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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Theoretical modeling of micro-scale biological phenomena in human coronary arteries显示文摘 | Kelvin Wong Jagannath Mazumdar Brandon Pincombe Stephen G. Worthley Prashanthan Sanders Derek Abbott | 2006 | Medical & Biological Engineering & Computing2006，，11： | 1 |
| 3 | Variations in soil aggregate stability and enzyme activities in a temperate agroforestry practice显示文摘 | Ranjith P. Udawatta Robert J. Kremer Brandon W. Adamson Stephen H. Anderson | 2007 | Applied Soil Ecology2007，，2： | 1 |
| 4 | Performance of a VisionBased tractor guidance system显示文摘 | J ROBERT BRANDON STEPHEN | 1990 | SAE Transactions1990，99，2： | 1 |
| 5 | Efficient and interpretable graph network representation for angle-dependent properties applied to optical spectroscopy显示文摘Graph neural networks are attractive for learning properties of atomic structures thanks to their intuitive graph encoding of atoms and bonds.However,conventional encoding does not include angular information,which is critical for describing atomic arrangements in disordered systems.In this work,we extend the recently proposed ALIGNN(Atomistic Line Graph Neural Network)encoding,which incorporates bond angles,to also include dihedral angles(ALIGNN-d).This simple extension leads to a memory-efficient graph representation that captures the complete geometry of atomic structures.ALIGNN-d is applied to predict the infrared optical response of dynamically disordered Cu(II)aqua complexes,leveraging the intrinsic interpretability to elucidate the relative contributions of individual structural components.Bond and dihedral angles are found to be critical contributors to the fine structure of the absorption response,with distortions that represent transitions between more common geometries exhibiting the strongest absorption intensity.Future directions for further development of ALIGNN-d are discussed. | Tim Hsu Tuan Anh Pham Nathan Keilbart Stephen Weitzner James Chapman Penghao Xiao S.Roger Qiu Xiao Chen Brandon C.Wood | 2022 | npj Computational Materials2022，，1： | 1 |
| 6 | Glucocorticoid Receptor Polymorphisms and Intraocular Pressure Response to Intravitreal Triamcinolone Acetonide显示文摘 | Sabrina M. Gerzenstein Mathew T. Pletcher Alessandra C. L. Cervino Nicholas F. Tsinoremas Brandon Young Carmen A. Puliafito M. Elizabeth Fini Stephen G. Schwartz | 2008 | Ophthalmic Genetics2008，，4： | 1 |
| 7 | Intravoxel incoherent motion imaging kinetics during chemoradiotherapy for human papillomavirus‐associated squamous cell carcinoma of the oropharynx: preliminary results from a prospective pilot study显示文摘 | Yao Ding John D. Hazle Abdallah S. R. Mohamed Steven J. Frank Brian P. Hobbs Rivka R. Colen G. Brandon Gunn Jihong Wang Jayashree Kalpathy‐Cramer Adam S. Garden Stephen Y. Lai David I. Rosenthal Clifton D. Fuller | 2015 | NMR Biomed2015，，12： | 1 |
| 8 | Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors 显示文摘 | Stephen S Antonysamy Brandon Aubol Jeff Blaney | 2008 | Bioorg Med Chem Lett2008，18，9： | 1 |
| 9 | Dissolved organic matter characteristics within the lake superior watershed 显示文摘 | Elizabeth Minor A Brandon Stephens | 2008 | Organic Geochemistry2008，39，10： | 1 |
| 10 | Robot-assisted Partial Nephrectomy: A Large Single-institutional Experience显示文摘 | Benjamin J. Scoll Robert G. Uzzo David Y.T. Chen Stephen A. Boorjian Alexander Kutikov Brandon J. Manley Rosalia Viterbo | 2010 | Urology2010，，6： | 1 |
| 11 | Anatomic Features of Enhancing Renal Masses Predict Malignant and High-Grade Pathology: A Preoperative Nomogram Using the RENAL Nephrometry Score <ce:link locator='eulogo1'/>显示文摘 | Alexander Kutikov Marc C. Smaldone Brian L. Egleston Brandon J. Manley Daniel J. Canter Jay Simhan Stephen A. Boorjian Rosalia Viterbo David Y.T. Chen Richard E. Greenberg Robert G. Uzzo | 2011 | European Urology2011，，2： | 1 |
| 12 | Consumption of energy beverage is associated with attenuation of arterial endothelial flow-mediated dilatation显示文摘AIM To investigate whether consumption of an energy drink will acutely impair endothelial function in young healthy adults. METHODS Energy drinks are being consumed more and more worldwide, and have been associated with some deaths in adolescents and young adults, especially when consumed while exercising. After fasting and not smoking for at least 8 h prior, eleven medical students(9 males) received an electrocardiogram, blood pressure and pulse check, and underwent baseline testing(BL) of endothelial function using the technique of endothelium-dependent flow mediated dilatation(FMD) with high-resolution ultrasound(according to recommended guidelines of the University of Wisconsin Atherosclerosis Imaging Research Program Core Laboratory). The subjects then drank an energy beverage(EB), a 24-oz can of Monster Energy, and the above was repeated at 90 min after consumption. The relative FMD(%) was calculated as the ratio between the average post-cuff release and the baseline diameter. Each image was checked for quality control, and each artery diameter was measured from the media to media points by two experts, 3 measurements at the QRS complex, repeated on 3 separate beats, and then all were averaged.RESULTS Subjects characteristics averages(given with standard deviations) include: Age 24.5 ± 1.5 years, sex 9 male and 2 female, weight 71.0 ± 9.1 kg, height 176.4 ± 6.0 cm, BMI 22.8 ± 2.7 kg/m^2. The hemodynamics were as follows, BL vs EB group respectively(mean ± SD): Heart rate 65.2 ± 11.3 vs 68.2 ± 11.8 beats per minute, systolic blood pressure 114.0 ± 10.4 mmH g vs 114.1 ± 10.4 mmH g, diastolic blood pressure 68.8 ± 9.3 mmH g vs 70.6 ± 7.1 mmH g; all were not significantly different. However after drinking the EB, a significantly attenuated peak FMD response was measured(mean ± SD): BL group 5.9% ± 4.6% vs EB group 1.9% ± 2.1%; P = 0.03). Given the increased consumption of energy beverages associated with exercise in young adults, more research is needed.CONCLUSION Energy beverage consumption has a negative impact on arterial endothelial function in young healthy adults. | John P Higgins Benjamin Yang Nikki E Herrin Santi Yarlagadda George T Le Brandon L Ortiz Asif Ali Stephen C Infanger | 2017 | World Journal of Cardiology2017，9，2： | 0 |
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