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| 1 | Toward a better understanding of microbiologically influenced corrosion caused by sulfate reducing bacteria显示文摘Sulfate reducing bacteria(SRB) are often the culprits of microbiologically influenced corrosion(MIC) in anoxic environments because sulfate is a ubiquitous oxidant. MIC of carbon steel caused by SRB is the most intensively investigated topic in MIC because of its practical importance. It is also because biogenic sulfides complicate mechanistic SRB MIC studies, making SRB MIC of carbon steel is a long-lasting topic that has generated considerable confusions. It is expedient to think that biogenic H_2S secreted by SRB acidifies the broth because it is an acid gas. However, this is not true because endogenous H_2S gets its H^+ from organic carbon oxidation and the fluid itself in the first place rather than an external source. Many people believe that biogenic H_2S is responsible for SRB MIC of carbon steel. However, in recent years,well designed mechanistic studies provided evidence that contradicts this misconception. Experimental data have shown that cathodic electron harvest by an SRB biofilm from elemental iron via extracellular electron transfer(EET) for energy production by SRB is the primary cause. It has been demonstrated that when a mature SRB biofilm is subjected to carbon source starvation, it switches to elemental iron as an electron source and becomes more corrosive. It is anticipated that manipulations of EET related genes will provide genetic-level evidence to support the biocathode theory in the future. This kind of new advances will likely lead to new gene probes or transcriptomics tools for detecting corrosive SRB strains that possess high EET capabilities. | Tingyue Gu Ru Jia Tuba Unsal Dake Xu | 2019 | Journal of Materials Science & Technology2019，35，4： | 28 |
| 2 | Leptin treatment ameliorates acute lung injury in rats with cerulein-induced acute pancreatitis显示文摘AIM:To determine the effect of exogenous leptin on acute lung injury (ALI) in cerulein-induced acute pancreatitis (AP). METHODS:Forty-eight rats were randomly divided into 3 groups. AP was induced by intraperitoneal (i.p.) injection of cerulein (50 μg/kg) four times,at 1 h intervals. The rats received a single i.p. injection of 10 μg/kg leptin (leptin group) or 2 mL saline (AP group) after cerulein injections. In the sham group,animals were given a single i.p. injection of 2 mL saline. Experimental samples were collected for biochemical and histological evaluations at 24 h and 48 h after the induction of AP or saline administration. Blood samples were obtained for the determination of amylase,lipase,tumor necrosis factor (TNF)-a,interleukin (IL)-1β,macrophage inflammatory peptide (MIP)-2 and soluble intercellular adhesion molecule (sICAM)-1 levels,while pancreatic and lung tissues were removed for myeloperoxidase (MPO) activity,nitric oxide (NOx) level,CD40 expression and histological evaluation. RESULTS:Cerulein injection caused severe AP,confirmed by an increase in serum amylase and lipase levels,histopathological findings of severe AP,and pancreatic MPO activity,compared to the values obtained in the sham group. In the leptin group,serum levels of MIP-2,sICMA-1,TNF-a,and IL-1b,pancreatic MPO activity,CD40 expression in pancreas and lung tissues,and NOx level in the lung tissue were lower compared to those in the AP group. Histologically,pancreatic and lungdamage was less severe following leptin administration. CONCLUSION:Exogenous leptin attenuates inflammatory changes,and reduces pro-inflammatory cytokines,nitric oxide levels,and CD40 expression in ceruleininduced AP and may be protective in AP associated ALI. | Fatma Ayca Gultekin Mustafa Kerem Ertan Tatlicioglu Aysel Aricioglu Cigdem Unsal Neslihan Bukan | 2007 | World Journal of Gastroenterology2007，13，21： | 23 |
