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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Trade remedies and World Trade Organization dispute settlement:why are so few challenged?显示文摘 | Bown C P | 2005 | The Journal of Legal Studies2005，34，2： | 1 |
| 3 | Trade Deflection and Trade Depression 显示文摘 | BOWN C P CROWLEY A | 2007 | Journal of International Economics2007，72，1： | 1 |
| 4 | Trade Defection and Trade Depression 显示文摘 | Bown Chad P Crowley Meredith A | 2005 | Federal Reserve Bank of Chicago Working Paper2005，，26： | 1 |
| 5 | Photodynamic therapy for villous adenomas of the colon and rectum显示文摘 | Loh CS Bliss P Bown SG | 1994 | Endoscopy1994，26，： | 1 |
| 6 | Outcomes from Gleason 7,intermediate risk,localized prostate cancer treated with Iodine- 125 monotherapy over 10 years显示文摘 | Munro NP A1-Qaisieh B Bownes P | 2010 | Radiother Oncol2010，96，1： | 1 |
| 7 | Ceramic coatings by anodic spark deposition显示文摘 | Writz G P Bown S D Kriven W M | 1991 | Materials and Manufacturing Processes1991，6，1： | 1 |
| 8 | Evaluating the effects of functional communication training in the presence and absence of establishing operations显示文摘 | BOWN K A WACKER D P DERBY K M | 2000 | J Appl Behavior Analysis2000，33，： | 1 |
| 9 | Loss of heterozygosity in childhood acute lymphoblastic leukemia detected by genome-wide microarray single nucleotide polymorphism analysis显示文摘 | Irving J A Bloodworth L Bown N P | 2005 | Cancer Res2005，65，8： | 1 |
| 10 | Photodynamic therapy for Villous adenomas of colon and rectum显示文摘 | LOH C S BLISS P BOWN S G | 1994 | Endoscopy1994，26，2： | 1 |
| 11 | Loss of Heterozygosity in Childhood Acute Lymphoblastic Leukemia Detected by Genome-Wide Microarray Single Nucleotide Polymorphism Analysis显示文摘 | Irving J A Bloodworth L Bown N P | 2005 | Cancer Res2005，65，8： | 1 |
| 12 | Midgut car- boxypeptidase from Helicoverpa armigera (Lepidoptera: Noctuidae)larvae:enzyme eharacterisation,cDNA cloning and expression 显示文摘 | Bown D P Wilkinson H S Gatehouse J A | 1998 | Insect Bioehem Mol Biol1998，28，10： | 1 |
| 13 | The uppermost Middle and Upper Albian succession at the Col de Palluel, Hautes-Alpes, France: An integrated study ( ammonites, inoceramid bivalves, planktonic foraminifera, nannofossils, geochemistry, stableoxygen and carbon isotopes, cyclostratigraphy) 显示文摘 | Gale A Bown P Caron M | 2011 | Creta- ceous Research2011，32，2： | 1 |
| 14 | Stereotactic radiosurgery for the treatment of brain metastases: impact of cerebral disease burden on survival显示文摘 | Banfill KE Bownes P J St Clair SE | 2012 | Br J Neurosurg2012，26，5： | 1 |
| 15 | Differentially regulated inhibitor-sensitive and insensitive protease genes from the phytophagous insect pest, Helicoverpa armigera , are members of complex multigene families显示文摘 | David P Bown Hillary S Wilkinson John A Gatehouse | 1997 | Insect Biochemistry and Molecular Biology1997，，7： | 1 |
| 16 | Trade Dispute and the Implementation of Protection Under the GATF: An Empirical Assess- ment 显示文摘 | Bown Chad P | 2004 | Journal of International Economics2004，，62： | 1 |
| 17 | Antidumping and retaliation threats显示文摘 | Blonigen B A Bown C P | 2003 | Journal of International Economics2003，60，2： | 1 |
| 18 | Shelf and open-ocean cal-careous phytoplankton assemblages across the Paleocene-EoceneThermal Maximum:Implications for global productivity gradients显示文摘 | Gibbs S Bralower T Bown P | 2006 | Geology2006，34，： | 1 |
| 19 | WTO Dispute Settlement and the Missing Developing Country Cases: Engaging the Private Sector 显示文摘 | Bown C P Hoekrnan BIVI | 2005 | Journal of International Economic Law2005，8，4： | 1 |
| 20 | Policy externalities:How US antidumping affects Japanese exports to the EU显示文摘 | Bown C P Crowley M A | 2006 | European Journal of Political Economy2006，22，3： | 1 |
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