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| 1 | Precise semi-analytical inverse kinematic solution for 7-DOF offset manipulator with arm angle optimization显示文摘Seven-degree-of-freedom redundant manipulators with link offset have many advantages,including obvious geometric significance and suitability for configuration control.Their configuration is similar to that of the experimental module manipulator(EMM)in the Chinese Space Station Remote Manipulator System.However,finding the analytical solution of an EMM on the basis of arm angle parameterization is difficult.This study proposes a high-precision,semi-analytical inverse method for EMMs.Firstly,the analytical inverse kinematic solution is established based on joint angle parameterization.Secondly,the analytical inverse kinematic solution for a non-offset spherical-roll-spherical(SRS)redundant manipulator is derived based on arm angle parameterization.The approximate solution of the EMM is calculated in accordance with the relationship between the joint angles of the EMM and the SRS manipulator.Thirdly,the error is corrected using a numerical method through the analytical inverse solution based on joint angle parameterization.After selecting the stride and termination condition,the precise inverse solution is computed for the EMM based on arm angle parameterization.Lastly,case solutions confirm that this method has high precision,and the arm angle parameterization method is superior to the joint angle parameterization method in terms of parameter selection. | Boyu MA Zongwu XIE Zainan JIANG Hong LIU | 2021 | Frontiers of Mechanical Engineering2021，16，3： | 5 |
| 2 | The occurrence of per-and polyfluoroalkyl substances(PFASs) in fluoropolymer raw materials and products made in China显示文摘Perfluorooctanoic acid(PFOA), its salts, and related compounds were listed as new persistent organic pollutants by the Stockholm Convention in 2019.In this study, the occurrence of residues of PFOA and other per-and polyfluoroalkyl substances(PFASs) in raw materials and fluoropolymer products from the Chinese fluoropolymer industries are reported for the first time.The PFOA concentrations in raw materials and fluoropolymer products were in the range of 6.7 to 1.1 × 10^(6) ng/g, and | Lingyi Meng Boyu Song Yao Lu Kun Lv Wei Gao Yawei Wang Guibin Jiang | 2021 | Journal of Environmental Sciences2021，33，9： | 2 |
| 3 | Restart-up Performance of a CFB Boiler after a Sudden Power Failure Accident显示文摘Due to the massive bed materials in its typical main loop,a circulating fluidized bed(CFB)boiler may face greater trouble in operation and restart-up if an unplanned sudden power failure happens in the power plant.This study aims to explore the restart-up performance of a 170 t/h natural circulation CFB boiler after a sudden power failure and evaluate whether the hot restart-up can be realized.The heat transfer process after the restoration of the primary air is modeled.Validating the isothermal property of the bed after the restoration of the power and air supply,the correlation among the accident duration time,bed temperature after the power restores,inlet air temperature,air supply time,and air velocity is proposed.The predicted results indicate that the major influencing factor of the bed temperature during this process is primary air velocity.To provide guidelines for judgment on whether the hot restart-up can be realized,the maximum values of the air supply time and accident duration time for hot restart-up for different types of coals are given.The results show both of them have a rapid decrease as the coal ignition temperature in a CFB boiler increases from 450°C to 650°C,which also means that the coal ignition temperature plays a very important role in the restart-up process.Based on the simulation results of bed temperature during the accident,it is also estimated that the drum level drops by 77.7 mm after 8 hours but still stays in the permissible range. | YAO Yuge JIANG Ling XIAO Huiren DENG Boyu ZHANG Man ZHANG Yang YANG Hairui LYU Junfu | 2022 | Journal of Thermal Science2022，31，3： | 2 |
| 4 | Catalytic Oxi- dation of Thiophene and Its Derivatives via Dual Activation for Ultra-Deep Desulfurization of Fuels 显示文摘 | Zhang Boyu Jiang Zongxuan Li Jun | 2012 | J Catal2012，287，： | 1 |