| 3 | 帕罗西汀与达帕西汀的对比,治疗早泄的新的选择性5-羟色胺再摄取抑制剂显示文摘达帕西汀氢氯化物是一种选择性5-羟色胺再摄取抑制剂,也是第一种被批准可以按需服用治疗早泄的药物。本文目的为研究按需服用达帕西汀(30mg和H60mg)和每日服用帕罗西汀(20mg)对早泄的疗效。研究募集了150名患者进行了长达1个月的研究。患者被分成3组,每组50人。第一组按需服用达帕西汀30mg。第二组按需服用达帕西汀60mg。第三组每日服用帕罗西汀20mg。治疗结束后,我们的结果检测值相对于基准阴道内射精潜伏期(IELT)延长了。与基准IELT相比,帕罗西汀组、30mg达帕西汀组和60mg达帕西汀组的治疗后IELT分别延长了117%(P〈0.01),117%(P〈0.01)和170%(P〈0.01)。30mg达帕西汀组和帕罗西汀组的IELT增幅相同(P〉0.05),而60mg达帕西汀组的IELT增幅明显高于30mg达帕西汀组(P〈0.05和帕罗西汀组P〈0.01)。性交前1~3小时服用达帕西汀60mg是针对早泄的非常有效的治疗方法。然而,与当前普遍使用的帕罗西汀相比,达帕西汀30mg疗效并不显著。 | Abdulmuttalip Simsek Sinan Levent Kirecci Onur Kucuktopcu Faruk Ozgor Mehmet Fatih Akbulut Omer Sarilar Unsal Ozkuvanci Zafer Gokhan Gurbuz | 2014 | Asian Journal of Andrology2014，16，5： | 10 |
| 4 | 年龄相关性黄斑变性的脉络膜厚度评价(英文)显示文摘目的:通过光学相干断层扫描(optical coherence tomography,OCT;RTVue 100-2;V 5.1,Optovue,Fremont,CA,USA)测量比较非新生血管性与新生血管性年龄相关性黄斑变性(age-related macular degeneration,AMD)黄斑中心凹下脉络膜厚度(subfoveal choroidal thickness,SFCT),并分析脉络膜厚度(choroidal thickness,CT)对AMD新血管形成的影响。方法:本研究为回顾性、横断面研究。以单侧眼患有新生血管性AMD且对侧眼患有非新生血管性AMD的24例患者(48眼)作为研究组,选取年龄与眼轴长度相匹配的40例健康眼作为对照组。非新生血管性AMD亚组研究对象是黄斑区有玻璃疣和/或色素变化眼,而新生血管性AMD亚组研究对象是由于脉络膜新生血管而致视网膜下或视网膜内有渗出液和/或脂性渗出眼。运用OCT垂直测量外侧高反射线(视网膜色素上皮层)到脉络膜巩膜交界面间的距离。选取7个不同点进行脉络膜厚度测量,测量区域为距黄斑中心凹颞侧和鼻侧1500μm范围,测量间距为500μm。测量结果在亚组间进行统计学对比研究。结果:研究组患者平均年龄为72.4±8.97(60~82)岁,对照组受试者平均年龄为71.2±8.8(58~81)岁。新生血管性AMD组中平均SFCT明显大于非新生血管性AMD组的厚度(P<0.05)。非新生血管性AMD组中,平均SFCT与平均鼻、颞侧脉络膜厚度比较,差异无统计学意义(P>0.05);而新生血管性AMD组中,平均SFCT与平均鼻、颞侧脉络膜厚度比较,差异有统计学意义(P<0.05)。结论:运用OCT对脉络膜厚度进行测量,有助于理解AMD的病理生理机制。然而,仍需要大型前瞻性研究来探求新生血管性AMD中SFCT增厚的原因。 | Erkan Unsal Kadir Eltutar Ozen Ayranci Osmanbasoglu Sibel Zιrtιloglu Osman Kιzιlay Hulya Gungel | 2014 | 国际眼科杂志2014，14，9： | 4 |
| 5 | Juvenile idiopathic arthritis显示文摘Juvenile idiopathic arthritis(JIA) is the most common chronic rheumatologic disease in childhood, which represents a nonhomogeneous group of disorders that share the clinical manifestation of arthritis lasting at least 6 wk under the age of 16. The exact diagnosis requires exclusion of other diseases that cause arthritis. The exact etiopathogenesis of JIA is still unknown. The interactions between genetic factors, environmental exposures and immune mechanisms are thought to contribute to pathogenesis of the disease. The 'International League Against Rheumatism' classification divides JIA into 7 subtypes: oligoarticular JIA, rheumatoid factor(RF) positive polyarticular JIA, RF negative polyarticular JIA, systemic-onset JIA, enthesitis-related arthritis, juvenile psoriatic arthritis and undifferentiated JIA. Each subgroup of JIA is characterized by a different mode of presentation, disease course and outcome. The improvements in treatment of JIA in the last 2decades, such as the early introduction of intraarticular corticosteroids, methotrexate and biologic agents, have dramatically upgraded the prognosis of the disease. If untreated, JIA may cause devastating results, such as disability from joint destruction, growth retardation, blindness from chronic iridocyclitis, and even multiple organ failure and death in systemic-onset JIA. The aim of treatment is the induction of remission and control the disease activity to minimize the pain and loss of function, and to maximize quality of life. JIA is a disease having a chronic course, which involves active and inactive cycles over the course of years. Recent studies showed that nearly half of the patients with JIA enter adulthood with their ongoing active disease. This review elucidates how recent advances have impacted diagnosis, pathogenesis and current treatment. | Balahan Makay Erbil Unsal Ozgur Kasapcopur | 2013 | World Journal of Rheumatology2013，3，3： | 3 |
