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| 1 | Increased oxidative damage of sperm and seminal plasma in men with idiopathic infertility is higher in patients with glutathione S-transferase Mu-1 null genotype显示文摘瞄准:检验一种关系是否与自发的不孕从病人在 glutathioneS-transferase Mu-1 (GSTM1 ) 基因多型性和精子和精液的血浆的危险性之间存在到氧化应力。方法:有自发的不孕的 52 个人和 60 个健康的肥沃的人被招募到这研究。GSTM1 基因多型性被聚合酶链反应(PCR ) 和两个决定不肥沃并且我们根据他们的 GSTM1 基因再划分进空的 GSTM1 和 GSTM1 积极的组的控制个人组织。Wecompared 反应的氧种类(ROS ) 产生, malondialdehyde (MDA ) ,蛋白质羰基和谷胱甘肽(GSH ) 集中,和在从关于 GSTM1 遗传型的不肥沃的病人和控制的精液的血浆和精子的谷胱甘肽 S-transferase (GST ) 活动。结果: 显著地,氧化应力和损坏标记的高水平与 GSTM1 积极遗传型与那些相比与 GSTM1 空遗传型在自发的不肥沃的人被发现。在为在自发的不肥沃的题目和肥沃的题目之间的 GSTM1 变体的遗传型分发没有重要差别。有 GSTM1 空遗传型的病人也与 GSTM1 积极遗传型比那些有更低的精子集中。结论:我们的结果建议到氧化应力的精子和精液的血浆的危险性与拥有基因的那些相比在有 GSTM1 空遗传型的自发的不肥沃的人是显著地更大的。因此,在有自发的不孕的病人,, GSTM1 多型性可能是在到氧化损坏的精子的危险性的变化的重要来源。 | Birsen Aydemir Ilhan Onaran Ali R. Kiziler Bulent Alici Mehmet C. Akyolcu | 2007 | Asian Journal of Andrology2007，9，1： | 7 |
| 2 | A PURCHASING DECISION: SELECTING A SUPPLIER FOR A CONSTRUCTION COMPANY显示文摘Supplier selection is one of the most crucial activities performed by organizations because of its strategic importance. Supplier selection is a multi-objective problem involving both quantitative and qualitative criteria. Over the years a number of quantitative approaches have been tried. Although the Analytic Hierarchy Process (AHP) has previously been used in supplier selection problems, one major weakness of the application-oriented AHP literature is that it tends to focus on the mechanics of AHP instead of on the theoretical and practical implications associated with finding a solution. Though it is one of the most extensively used Multiple Criteria Decision Analysis methodologies, our literature search indicated that most studies found the best solution and stopped there, ignoring sensitivity analysis. Performing sensitivity analysis is very important for practical decision making, sometimes even as important as finding the best solution. In this paper for the first time a comprehensive application of AHP for a real-world case is presented along with sensitivity analysis in choosing the best suppliers for a Turkish construction company. As a result of this study the company decided to allocate the order quantities between the two top suppliers. | Ozden BAYAZIT Birsen KARPAK Ayhan YAGCI | 2006 | Journal of Systems Science and Systems Engineering2006，15，2： | 3 |
| 3 | Serum levels of hepatoprotective peptide adiponectin in non-alcoholic fatty liver disease显示文摘 | Cem Aygun Omer Senturk Saadettin Hulagu Suleyman Uraz Altay Celebi Tolga Konduk Birsen Mutlu Zeynep Canturk | 2006 | European Journal of Gastroenterology & Hepatology2006，，2： | 2 |
| 4 | Lactic acid bacteria as pro-technological,bioprotective and health-promoting cultures in the dairy food industry显示文摘Lactic acid bacteria (LAB) constitute pivotal microorganisms for the food industry due to their considerable technological and functional potential.Fermented dairy products,that is ancient traditions worldwide,still have been accepted and consumed today for their nutritional and organoleptic attributes.In accordance with the current trends in the market and greater awareness of consumer well-being,a detailed assessment of the health effects of dairy product consumption has been undertaken with particular reference to the production of bioactive metabolites including i.e.,γ-aminobutyric acid,conjugated linoleic acid,bioactive peptides,exopolysaccharides as well as vitamins during LAB fermentation.The long histories of yogurt,kefir,and traditional fermented milk drink as sources of some certain probiotic bacteria as well as the opportunity to bio-fortify the matrix with bioactive microbial compounds in situ make fermented dairy products an attractive model in the efforts to develop sustainable functional food systems.Therefore,this review provides the main biochemical characteristics and biotechnological application of LAB as pro-technological,bioprotective,and health-promoting in the food chain. | Duygu Ağagündüz Teslime Özge Şahin Şerife Ayten Birsen Yılmaz Bartu Eren Güneşliol Pasquale Russo Giuseppe Spano Fatih Özogul | 2022 | Food Bioscience2022，47，3： | 2 |