| 5 | Side-polished SMS based RI sensor employing macro-bending perfluorinated POF显示文摘A refractive index(RI)sensor based on perfluorinated plastic optical fiber(PF-POF)is introduced in this paper.The PF-POF as multi-mode fiber was side-polished(SP)to form a macro-bending single-mode-multimode-single-mode(SMS)structure.Both ends of the sensor were closely connected to single-mode quartz optical fiber(SMF).The spectral char-acteristics of the sensor are measured,analyzed and discussed.The results show that when the length of PF-POF is 8 cm,the macro-bending radius is 3 cm,and the SP-depth is 20μm.The intensity sensitivity reaches−219.504 dBm/RIU in the range of RI=1.330~1.356.A reference is provided for the application of PF-POF in RI sensor in the future.The sensor is featured with low-cost,good flexibility and high efficiency. | Xuezhi Zhang Boyue Yang Junfeng Jiang Kun Liu Xiaojun Fan Zhaozhu Liu Min Peng Guanlong Chen Tiegen Liu | 2021 | Opto-Electronic Advances2021，4，10： | 1 |
| 6 | Presence of organophosphate flame retardants(OPEs)in different functional areas in residential homes in Beijing,China显示文摘The production and application of organophosphate esters(OPEs)have dramatically increased in recent years due to their use as a replacement for brominated flame retardants.In this study,13 OPEs(∑_(13)OPEs)were analyzed in indoor air samples from kitchens and living rooms in 14 residential homes in Beijing,China.The concentrations of ∑_(13)OPEs in kitchen air samples(mean:13 ng/m^(3))were significantly(p<0.05)higher than in living room air samples(5.0 ng/m^(3)).In addition,paired window surface organic film samples were collected and analyzed to investigate film-air partitioning,exhibiting a mean concentration of ∑_(13)OPEs of 4100 ng/m^(2).The congener profiles showed that tris(2-chloroisopropyl)phosphate(TCPP)was the predominant compound in both window film samples(48%)and the corresponding indoor air sample(56%).The estimated daily intakes(EDI)of OPEs via indoor air inhalation were 2.8 and 1.4 ng/kg/day for infants and adults,respectively,both of which are below the reference dose values(RfDs).Overall,these findings indicate that OPEs in the indoor air environment of residential homes in Beijing are not likely to pose a health risk to the general population. | Kun Lv Lu Bai Boyu Song Xindong Ma Minmin Hou Jie Fu Yali Shi Yawei Wang Guibin Jiang | 2022 | Journal of Environmental Sciences2022，34，5： | 1 |
| 7 | Serum N1-Methylnicotinamide Is Associated With Obesity and Diabetes in Chinese显示文摘 | Ming Liu Lihua Li Jihong Chu Boyu Zhu Qingtao Zhang Xueyan Yin Weimin Jiang Guoliang Dai Wenzheng Ju Zhenxing Wang Qin Yang Zhuyuan Fang | 2015 | The Journal of Clinical Endocrinology & Metabolis2015，，8： | 1 |
| 8 | Catalytic Oxi- dation of Thiophene and Its Derivatives via Dual Activation for Ultra-Deep Desulfurization of Fuels显示文摘 | Zhang Boyu Jiang Zongxuan Li Jun | 2012 | J Catal2012，287，： | 1 |
| 9 | A High-Temperature Superconducting Wideband Bandpass Filter at the L Band for Radio Astronomy显示文摘In order to ensure the normal operation of radio astronomy observations,an extremely sensitive receiver system needs to be equipped in front of the large radio telescope.An 8-pole wideband high-temperature superconducting(HTS)filter using a Coplanar Spiral Resonator Structure with a passband of 1160~1670 MHz is developed to suppress strong radio interference.The filter is fabricated on a 36 mm×14 mm YBCO HTS film,which is deposited on a 0.5 mm thick MgO substrate.The minimum insertion loss measured in the liquid nitrogen temperature region is 0.03 dB,and the first parasitic passband appears at 2600 MHz.The measured results are in good agreement with the simulations.The filter can be used in radio telescope receivers for the observation of neutral hydrogen and pulsars,as well as in high-sensitivity satellite navigation instruments. | Xinyu Zhu Jianbin Li Boyu Lu Bin Wei Yifan Jiang Linan Jiang Chao Hu | 2023 | Research in Astronomy and Astrophysics2023，23，11： | 0 |
| 10 | Studies of the linearity of the readout module assembling using the eXTP-GPD chips显示文摘Background The Gas Pixel Detector(GPD)is a key part of the Polarimetry Focusing Array(PFA)sub-system onboard the enhance X-ray Timing and Polarimetry mission(eXTP).The GPD can accurately provide the polarized angle and degree for incoming soft X-rays(requirements of minimum detectable polarization<1%(10^(6) s,1 mCrab))from celestial objects under extreme conditions of density,gravity and magnetism.Purpose Paste the GPD chips on a matched ceramic package is one of the most important procedures for the GPD assembly,and the parallelism between the top surface of an ASIC chip and the bottom surface of a Gas Electron Multiplier(GEM)foil can have impact on the distribution of electric field within transfer