| 6 | Etiological role of brucellosis in autoimmune hepatitis显示文摘To show that brucellosis may trigger autoimmune hepatitis(AIH), in addition to nonspecific liver involvement and toxic hepatitis, due to a class effect of tetracycline family used for treatment. We present a female patient admitted to our hospital due to partially improved fatigue and elevated liver enzymes following doxycycline and streptomycin usage for brucellosis. Brucellosis is endemic in our country, Turkey. It may involve any organ in the body. Liver is frequently involved. Doxycycline used for treatment occasionally may lead to hepatotoxicity. AIH is a necroinflammatory disease of the liver. Certain drugs (e.g. Minocycline), toxins, and viruses (hepatitis B, hepatitis C, EBV, etc.) can trigger AIH. Only one case of AIH probably caused by doxycycline and brucellosis was reported. We discuss the relationship between brucellosis, AIH, and hepatotoxicity of doxycycline. Brucellosis may trigger AIH. | Colakoglu Onder Taskiran Bengur Adnan Kirci Tunakan Mine Buyrac Zafer Unsal Belkis Aksoz Kadir Yorukoglu Gazi | 2005 | World Journal of Gastroenterology2005，11，14： | 3 |
| 7 | Anatomic and functional results of idiopathic macular epiretinal membrane surgery显示文摘AIM: To assess the impact of macular surgery on the functional and anatomic outcomes in patients with grade 2 epiretinal membrane(ERM), and the effect of internal limiting membrane(ILM) peeling on visual acuity and to analyze the long-term effect of pars plana vitrectomy(PPV) on intraocular pressure(IOP).METHODS: Pseudophakic eyes(62 eyes) diagnosed as idiopathic grade 2 ERM with at least 6 mo postoperative follow-up were included in this retrospective study. The fellow eye was nonvitrectomized. Patients were divided into two groups: group 1(29 eyes) treated with ERM and ILM peeling and group 2(33 eyes) with only ERM peeling. Preoperative and postoperative best corrected visual acuity(BCVA), slit-lamp, and a dilated fundus examination was performed. IOP was measured with Goldman applanation tonometer before, day 1 and first week and each visit after surgery. The incidence of significant IOP elevation was compared between vitrectomized eyes and nonvitrectomized fellow eyes.RESULTS: Visual improvement was statistically significant and similar in both groups(P=0.008 in group 1, P=0.002 in group 2, P=0.09 inter-group). The amount of decrease in central macular thickness was statistically significant and similar in both groups(P=0.005 group 1, P=0.008 group 2, P=0.37 intergroup). At the final follow-up(14.1±9.6 mo) the incidence of significant IOP elevation was 4% in vitrectomized eyes(three eyes) and 3%(two eyes) in the nonvitrectomized fellow eyes(P=0.12). Four eyes(12.1%) had recurrent ERM after a mean follow-up of 8.6±1.1 mo in group 2, there was no recurrence in group 1(P=0.01).CONCLUSION: Recurrence of ERM may be decreased by ILM peeling during ERM surgery. However, it seems that ILM peeling do not affect the functional outcome and 23-gauge PPV alone do not have a significant effect on IOP. | Mehmet Ozgur Cubuk Erkan Unsal | 2020 | International Journal of Ophthalmology(English edition)2020，13，4： | 3 |
| 8 | Prevalence of hypertension among individuals aged 50 years and over and its impact on health related quality of life in a semi-rural area of western TUrkey显示文摘背景高血压是普通的,特别在 40 年并且在上的个人,并且它试图 50 年并且在上在个人之中决定高血压的频率和风险因素的 60 年和 over.This 学习关于人口的一半影响,并且联系了生活( HRQOL )的质量在健康上检验它的效果 .Methods 这基于人口的代表性的研究在在3月1日和4月30,2007日 .A | Didem Arslantas Unal Ayranci Alaettin Unsal Mustafa Tozun | 2008 | Chinese Medical Journal2008，，16： | 3 |