| 5 | Oxidative stress in portal hypertension-induced rats with particular emphasis on nitric oxide and trace metals显示文摘AIM: To investigate the oxidative-stress-related changes in rats with portal hypertension with particular emphasis on nitric oxide (NO) and trace metals. METHODS: Cirrhosis was induced by partial portal vein ligation (PVL) in Wistar rats. The lipid peroxidation marker (malondialdehyde, MDA), antioxidant defense enzymes including superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and agents known to have antioxidant features including nitric oxide (NO), zinc (Zn), copper (Cu) were determined both in serum and in liver tissue at 4 wk after surgery in PVL and sham-operated rats. Portal pressure of all experimental animals was measured. MDA was detected by thiobarbituric acid reactivity assay.SOD activity was determined by inhibition of nitroblue tetrazolium reduction with xanthine/xanthine oxidase used asa superoxide generator. CAT activity was determined by the breakdown of hydrogen peroxide. GSH concentrations were measured by using metaphosphoric acid for protein precipitation and 5'-5'-dithio-bis-2-nitrobenzoic acid for color development. NO was detected by the Griess method after reduction of nitrate to nitrite with nitrate reductase, and the concentrations of Zn and Cu were measured by a Shimadzu 680 AA atomic absorption spectrometer. Histopathological confirmation was done under light microscope. Statistical analyses were done by Student's t-test, and significance of the difference was tested by the unpaired Mann-Whitney test. P<0.05 was considered statistically significant.RESULTS: Histopathological studies confirmed PVL induced cirrhotic changes. There was a statistically significant difference in portal pressure between PVL and control groups (P<0.001). The results showed significant increases in the levels of MDA and NO in both tissue and serum (P<0.05 and P<0.001, respectively in tissue; P<0.001 for each in serum), and Zn only in tissue (P<0.001)in rats with PVL compared with sham-operated rats. Besides, PVL rats exhibited reduced plasma and tissue GSH, CAT, SOD (P<0.001 for each). Serum and tissue Cu concentration did not change.CONCLUSION: Our findings suggest that PVL in rats induces important biochemical and molecular changes related to oxidative stress in the liver. | Titiz Izzet Krand Osman Unal Ethem Yavuz Nihat Kusaslan Ramazan Dogan Mustafa Uzun Hafize Kiziler Ali Riza Aydemir Birsen Genc Habibe Aydin Seval Simsek Gonul | 2005 | World Journal of Gastroenterology2005，11，23： | 1 |
| 6 | An analytical network process-based framework for successful total quality management (TQM) : An assessment of turkish manufacturing industry readiness显示文摘 | Ozden B Birsen K | 2007 | International Journal of Production Economics2007，105，1： | 1 |
| 7 | Initial experience with a new articulating energy device for laparoscopic liver resection显示文摘 | Eren Berber Muhammet Akyuz Federico Aucejo Shamil Aliyev Erol Aksoy Onur Birsen Eren Taskin | 2014 | Surgical Endoscopy2014，，3： | 1 |
| 8 | A grape ASR protein involved in sugar and abscisic acid signaling显示文摘 | BIRSEN C ALICE A CECILE G | 2003 | The Plant Cell2003，15，9： | 1 |