region and reconstruction of photoelectric trajectories,resulting in deterioration of the GPD sensitivity.This study quantifies the influence and gives a reasonable expectation of the parallelism.Methods A simulation framework of the GPD is constructed to quantify the influence on the GPD performance and values of the parallelism are measured by a gauge with a position resolution of o.1μm.Results:The difference of degree of modulation is less than 1% comparing the parallelism with a value of 20μm to a value of 0μm in response to both polarized and unpolarized X-rays.Meanwhile,the value of parallelism can reach 6.9±3.4μm(0.0176°±0.0087°)by testing and verifying.Conclusions The impact on the GPD performance can be less than 1%as the parallelism with an order of 20μm,and we also give a reasonable measuring method and verify the controllability and feasibility of the parallelism with an order of 20μm for pasting the ASIC chip on the surface of a ceramic package. | Jiechen Jiang Liang Sun Yang Jiao Weichun Jiang Yupeng Xu Huilin He Xiaohua Liu Yuanyuan Du Sheng Yang Zefang Dong Xiaojing Liu Boyu Dai | 2023 | Radiation Detection Technology and Methods2023，7，2： | 0 |
| 11 | A novel investigation on the influence of Cu-P modifier on the,microstructure,mechanical performance,and melting process of Al-50Si alloys treated by overheating显示文摘As an efficient modifier,phosphorus(P)can significantly reduce the size of primary silicon(Si)crystals.However,modifier can aggregate when the P content exceeds a certain proportion,which decreases refining efficiency.In this study,the evolution of microstructures and mechanical properties of Al-50Si alloy have been studied by combining superheating and modification treatments.After modification,the mean size of the primary Si phase increased with superheating temperature,while the hardness decreased with increased superheating.Although the alloy was in an over-modified state when the modified content was 7 wt%,the overall alloy hardness was the highest Nanoindentation tests were used to examine the mechanical properties of each alloy phase and the results showed that the nano-hardness of AI2CU phase was 5.52 GPa,three times that of an A1 matrix,and was considered to be the reason for increased alloy hardness after over-modification.This phenomenon indicated that,except for size and distribution of the primary Si phase,intermetallic compounds,such as AI2CU,also played important roles in modifying alloy mechanical properties.The alloy melting process was observed in-situ using a laser confocal high-temperature scanning microscope and results indicated that the melting temperature of a-Al decreased with increased matrix Cu content.A model for calculating distortion energy was proposed and its rationality verified.Calculation results showed that,with increased matrix Cu content,the distortion energy gradually increased,which was the main reason for decreased matrix melting temperature.Moreover,the existence of distortion energy was verified using the EBSD method. | Tao Jiang Chuang Yu Boyue Xu Wei Yu Guangming Xu Yong Li Zhaodong Wang Guodong Wang | 2021 | Progress in Natural Science:Materials International2021，31，3： | 0 |
| 12 | FBXW7βloss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth显示文摘Continuous de novo fatty acid synthesis is required for the biosynthetic demands of tumor.FBXW7 is a highly mutated gene in CRC,but its biological functions in cancer are not fully characterized.Here,we report that FBXW7β,a FBXW7 isoform located in the cytoplasm and frequently mutated in CRC,is an E3 ligase of fatty acid synthase(FASN).Cancer-specific FBXW7βmutations that could not degrade FASN can lead to sustained lipogenesis in CRC.COP9 signalosome subunit 6(CSN6),an oncogenic marker of CRC,increases lipogenesis via interacting with and stabilizing FASN.Mechanistic studies show that CSN6 associates with both FBXW7βand FASN,and antagonizes FBXW7β’s activity by enhancing FBXW7βautoubiquitination and degradation,which in turn prevents FBXW7β-mediated FASN ubiquitination and degradation,thereby regulating lipogenesis positively.Both CSN6 and FASN are positively correlated in CRC,and CSN6-FASN axis,regulated by EGF,is responsible for poor prognosis of CRC.The EGF-CSN6-FASN axis promotes tumor growth and implies a treatment strategy of combination of orlistat and cetuximab.Patient-derived xenograft experiments prove the effectiveness of employing orlistat and cetuximab combination in suppressing tumor growth for CSN6/FASN-high CRC.Thus,CSN6-FASN axis reprograms lipogenesis