| 9 | Clinical outcomes of lung metastasectomy in patients with colorectal cancer显示文摘AIM:To investigate prognostic factors of survival following curative,non-palliative surgical removal of lung metastases secondary to colorectal cancer (CRC).METHODS:Between 1999 and 2009,a radical metastasectomy with curative intent was performed on lung metastases in 21 patients with CRC (15 male and 6 female;mean age:57.4 ± 11.8 years;age range:29-74 years) who had already undergone primary tumour resection.RESULTS:The mean number of lung metastases ranged from one to five.The mean overall survival was 71 ± 35 mo (median:25 mo).After adjusting for potential confounders,multivariable Cox regression analyses predicted only the number of lung metastases (1 vs ≥ 2;hazard ratio:7.60,95% confidence interval:1.18-17.2,P=0.03) as an independent predictor of poor survival following lung resection for metastatic CRC.CONCLUSION:Resection of lung metastases is a safe and effective treatment in selected CRC patients with single lung metastases. | Omer Fatih Olmez Erdem Cubukcu Ahmet Sami Bayram Unsal Akcali Turkkan Evrensel Cengiz Gebitekin | 2012 | World Journal of Gastroenterology2012，18，7： | 3 |
| 10 | Comparison of retrograde intrarenal surgery, shockwave lithotripsy, and percutaneous nephrolithotomy for treatment of medium-sized radiolucent renal stones显示文摘 | Berkan Resorlu Ali Unsal Tevfik Ziypak Akif Diri Gokhan Atis Selcuk Guven Ahmet Ali Sancaktutar Abdulkadir Tepeler Omer Faruk Bozkurt Derya Oztuna | 2013 | World Journal of Urology2013，，6： | 2 |
| 11 | Reticulated platelet levels in patients with ulcerative colitis显示文摘 | Hasan Kayahan Mesut Akarsu Mehmet Ali Ozcan Serdal Demir Halil Ates Belkis Unsal Hale Akpinar | 2007 | International Journal of Colorectal Disease2007，，12： | 2 |
| 12 | Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints 显示文摘 | Sancar A Lindsey - Boltz LA Unsal - Kacmaz K | 2004 | Annu Rev Biochem2004，73，： | 1 |
| 13 | The effect of improved periodontal health on metabolic control in type 2 diabetes mellitus 显示文摘 | Kiran M Arpak N Unsal E | 2005 | J Clin Periodontol2005，32，3： | 1 |
| 14 | Evaluation of mobile phone ad- diction level and sleep quality in university students 显示文摘 | Sahin S Ozdemir K Unsal A | 2013 | Pak J Med Sci2013，29，4： | 1 |
| 15 | Fungal peritonitis in peritoneal dialy- sis:a 10 year retrospective analysis in a single center 显示文摘 | Basturk T Koc Y Unsal A | 2012 | Eur Rev Med Pharmacol Sci2012，16，12： | 1 |
| 16 | Ultrasonographic prenatal diagnosis of isolated acephaly 显示文摘 | Unsal A Sezer S D Meteoale L | 2007 | Diagn Interv Radial2007，13，4： | 1 |
| 17 | Stripping/flocculation/membrane bioreactor/reverse osmosis treatment of municipal landfill leachate显示文摘 | Hasar H Unsal S A Ipek U | 2009 | Journal of Hazardous Materials2009，171，1： | 1 |
| 18 | 资本流动与金融稳定:货币政策和宏观审慎对策(下)1显示文摘发表在国际清算银行(BIS)2013年一季度《中央银行国际期刊》上的'资本流动与金融稳定:货币政策和宏观审慎对策'一文,通过分析在开放经济DSGE模型下货币政策和宏观审慎政策之间的相互影响,指出在发生引起资本流入的金融冲击时,宏观审慎措施作为货币政策有效补充的作用能够得以充分彰显,同时,在'最优简单规则'下,宏观审慎措施可以改善社会福利。此外,本文还认为若要将宏观审慎工具作为单独政策工具,汇率机制的作用至关重要。 | D. Filiz Unsal 梁婷 穆蕾 王芳 刘迪 | 2014 | 西部金融2014，，5： | 1 |
| 19 | The effect of improved periodontal health on metabolic control in type 2 diabetes mellitus显示文摘 | Kiran M Arpak N Unsal E | 2005 | J Clin Periodontol2005，32，3： | 1 |
| 20 | Vascular endothelial growth factor immunostaining correlates with postoperative relapse and survival in non-small cell lung caneer显示文摘 | Yilmaz A Emam D Unsal E | 2007 | Arch Med Res2007，38，7： | 1 |
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