|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Bone morphogenetic protein-2 is a negative regulator of hepatocyte proliferation downregulated in the regenerating liver显示文摘AIM: To characterize the expression and dynamic changes of bone morphogenetic protein (BMP)-2 in hepatocytes in the regenerating liver in rats after partial hepatectomy (PH), and examine the effects of BMP-2 on proliferation of human Huh7 hepatoma cells. METHODS: Fifty-four adult male Wistar rats were randomly divided into three groups: A normal control (NC) group, a partial hepatectomized (PH) group and a sham operated (SO) group. To study the effect of liver regeneration on BMP-2 expression, rats were sacrificed before and at different time points after PH or the sham intervention (6, 12, 24 and 48 h). For each time point, six rats were used in parallel. Expression and distribution of BMP-2 protein were determined in regenerating liver tissue by Western blot analysis and immunohistochemistry. Effects of BMP-2 on cell proliferation of human Huh7 hepatoma cell line were assessed using an MTT assay.RESULTS: In the normal liver strong BMP-2 expression was observed around the central and portal veins. The expression of BMP-2 decreased rapidly as measured by both immunohistochemistry and Western blot analysis. This decrease was at a maximum of 3.22 fold after 12 h and returned to normal levels at 48 h after PH. No significant changes in BMP-2 immunoreactivity were observed in the SO group. BMP-2 inhibited serum induced Huh7 cell proliferation.CONCLUSION: BMP-2 is expressed in normal adult rat liver and negatively regulates hepatocyte proliferation. The observed down regulation of BMP-2 following partial hepatectomy suggests that such down regulation may be necessary for hepatocyte proliferation. | Cui-Ping Xu Wen-Min Ji Gijs R van den Brink Maikel P Peppelenbosch | 2006 | World Journal of Gastroenterology2006，12，47： | 10 |
| 2 | Adhesive wear mechanisms uncovered by atomistic simulations显示文摘In this review, we discuss our recent advances in modeling adhesive wear mechanisms using coarse-grained atomistic simulations. In particular, we present how a model pair potential reveals the transition from ductile shearing of an asperity to the formation of a debris particle. This transition occurs at a critical junction size, which determines the particle size at its birth. Atomistic simulations also reveal that for nearby asperities, crack shielding mechanisms result in a wear volume proportional to an effective area larger than the real contact area. As the density of microcontacts increases with load, we propose this crack shielding mechanism as a key to understand the transition from mild to severe wear. We conclude with open questions and a road map to incorporate these findings in mesoscale continuum models. Because these mesoscale models allow an accurate statistical representation of rough surfaces, they provide a simple means to interpret classical phenomenological wear models and wear coefficients from physics-based principles. | Jean-Fran?ois MOLINARI Ramin AGHABABAEI Tobias BRINK Lucas FRéROT Enrico MILANESE | 2018 | Friction2018，6，3： | 6 |
| 3 | 中加两国精神障碍患者无责任能力评定跨文化比较研究显示文摘目的 :对中国湖南省和加拿大BC省两地无责任能力精神障碍患者人口学等资料进行比较 ,探讨不同的法律体系中无责任能力的精神障碍患者的基本特点。方法 :对两地已有的精神障碍患者责任能力评定数据库进行整合 ;共提取年龄、性别、婚姻、教育、犯罪史、精神病史、鉴定时案型、诊断 8个变量进行统计处理 ;BC组和湖南组入组病例数分别为 2 73例和 35 4例。结果 :除性别和精神病史外 ,其他各变量差异显著。BC组的离婚率、犯罪史、最高教育程度明显高于湖南组 ,评估时年龄明显大于湖南组 ;而湖南组的严重犯罪和精神分裂症的诊断比例明显高于BC组 (P均 <0 .0 1)。结论 :不同的法律体系。 | 王小平 Murphy E Brink J Livingston JD | 2004 | 中国临床心理学杂志2004，12，4： | 4 |
| 4 | 复杂性区域疼痛综合征和纤维肌痛病人的身体变化及感官敏感度显示文摘复杂性区域性疼痛综合征(CRPS)和纤维肌痛都是病因不明的慢性疼痛性疾病。除了诊断标准中的症状外,病人还可主诉视力以及其他感觉或身体机能的变化。目前尚不清楚这些症状是否与年龄增长、持续的慢性疼痛或慢性疼痛的常见共患病(如抑郁或焦虑)有关。本文作者进行了一项在线调查,纳入CRPS(n=390)、纤维肌痛(n=425)以及同时患有CRPS和纤维肌痛(n=88)的病人,评估他们的躯体症状、身体变化以及感官敏感度的频率和类型的改变,并与其他慢性疼痛病人对照组(n=331)和无疼痛对照组(n=441)相比较。该调查评估了躯体症状(病人健康问卷,Patient health questionnaire-15,PHQ-15)、身体变化、疼痛/不适/困扰的诱发因素和疼痛的加剧因素。将年龄、性别、抑郁症量表(patient health questionnaire-9,PHQ-9)、广泛性焦虑障碍量表(generalized anxiety disorder,GAD-7)、疼痛持续时间、每天疼痛时间和与疼痛相关的诊断数量作为协变量分析其协方差。在控制协变量后,CRPS和/或纤维肌痛病人的躯体症状、身体变化包括运动及生理反应的变化、疼痛、不适、困扰的诱发因素和疼痛加剧因素均多于其他慢性疼痛及无疼痛对照组的病人。纤维肌痛与视力、听力、泌尿/肠道功能及饮食的改变相关。CRPS与头发、皮肤和指甲的改变相关,且与感染和愈合相关。同时患有CRPS和纤维肌痛的病人表现出这两种疾病的特征,除此之外,基本无其他症状。本研究的发现提示:尽管其具体的机制可能不同,但CRPS和纤维肌痛有共同的病理生理学基础。 | Ten Brink AF Peters L Kompouli PI 商澜镨(译) 李水清(校) | 2021 | 中国疼痛医学杂志2021，27，3： | 3 |