to promote tumor growth and is a target for cancer intervening strategy in CRC. | Wenxia Wei Baifu Qin Weijie Wen Boyu Zhang Haidan Luo Yuzhi Wang Hui Xu Xiaoshan Xie Sicheng Liu Xin Jiang Mengan Wang Qin Tang Jiayu Zhang Runxiang Yang Zongmin Fan Haiwen Lyu Junzhong Lin Kai Li Mong-Hong Lee | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 13 | Influence of Recirculated Flue Gas Distribution on Combustion and NOx Formation Characteristics in S-CO_(2) Coal-fired Boiler显示文摘Supercritical carbon dioxide(S-CO_(2))Brayton power cycle power generation technology,has attracted more and more scholars'attention in recent years because of its advantages of high efficiency and flexibility.Compared with conventional steam boilers,S-CO_(2) has different heat transfer characteristics,it is easy to cause the temperature of the cooling wall of the boiler to rise,which leads to higher combustion gas temperature in the furnace,higher NOX generation concentration.The adoption of flue gas recirculation has a significance impact on the combustion process of pulverized coal in the boiler,and it is the most effective ways to reduce the emission of NOX and the combustion temperature in the boiler.This paper takes 1000MW S-CO_(2) T-type coal-fired boiler as the research target to investigate the combustion and NOX generation characteristics of S-CO_(2) coal-fired boilers under flue gas recirculation condition,the influence of recirculated flue gas distribution along the furnace height on the characteristics of NOX formation and the combustion of pulverized coal.The results show that the recirculated flue gas distribution has the great impact on the concentration of NOX at the boiler outlet.When the bottom recirculation flue gas rate is gradually increased,the average temperature of the lower boiler decreases and the average temperature of the upper boiler increases slightly;The concentration of NOx at the furnace outlet increases. | Peipei WANG Mingyan GU Yao FANG Boyu JIANG Mingming WANG Ping CHEN | 2021 | Mechanical Engineering Science2021，3，2： | 0 |
| 14 | Nanomaterials with dual immunomodulatory functions for synergistic therapy of breast cancer brain metastases显示文摘A long-standing paucity of effective therapies results in the poor outcomes of triple-negative breast cancer brain metastases.Immunotherapy has made progress in the treatment of tumors,but limited by the non-immunogenicity of tumors and strong immunosuppressive environment,patients with TNBC brain metastases have not yet benefited from immunotherapy.Dual immunoregulatory strategies with enhanced immune activation and reversal of the immunosuppressive microenvironment provide new therapeutic options for patients.Here,we propose a cocktail-like therapeutic strategy of microenvironment regulation-chemotherapy-immune synergistic sensitization and construct reduction-sensitive immune microenvironment regulation nanomaterials(SIL@T).SIL@T modified with targeting peptide penetrates the BBB and is subsequently internalized into metastatic breast cancer cells,releasing silybin and oxaliplatin responsively in the cells.SIL@T preferentially accumulates at the metastatic site and can significantly prolong the survival period of model animals.Mechanistic studies have shown that SIL@T can effectively induce immunogenic cell death of metastatic cells,activate immune responses and increase infiltration of CD8+T cells.Meanwhile,the activation of STAT3 in the metastatic foci is attenuated and the immunosuppressive microenvironment is reversed.This study demonstrates that SIL@T with dual immunomodulatory functions provides a promising immune synergistic therapy strategy for breast cancer brain metastases. | Zhenhao Zhao Chufeng Li Yiwen Zhang Chao Li Yongchao Chu Xuwen Li Peixin Liu Hongyi Chen Yu Wang Boyu Su Qinjun Chen Tao Sun Chen Jiang | 2023 | Bioactive Materials2023，，9： | 0 |
| 15 | The Environmental Impact of Plastic Waste显示文摘The pollution caused by disposable plastic products is becoming moreand more serious, and “plastic limit” has become a global consensus. Thisarticle mainly discusses the pollution problem from the following aspects:Integrate all relevant important indicators to establish a multiple regressionmodel of the maximum amount of disposable plastic waste to estimatethe maximum amount of disposable waste in the future without causingfurther damage to the environment;Establish an environmental safety levelevaluation model and analyze the impact of plastic waste on environmentalsafety;Try to set the lowest level target that can be achieved by globalwaste at this stage, and conduct correlation analysis on the impact ofhumans, enterprises, and the environment;Select several countries basedon their comprehensive strengths, conduct a comparative analysis of theirplastic production, economic strength, and environment, and try to exploretheir responsibilities. | Boyu Jiang Jiming Yu Yihang Liu | 2020 | Journal of Environmental & Earth Sciences2020，2，2： | 0 |
