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您的检索式：作者名="Biqing Yang"
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| 1 | Transferrin plays a central role in coagulation balance by interacting with clotting factors显示文摘Coagulation balance is maintained through fine-tuned interactions among clotting factors,whose physiological concentrations vary substantially.In particular,the concentrations of coagulation proteases(pM to nM)are much lower than their natural inactivator antithrombin(AT,〜3μM),suggesting the existence of other coordinators.In the current study,we found that transferrin(norm plasma concentration〜40 μM)interacts with fibrinogen,thrombin,factor Xlla(FXlla),and AT with different affinity to maintain coagulation balance.Normally,transferrin is sequestered by binding with fibrinogen(normal plasma concentration〜10 μM)at a molar ratio of 4:1.In atherosclerosis,abnormally up-regulated transferrin interacts with and potentiates thrombin/FXlla and blocks ATs inactivation effect on coagulation proteases by binding to AT,thus inducing hypercoagulability.In the mouse model,transferrin overexpression aggravated atherosclerosis,whereas transferrin inhibition via shRNA knockdown or treatment with antitransferrin antibody or designed peptides interfering with transferrin-thrombin/FXlla interactions alleviated atherosclerosis.Collectively,these findings identify that transferrin is an important clotting regulator and an adjuster in the maintenance of coagulation balance and modifies the coagulation cascade. | Xiaopeng Tang Zhiye Zhang Mingqian Fang Yajun Han Gan Wang Sheng Wang Min Xue Yaxiong Li Li Zhang Jian Wu Biqing Yang James Mwangi Qiumin Lu Xiaoping Du Ren Lai | 2020 | Cell Research2020，30，2： | 2 |
| 2 | Experimental Study of Mode-I and Mode-II Interlaminar Fracture Characteristics of Poplar LVL显示文摘Fracture is a common failure form of poplar laminated veneer lumber(LVL).In the present work,we performed an experimental study on the mode-I along-grain interlaminar fracture,mode-I cross-grain interlaminar fracture,and mode-II interlaminar fracture of poplar LVL.We investigated stress mechanisms,failure modes,and fracture toughness values of the different fracture types.The experimental results revealed that the crack in the mode-I along-grain interlaminar fracture specimen propagated along the prefabricated crack direction,and the crack tip broke.The mode-I cross-grain interlaminar fracture specimen had cracks in the vertical direction near the prefabricated crack.In the mode-II interlaminar fracture specimen,cracks appeared along the initial prefabricated crack direction.The load–displacement curves of these three specimens were linear in the early stage of loading.With the increase in the load,a nonlinear segment appeared before crack propagation and a descending segment appeared after crack propagation.The nonlinear segments of the mode-I along-grain interlaminar fracture and mode-II interlaminar fracture were very short,and cracks expanded quickly after their initiation,resulting in brit-tle fracture.The nonlinear segment of the mode-I cross-grain interlaminar fracture was long,resulting in plastic failure.The average toughness values of the mode-I along-grain interlaminar fracture,mode-I cross-grain inter-laminar fracture,and mode-II interlaminar fracture were 15.43,270.15,and 39.72 MPa·mm^(1/2),respectively. | Zhongping Xiao Chen Li Biqing Shu Shukai Tang Xinghuan Yang Yan Liu | 2023 | Journal of Renewable Materials2023，11，1： | 0 |
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