| 5 | Superconducting single-photon detectors integrated with diamond nanophotonic circuits显示文摘Photonic quantum technologies hold promise to repeat the success of integrated nanophotonic circuits in non-classical applications.Using linear optical elements,quantum optical computations can be performed with integrated optical circuits and can therefore overcome the existing limitations in terms of scalability.In addition to passive optical devices for realizing photonic quantum gates,active elements,such as single-photon sources and single-photon detectors,are essential ingredients for future optical quantum circuits.Material systems that allow for the monolithic integration of all components are particularly attractive,including III-V semiconductors,silicon and diamond.Here,we demonstrate nanophotonic integrated circuits made from high-quality polycrystalline diamond thin films in combination with on-chip single-photon detectors.By using superconducting nanowires that are coupled evanescently to traveling waves,we achieve high detection efficiencies of up to 66%as well as low dark count rates and a timing resolution of 190 ps.Our devices are fully scalable and hold promise for functional diamond photonic quantum devices. | Patrik Rath Oliver Kahl Simone Ferrari Fabian Sproll Georgia Lewes-Malandrakis Dietmar Brink Konstantin Ilin Michael Siegel Christoph Nebel Wolfram Pernice | 2015 | Light(Science & Applications)2015，4，1： | 3 |
| 6 | Past,present and future of industrial plantation forestry and implication on future timber harvesting technology显示文摘Plantation forests are established,and expanding,to satisfy increasing global demand for timber products.Shifting societal values,such as safety,productivity,environmental,quality and social are influencing the plantation forestry sector.This is primarily driven through an ever increasing world population,which in turn influences the way nations view the value systems by which they live.More people require more resources-also forest products.Also,the availability of information is influencing the pace of technological development.These changes could result in a difference in the management of plantations that could affect the forest engineering systems of the future.This review aimed to summarize the current status of plantation forests;summarize future developments and possible scenarios in forest plantation management for the various products;and assess whether these developments in a plantation environment could affect the harvesting systems used.Factors influencing the form of plantations include the type and nature of the plantation owner;the change in demand for different and new forest products;climate change factors,including the use of biomass for energy,carbon sequestration and trading;ecosystem services and other products and services;and sustainability certification of forest management.The impact and influence of these factors were summarised into a series of key drivers that will influence the technology used in harvesting machines,as well as the choice of harvesting machines,systems and methods.These drivers were the effect of variations in tree size,the expansion of plantation areas onto more difficult terrain,diversity in plantation design,increased attention towards site impacts and the increased use of biomass for energy.Specific information is provided regarding how the harvesting systems could be affected. | Andrew McEwan Enrico Marchi Raffaele Spinelli Michal Brink | 2020 | Journal of Forestry Research2020，31，2： | 3 |
| 7 | Comprehensive scan for nonmagnetic Weyl semimetals with nonlinear optical response显示文摘First-principles calculations have recently been used to develop comprehensive databases of nonmagnetic topological materials that are protected by time-reversal or crystalline symmetry.However,owing to the low symmetry requirement of Weyl points,a symmetry-based approach to identifying topological states cannot be applied to Weyl semimetals(WSMs).To date,WSMs with Weyl points in arbitrary positions are absent from the well-known databases. | Qiunan Xu Yang Zhang Klaus Koepernik Wujun Shi Jeroen van den Brink Claudia Felser Yan Sun | 2020 | npj Computational Materials2020，，1： | 3 |
