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| 1 | Comparison of multichannel intraluminal impedance-pH monitoring and reflux scintigraphy in pediatric patients with suspected gastroesophageal reflux显示文摘AIM To evaluate the agreement of multichannel intraluminal impedance-p H monitoring(MII-p HM) and gastroesophageal reflux scintigraphy(GES) for the diagnosis of gastroesophageal reflux disease. METHODS Seventy-five consecutive patients with suspectedgastroesophageal reflux disease(GERD) underwent 24-h combined MII-p HM recording and one hour radionuclide scintigraphy during the course of the MIIpH M study. Catheters with 6 impedance channels and 1 p H sensor were placed transnasally. Impedance and p H data analysis were performed automatically and manually. For impedance monitoring, reflux was defined as a retrograde 50% drop in impedance, starting distally and propagating retrogradely to at least the next two more proximal measuring channels. Reflux index(RI, percentage of the entire record that esophageal p H is < 4.0) greater than 4.2% for p HM and number of refluxes more than 50 for 24 h for MII were accepted as positive test results. At scintigraphy, 240 frames of 15 seconds duration were acquired in the supine position. Gastroesophageal reflux was defined as at least one reflux episode in the esophagus. After scintigraphic evaluation, impedance-pH recordings and scintigraphic images were evaluated together and agreement between tests were evaluated with Cohen's kappa.RESULTS Sufficient data was obtained from 60(80%) patients(34 male, 56.7%) with a mean age of 8.7 ± 3.7 years(range: 2.5-17.3 years; median: 8.5 years). Chronic cough, nausea, regurgitation and vomiting were the most frequent symptoms. The mean time for recording of MII-pH M was 22.8 ± 2.4 h(range: 16-30 h; median: 22.7 h). At least one test was positive in 57(95%) patients. According to diagnostic criteria, GERD was diagnosed in 34(57.7%), 44(73.3%), 47(78.3%) and 51(85%) patients by means of p HM, MII, GES and MII-p HM, respectively. The observed percentage agreements/κ values for GES and p HM, GES and MII, GES and MII-p HM, and MII and p HM are 48.3%/-0.118; 61.7%/-0.042; 73.3%/0.116 and 60%/0.147, respectively. There was no or slight agreement between GES and p HM alone, MII alone or MII-p HM. p H monitoring alone missed 17 patients compared to combined MII-p HM. The addition of MII to pH monitoring increased the diagnosis rate by 50%.CONCLUSION No or slight agreement was found among p H monitoring, MII monitoring, MII-pH monitoring and GES for the diagnosis of gastroesophageal reflux disease. | Nuray Uslu Kizilkan Murat Fani Bozkurt Inci Nur Saltik Temizel Hülya Demir Aysel Yüce Biray Caner Hasan Ozen | 2016 | World Journal of Gastroenterology2016，22，43： | 2 |
| 2 | Technitium-^99m-MIBI uptake in benign and malignant bone lesions: a comparative study with technefium-^99m-MDP显示文摘 | Biray Caner Mehment K Mustafa U | 1992 | J Nucl Med1992，33，3： | 1 |
| 3 | The relationship of the apolipoprotein E gene polymorphism Turkish Type 2 diabetic patients with and without nephropathy显示文摘 | Erdogan M Eroglu Z Biray C | 2009 | J Endocrinollnvest2009，32，3： | 1 |
| 4 | Effects of Manisa propo- lis on tehmwrase activity in leukemia cells obtained i)'om the bone marrow of leukemia patients 显示文摘 | COGULU O BIRAY C GUNDUZ C | 2009 | Int J Food Sci Nutr2009，60，7： | 1 |
| 5 | Evaluation of Manisa propolis effect on leukemia cell line by telomerase activity显示文摘 | GUNDUZ C BIRAY C KOXOVA B | 2005 | Leukemia2005，29，11： | 1 |
| 6 | The relation of adiponectin and tumor necrosis factor alpha levels between endothelial nitric oxide synthase angiotensin-converting enzyme, transforming growth factor beta, and tumor necrosis factor alpha gene polymorphism in adrenal incidentalomas 显示文摘 | Harman E Karadeniz M Biray C | 2009 | Endocrinol Invest2009，32，11： | 1 |
| 7 | The relationship of the apolipoprotein E gene polymorphism Turkish type 2 diabetic patients with and without nephropathy显示文摘 | Erdogan M Eroglu Z Biray C | 2009 | J Endocrinol Invest2009，32，3： | 1 |
| 8 | STAT pathway in the regulation of zoledronic acid-induced apoptosis in chronic myeloid leukemia cells显示文摘 | Hatice Demet Kiper Burcin Tezcanli Aysun Adan Gokbulut Nur Selvi Cigir Biray Avci Buket Kosova Guniz Iskender Cumhur Gunduz Fahri Sahin Yusuf Baran Guray Saydam | 2013 | Biomedicine & Pharmacotherapy2013，，： | 1 |
| 9 | Effects of Manisa propolis on telomerase activity in leukemia cells obtained from the bone marrow of leukemia patients 显示文摘 | Cogulu O Biray C Gunduz C | 2009 | Int J Food Sei Nutr2009，60，7： | 1 |
| 10 | Comparison of99mTc(V)-DMSA,201Tl and99mTc-MIBI imaging in the follow-up of patients with medullary carcinoma of the thyroid显示文摘 | ?mer U?ur Lale Kostako?lu Nilüter Güler Biray Caner U?ur Uysal Nazenin Elahi Mithat Haflo?lu Do?angün Yüksel Tülin Aras Hikmet Bayhan Co?kun Bekdik | 1996 | European Journal of Nuclear Medicine1996，，10： | 1 |
| 11 | The relation- ship of the apolipoprotein E gene polymorphism turkish type 2 diabetic patients with and without nephropathy 显示文摘 | ERDOGAN M EROGLU Z BIRAY C | 2009 | J Endocrinol Invest2009，32，3： | 1 |
| 12 | Combined use of bone and bone marrow scintigraphies for the diagnosis of ac-tive sacroiliitis:A new approach显示文摘 | MURAT FB IHSAN ERTEN BIRAY CANER | 2001 | Annals of Nuclear Medicine2001，15，2： | 1 |
| 13 | Evaluation of Manisa propolis effect on leukemia cell line by telomerase activity显示文摘 | Gunduz C Biray C Kosova B | 2005 | Leukemia2005，29，11： | 1 |
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