| 16 | Beam Scheduling with Various Mission Demands in Data Relay Satellite Systems显示文摘Beam scheduling is one of the most important issues regarding data relay satellite systems,which can improve the utilization efficiency of limited system resources by programming beam allocation for relay missions.The ever-increasing relay missions create a substantial challenge for beam scheduling due to an increase in different mission demands.The cooperative usage of different beams further increases the complexity of this problem.Therefore,we develop a novel optimization method to solve the beam scheduling problem for the scenario of various mission demands in the data relay satellite system(DRSS).Based on the analysis of mission demands and resource features,we first construct a heterogeneous parallel machines scheduling model to formulate the beam scheduling problem in the DRSS.To solve this complicated model,we investigate the matching method between mission demands and beam resources,and introduce two concepts,the loose duration and the number of available beams,to make the matching process more effective.Then,the following three algorithms are proposed.Our first approach,the maximized completion probability algorithm(MCPA),applies a greedy strategy based on the new concepts to allocate beams for missions;and two improved versions of this algorithm are also presented,which employ the strategies of mission insertion optimization and mission sequence optimization,respectively.Our simulation results show that the proposed algorithms are superior to the existing algorithms in terms of the scheduled missions,the weight of scheduled missions,and the processing time,which significantly improves the performance of beam scheduling in the DRSS. | Boyu Deng Chunxiao Jiang Jingchao Wang Linling Kuang | 2021 | Journal of Communications and Information Networks2021，6，4： | 0 |
| 17 | A neutrophil-biomimic platform for eradicating metastatic breast cancer stem-like cells by redox microenvironment modulation and hypoxia-triggered differentiation therapy显示文摘Metastasis accounts for 90%of breast cancer deaths,where the lethality could be attributed to the poor drug accumulation at the metastatic loci.The tolerance to chemotherapy induced by breast cancer stem cells(BCSCs)and their particular redox microenvironment further aggravate the therapeutic dilemma.To be specific,therapy-resistant BCSCs can differentiate into heterogeneous tumor cells constantly,and simultaneously dynamic maintenance of redox homeostasis promote tumor cells to retro-differentiate into stem-like state in response to cytotoxic chemotherapy.Herein,we develop a specifically-designed biomimic platform employing neutrophil membrane as shell to inherit a neutrophil-like tumor-targeting capability,and anchored chemotherapeutic and BCSCs-differentiating reagents with nitroimidazole(NI)to yield two hypoxia-responsive prodrugs,which could be encapsulated into a polymeric nitroimidazole core.The platform can actively target the lung metastasis sites of triple negative breast cancer(TNBC),and release the escorted drugs upon being triggered by the hypoxia microenvironment.During the responsiveness,the differentiating agent could promote transferring BCSCs into non-BCSCs,and simultaneously the nitroimidazole moieties conjugated on the polymer and prodrugs could modulate the tumor microenvironment by depleting nicotinamide adenine dinucleotide phosphate hydrogen(NADPH)and amplifying intracellular oxidative stress to prevent tumor cells retro-differentiation into BCSCs.In combination,the BCSCs differentiation and tumor microenvironment modulation synergistically could enhance the chemotherapeutic cytotoxicity,and remarkably suppress tumor growth and lung metastasis.Hopefully,this work can provide a new insight in to comprehensively treat TNBC and lung metastasis using a versatile platform. | Yongchao Chu Yifan Luo Boyu Su Chao Li Qin Guo Yiwen Zhang Peixin Liu Hongyi Chen Zhenhao Zhao Zheng Zhou Yu Wang Chen Jiang Tao Sun | 2023 | Acta Pharmaceutica Sinica B2023，13，1： | 0 |
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