinlong Tian Yuehua Wang Jiyue Zhang Binxu Li Bin Li | 2023 | Food Science and Human Wellness2023，12，5： | 0 |
| 3 | High-resolution single-cell analysis paves the cellular path for brain regeneration in salamanders显示文摘Salamanders are excellent models for studying vertebrate brain regeneration,with the promise of developing novel therapies for human brain lesions.Yet the molecular and cellular mechanism of salamander brain regeneration remains largely elusive.The insight into the evolution of complex brain structures that lead to advanced functions in the mammalian brain is also inadequate.With high-resolution single-cell RNA sequencing and spatial transcriptomics,three recent studies have reported the differentiation paths of cells in the salamander telencephalon in the journal Science,bringing both old and new cell types into the focus and shedding light on vertebrate brain evolution,devel-opment,and regeneration. | Binxu Yin Xinyun Li Gufa Lin Heng Wang | 2022 | Cell Regeneration2022，11，1： | 0 |
| 4 | Modification Mechanism and Uniaxial Fatigue Performances of A356.2 Alloy Treated by Al-Sr-La Composite Refinement-Modification Agent显示文摘Modification mechanism and uniaxial fatigue properties of A356.2 alloy treated by Al-6Sr-7La and traditional Al-5Ti-1B/Al-10Sr(hereinafter refers to traditional treated alloy) were investigated by constant stress amplitude method. Microstructure, dislocation and Si twinning of the alloys were studied by thermal analysis, scanning electron microscopy(SEM) and transmission electron microscopy(TEM). The results showed that Al-6Sr-7La possesses better refining and modification effect than Al-5Ti-1B/Al-10Sr. Meanwhile, fatigue properties of the alloy treated by Al-6Sr-7La are higher than traditional treated alloy, and this is mainly owing to that Al-6Sr-7La treated alloy has more twins in eutectic Si and lower twin spacing. In addition, higher density of nanophases formed on twin faces and La-rich clusters appear at multiple twin intersections. Stacking faults and entrapped nanophases appeared on growing Si twin faces. Impurity induced twinning(IIT) mechanism and twin plane re-entrant edge(TPRE) mechanism are valid for eutectic Si which are important for mechanical optimization of A356.2 alloy. | Liang Chang Qingfeng Zhao Xingchuan Xia Yuming Ding Binxu Guo Jian Ding Ying Tang Zan Zhang Chong Li Xiaomian Sun Junjie Guo Kaihong Song Yongchang Liu | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，6： | 0 |
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