| 9 | Kasuganti,Purchasing materials in the supply chain:managing a multi-objective task显示文摘 | Erdogan Kumcu Rammohan R | 2001 | European Journal of Puchasing & Supply Management2001，7，： | 1 |
| 10 | Recent developments in dairy kefir-derived lactic acid bacteria and their health benefits显示文摘Kefir is one of the most consumed traditional fermented dairy products and it has a complex probiotic and nutritional composition.Kefir grain contains casein and other milk solids together with the yeasts and lactobacilli that cause the characteristic kefir fermentation and serve as a starter to induce this fermentation when introduced into fresh milk.Both kefir and kefir grains have a rich microbiota and their composition is affected by many parameters like kefir origin,production method(artisanal or industrial),kefir grain:milk ratio,type of milk,fermentation conditions,inoculum source,equipment used in production and storage conditions.Lactic acid bacteria(LAB)are a significant part of the kefir’s microbial composition and the health-promoting effects.Kefir-derived LAB have beneficial effects on colorectal cancer,cardiovascular diseases,type 2 diabetes mellitus,obesity,kidney diseases,modulation of the immune system as well as intestinal microbiota through different biological mechanisms.In addition,bioactive peptides and metabolic products of kefir have shown promising results as health beneficial components along with certain antiviral effects including COVID-19.Therefore,this article is up-to-date information about the production,processing as well as health benefits of dairy kefir-derived LAB with future prospect of work. | Birsen Yilmaz Heena Sharma Ebru Melekoglu Fatih Ozogul | 2022 | Food Bioscience2022，46，2： | 1 |
| 11 | Flavin conlai- ning monooxygenase 3 genetic polymorphisms Glu158Lys and Glu308Gly and their relation to isehemie stroke 显示文摘 | Aysun Ttirkano~lu i~z~ elik Birsen Can Demirdi~en | 2013 | Gene2013，521，： | 1 |
| 12 | Preconcentration copper ion in aqueous phase on methacrylate polymers 显示文摘 | Birsen D-O Gulciz G Aysegul O-K | 1996 | J Appl Polym Sci1996，62，： | 1 |
| 13 | An analytical network process-based framework for successful total quality management (TQM) :An assessment of Turkish manufacturing industry readiness显示文摘 | Ozden Bayazit Birsen Karpak | 2007 | International Journal of Production Economics2007，105，1： | 1 |
| 14 | The Possible Usage of Ex-ADU Uranium Dioxide Fuel Pellets With Low-temperature Sintering显示文摘 | Birsen A Nezihi BA | 2000 | Journal of Nuclear Materials2000，280，： | 1 |
| 15 | Risky anatomic variations of sphenoid sinus for surgery显示文摘 | Birsen Unal Gulsah Bademci Yasemin K. Bilgili Funda Batay Emel Avci | 2006 | Surgical and Radiologic Anatomy2006，，2： | 1 |
| 16 | Adsorptive remo- val of methylene blue from simulated dyeing wastewater with melamine-formaldehyde-urea resin显示文摘 | Ayca Ozdemir F Birsen Demirata | 2009 | J Appl Polym Sci2009，112，6： | 1 |
| 17 | Multi-ob- jective decision-making in supplier selection: an application of visual interactive goal programming显示文摘 | BIRSEN K RAMMOHAN R K ERD(X ANK | 1999 | Journal of Allied Business Research1999，15，2： | 1 |
| 18 | Statistical pattern analysis of partial discharge mea- surements of quality assessment of insulation systems in high- voltage electrical machinery显示文摘 | BIRSEN Y | 2004 | IEEE Transactions on Industry Applications2004，40，6： | 1 |
| 19 | Purchasing materials in the supply chain: managing a multi -objective task 显示文摘 | Birsen Karpark Erdogan Ranmohan R Kasuganti | 2001 | European Journal of Purchasing & Supply Management2001，，7： | 1 |
| 20 | Simultaneous Speetrophotometric Determination of Cyanide and Thiocyanate After Separation on a Melamine-Formaldehyde Resin显示文摘 | Gulein G Birsen D Resat A | 2000 | Talanta2000，53，2： | 1 |
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