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| 1 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 2 | Guidelines for Conscious Sedation and Monitoring During Gastrointestinal Endoscopy显示文摘 | J.Patrick Waring Todd H Baron William K Hirota Jay L Goldstein Brian C Jacobson Jonathan A Leighton J.Shawn Mallery Douglas O Faigel | 2003 | Gastrointestinal Endoscopy2003，，3： | 1 |
| 3 | Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma显示文摘 | Matthias L?hr Anne Hoffmeyer Jens-Christian Kr?ger Mathias Freund Johannes Hain Albrecht Holle Peter Karle Wolfram T Kn?fel Stefan Liebe Petra Müller Horst Nizze Matthias Renner Robert M Saller Thomas Wagner Karlheinz Hauenstein Walter H Günzburg Brian Sa | 2001 | The Lancet2001，，9268： | 1 |
| 4 | Leakage Current Monitoring of Composite Long Rod Insulators显示文摘 | BRIAN P COLIN L DON H | 1994 | Properties and Applications of Diejectric Materials1994，，4： | 1 |
| 5 | Does Perceived Organizational Support Mediate the Relationship between Procedural Justice and Behavior? 显示文摘 | Robert H M Gerald L B Brian P N | 1998 | Academy of Organizational Citizenship Management Journal1998，41，3： | 1 |
| 6 | Tacrolimus for the treatment of fistulas in patients with crohn’s disease: a randomized, placebo-controlled trial显示文摘 | William J Sandborn Daniel H Present Kim L Isaacs Douglas C Wolf Eugene Greenberg Stephen B Hanauer Brian G Feagan Lloyd Mayer Therese Johnson Joseph Galanko Christopher Martin Robert S Sandler | 2003 | Gastroenterology2003，，2： | 1 |
| 7 | Effects of global climate change on agriculture : an interpretative review显示文摘 | Richard M A Brian H H Stephanie L | 1998 | Climate Research1998，11，： | 1 |
| 8 | Acyl homoserine-lactone quorum-sensing signal generation 显示文摘 | Matthew R P Dale L V Brian L H | 1999 | Prog Natl Acad Sci USA1999，96，： | 1 |
| 9 | Secretory Group IIA Phosholipase A2Generates Anti-apoptotic Survival in Kidney Fibroblast显示文摘 | Zhang YP John L Brian H | 1999 | The Biological Chemistry1999，274，27： | 1 |
| 10 | Cytoreductive Surgery with Intraperitoneal Hyperthermic Chemotherapy for advanced Cancer显示文摘 | Jason J H Brian W L Parry S | 2004 | The Society for Surgery of the Alimentary Tract2004，8，4： | 1 |
| 11 | Comparison of Dried Plum Puree,Rosemary Extract,and BHA/BHT as Antioxidants in Irradiated Ground Beef Patties显示文摘 | MOVILEANU L D E GONZLEZM T N BRIAN H B | 2013 | International Journal of Food Science2013，2013，： | 1 |
| 12 | Performance of CFST column to steel beam joints subjected to simulated fire including the cooling phase 显示文摘 | Song T Y Han L H Brian Uy | 2010 | Journal of Constructional Steel Research2010，66，3： | 1 |
| 13 | Study on hydro- mechanical deep drawing with uniform pressure onto the blank 显示文摘 | Lang L H Joachim Danckert Karl Brian Nielsen | 2004 | International Journal of Machine Tools & Manfaclure2004，，44： | 1 |
| 14 | Pulsed Miocene range growth in northeastern Tibet: Insights from Xunhua basin magrletostratigraphy and provenance显示文摘 | Richard O L Douglas W B Brian H | 2011 | Geological Society of America2011，124，56： | 1 |
| 15 | Predictions from Uncertain Categorization显示文摘 | Murphy G L Brian H R | 1994 | Cog- nitive Psychology1994，，27： | 1 |
| 16 | The two faces of typicality in category-based induction显示文摘 | Murphy G L Brian H R | 2005 | Cognition2005，，95： | 1 |
| 17 | Overall survival advantage with partial nephrectomy:A bias of observational data显示文摘 | Brian S Janet H Julie L | 2013 | Cancer2013，119，16： | 1 |
| 18 | Mars exploration rover mobility development显示文摘 | RANDEL L DONALD B BRIAN H | 2006 | IEEE Robotics & Automation Magazine2006，2，2： | 1 |
| 19 | Dearomatization and functionalization of terpyridine by lutetium(Ill) alkyl complexes显示文摘 | Kimberly C J Brian L S Jeffrey H | 2006 | J Am Chem Soe2006，128，19： | 1 |
| 20 | Nontraumatic lower-extremity acute arterial ischemia显示文摘 | Timothy J Nypaver Brian R Whyte Eric D Endean Thomas H Schwarcz Gordon L Hyde | 1998 | The American Journal of Surgery1998，，2： | 1 |
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