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| 1 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 2 | Transcranial direct current stimulation in psychiatric disorders显示文摘The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry. | Gabriel Tortella Roberta Casati Luana V M Aparicio Antonio Mantovani Natasha Senco Giordano D’Urso Jerome Brunelin Fabiana Guarienti Priscila Mara Lorencini Selingardi Débora Muszkat Bernardo de Sampaio Pereira Junior Leandro Valiengo Adriano H Moffa Marcel Simis Lucas Borrione André R Brunoni | 2015 | World Journal of Psychiatry2015，5，1： | 6 |
| 3 | Reliability tests of pulse width modulation(PWM)valves for flow rate control of anhydrous ammonia显示文摘 | Bora G C Schrock M D Oard D L | 2005 | Applied Engineering in Agriculture2005，21，6： | 1 |
| 4 | 显示文摘 | Grachev S Boras D M Vongtragool S | 2001 | Surf Sci2001，，： | 1 |
| 5 | Development of a precast concrete shear - wall system requiring special code acceptance 显示文摘 | Bora C Oliva M G Nakaki S D | 2007 | PCI journal2007，52，1： | 1 |
| 6 | Acute hepatic failure in a patient with hyperthyroidism and virus B hepatitis:recovery after plasmapheresis and thyroidectomy-a case report显示文摘 | Débora VS Luiz TN Márcia CB | 2008 | Arq Bras Endocrinol Metab2008，52，3： | 1 |
| 7 | Electrostatic pickup rejection in low plasma current measurement 显示文摘 | Paul M K Chattopadhyay P K Bora D | 2007 | Measurement Science and Technology2007，18，： | 1 |
| 8 | Influence of locoregional radiation treatment on tumor necrosis factor-αand interleukin-6 in the serum of patients with head and neck cancer显示文摘 | Akmansu M Unsal D Bora H | 2005 | Cytokine2005，31，1： | 1 |
| 9 | Biostimulation of anaerobic BTEX biodegradation under fermentative methanogenic conditions at source-zone groundwater contaminated with a biodiesel blend (B20)显示文摘 | Débora Toledo Ramos Márcio Luis Busi Silva Helen Simone Chiaranda Pedro J. J. Alvarez Henry Xavier Corseuil | 2013 | Biodegradation2013，，3： | 1 |
| 10 | Kinetics of cytokine pro- duction in experimental autoimmune anterior uveitis (EAAU) 显示文摘 | WOON M D KAPLAN H J BORA N S | 1998 | Curr Eye Res1998，17，： | 1 |
| 11 | Comprehensive two-dimensional gas chromatography with time of flight mass spectrometry applied to biomarker analysis of oils from Colombia显示文摘 | Raphael S.F. Silva Hélen G.M. Aguiar Mário D. Rangel Débora A. Azevedo Francisco R. Aquino Neto | 2011 | Fuel2011，，8： | 1 |
| 12 | Characterization of organic matter from composting of different residues by physicochemical and spectroscopic methods显示文摘 | Lucimar L F Wilson T L Débora M B P | 2010 | Bioresource Technology2010，101，6： | 1 |
| 13 | A closed chest pig model of sustained ventricular tachycardia 显示文摘 | Ohad D BorA | 1994 | PACE1994，17，： | 1 |
| 14 | Multiscale roughness and modeling of MEMS interfaces显示文摘 | Bora C K Flater E E Street M D | 2005 | Tribology Letters2005，19，1： | 1 |
| 15 | Development of a precast concrete shear-wall system requiring special code acceptance 显示文摘 | Bora C Oliva M G Nakaki S D | 2007 | PCI Journal2007，52，1： | 1 |
| 16 | Efficacy of Heatsynch protocol for induction of estrus, synchronization of ovulation and timed artificial insemination in yaks (Poephagus grunniens L) 显示文摘 | Sarkar M Sengupta D H Bora B D | 2008 | Anita Reprod Sci2008，104，24： | 1 |
| 17 | Results of chemoirradiation after curative resection of locally advanced gastric cancer显示文摘 | Bora H Unsal D Akmansu M | 2004 | Int J Clin Pract2004，58，5： | 1 |
| 18 | Total carbon measurement in whole tropical soil sample 显示文摘 | da Silva R M Milori D bora M B P Ferreira E C | 2008 | Spectrochimica Acta Part B2008，63，10： | 1 |
| 19 | Neurobiological markers of illness onset in psychosis and schizophrenia:the search for a moving target显示文摘 | Pantelis C Y ü cel M Bora E Fornito A Testa R Brewer W J Velakoulis D Wood SJ | | 0，，3： | 1 |
| 20 | Results of chemoirradiation after curative resection of locally advanced gastric cancer显示文摘 | Bora H Unsal D Akmansu M | | 0，，： | 1 |
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