| 8 | Lgr5 +ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro显示文摘 | Nick Barker Meritxell Huch Pekka Kujala Marc van de Wetering Hugo J. Snippert Johan H. van Es Toshiro Sato Daniel E. Stange Harry Begthel Maaike van den Born Esther Danenberg Stieneke van den Brink Jeroen Korving Arie Abo Peter J. Peters Nick Wright Richa | 2010 | Cell Stem Cell2010，，1： | 2 |
| 9 | Regulatory macrophages induced by infliximab are involved in healing in vivo and in vitro显示文摘 | Anne Christine W.Vos Manon E.Wildenberg IngridArijs MarjolijnDuijvestein Auke P.Verhaar Gertde Hertogh SéverineVermeire PaulRutgeerts Gijs R.van den Brink Daniel W.Hommes | 2012 | Inflamm Bowel Dis2012，，3： | 2 |
| 10 | Formation of polychlorinated benzenes during the catalytic combustion of chlorobenzene using a Pt/v-Al2O3 catalyst显示文摘 | R W von den Brink R Louw P Mulder | 1998 | Applied Catalysis B:Environmental1998，16，： | 2 |
| 11 | Involuntary admission and treatment of patients with mental disorder显示文摘Despite the efforts of the World Health Organization to internationally standardize strategies for mental-health care delivery,the rules and regulations for involuntary admission and treatment of patients with mental disorder still differ markedly across countries. This review was undertaken to describe the regulations and mental-health laws from diverse countries and districts of Europe(UK,Austria,Denmark,France,Germany,Italy,Ireland,and Norway),the Americas(Canada,USA,and Brazil),Australasia(Australia and New Zealand),and Asia(Japan and China). We outline the criteria and procedures for involuntary admission to psychiatric hospitals and to community services,illustrate the key features oflaws related to these issues,and discuss their implications for contemporary psychiatric practice. This review may help to standardize the introduction oflegislation that allows involuntary admission and treatment of patients with mental disorders in the mainland of China,and contribute to improved mental-health care. In this review,involuntary admission or treatment does not include the placement of mentally-ill offenders,or any other aspect of forensic psychiatry. | Simei Zhang Graham Mellsop Johann Brink Xiaoping Wang | 2015 | Neuroscience Bulletin2015，31，1： | 2 |
| 12 | Analysis the presence and physiological relevance of subcanducting states of connexin 43-derived gap junction channels in cultured human corporal vascular smooth muscle cells 显示文摘 | Christ GJ Brink PR | 1999 | Circ Res1999，84，7： | 1 |
| 13 | Hedgehog signaling in development and homeostasis of the gastrointestinal tract 显示文摘 | van den Brink GR | 2007 | Physiol Rev2007，87，4： | 1 |
| 14 | Coronary side-effect potential of current and prospective antimigraine drugs 显示文摘 | Reekers M Bax WA Ferrari MD | 1998 | Circulation1998，98，1： | 1 |
| 15 | Prosthetic heart valves:Catering for the few显示文摘 | Brink J Human P Bezuidenhout D | 2008 | Biomaterials2008，29，4： | 1 |
| 16 | The sonographic diagnosis of acute gangrenous cholecystitis:importance of the Murphy sign 显示文摘 | Simeone JF Brink JA Mueler PR | 1989 | A JR Am J Roentgenol1989，152，2： | 1 |
| 17 | The value of indicated computed tomography scan of the chest and abdomen in addition to the conventional radiologic work-up for blunt trauma patients显示文摘 | Deunk J Dekker H M Brink M | 2007 | J Trauma2007，63，4： | 1 |
| 18 | Rare earth major and trace elements in chert from the Franciscan complex and Monterey Group,California, Assessing REE sources to finegrained marine sediments显示文摘 | Murray R W Buchholtz T Brink M R | 1991 | Geochimica et Cosmochimica Acta1991，55，： | 1 |
| 19 | Molecular and biological characterization of human monoclonal antibodies bingding to the spike and nucleocapsid proteins of Severe Acute Respiratory Syndrome Coronavirus显示文摘 | Van den Brink E N Meulen J Cox F | 2005 | J Virol2005，79，： | 1 |
| 20 | Desorption of LiAlH4 with Ti-and V-based additives显示文摘 | Blanchard D Brinks H W Hauback B C | 2004 | Mater Sci Eng2004，108，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员